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Clinical utility of salivary cortisol for diagnosis and therapeutic monitoring in adrenal insufficiency. 唾液皮质醇在肾上腺功能不全诊断和治疗监测中的临床应用。
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1007/s12020-025-04455-w
Pablo Fernández-Velasco, Inés Anibarro Miralles, Sara Rubio Lanchas, Beatriz Torres Torres, Ana Ortolá Buigues, Emilia Gómez Hoyos, Wysali Trapiello Fernández, Dolores Calvo Nieves, Daniel de Luis Román, Gonzalo Díaz-Soto
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引用次数: 0
Neuroendocrine tumors in patients with inflammatory bowel disease: a case series. 炎性肠病患者的神经内分泌肿瘤：一个病例系列
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1007/s12020-025-04465-8
Roberta Elisa Rossi, Benedetta Masoni, Giulia Migliorisi, Cristina Bezzio, Alexia Francesca Bertuzzi, Silvia Uccella, Andrea Gerardo Antonio Lania, Alessandro Zerbi, Antonino Spinelli, Cesare Hassan, Alessandro Repici, Alessandro Armuzzi
{"title":"Neuroendocrine tumors in patients with inflammatory bowel disease: a case series.","authors":"Roberta Elisa Rossi, Benedetta Masoni, Giulia Migliorisi, Cristina Bezzio, Alexia Francesca Bertuzzi, Silvia Uccella, Andrea Gerardo Antonio Lania, Alessandro Zerbi, Antonino Spinelli, Cesare Hassan, Alessandro Repici, Alessandro Armuzzi","doi":"10.1007/s12020-025-04465-8","DOIUrl":"10.1007/s12020-025-04465-8","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1168-1172"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal function, morbidity and mortality in patients with COVID-19. COVID-19患者的肾上腺功能、发病率和死亡率。
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1007/s12020-025-04401-w
Karina Rozenfeld, Elad Shemesh, Elena Izkhakov, Miguel M Moshiashvili, Eugene Feigin, Ilana Goldiner, Ben-Zion Katz, Karen Tordjman, Gabi Shefer, Yona Greenman
{"title":"Adrenal function, morbidity and mortality in patients with COVID-19.","authors":"Karina Rozenfeld, Elad Shemesh, Elena Izkhakov, Miguel M Moshiashvili, Eugene Feigin, Ilana Goldiner, Ben-Zion Katz, Karen Tordjman, Gabi Shefer, Yona Greenman","doi":"10.1007/s12020-025-04401-w","DOIUrl":"10.1007/s12020-025-04401-w","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1490-1500"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification system of ultrasound patterns of non-nodular thyroid diseases. 甲状腺非结节性疾病的超声图像分类系统。
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1007/s12020-025-04460-z
Pierpaolo Trimboli, Jörg Bojunga
{"title":"Classification system of ultrasound patterns of non-nodular thyroid diseases.","authors":"Pierpaolo Trimboli, Jörg Bojunga","doi":"10.1007/s12020-025-04460-z","DOIUrl":"10.1007/s12020-025-04460-z","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1089-1097"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Fructose and insulin: A sweet sabotage hypothesis? 更正：果糖和胰岛素：甜蜜破坏假说？
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 DOI: 10.1007/s12020-025-04466-7
