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Associations between transport modes and site-specific cancers: a systematic review and meta-analysis 交通模式与特定地点癌症之间的关系:系统回顾与荟萃分析
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-04-13 DOI: 10.1186/s12940-024-01081-3
Win Thu, Alistair Woodward, Alana Cavadino, Sandar Tin Tin
Physical inactivity is a global public health problem. A practical solution would be to build physical activity into the daily routine by using active modes of transport. Choice of transport mode can influence cancer risk through their effects on levels of physical activity, sedentary time, and environmental pollution. This review synthesizes existing evidence on the associations of specific transport modes with risks of site-specific cancers. Relevant literature was searched in PubMed, Embase, and Scopus from 1914 to 17th February 2023. For cancer sites with effect measures available for a specific transport mode from two or more studies, random effects meta-analyses were performed to pool relative risks (RR) comparing the highest vs. lowest activity group as well as per 10 Metabolic Equivalent of Task (MET) hour increment in transport-related physical activity per week (∼150 min of walking or 90 min of cycling). 27 eligible studies (11 cohort, 15 case-control, and 1 case-cohort) were identified, which reported the associations of transport modes with 10 site-specific cancers. In the meta-analysis, 10 MET hour increment in transport-related physical activity per week was associated with a reduction in risk for endometrial cancer (RR: 0.91, 95% CI: 0.83–0.997), colorectal cancer (RR: 0.95, 95% CI: 0.91–0.99) and breast cancer (RR: 0.99, 95% CI: 0.89–0.996). The highest level of walking only or walking and cycling combined modes, compared to the lowest level, were significantly associated with a 12% and 30% reduced risk of breast and endometrial cancers respectively. Cycling, compared to motorized modes, was associated with a lower risk of overall cancer incidence and mortality. Active transport appears to reduce cancer risk, but evidence for cancer sites other than colorectum, breast, and endometrium is currently limited.
缺乏运动是一个全球性的公共健康问题。一个切实可行的解决方案是通过使用积极的交通方式,将体育锻炼纳入日常生活。交通方式的选择可通过对体力活动水平、久坐时间和环境污染的影响来影响癌症风险。本综述综合了特定交通方式与特定癌症风险之间关系的现有证据。在 PubMed、Embase 和 Scopus 中检索了 1914 年至 2023 年 2 月 17 日期间的相关文献。对于有两项或更多研究提供了特定交通方式效应测量值的癌症部位,我们进行了随机效应荟萃分析,以汇集最高活动量组与最低活动量组的相对风险系数(RR),以及每周与交通相关的体力活动(步行 150 分钟或骑自行车 90 分钟)每增加 10 个代谢当量任务(MET)小时的相对风险系数(RR)。共发现了 27 项符合条件的研究(11 项队列研究、15 项病例对照研究和 1 项病例队列研究),这些研究报告了交通方式与 10 种特定癌症的关系。在荟萃分析中,每周增加 10 个 MET 小时与交通相关的体力活动与子宫内膜癌(RR:0.91,95% CI:0.83-0.997)、结肠直肠癌(RR:0.95,95% CI:0.91-0.99)和乳腺癌(RR:0.99,95% CI:0.89-0.996)风险的降低有关。与最低水平相比,最高水平的仅步行或步行与骑自行车相结合的模式与乳腺癌和子宫内膜癌的风险分别降低 12% 和 30% 显著相关。与机动车模式相比,骑自行车与总体癌症发病和死亡风险降低有关。主动交通似乎可以降低癌症风险,但目前除结肠直肠癌、乳腺癌和子宫内膜癌外,其他癌症部位的证据还很有限。
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引用次数: 0
The changing health effects of air pollution exposure for respiratory diseases: a multicity study during 2017–2022 空气污染暴露对呼吸系统疾病健康影响的变化:2017-2022 年期间的多主体研究
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-04-13 DOI: 10.1186/s12940-024-01083-1
Siyu Jiang, Longjuan Tang, Zhe Lou, Haowei Wang, Ling Huang, Wei Zhao, Qingqing Wang, Ruiyun Li, Zhen Ding
