Pub Date : 2023-12-03DOI: 10.21608/ejchem.2023.247180.8829
zeinab Belal, E. A. Abou El-Anwar, Salman Salman, El monster Seleem, Ahmed A. Asmoay
{"title":"Rare Earth Elements in Nile sediments at Luxor and Aswan Districts: geochemistry, enrichment and environmental impact","authors":"zeinab Belal, E. A. Abou El-Anwar, Salman Salman, El monster Seleem, Ahmed A. Asmoay","doi":"10.21608/ejchem.2023.247180.8829","DOIUrl":"https://doi.org/10.21608/ejchem.2023.247180.8829","url":null,"abstract":"","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"25 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.236460.8616
Mohamed Nasr, Mervat Elsedik, Yehia Youssef
{"title":"Removal of Anthraquinone Dyes from Aqueous Solutions Using Activated Carbon Fiber Prepared from Polyacrylonitrile Waste","authors":"Mohamed Nasr, Mervat Elsedik, Yehia Youssef","doi":"10.21608/ejchem.2023.236460.8616","DOIUrl":"https://doi.org/10.21608/ejchem.2023.236460.8616","url":null,"abstract":"","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":" 29","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.243862.8757
Manar Ayman, Sobhi M. Gomha, Magda Abdallah, doaa ElNashar, AbdelMohsen Soliman, Huda R. M. Rashdan
Acetyl thiazole thiosemicarbazone 3 was used as key intermediate for preparation of novel series of thiazolylhydrazono thiazole derivatives via reaction of 3 with two types of hydrazonoyl halides. Also, compound 3 reacted with α-haloketones and α-haloester in ethanol or in acetic acid containing anhydrous sodium acetate under reflux to give another new thiazole based compounds. Addionally, the
{"title":"In Sight into Innovative Cancer Therapeutic Approach Based on Nanotechnology: Chitosan (CS) / Polyvinyl alcohol (PVA) Films loaded with Synthesized Bisthiazole Derivative for Cancer Treatment","authors":"Manar Ayman, Sobhi M. Gomha, Magda Abdallah, doaa ElNashar, AbdelMohsen Soliman, Huda R. M. Rashdan","doi":"10.21608/ejchem.2023.243862.8757","DOIUrl":"https://doi.org/10.21608/ejchem.2023.243862.8757","url":null,"abstract":"Acetyl thiazole thiosemicarbazone 3 was used as key intermediate for preparation of novel series of thiazolylhydrazono thiazole derivatives via reaction of 3 with two types of hydrazonoyl halides. Also, compound 3 reacted with α-haloketones and α-haloester in ethanol or in acetic acid containing anhydrous sodium acetate under reflux to give another new thiazole based compounds. Addionally, the","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"48 12","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.245709.8801
Islam Ragab, Rasha Abd El-Hady
Alkylation of pyridine 1a,b with 3-chloropropanol, 1,3-dichloroisopropanol, epichlorohydrin and methyl bromoacetate under microwave irradiation afforded N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(4-isopropylphenyl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide (2a), N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(thiophen-2-yl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide
{"title":"Study of the Biological Activity of Microwave Synthesized of some new Pyridine derivatives fused with Sulfonamide Moiety","authors":"Islam Ragab, Rasha Abd El-Hady","doi":"10.21608/ejchem.2023.245709.8801","DOIUrl":"https://doi.org/10.21608/ejchem.2023.245709.8801","url":null,"abstract":"Alkylation of pyridine 1a,b with 3-chloropropanol, 1,3-dichloroisopropanol, epichlorohydrin and methyl bromoacetate under microwave irradiation afforded N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(4-isopropylphenyl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide (2a), N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(thiophen-2-yl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"37 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.238209.8653
Ehab Zayed, Wael A. El-Sayed, Hayam A. Abd El Salam, Gehad Mohamed
The goal of our current research is to create novel compounds of Co(II), Ni(II), Cu(II), Cr(III), Fe(III) and Zn(II) metal ions from heterocyclic dioxatetraaza ligand by the reaction of N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine)with 2,2'-(ethane-1,2-diylbis(oxy))dibenzaldehyde to find out combating agent against microorganism diseases. Various physicochemical and spectroscopic techniques, including FT-IR, 1H and magnetic susceptibility, mass spectrometry, TGA, and others, were used to precisely characterize the synthesized compounds. These techniques suggested that the complexes' octahedral geometry was formed by epoxy oxygen atoms, azomethine nitrogen atomsof the dioxatetraaza ligand, and oxygen from the water molecules. The compounds' in vitro antibacterial activity against two bacterial and fungal pathogens was evaluated using the serial dilution method. Theoretical molecular docking was used to confirm these findings.