Nazmi Özer, Özlem Dalmızrak, Salaheldin Elabiad, I Hamdi Öğüş
{"title":"Correction: Fructose and insulin: A sweet sabotage hypothesis?","authors":"Nazmi Özer, Özlem Dalmızrak, Salaheldin Elabiad, I Hamdi Öğüş","doi":"10.1007/s12020-025-04466-7","DOIUrl":"10.1007/s12020-025-04466-7","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1601"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of an accurate prediction system for gestational diabetes mellitus based on the characteristics of metabolic kinetics in early pregnancy: a prospective two-center cohort study in population according to IOM criteria. 基于妊娠早期代谢动力学特征的妊娠期糖尿病准确预测系统的建立：一项符合IOM标准的人群前瞻性双中心队列研究
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-11-06 DOI: 10.1007/s12020-025-04415-4
Junxiang Gao, Shuoning Song, Yanbei Duo, Xiaolin Qiao, Yuemei Zhang, Jiyu Xu, Jing Zhang, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Ailing Wang, Wei Sun, Yong Fu, Mengmeng Zhang, Yingyue Dong, Zechun Lu, Tao Yuan, Weigang Zhao
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引用次数: 0
Clinical outcomes and treatment adequacy assessment in congenital adrenal hyperplasia: A Single-Center experience with Long-Term Follow-Up. 先天性肾上腺增生的临床结果和治疗充分性评估：长期随访的单中心经验。
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1007/s12020-025-04411-8
Neslihan Koray Fedai, Ilknur Ozturk Unsal, Sema Hepsen, Bekir Ucan, Mustafa Ozbek, Erman Cakal
{"title":"Clinical outcomes and treatment adequacy assessment in congenital adrenal hyperplasia: A Single-Center experience with Long-Term Follow-Up.","authors":"Neslihan Koray Fedai, Ilknur Ozturk Unsal, Sema Hepsen, Bekir Ucan, Mustafa Ozbek, Erman Cakal","doi":"10.1007/s12020-025-04411-8","DOIUrl":"10.1007/s12020-025-04411-8","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1509-1517"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of the atherogenic index of plasma with the risk of cardiovascular disease and death among diabetic or prediabetic adults. 糖尿病或糖尿病前期成人血浆动脉粥样硬化指数与心血管疾病和死亡风险的关系
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1007/s12020-025-04416-3
Yang Wang, Zhengqin Ye, Wei Xu, Sijing Tang, Hemin Huang, Ping Fang, Miao Xuan, Keqin Zhang, Ying Xue, Qi Liu
{"title":"Association of the atherogenic index of plasma with the risk of cardiovascular disease and death among diabetic or prediabetic adults.","authors":"Yang Wang, Zhengqin Ye, Wei Xu, Sijing Tang, Hemin Huang, Ping Fang, Miao Xuan, Keqin Zhang, Ying Xue, Qi Liu","doi":"10.1007/s12020-025-04416-3","DOIUrl":"10.1007/s12020-025-04416-3","url":null,"abstract":"","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"1221-1232"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Evaluation of progranulin expression in parathyroid adenomas and its relationship with clinical parameters". 甲状旁腺瘤中颗粒前蛋白表达的评价及其与临床参数的关系
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-11-01 Epub Date: 2025-08-26 DOI: 10.1007/s12020-025-04391-9
Bilge Can Uyar, Nese Cinar, Yelda Dere, Onder Ozcan, Gulhan Akbaba

