R. E. Rivera, Alejandra Zuluaga, K. Arango, I. Kadar, Paola Andrea Pinillos, L. Montes, E. Cepeda, E. González, P. A. Alfonso, A. Villalba, Luis Fernando Cieza Casanova, Adolfo Pérez, Armando Roa, Martha Arias, Jorge Cuellar, L. Pedraza, A. A. Vasquez, Blanca Lynne Suárez, B. Gómez, C. Bedout, L. Cano
The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history, oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans (52%), C. parapsilosis (17.9%), and C. dubliniensis (7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses (P<0.006), dental apparatuses (P=0.016) and O'Leary index (P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.
{"title":"Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics","authors":"R. E. Rivera, Alejandra Zuluaga, K. Arango, I. Kadar, Paola Andrea Pinillos, L. Montes, E. Cepeda, E. González, P. A. Alfonso, A. Villalba, Luis Fernando Cieza Casanova, Adolfo Pérez, Armando Roa, Martha Arias, Jorge Cuellar, L. Pedraza, A. A. Vasquez, Blanca Lynne Suárez, B. Gómez, C. Bedout, L. Cano","doi":"10.7555/JBR.33.20180067","DOIUrl":"https://doi.org/10.7555/JBR.33.20180067","url":null,"abstract":"The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history, oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans (52%), C. parapsilosis (17.9%), and C. dubliniensis (7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses (P<0.006), dental apparatuses (P=0.016) and O'Leary index (P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116811726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesh hernia repair is one of the commonest open techniques of inguinal hernia repair. The main limiting factor in the use of new meshes is the cost. We carried out a prospective randomized double blind study and comprising of a hundred patients with 100 inguinal hernias admitted consecutively for elective surgery, divided into the polypropylene mesh (PPM) group and the mosquito net mesh (MNM) group each containing fifty patients. All cases were completed successfully and results revealed no difference in two groups. The results of the present study, in consistent with the published literature, reveal that the cheap indigenous mosquito mesh, which has similar properties of an imported mesh, can be safely used for tension-free inguinal hernia repair in adults. Further trials with a larger number of patients and longer follow-ups are justified and recommended.
{"title":"Cost effective use of mosquito net mesh in inguinal hernia repair","authors":"Mudassir M. Wani, A. Durrani","doi":"10.7555/JBR.33.20170138","DOIUrl":"https://doi.org/10.7555/JBR.33.20170138","url":null,"abstract":"Mesh hernia repair is one of the commonest open techniques of inguinal hernia repair. The main limiting factor in the use of new meshes is the cost. We carried out a prospective randomized double blind study and comprising of a hundred patients with 100 inguinal hernias admitted consecutively for elective surgery, divided into the polypropylene mesh (PPM) group and the mosquito net mesh (MNM) group each containing fifty patients. All cases were completed successfully and results revealed no difference in two groups. The results of the present study, in consistent with the published literature, reveal that the cheap indigenous mosquito mesh, which has similar properties of an imported mesh, can be safely used for tension-free inguinal hernia repair in adults. Further trials with a larger number of patients and longer follow-ups are justified and recommended.","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123984739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Shen, Bo’ang Han, Y. Leng, Sen Yan, Junfeng Shi, S. Yue, Steven Y. Cheng
As one of the most common tumors in women, breast cancer has drawn considerable interest from investigators and clinicians in recent years. Despite early diagnosis and best therapeutic regimens available, the prognosis of malignant or metastatic breast cancer patients is still not optimistic. Hedgehog signaling, a classical pathway indispensable to embryonic development, participates in the growth of a variety of tumors. In the present study, the effect of Sonic Hedgehog (Shh) on breast cancer cells was investigated. We identified that Shh signal stimulated the migration of MCF-7 breast cancer cells. Smo and Gli1 were involved in Shh-stimulated migration of MCF-7 cells. Activating Smo and Gli1 induced cell migration, which was blocked by their specific antagonists. The effect of Shh signaling on MCF-7 cells was independent of Wnt5a, Dvl2 and Rab35, but directly dependent on Rac1. In conclusion, our study suggested that Shh promotes breast cancer cell migration via Rac1 independently of the non-canonical Wnt signaling pathway, which may represent a rational molecular target for combination medication in breast cancer.
