NmrA-like proteins are NAD(P) (H) interacting molecules whose structures are similar to that of short-chain dehydrogenases. In this review, we focus on an NADP(H) sensor, HSCARG (also named NMRAL1), which is a NmrA-like protein that is widely present in mammals, and provide a comprehensive overview of the current knowledge of its structure and physiological functions. HSCARG selectively binds to the reduced form of type II coenzyme NADPH via its Rossmann fold domain. In response to reduction of intracellular NADPH concentration, HSCARG transforms from homodimer to monomer and exhibits enhanced interactions with its binding partners. In the cytoplasm, HSCARG negatively regulates innate immunity through impairing the activities of NF- κ B and RLR pathways. Besides, HSCARG regulates redox homeostasis via suppression of ROS and NO generation. Intensive and persistent oxidative stress leads to translocation of HSCARG from the cytoplasm to the nucleus, where it regulates the DNA damage response. Taken together, HSCARG functions as a linkage between cellular redox status and other signaling pathways and fine-tunes cellular response to redox changes.
{"title":"FREE","authors":"R. L. Pritchard, K. Meyer-Abich","doi":"10.2307/j.ctv29cz0bm.26","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.26","url":null,"abstract":"NmrA-like proteins are NAD(P) (H) interacting molecules whose structures are similar to that of short-chain dehydrogenases. In this review, we focus on an NADP(H) sensor, HSCARG (also named NMRAL1), which is a NmrA-like protein that is widely present in mammals, and provide a comprehensive overview of the current knowledge of its structure and physiological functions. HSCARG selectively binds to the reduced form of type II coenzyme NADPH via its Rossmann fold domain. In response to reduction of intracellular NADPH concentration, HSCARG transforms from homodimer to monomer and exhibits enhanced interactions with its binding partners. In the cytoplasm, HSCARG negatively regulates innate immunity through impairing the activities of NF- κ B and RLR pathways. Besides, HSCARG regulates redox homeostasis via suppression of ROS and NO generation. Intensive and persistent oxidative stress leads to translocation of HSCARG from the cytoplasm to the nucleus, where it regulates the DNA damage response. Taken together, HSCARG functions as a linkage between cellular redox status and other signaling pathways and fine-tunes cellular response to redox changes.","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123831610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerry is visiting her brother, Mike, for the first tme in his new home. She sees a sign for a fortune teller. Mike doesn't believe in fortune tellers, but he goes, too. What does Rosie say to him? And is she right?
{"title":"GOOD DAY, BAD DAY","authors":"P. Shipton","doi":"10.2307/j.ctv29cz0bm.15","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.15","url":null,"abstract":"Kerry is visiting her brother, Mike, for the first tme in his new home. She sees a sign for a fortune teller. Mike doesn't believe in fortune tellers, but he goes, too. What does Rosie say to him? And is she right?","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126922156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One day last January, I pulled my bicycle out of the garage and pedaled for the nearest Barnes and Noble. I was looking for a new book by Philip Dray, At the Hands of Persons Unknown: The Lynching of Black America, already praised in The New Yorker and elsewhere. I suppose all shoppers instinctively understand that the managers of bookstores organize their inventory in a strict hierarchy. Just inside the front door I encountered the bargain bins. Passing through a second door, I squarely confronted the first display table, exhibiting the hot new books, including novels by Nevada Barr and John Grisham.
去年1月的一天，我把自行车从车库里拖出来，骑车去了最近的巴诺书店(Barnes and Noble)。我正在寻找菲利普·德雷的新书《在无名之人手中:美国黑人的私刑》，这本书已经在《纽约客》和其他地方得到了好评。我想所有的顾客都本能地知道书店的经理们是按照严格的等级来组织他们的存货的。就在前门，我遇到了廉价的垃圾箱。穿过第二扇门，我正对着第一张展示桌，上面陈列着热门新书，包括内华达·巴尔和约翰·格里沙姆的小说。
{"title":"INVISIBLE","authors":"Christopher R. Waldrep, P. Dray, Jack Robinson","doi":"10.2307/j.ctv29cz0bm.9","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.9","url":null,"abstract":"One day last January, I pulled my bicycle out of the garage and pedaled for the nearest Barnes and Noble. I was looking for a new book by Philip Dray, At the Hands of Persons Unknown: The Lynching of Black America, already praised in The New Yorker and elsewhere. I suppose all shoppers instinctively understand that the managers of bookstores organize their inventory in a strict hierarchy. Just inside the front door I encountered the bargain bins. Passing through a second door, I squarely confronted the first display table, exhibiting the hot new books, including novels by Nevada Barr and John Grisham.","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115011447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Fox, Michael Richeson, J. Lloyd, Kimberly Felton, Barry Hubbell