Multifaceted SARS-CoV-2 interventions have modified exposure to air pollution and dynamics of respiratory diseases. Identifying the most vulnerable individuals requires effort to build a complete picture of the dynamic health effects of air pollution exposure, accounting for disparities across population subgroups. We use generalized additive model to assess the likely changes in the hospitalisation and mortality rate as a result of exposure to PM2.5 and O3 over the course of COVID-19 pandemic. We further disaggregate the population into detailed age categories and illustrate a shifting age profile of high-risk population groups. Additionally, we apply multivariable logistic regression to integrate demographic, socioeconomic and climatic characteristics with the pollution-related excess risk. Overall, a total of 1,051,893 hospital admissions and 34,954 mortality for respiratory disease are recorded. The findings demonstrate a transition in the association between air pollutants and hospitalisation rates over time. For every 10 µg/m3 increase of PM2.5, the rate of hospital admission increased by 0.2% (95% CI: 0.1–0.7%) and 1.4% (1.0–1.7%) in the pre-pandemic and dynamic zero-COVID stage, respectively. Conversely, O3-related hospitalization rate would be increased by 0.7% (0.5–0.9%) in the pre-pandemic stage but lowered to 1.7% (1.5–1.9%) in the dynamic zero-COVID stage. Further assessment indicates a shift of high-risk people from children and young adolescents to the old, primarily the elevated hospitalization rates among the old people in Lianyungang (RR: 1.53, 95%CI: 1.46, 1.60) and Nantong (RR: 1.65, 95%CI: 1.57, 1.72) relative to those for children and young adolescents. Over the course of our study period, people with underlying diseases would have 26.5% (22.8–30.3%) and 12.7% (10.8–14.6%) higher odds of having longer hospitalisation and over 6 times higher odds of deaths after hospitalisation. Our estimates provide the first comprehensive evidence on the dynamic pollution-health associations throughout the pandemic. The results suggest that age and underlying diseases collectively determines the disparities of pollution-related health effect across population subgroups, underscoring the urgency to identifying the most vulnerable individuals to air pollution.
多方面的 SARS-CoV-2 干预措施改变了空气污染暴露和呼吸系统疾病的动态变化。要识别最易受影响的人群,就必须努力建立一个完整的空气污染暴露对健康影响的动态图景,并考虑到不同人群亚群之间的差异。我们使用广义相加模型来评估 COVID-19 大流行期间暴露于 PM2.5 和 O3 导致的住院率和死亡率的可能变化。我们将人口进一步细分为详细的年龄类别,并说明了高危人群的年龄分布变化。此外,我们还应用多变量逻辑回归将人口、社会经济和气候特征与污染相关超额风险结合起来。总体而言,共有 1,051,893 人因呼吸道疾病入院治疗,34,954 人因呼吸道疾病死亡。研究结果表明,随着时间的推移,空气污染物与住院率之间的关系发生了变化。PM2.5 每增加 10 微克/立方米,入院率在大流行前和零 COVID 动态阶段分别增加 0.2%(95% CI:0.1-0.7%)和 1.4%(1.0-1.7%)。相反,在大流行前阶段,与 O3 相关的住院率将增加 0.7% (0.5-0.9%),但在动态零 COVID 阶段则会降低至 1.7% (1.5-1.9%)。进一步的评估表明,高危人群从儿童和青少年转移到了老年人,主要是连云港(RR:1.53,95%CI:1.46,1.60)和南通(RR:1.65,95%CI:1.57,1.72)老年人的住院率高于儿童和青少年。在我们的研究期间,患有基础疾病的患者住院时间更长的几率为26.5%(22.8%-30.3%),住院后死亡的几率为12.7%(10.8%-14.6%),住院后死亡的几率为基础疾病患者的6倍多。我们的估计结果首次提供了关于整个大流行期间污染与健康之间动态关系的全面证据。结果表明,年龄和基础疾病共同决定了不同人群中与污染相关的健康影响的差异,这突出了识别最易受空气污染影响的人群的紧迫性。
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引用次数: 0
Exposure to ambient air pollution and cognitive function: an analysis of the English Longitudinal Study of Ageing cohort 暴露于环境空气污染与认知功能:对英国老龄化纵向研究队列的分析
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-04-05 DOI: 10.1186/s12940-024-01075-1