Purpose: In the pathogenesis of the primary hyperparathyroidism (PHPT), dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2), c-Jun N-terminal kinase (JNK), and phosphatidylinositol 3 kinase (PI3K) pathways. Progranulin (PGRN) is a glycoprotein found in many tissues and has been observed to activate MAPK, JNK, PI3K pathways in multiple studies. We aim to investigate the progranulin expression in parathyroid adenomas and establish its relationship with clinical parameters and comorbidities in patients with PHPT.

Methods: 182 cases were included in our study, consisting of 102 patients with PHPT and 80 controls. All cases with PHPT were operated and parathyroid adenomas were pathologically confirmed. The PGRN staining patterns were examined by applying anti-granulin (anti-GRN) antibody at 1/300 dilution to the parathyroid samples of the cases.

Results: Within the patient group, negative staining was observed in 59 (57.8%) samples, mild staining in 26 (25.5%) samples, and strong staining in 17 (16.7%) samples. In the control group, all samples showed strong staining. There was a significant decrease in PGRN staining in the patient group compared to the control group (p < 0.001). There was no significant relationship between the degree of PGRN staining and age, biochemical parameters in patients with PHPT. Patients were compared in terms of PHPT-related complications and PGRN expression, no significant difference was observed.

Conclusion: Our findings show that adenomas expressed lower PGRN compared to normal parathyroid tissue, suggesting that PGRN expression loss may play an important role in pathogenesis of parathyroid adenomas.

目的：在原发性甲状旁腺功能亢进症（PHPT）的发病机制中，细胞外信号调节1/2 （ERK /2）、c-Jun n末端激酶（JNK）和磷脂酰肌醇3激酶（PI3K）通路出现异常。前颗粒蛋白（PGRN）是一种存在于许多组织中的糖蛋白，在多项研究中发现它可以激活MAPK、JNK、PI3K通路。我们的目的是研究颗粒前蛋白在甲状旁腺瘤中的表达，并建立其与PHPT患者临床参数和合并症的关系。方法：182例PHPT患者102例，对照组80例。所有PHPT患者均行手术治疗，病理证实为甲状旁腺瘤。将抗颗粒蛋白（anti-GRN）抗体按1/300稀释至甲状旁腺样本，检测PGRN染色模式。结果：患者组阴性59例（57.8%），轻度染色26例（25.5%），强染色17例（16.7%）。在对照组中，所有样品均呈强染色。结论：我们的研究结果表明，腺瘤组织中PGRN的表达低于正常甲状旁腺组织，提示PGRN表达缺失可能在甲状旁腺瘤的发病机制中起重要作用。
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引用次数: 0
Machine learning in endocrinology: current applications and future perspectives. 内分泌学中的机器学习：当前应用和未来展望。
IF 2.9 3区 医学 Q2 Medicine
Endocrine
Pub Date : 2025-11-01 Epub Date: 2025-08-20 DOI: 10.1007/s12020-025-04378-6
Magdalena Kamińska, Małgorzata Trofimiuk-Müldner, Grzegorz Sokołowski, Alicja Hubalewska-Dydejczyk

Purpose: In recent years, endocrinology research has increasingly focused on machine learning (ML) applications. ML offers the possibility of utilizing large data sets and extracting imperceptible patterns. It might contribute in optimizing healthcare outcomes and unveiling new understandings of the intricate mechanisms of endocrine disorders. This review covers the basic aspects of ML and highlights specific areas of endocrinology with potential of ML application.

Methods: This narrative review with a systematic literature search comprises studies on endocrine conditions with ML methods used in statistical analysis, published between January 2000 and December 2024.

Results: A total of 1130 studies were analyzed. Thyroid-related research was the most prevalent, followed by studies concerning the pituitary, adrenal and parathyroid glands. ML applications included medical imaging analysis, tumor classification, treatment response prediction, complication risk estimation and identification of molecular markers.

Conclusion: ML has the potential to enhance the diagnosis, treatment and understanding of endocrine diseases. However, the use of ML is still limited by issues such as lack of model transparency, data imbalance and difficulties with clinical implementation. To enable safe and effective application of ML in endocrinology, further validation, interdisciplinary collaboration and standardized approaches are essential.

目的：近年来，内分泌学研究越来越关注机器学习（ML）的应用。ML提供了利用大型数据集和提取难以察觉的模式的可能性。它可能有助于优化医疗保健结果和揭示内分泌紊乱的复杂机制的新认识。本文综述了机器学习的基本方面，并重点介绍了具有机器学习应用潜力的内分泌学特定领域。方法：对2000年1月至2024年12月间发表的有关内分泌疾病的研究进行了系统的文献检索，并采用ML方法进行了统计分析。结果：共分析1130项研究。甲状腺相关的研究最为普遍，其次是垂体、肾上腺和甲状旁腺的研究。ML的应用包括医学影像分析、肿瘤分类、治疗反应预测、并发症风险评估和分子标记识别。结论：ML具有提高内分泌疾病诊断、治疗和认识的潜力。然而，ML的使用仍然受到模型缺乏透明度、数据不平衡和临床实施困难等问题的限制。为了使机器学习在内分泌学中安全有效的应用，进一步的验证、跨学科合作和标准化的方法是必不可少的。
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引用次数: 0
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