Aim/Background: First-line A significantly improved progression-free survival (PFS) vs CT in pts with EGFR mutation-positive NSCLC in the LL3 and LL6 trials (LL3: 11.1 vs 6.9 months, HR 0.58; p<0.001; LL6: 11.0 vs 5.6 months, HR 0.28; p<0.0001). Overall survival (OS) was significantly improved with Avs CT in pts with Del19 mutations (LL3: 33.3 vs 21.1 months, HR 0.54, p=0.0015; LL6: 31.4 vs 18.4 months, HR 0.64, p=0.023). The efficacyand safetyof Avs CT in pts aged ≥ 65 years in the LL3 and LL6 trials are reported. Methods: Pts with EGFR mutation-positive stage IIIB or IV NSCLC (345 in LL3 and 364 in LL6) were randomized 2:1 to oral A (40 mg/day) or up to 6 cycles of CT (LL3: cisplatin/pemetrexed; LL6: cisplatin/gemcitabine). Pts were stratified by EGFR mutation (Del19/L858R/other) and race (LL3 only; Asian/non-Asian). Analyses byage (<65, ≥ 65) were pre-specified for both trials, analyses byagewithin mutation subgroups were post-hoc. Results: In LL3 and LL6, 134 and 86 pts aged ≥ 65 years, respectively,were randomized. PFS was significantly improved with Avs CT in these pts (LL3: 13.6 vs 8.2 months, HR 0.60 [95% CI 0.37 – 0.96], p=0.03; LL6: 13.1 vs 4.1 months, HR 0.17 [95% CI 0.07 – 0.41], p<0.0001). OS was similar with Avs CT in all pts aged ≥ 65 years, with atrend towards improved OS with Avs CT noted in those with common EGFR mutations (LL3: 31.6 vs 24.9 months; HR 0.73
目的/背景:在LL3和LL6试验中，一线A治疗显著改善了EGFR突变阳性NSCLC患者的无进展生存期(PFS)和CT (LL3: 11.1个月vs 6.9个月，HR 0.58;p < 0.001;LL6: 11.0 vs 5.6个月，HR 0.28;p < 0.0001)。Del19突变患者的Avs CT显著改善了总生存期(OS) (LL3: 33.3 vs 21.1个月，HR 0.54, p=0.0015;LL6: 31.4 vs 18.4个月，HR 0.64, p=0.023)。在LL3和LL6试验中，Avs CT在年龄≥65岁的患者中的有效性和安全性被报道。方法:EGFR突变阳性的IIIB或IV期非小细胞肺癌患者(LL3 345例，LL6 364例)按2:1随机分为口服A (40 mg/天)或最多6个周期的CT (LL3:顺铂/培美曲塞;LL6:顺铂/吉西他滨)。患者按EGFR突变(Del19/L858R/other)和种族(LL3;亚洲/非亚洲)。两项试验的年龄分析(<65，≥65)都是预先指定的，突变亚组内的年龄分析是事后指定的。结果:在LL3和LL6中，年龄≥65岁的患者分别有134例和86例被随机化。Avs CT显著改善了这些患者的PFS (LL3: 13.6 vs 8.2个月，HR 0.60 [95% CI 0.37 - 0.96]， p=0.03;LL6: 13.1 vs 4.1个月，HR 0.17 [95% CI 0.07 - 0.41]， p<0.0001)。年龄≥65岁的所有患者的OS与Avs CT相似，在常见EGFR突变的患者中，Avs CT有改善OS的趋势(LL3: 31.6 vs 24.9个月;0.73人力资源
{"title":"Thoracic Cancer","authors":"S. Rana, C. Ord, C. R. Thomas","doi":"10.1111/(issn)1759-7714","DOIUrl":"https://doi.org/10.1111/(issn)1759-7714","url":null,"abstract":"Aim/Background: First-line A significantly improved progression-free survival (PFS) vs CT in pts with EGFR mutation-positive NSCLC in the LL3 and LL6 trials (LL3: 11.1 vs 6.9 months, HR 0.58; p<0.001; LL6: 11.0 vs 5.6 months, HR 0.28; p<0.0001). Overall survival (OS) was significantly improved with Avs CT in pts with Del19 mutations (LL3: 33.3 vs 21.1 months, HR 0.54, p=0.0015; LL6: 31.4 vs 18.4 months, HR 0.64, p=0.023). The efficacyand safetyof Avs CT in pts aged ≥ 65 years in the LL3 and LL6 trials are reported. Methods: Pts with EGFR mutation-positive stage IIIB or IV NSCLC (345 in LL3 and 364 in LL6) were randomized 2:1 to oral A (40 mg/day) or up to 6 cycles of CT (LL3: cisplatin/pemetrexed; LL6: cisplatin/gemcitabine). Pts were stratified by EGFR mutation (Del19/L858R/other) and race (LL3 only; Asian/non-Asian). Analyses byage (<65, ≥ 65) were pre-specified for both trials, analyses byagewithin mutation subgroups were post-hoc. Results: In LL3 and LL6, 134 and 86 pts aged ≥ 65 years, respectively,were randomized. PFS was significantly improved with Avs CT in these pts (LL3: 13.6 vs 8.2 months, HR 0.60 [95% CI 0.37 – 0.96], p=0.03; LL6: 13.1 vs 4.1 months, HR 0.17 [95% CI 0.07 – 0.41], p<0.0001). OS was similar with Avs CT in all pts aged ≥ 65 years, with atrend towards improved OS with Avs CT noted in those with common EGFR mutations (LL3: 31.6 vs 24.9 months; HR 0.73","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127553567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-1-4614-6400-6_1