Dylan Wood, Dimitris Evangelopoulos, Sean Beevers, Nutthida Kitwiroon, Panayotes Demakakos, Klea Katsouyanni
An increasing number of studies suggest adverse effects of exposure to ambient air pollution on cognitive function, but the evidence is still limited. We investigated the associations between long-term exposure to air pollutants and cognitive function in the English Longitudinal Study of Ageing (ELSA) cohort of older adults. Our sample included 8,883 individuals from ELSA, based on a nationally representative study of people aged ≥ 50 years, followed-up from 2002 until 2017. Exposure to air pollutants was modelled by the CMAQ-urban dispersion model and assigned to the participants’ residential postcodes. Cognitive test scores of memory and executive function were collected biennially. The associations between these cognitive measures and exposure to ambient concentrations of NO2, PM10, PM2.5 and ozone were investigated using mixed-effects models adjusted for time-varying age, physical activity and smoking status, as well as baseline gender and level of education. Increasing long-term exposure per interquartile range (IQR) of NO2 (IQR: 13.05 μg/m3), PM10 (IQR: 3.35 μg/m3) and PM2.5 (IQR: 2.7 μg/m3) were associated with decreases in test scores of composite memory by -0.10 (95% confidence interval [CI]: -0.14, -0.07), -0.02 [-0.04, -0.01] and -0.08 [-0.11, -0.05], respectively. The same increases in NO2, PM10 and PM2.5 were associated with decreases in executive function score of -0.31 [-0.38, -0.23], -0.05 [-0.08, -0.02] and -0.16 [-0.22, -0.10], respectively. The association with ozone was inverse across both tests. Similar results were reported for the London-dwelling sub-sample of participants. The present study was based on a long follow-up with several repeated measurements per cohort participant and long-term air pollution exposure assessment at a fine spatial scale. Increasing long-term exposure to NO2, PM10 and PM2.5 was associated with a decrease in cognitive function in older adults in England. This evidence can inform policies related to modifiable environmental exposures linked to cognitive decline.
越来越多的研究表明,暴露于环境空气污染中会对认知功能产生不利影响,但相关证据仍然有限。我们在英国老龄化纵向研究(ELSA)的老年人队列中调查了长期暴露于空气污染物与认知功能之间的关系。我们的样本包括来自 ELSA 的 8,883 人,该研究基于对年龄≥ 50 岁的人进行的一项具有全国代表性的研究,从 2002 年一直跟踪到 2017 年。空气污染物暴露是通过CMAQ-城市分散模型进行模拟的,并分配给参与者的居住地邮编。每两年收集一次记忆和执行功能的认知测试分数。采用混合效应模型研究了这些认知指标与二氧化氮、可吸入颗粒物(PM10)、可吸入颗粒物(PM2.5)和臭氧的环境浓度之间的关系,并对随时间变化的年龄、体育锻炼和吸烟状况以及基线性别和教育水平进行了调整。二氧化氮(IQR:13.05 μg/m3)、可吸入颗粒物(PM10,IQR:3.35 μg/m3)和 PM2.5(IQR:2.7 μg/m3)每四分位数间距(IQR)的长期暴露量的增加与综合记忆测试分数的下降相关,分别为-0.10(95% 置信区间 [CI]:-0.14,-0.07)、-0.02 [-0.04,-0.01] 和-0.08 [-0.11,-0.05]。同样,二氧化氮、可吸入颗粒物 10 和 PM2.5 的增加与执行功能得分的下降相关,分别为 -0.31 [-0.38, -0.23], -0.05 [-0.08, -0.02] 和 -0.16 [-0.22, -0.10]。在这两项测试中,与臭氧的关系呈反比。在伦敦居住的参与者子样本中也报告了类似的结果。本研究基于对每个队列参与者进行多次重复测量的长期跟踪,以及精细空间尺度的长期空气污染暴露评估。二氧化氮、可吸入颗粒物10和可吸入颗粒物2.5长期暴露量的增加与英格兰老年人认知功能的下降有关。这一证据可为制定与认知功能下降有关的可改变环境暴露相关政策提供依据。
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引用次数: 0
Correction: Modification of the PM2.5- and extreme heat-mortality relationships by historical redlining: A case-crossover study in thirteen U.S. states 更正:通过历史重划修改 PM2.5 和极端高温与死亡率的关系:美国十三个州的案例交叉研究
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-04-02 DOI: 10.1186/s12940-024-01072-4
Edgar Castro, Abbie Liu, Yaguang Wei, Anna Kosheleva, Joel Schwartz

