Pub Date : 2018-12-01DOI: 10.21608/ejfs.2018.85916
K. Selim, Laila A. Rabee, Mohammed Abdel-Bary, -. MagdaAbdel, Baki
In recent years, liver diseases became one of the very important worldwide health problems (Kavitha et al. 2011). Liver was found to be subjected to recurrent metabolic insults because of it is accomplish an indispensable assignment in detoxification, metabolism of a variety of drugs and xenobiotics and exposure to toxic chemicals including insecticides, pesticides and environmental pollutants (Sethuraman, 2003). CCl 4 was reported to be used in animal models to study the chemical toxin-induced liver damage (Elbakry et al., 2017). The toxicity of CCl 4 is attributed to its metabolized and producing a highly reactive free radicals and oxygen species which lead to lipid peroxidation of cell lipid and liver injury (Manickam et al., 2017). The hepatocyte injury of liver including that relating to CCl 4 was found to activate the Kupffer cells which promote tissue damage (Muriel and Escobar, 2003).
近年来，肝脏疾病成为世界范围内非常重要的健康问题之一(kavavitha et al. 2011)。由于肝脏在解毒、各种药物和外源药物的代谢以及暴露于包括杀虫剂、杀虫剂和环境污染物在内的有毒化学物质中发挥着不可或缺的作用，因此肝脏被发现会受到反复的代谢损伤(Sethuraman, 2003)。据报道，CCl - 4被用于动物模型研究化学毒素引起的肝损伤(Elbakry et al.， 2017)。ccl4的毒性归因于其代谢并产生高度活性的自由基和氧，导致细胞脂质过氧化和肝脏损伤(Manickam et al.， 2017)。肝脏的肝细胞损伤，包括与ccl4相关的损伤，被发现可以激活Kupffer细胞，从而促进组织损伤(Muriel和Escobar, 2003)。
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