C. Ord, C. Kubicky
{"title":"Central Nervous System Tumors: Adult and Pediatric","authors":"C. Ord, C. Kubicky","doi":"10.1007/978-1-4614-6400-6_1","DOIUrl":"https://doi.org/10.1007/978-1-4614-6400-6_1","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134002010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-1-4614-6400-6_7
Faisal A Siddiqui, C. Ord, Charles R. Thomas
{"title":"Upper Gastrointestinal Cancers","authors":"Faisal A Siddiqui, C. Ord, Charles R. Thomas","doi":"10.1007/978-1-4614-6400-6_7","DOIUrl":"https://doi.org/10.1007/978-1-4614-6400-6_7","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124351974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-1-4614-6400-6_8
S. Chennupati, C. Ord, Charles R. Thomas
{"title":"Lower Gastrointestinal Cancers","authors":"S. Chennupati, C. Ord, Charles R. Thomas","doi":"10.1007/978-1-4614-6400-6_8","DOIUrl":"https://doi.org/10.1007/978-1-4614-6400-6_8","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"265 1-2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116842945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-3-030-53687-9_6
C. Marquez, P. Hartvigson, K. Cook, S. Rana, C. Ord, C. Kubicky
{"title":"Breast Cancer","authors":"C. Marquez, P. Hartvigson, K. Cook, S. Rana, C. Ord, C. Kubicky","doi":"10.1007/978-3-030-53687-9_6","DOIUrl":"https://doi.org/10.1007/978-3-030-53687-9_6","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126395421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-3-030-53687-9_3
D. Elliott, N. Nabavizadeh, K. Hiluf, J. Holland
{"title":"Head and Neck Cancer","authors":"D. Elliott, N. Nabavizadeh, K. Hiluf, J. Holland","doi":"10.1007/978-3-030-53687-9_3","DOIUrl":"https://doi.org/10.1007/978-3-030-53687-9_3","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131286258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-3-030-53687-9_9
T. Mitin, C. Deig, S. Rana, C. Ord, E. Hansen
{"title":"Cancers of the Urinary System","authors":"T. Mitin, C. Deig, S. Rana, C. Ord, E. Hansen","doi":"10.1007/978-3-030-53687-9_9","DOIUrl":"https://doi.org/10.1007/978-3-030-53687-9_9","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131005790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-1-4614-6400-6_15
C. Ord, J. Holland
{"title":"Benign and Metastatic Disease","authors":"C. Ord, J. Holland","doi":"10.1007/978-1-4614-6400-6_15","DOIUrl":"https://doi.org/10.1007/978-1-4614-6400-6_15","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130079230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.1007/978-3-030-53687-9_12
B. Dyer, P. Gagnon, C. Ord, C. Marquez
{"title":"Heme Malignancies","authors":"B. Dyer, P. Gagnon, C. Ord, C. Marquez","doi":"10.1007/978-3-030-53687-9_12","DOIUrl":"https://doi.org/10.1007/978-3-030-53687-9_12","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121431401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1007/978-3-030-53687-9_13
Christina Binder, C. Ord, A. Hung
{"title":"Soft Tissue Sarcomas and Bone Tumors","authors":"Christina Binder, C. Ord, A. Hung","doi":"10.1007/978-3-030-53687-9_13","DOIUrl":"https://doi.org/10.1007/978-3-030-53687-9_13","url":null,"abstract":"","PeriodicalId":116749,"journal":{"name":"Radiation Oncology Study Guide","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114018384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：