Correction: Environ Health 23, 16 (2024)

https://doi.org/10.1186/s12940-024-01055-5


Following publication of [1], errors were found in the code used to prepare the cohort for a case-crossover analysis and the resulting data that was used for the analysis. Despite these errors, results were only marginally effected and all conclusions remain the same. A few typos were also found in the manuscript. A table of all affected texts is shown below.

Section

Lines

Text

Abstract

48-51

Individuals who lived in redlined areas had an interaction odds ratio for mortality of 1.0093 1.0104 (95% confidence interval [CI]: 1.0084 1.0095, 1.0101 1.0114) for each 10 µg m-3 increase in same-day ambient PM2.5 compared to individuals who did not live in redlined areas. For extreme heat, the interaction odds ratio was 1.0218 1.0146 (95% CI 1.0031 1.0039, 1.0408 1.0457).

Methods

159-161

To derive measures of extreme heat, we first calculated various percentiles of minimum temperature in each block group in each year. For our main analysis, we considered the 95 th 90 th percentile.

Methods

163-165

In other words, if the minimum temperature on a certain day met or exceeded the 95 th 90 th percentile of minimum temperature in that block group in that year, then that day was marked as an extreme heat day.

Results

229-237

We obtained 11,115,380 11,076,020 mortality records from the twelve thirteen state departments of public health. From these records, we sequentially excluded 466,874 453,754 deaths involving external causes; 139,908 133,348 deaths involving individuals younger than 18 years old; 196,558 deaths with geocodes that were missing or coarser than block group-level; 331 deaths involving individuals whose home locations were outside of the state that reported their death; 1,392,423 1,372,743 deaths before January 5th, 2001 or after December 31st, 2016 and 537 deaths whose home block groups had a population of zero according to the preceding Decennial Census (for which 4-day moving averages of population-weighted PM2.5 could not be calculated); and 34,016 deaths with lag days from 0 to 4 that included December 31st on leap years (for which Daymet predictions are not available; Figure 3)

Results

272-278

We found a significant interaction with exposure to any extreme heat (interaction odd