{"title":"Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.","authors":"Ehab Zayed, Wael A. El-Sayed, Hayam A. Abd El Salam, Gehad Mohamed","doi":"10.21608/ejchem.2023.238209.8653","DOIUrl":"https://doi.org/10.21608/ejchem.2023.238209.8653","url":null,"abstract":"The goal of our current research is to create novel compounds of Co(II), Ni(II), Cu(II), Cr(III), Fe(III) and Zn(II) metal ions from heterocyclic dioxatetraaza ligand by the reaction of N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine)with 2,2'-(ethane-1,2-diylbis(oxy))dibenzaldehyde to find out combating agent against microorganism diseases. Various physicochemical and spectroscopic techniques, including FT-IR, 1H and magnetic susceptibility, mass spectrometry, TGA, and others, were used to precisely characterize the synthesized compounds. These techniques suggested that the complexes' octahedral geometry was formed by epoxy oxygen atoms, azomethine nitrogen atomsof the dioxatetraaza ligand, and oxygen from the water molecules. The compounds' in vitro antibacterial activity against two bacterial and fungal pathogens was evaluated using the serial dilution method. Theoretical molecular docking was used to confirm these findings.","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"390 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.244506.8770
Salma A. Ellithy, Adel A-H Abdel-Rahman, Nasser A. Hassan, Mohamed Elsawalhy, E. Abou‐Amra, Allam Hassan
In this research, we successfully synthesized a distinctive group of iminothiazolidinone derivatives, using glucose isothiocyanate as the starting material. The structural elucidation of these newly created compounds was achieved through a combination of analytical techniques, including IR, 1 H NMR, and 13 C NMR. We then evaluated the inhibitory activity of these compounds against acetylcholinesterase (AChE) using the Ellman's method spectrophotometer, comparing their performance to standard drugs like donepezil, rivastigmine, and tacrine. Impressively, the majority of the tested compounds demonstrated inhibitory activity against AChE, with iminothiazolidinone derivative (5a) standing out as the most potent (IC 50 = 0.209 μ g/mL). It even surpassed the effectiveness of rivastigmine and tacrine, coming close to the potency of donepezil. Further investigation into the potential of these compounds as AChE inhibitors for Alzheimer's disease drug development involved docking simulations using Molecular Operating Environment (MOE). Derivatives 3,5-disubstituted-(2,3,4,6-tetra-o-acetyl-β -D- glucopyranosyl) imino) thiazolidin-4-ones (5a), (5f), (6c) and 3,5-disubstituted-( β -D-glucopyranosyl)imino)thiazolidin-4-one (6d) displayed promising docking scores in MOE simulations. In Silico ADMET experiments assessed their pharmacokinetic and toxicity studies, demonstrating strong binding affinity and favorable interactions with the target protein. Pharmacophore models confirmed their potential as selective enzyme inhibitors through 3D virtual screening.