{"title":"LOOKING FOR HOPE","authors":"G. Fox, Michael Richeson, J. Lloyd, Kimberly Felton, Barry Hubbell","doi":"10.2307/j.ctv29cz0bm.14","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.14","url":null,"abstract":"","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121150122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seit Henry David Thoreaus »Walden, or, Life in the Woods« (1854) etabliert sich das Nachdenken und Schreiben über Wildnis als Dreh- und Angelpunkt des geschichtlichen, kulturellen und politischen Selbstverständnisses der USA. Arno Heller stellt die Formen dieser Auseinandersetzung von ihren Anfängen bis in die unmittelbare Gegenwart vor und entfaltet ein kulturhistorisch ungemein aufschlussreiches Panorama, das in der europäischen und deutschen Kultur keine Entsprechung hat. Nicht nur die großen Erinnerungsorte in Neuengland, wo die zentralen Fragen nach nationaler Identität erstmals gestellt wurden, sondern auch diese Wilderness-Texte widerlegen eindrucksvoll das europäische Vorurteil eines geschichtslosen Amerikas. Vor nur 200 Jahren war die gesamte Westhälfte des amerikanischen Kontinents eine spärlich bewohnte Wildnis. In einem gewaltigen Kraftakt gelang es der berühmt-berüchtigten ›Westexpansion‹, dieses riesige Territorium zu ›erobern‹ und der ›westlichen Zivilisation‹ zugänglich zu machen. Diese Erfahrung blieb als prägendes Urerlebnis im kollektiven Bewusstsein Nordamerikas lebendig. Sie brachte einen spezifischen Mythos der Wildnis hervor, der bis heute in zahllosen Büchern und Filmen nachwirkt. Trotz der enormen Vielfalt von Schauplätzen, Charakteren und individuellen Zugängen zeichnet sich dabei ein wiederkehrendes Strukturmuster ab: Die Protagonisten sind wilderness-Enthusiasten, Einzelgängerinnen, survival-Abenteurer, zivilisationsmüde Aussteiger, patriarchalisch traumatisierte Frauen, Naturforscherinnen und spirituelle Sinnsucher. Sie unternehmen eine äußere Reise aus der Zivilisation in eine unberührte Wildnis, die sich zu einer »inneren Landschaft« ausweitet und einen tiefgreifenden persönlichen Wandel auslöst.
{"title":"WILDERNESS","authors":"A. Heller","doi":"10.2307/j.ctv29cz0bm.24","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.24","url":null,"abstract":"Seit Henry David Thoreaus »Walden, or, Life in the Woods« (1854) etabliert sich das Nachdenken und Schreiben über Wildnis als Dreh- und Angelpunkt des geschichtlichen, kulturellen und politischen Selbstverständnisses der USA.\u0000 Arno Heller stellt die Formen dieser Auseinandersetzung von ihren Anfängen bis in die unmittelbare Gegenwart vor und entfaltet ein kulturhistorisch ungemein aufschlussreiches Panorama, das in der europäischen und deutschen Kultur keine Entsprechung hat. Nicht nur die großen Erinnerungsorte in Neuengland, wo die zentralen Fragen nach nationaler Identität erstmals gestellt wurden, sondern auch diese Wilderness-Texte widerlegen eindrucksvoll das europäische Vorurteil eines geschichtslosen Amerikas.\u0000 Vor nur 200 Jahren war die gesamte Westhälfte des amerikanischen Kontinents eine spärlich bewohnte Wildnis. In einem gewaltigen Kraftakt gelang es der berühmt-berüchtigten ›Westexpansion‹, dieses riesige Territorium zu ›erobern‹ und der ›westlichen Zivilisation‹ zugänglich zu machen. Diese Erfahrung blieb als prägendes Urerlebnis im kollektiven Bewusstsein Nordamerikas lebendig. Sie brachte einen spezifischen Mythos der Wildnis hervor, der bis heute in zahllosen Büchern und Filmen nachwirkt. Trotz der enormen Vielfalt von Schauplätzen, Charakteren und individuellen Zugängen zeichnet sich dabei ein wiederkehrendes Strukturmuster ab: Die Protagonisten sind wilderness-Enthusiasten, Einzelgängerinnen, survival-Abenteurer, zivilisationsmüde Aussteiger, patriarchalisch traumatisierte Frauen, Naturforscherinnen und spirituelle Sinnsucher. Sie unternehmen eine äußere Reise aus der Zivilisation in eine unberührte Wildnis, die sich zu einer »inneren Landschaft« ausweitet und einen tiefgreifenden persönlichen Wandel auslöst.","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"67 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130045865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE DANCE","authors":"L. Martinez, G. Brooks, Tony Arata","doi":"10.2307/j.ctv29cz0bm.18","DOIUrl":"https://doi.org/10.2307/j.ctv29cz0bm.18","url":null,"abstract":"","PeriodicalId":114558,"journal":{"name":"Bipolar Faith","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126315278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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