99400.99860.75Lags 0–30.99720.99480.99950.810.98870.98620.99130.40Lags 0–40.98460.98200.98710.240.97360.97070.97640.072003Lag 00.98950.98770.99120.231.00541.00351.00740.58Lags 0-10.98500.98280.98710.171.00991.00741.01230.43Lags 0-20.95900.95660.9614 <0.050.99400.99110.99700.69Lags 0-30.95770.95500.9604 < 0.050.99980.99641.00320.99Lags 0-40.95700.95400.9600 < 0.051.00110.99731.00490.962004Lag 01.03981.03871.0410 < 0.051.01371.01251.0149< 0.05Lags 0-11.04281.04141.0441< 0.051.01531.01391.0168< 0.05Lags 0-21.04101.03951.0426< 0.051.01531.01371.01690.06Lags 0-31.04281.04111.0445<0.051.01781.01591.01960.05Lags 0-41.03881.03691.0407<0.051.01191.01001.01390.242005Lags 01.05151.05031.0527<0.051.01351.01221.01490.05Lags 0-11.07791.07641.0793<0.051.02081.01921.0225<0.05Lags 0-21.11141.10971.1132< 0.051.02901.02711.0309< 0.05Lags 0-31.13551.13351.1375< 0.051.03321.03101.0353< 0.05Lags 0-41.14941.14721.1516<0.051.02901.02671.0313<0.052006Lags 00.99100.98980.99210.141.01081.00951.01220.11Lags 0-10.99000.98860.99140.161.01581.01421.01740.05Lags 0-20.98410.98250.9856<0.051.01941.01751.0212<0.05Lags 0-30.97820.97640.9799<0.051.02021.01811.02220.05Lags 0-40.97590.97400.9778 < 0.051.02371.02141.0260 < 0.052007Lag 01.00411.00361.00450.091.01131.01081.0118 < 0.05Lags 0-10.99930.99880.99980.791.01221.01161.0128< 0.05Lags 0-20.99440.99380.99500.061.01101.01031.0116< 0.05Lags 0-30.99140.99070.9920< 0.051.00921.00851.0099< 0.05Lags 0-40.99030.98960.9910< 0.051.00981.00901.0106< 0.052008Lag 00.95520.95470.9557< 0.051.00621.00561.0067< 0.05Lags 0-10.95040.94980.9509<0.051.01051.00991.0112<0.05Lags 0-20.94130.94070.9419<0.051.00881.00811.0095<0.05Lags 0-30.93190.93120.9325<0.051.00771.00691.00850.06Lags 0-40.92500.92430.9257<0.051.00751.00661.00840.102009Lag 01.03191.03141.0324 <0.051.00671.00621.0072<0.05Lags 0-11.03531.03471.0358<0.051.00981.00921.0104<0.05Lags 0-21.03441.03381.0350<0.051.00931.00871.0100< 0.05Lags 0-31.03461.03391.0352< 0.051.00851.00771.0092< 0.05Lags 0-41.03551.03481.0362< 0.051.00691.00611.00770.082010Lags 01.02681.02631.0273< 0.051.01021.00971.0107< 0.05Lags 0-11.03741.03681.0379< 0.051.01361.01311.0142< 0.05Lags 0-21.04251.04191.0431< 0.051.01261.01201.0133< 0.05Lags 0-31.04421.04351.0448< 0.051.01131.01061.0120< 0.05Lags 0-41.04361.04291.0443< 0.051.00981.00901.0105< 0.052011Lag 01.00921.00871.0097< 0.051.00711.00661.0076< 0.05Lags 0-11.00751.00701.0081< 0.051.00901.00841.0096< 0.05Lags 0-21.00131.00071.00190.681.00971.00901.0104< 0.05Lags 0-30.99600.99530.99660.231.00831.00761.0090< 0.05Lags 0–40.99340.9927
{"title":"Correction: Modification of the PM2.5- and extreme heat-mortality relationships by historical redlining: A case-crossover study in thirteen U.S. states","authors":"Edgar Castro, Abbie Liu, Yaguang Wei, Anna Kosheleva, Joel Schwartz","doi":"10.1186/s12940-024-01072-4","DOIUrl":"https://doi.org/10.1186/s12940-024-01072-4","url":null,"abstract":"<p>\u0000<b>Correction</b><b>: </b>\u0000<b>Environ Health 23, 16 (2024)</b>\u0000</p><p>\u0000<b>https://doi.org/10.1186/s12940-024-01055-5</b>\u0000</p><br/><p>Following publication of [1], errors were found in the code used to prepare the cohort for a case-crossover analysis and the resulting data that was used for the analysis. Despite these errors, results were only marginally effected and all conclusions remain the same. A few typos were also found in the manuscript. A table of all affected texts is shown below.\u0000</p><table><thead><tr><th><p>Section</p></th><th><p>Lines</p></th><th><p>Text</p></th></tr></thead><tbody><tr><td><p>Abstract</p></td><td><p>48-51</p></td><td><p>Individuals who lived in redlined areas had an interaction odds ratio for mortality of <s>1.0093</s> <b>1.0104</b> (95% confidence interval [CI]: <s>1.0084</s> <b>1.0095</b>, <s>1.0101</s> <b>1.0114)</b> for each 10 µg m<sup>-3</sup> increase in same-day ambient PM2.5 compared to individuals who did not live in redlined areas. For extreme heat, the interaction odds ratio was <s>1.0218</s> <b>1.0146</b> (95% CI <s>1.0031</s> <b>1.0039</b>, <s>1.0408</s> <b>1.0457</b>).</p></td></tr><tr><td><p>Methods</p></td><td><p>159-161</p></td><td><p>To derive measures of extreme heat, we first calculated various percentiles of minimum temperature in each block group in each year. For our main analysis, we considered the <s>95</s> <sup><s>th</s></sup> <b>90</b> <sup><b>th</b></sup> percentile.</p></td></tr><tr><td><p>Methods</p></td><td><p>163-165</p></td><td><p>In other words, if the minimum temperature on a certain day met or exceeded the <s>95</s> <sup><s>th</s></sup> <b>90</b> <sup><b>th</b></sup> percentile of minimum temperature in that block group in that year, then that day was marked as an extreme heat day.</p></td></tr><tr><td><p>Results</p></td><td><p>229-237</p></td><td><p>We obtained <s>11,115,380</s> <b>11,076,020</b> mortality records from the <s>twelve</s> <b>thirteen</b> state departments of public health. From these records, we sequentially excluded <s>466,874</s> <b>453,754</b> deaths involving external causes; <s>139,908</s> <b>133,348</b> deaths involving individuals younger than 18 years old; 196,558 deaths with geocodes that were missing or coarser than block group-level; 331 deaths involving individuals whose home locations were outside of the state that reported their death; <s>1,392,423</s> <b>1,372,743</b> deaths before January 5<sup>th</sup>, 2001 or after December 31<sup>st</sup>, 2016 and 537 deaths whose home block groups had a population of zero according to the preceding Decennial Census (for which 4-day moving averages of population-weighted PM2.5 could not be calculated); and 34,016 deaths with lag days from 0 to 4 that included December 31<sup>st</sup> on leap years (for which Daymet predictions are not available; Figure 3)</p></td></tr><tr><td><p>Results</p></td><td><p>272-278</p></td><td><p>We found a significant interaction with exposure to any extreme heat (interaction odd","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems for rating bodies of evidence used in systematic reviews of air pollution exposure and reproductive and children's health: a methodological survey. 空气污染暴露与生殖健康和儿童健康系统综述中使用的证据评级系统:方法学调查。
IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-03-28 DOI: 10.1186/s12940-024-01069-z
Sophie K F Michel, Aishwarya Atmakuri, Ondine S von Ehrenstein