{"title":"Glycosyl Thiourea: Synthesis, Cyclization, Reaction, Molecular Docking, and Evaluation as Potential Acetylcholinesterase Inhibitors","authors":"Salma A. Ellithy, Adel A-H Abdel-Rahman, Nasser A. Hassan, Mohamed Elsawalhy, E. Abou‐Amra, Allam Hassan","doi":"10.21608/ejchem.2023.244506.8770","DOIUrl":"https://doi.org/10.21608/ejchem.2023.244506.8770","url":null,"abstract":"In this research, we successfully synthesized a distinctive group of iminothiazolidinone derivatives, using glucose isothiocyanate as the starting material. The structural elucidation of these newly created compounds was achieved through a combination of analytical techniques, including IR, 1 H NMR, and 13 C NMR. We then evaluated the inhibitory activity of these compounds against acetylcholinesterase (AChE) using the Ellman's method spectrophotometer, comparing their performance to standard drugs like donepezil, rivastigmine, and tacrine. Impressively, the majority of the tested compounds demonstrated inhibitory activity against AChE, with iminothiazolidinone derivative (5a) standing out as the most potent (IC 50 = 0.209 μ g/mL). It even surpassed the effectiveness of rivastigmine and tacrine, coming close to the potency of donepezil. Further investigation into the potential of these compounds as AChE inhibitors for Alzheimer's disease drug development involved docking simulations using Molecular Operating Environment (MOE). Derivatives 3,5-disubstituted-(2,3,4,6-tetra-o-acetyl-β -D- glucopyranosyl) imino) thiazolidin-4-ones (5a), (5f), (6c) and 3,5-disubstituted-( β -D-glucopyranosyl)imino)thiazolidin-4-one (6d) displayed promising docking scores in MOE simulations. In Silico ADMET experiments assessed their pharmacokinetic and toxicity studies, demonstrating strong binding affinity and favorable interactions with the target protein. Pharmacophore models confirmed their potential as selective enzyme inhibitors through 3D virtual screening.","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"88 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/ejchem.2023.241973.8775
Moustafa Mansour, Magdy Saber, Reda Ahmed, Khamis Youssef
A survey of some fungal diseases on date palm trees recorded the highest disease incidence (DI %) at Giza, New Valley, Aswan, El Beheira and El Sharkia governorates. Alternaria alternata recorded the most frequency (67.38%) followed by Nigrospora
{"title":"Biological, Chemical and Electrolyzed Water Methods for Controlling some Date Palm Diseases in Egypt","authors":"Moustafa Mansour, Magdy Saber, Reda Ahmed, Khamis Youssef","doi":"10.21608/ejchem.2023.241973.8775","DOIUrl":"https://doi.org/10.21608/ejchem.2023.241973.8775","url":null,"abstract":"A survey of some fungal diseases on date palm trees recorded the highest disease incidence (DI %) at Giza, New Valley, Aswan, El Beheira and El Sharkia governorates. Alternaria alternata recorded the most frequency (67.38%) followed by Nigrospora","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":" 7","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138618061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Synthesis and Characterization of Azoles, Azines and Azepines Based on Cinnamoyl Thiourea Derivatives","authors":"Islam Ragab","doi":"10.21608/ejchem.2023.243272.8798","DOIUrl":"https://doi.org/10.21608/ejchem.2023.243272.8798","url":null,"abstract":"(Acryloyl)thioureido)benzoic acid) derivative 3a-c was obtained by reacting cinnamoyl isothiocyanate 2a-c with 2-aminobenzoic","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"246 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139016056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-29DOI: 10.21608/ejchem.2023.243470.8748
Mohamed Abouzeid, Mohamed Ibrahim
{"title":"Multi-step differential transform method for both Hall currents and mixed convection effects on MHD flow of non-Newtonian fluid with Al2 O3 nanoparticles","authors":"Mohamed Abouzeid, Mohamed Ibrahim","doi":"10.21608/ejchem.2023.243470.8748","DOIUrl":"https://doi.org/10.21608/ejchem.2023.243470.8748","url":null,"abstract":"","PeriodicalId":11498,"journal":{"name":"Egyptian Journal of Chemistry","volume":"24 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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