{"title":"Sonic Hedgehog stimulates migration of MCF-7 breast cancer cells through Rac1","authors":"T. Shen, Bo’ang Han, Y. Leng, Sen Yan, Junfeng Shi, S. Yue, Steven Y. Cheng","doi":"10.7555/JBR.32.20180100","DOIUrl":"https://doi.org/10.7555/JBR.32.20180100","url":null,"abstract":"As one of the most common tumors in women, breast cancer has drawn considerable interest from investigators and clinicians in recent years. Despite early diagnosis and best therapeutic regimens available, the prognosis of malignant or metastatic breast cancer patients is still not optimistic. Hedgehog signaling, a classical pathway indispensable to embryonic development, participates in the growth of a variety of tumors. In the present study, the effect of Sonic Hedgehog (Shh) on breast cancer cells was investigated. We identified that Shh signal stimulated the migration of MCF-7 breast cancer cells. Smo and Gli1 were involved in Shh-stimulated migration of MCF-7 cells. Activating Smo and Gli1 induced cell migration, which was blocked by their specific antagonists. The effect of Shh signaling on MCF-7 cells was independent of Wnt5a, Dvl2 and Rab35, but directly dependent on Rac1. In conclusion, our study suggested that Shh promotes breast cancer cell migration via Rac1 independently of the non-canonical Wnt signaling pathway, which may represent a rational molecular target for combination medication in breast cancer.","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123944362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kannan Sridharan, Shamik Shah, Mona Al Hammad, Fatima Ali Mohammed, Sindhan Veeramuthu, Mona Abdulla Taher, Mustafa Mohamed Hammad, Lamees Jawad, Eman Farid
{"title":"Description of serum Kidney Injury Molecule-1 and Cystatin C in renal transplants on immunosuppressants","authors":"Kannan Sridharan, Shamik Shah, Mona Al Hammad, Fatima Ali Mohammed, Sindhan Veeramuthu, Mona Abdulla Taher, Mustafa Mohamed Hammad, Lamees Jawad, Eman Farid","doi":"10.7555/jbr.37.20220211","DOIUrl":"https://doi.org/10.7555/jbr.37.20220211","url":null,"abstract":"","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123800184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Xu, L. Zhang, Lan Lin, Zhiyi Qiang, Wei Liu, Jian Yang
✉Corresponding author: Jian Yang, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 211166, China, Tel: +86-25-86869408, Email: jianyang@njmu.edu.cn. Received: 05 March 2023; Revised: 17 May 2023; Accepted: 23 May 2023; Published online: 28 May 2023 CLC number: R96, Document code: A The authors reported no conflict of interests. This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. (bp) +/+−/− 1 2 3 4 5 6 1 2 3 4 5 6 DEC1+/+ DEC1−/−
{"title":"Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1","authors":"Min Xu, L. Zhang, Lan Lin, Zhiyi Qiang, Wei Liu, Jian Yang","doi":"10.7555/jbr.37.20230047","DOIUrl":"https://doi.org/10.7555/jbr.37.20230047","url":null,"abstract":"✉Corresponding author: Jian Yang, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 211166, China, Tel: +86-25-86869408, Email: jianyang@njmu.edu.cn. Received: 05 March 2023; Revised: 17 May 2023; Accepted: 23 May 2023; Published online: 28 May 2023 CLC number: R96, Document code: A The authors reported no conflict of interests. This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. (bp) +/+−/− 1 2 3 4 5 6 1 2 3 4 5 6 DEC1+/+ DEC1−/−","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131581313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziyu Zhao, Yi Zhou, Jinxing Guan, Yan Yan, Jing Zhao, Zhihang Peng, Feng Chen, Yang Zhao, Fang Shao
{"title":"The relationship between compartment models and their stochastic counterparts: A comparative study with examples of the COVID-19 epidemic modeling","authors":"Ziyu Zhao, Yi Zhou, Jinxing Guan, Yan Yan, Jing Zhao, Zhihang Peng, Feng Chen, Yang Zhao, Fang Shao","doi":"10.7555/jbr.37.20230137","DOIUrl":"https://doi.org/10.7555/jbr.37.20230137","url":null,"abstract":"","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116667182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiyin Zheng, Lulu Yin, Jing E Song, Juan Chen, Wensha Gu, Mingqing Shi, Hong Zhang
{"title":"ELABELA protects against diabetic kidney disease by activating high glucose-inhibited renal tubular autophagy","authors":"Xiyin Zheng, Lulu Yin, Jing E Song, Juan Chen, Wensha Gu, Mingqing Shi, Hong Zhang","doi":"10.7555/jbr.37.20220214","DOIUrl":"https://doi.org/10.7555/jbr.37.20220214","url":null,"abstract":"","PeriodicalId":116796,"journal":{"name":"The Journal of Biomedical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129408266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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