Background: Translating findings from systematic reviews assessing associations between environmental exposures and reproductive and children's health into policy recommendations requires valid and transparent evidence grading.

Methods: We aimed to evaluate systems for grading bodies of evidence used in systematic reviews of environmental exposures and reproductive/ children's health outcomes, by conducting a methodological survey of air pollution research, comprising a comprehensive search for and assessment of all relevant systematic reviews. To evaluate the frameworks used for rating the internal validity of primary studies and for grading bodies of evidence (multiple studies), we considered whether and how specific criteria or domains were operationalized to address reproductive/children's environmental health, e.g., whether the timing of exposure assessment was evaluated with regard to vulnerable developmental stages.

Results: Eighteen out of 177 (9.8%) systematic reviews used formal systems for rating the body of evidence; 15 distinct internal validity assessment tools for primary studies, and nine different grading systems for bodies of evidence were used, with multiple modifications applied to the cited approaches. The Newcastle Ottawa Scale (NOS) and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework, neither developed specifically for this field, were the most commonly used approaches for rating individual studies and bodies of evidence, respectively. Overall, the identified approaches were highly heterogeneous in both their comprehensiveness and their applicability to reproductive/children's environmental health research.

Conclusion: Establishing the wider use of more appropriate evidence grading methods is instrumental both for strengthening systematic review methodologies, and for the effective development and implementation of environmental public health policies, particularly for protecting pregnant persons and children.

背景:要将评估环境暴露与生殖健康和儿童健康之间关系的系统综述结果转化为政策建议,需要对证据进行有效、透明的分级:我们的目标是通过对空气污染研究进行方法学调查,包括对所有相关系统综述进行全面搜索和评估,对环境暴露与生殖/儿童健康结果的系统综述中使用的证据进行分级的系统进行评估。为了评估用于评定主要研究的内部有效性和对证据体(多项研究)进行分级的框架,我们考虑了是否以及如何针对生殖/儿童的环境健康来操作特定的标准或领域,例如,是否针对易受影响的发育阶段来评估暴露评估的时机:在 177 篇系统综述中,有 18 篇(9.8%)使用了正式的证据分级系统;对主要研究使用了 15 种不同的内部有效性评估工具,对证据体使用了 9 种不同的分级系统,并对引用的方法进行了多种修改。纽卡斯尔-渥太华量表(Newcastle Ottawa Scale, NOS)和建议、评估、发展与评价分级(GRADE)框架都不是专门为该领域开发的,但分别是最常用的单项研究和证据体分级方法。总体而言,已确定的方法在其全面性和对生殖/儿童环境健康研究的适用性方面存在很大差异:结论:更广泛地使用更合适的证据分级方法有助于加强系统综述方法,也有助于有效地制定和实施环境公共卫生政策,特别是保护孕妇和儿童的政策。
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引用次数: 0
PFOA and testis cancer in the Veneto Region (Italy) 全氟辛烷磺酸与威尼托大区(意大利)的睾丸癌
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-03-28 DOI: 10.1186/s12940-024-01064-4
Mario Saugo, Enrico Ioverno, Armando Olivieri, Francesco Bertola, Angela Pasinato, Alan Ducatman
The largest documented episode of human contamination by PFOA in the world (approximately 150,000 actual residents on 1 January 2020) has occurred in Italy’s Veneto Region. In this large, mostly flat plain area, a cluster of testicular cancers has also been observed. Preliminary data are reported, and the most relevant and recent recommendations regarding the health surveillance of exposed individuals are emphasized.
在意大利威尼托大区,发生了世界上有记录的最大一次全氟辛烷磺酸对人类的污染事件(2020 年 1 月 1 日,实际居民约为 15 万人)。在这个幅员辽阔、多为平原的地区,还发现了睾丸癌群。报告了初步数据,并强调了关于接触者健康监测的最新相关建议。
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引用次数: 0
Residents' experiences during a hydrogen sulfide crisis in Carson, California. 加利福尼亚州卡森市居民在硫化氢危机中的经历。
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-03-23 DOI: 10.1186/s12940-024-01071-5
Arbor J L Quist, April Hovav, Alexander D Silverman, Bhavna Shamasunder, Jill E Johnston

Background: In early October 2021, thousands of residents in Carson, California began complaining of malodors and headaches. Hydrogen sulfide (H2S), a noxious odorous gas, was measured at concentrations up to 7000 parts per billion (ppb) and remained above California's acute air quality standard of 30 ppb for a month. Intermittent elevations of H2S continued for 3 months. After 2 months of malodor in this environmental justice community, a government agency attributed the H2S to environmental pollution from a warehouse fire. Research has yielded conflicting results on the health effects of H2S exposure at levels that were experienced during this event. This research fills a critical need for understanding how people perceive and experience emergent environmental health events and will help shape future responses.

Methods: Through a community-academic partnership, we conducted 6 focus groups with 33 participants who resided in the Carson area during the crisis. We sought to understand how this incident affected residents through facilitated discussion on topics including information acquisition, impressions of the emergency response, health symptoms, and ongoing impacts.

Results: The majority of participants were women (n = 25), identified as Latina/o (n = 19), and rent their homes (n = 21). Participants described difficulty obtaining coherent information about the emergency, which resulted in feelings of abandonment. Most participants felt that local government and healthcare providers downplayed and/or disregarded their concerns despite ongoing odors and health symptoms. Participants described experiencing stress from the odors' unknown health effects and continued fear of future odor incidents. Residents sought to take control of the crisis through information sharing, community networking, and activism. Participants experienced longer term effects from this event, including increased awareness of pollution and reduced trust in local agencies.

Discussion: This study demonstrates the necessity of clear, comprehensive, and prompt responses by relevant decisionmakers to chemical emergencies to appropriately address residents' fears, curb the spread of misinformation, and minimize adverse health effects. Participant responses also point to the benefit of supporting horizontal community networks for improved information sharing. By engaging directly with community members, researchers and disaster responders can better understand the various and complex impacts of chemical disasters and can improve response.

背景:2021 年 10 月初,加利福尼亚州卡森市的数千名居民开始抱怨恶臭和头痛。硫化氢 (H2S) 是一种有毒的恶臭气体,测量到的浓度高达 7000 ppb,并且在一个月内一直高于加利福尼亚州急性空气质量标准 30 ppb。H2S 的间歇性升高持续了 3 个月。在这个环境正义社区出现恶臭 2 个月后,一家政府机构将 H2S 归因于仓库火灾造成的环境污染。在这次事件中,关于暴露于 H2S 水平对健康的影响的研究结果相互矛盾。这项研究满足了了解人们如何感知和体验突发环境健康事件的关键需求,并将有助于制定未来的应对措施:通过社区与学术界的合作,我们与危机期间居住在卡森地区的 33 名参与者进行了 6 次焦点小组讨论。我们试图通过对信息获取、应急响应印象、健康症状和持续影响等主题的讨论,了解此次事件对居民的影响:大多数参与者为女性(25 人),拉美裔(19 人),租房居住(21 人)。据参与者描述,她们很难获得有关紧急情况的连贯信息,因此产生了被遗弃的感觉。大多数参与者认为,尽管异味和健康症状持续存在,但当地政府和医疗服务提供者轻视和/或无视他们的担忧。参与者描述了臭味对健康的未知影响和对未来臭味事件的持续恐惧所带来的压力。居民们试图通过信息共享、社区网络和行动主义来控制危机。这次事件对参与者产生了长期影响,包括污染意识的增强和对当地机构信任度的降低:本研究表明,相关决策者有必要对化学品突发事件做出清晰、全面和迅速的反应,以适当消除居民的恐惧,遏制错误信息的传播,并最大限度地减少对健康的不利影响。参与者的回答还表明了支持横向社区网络以改善信息共享的益处。通过与社区成员直接接触,研究人员和救灾人员可以更好地了解化学灾害的各种复杂影响,并改进应对措施。
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引用次数: 0
Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism 血浆中十氯酮浓度与酒精性肝纤维化进展之间的反向关系:肝脏代谢的作用
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-03-20 DOI: 10.1186/s12940-024-01054-6
Moana Gelu-Simeon, Marie-Josée Lafrance, Leah Michineau, Eric Saillard, Jean Pierre Thomé, Claude Emond, Michel Samson, Luc Multigner
Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has been demonstrated in animal models. We investigated the relationship between environmental exposure to chlordecone and the progression of liver fibrosis. This study included 182 consecutive patients with chronic alcoholic hepatitis whose liver fibrosis was assessed using non-invasive methods. Measured plasma chlordecone concentrations at inclusion were used as surrogate of long-term exposure under steady-state conditions. As the pharmacokinetic processing of chlordecone is largely determined by the liver, we used a human physiologically based pharmacokinetic model to predict plausible changes in the steady-state blood chlordecone concentrations induced by liver fibrosis. With a median follow-up of 27.1 years after the onset of alcohol consumption, we found a significant decrease in the risk of advanced liver fibrosis with increasing plasma chlordecone concentration (adjusted hazard ratio = 0.56; 95% confidence interval: 0.34–0.95 for the highest vs. lowest tertile, p = 0.04). Changes induced by liver fibrosis influenced the pharmacokinetic processing of chlordecone, resulting in substantial modifications in its steady-state blood concentrations. According to this human model of coexposure to alcohol, reverse causality is the most plausible explanation of this inverse association between plasma chlordecone concentrations and progression of liver fibrosis. This study underlines the importance of considering the pharmacokinetic of environmental contaminants in epidemiological studies when biomarkers of exposure are used to investigate their own impact on the liver. ClinicalTrials.gov Identifier: NCT03373396.
十氯酮是一种持久性有机氯杀虫剂,在法属西印度群岛被广泛使用,三十多年来一直污染着当地居民。在动物模型中,十氯酮对肝毒性药物的增效作用已得到证实。我们研究了环境中接触十氯酮与肝纤维化进展之间的关系。这项研究共纳入了182名慢性酒精性肝炎患者,采用非侵入性方法对他们的肝纤维化程度进行了评估。纳入研究时测得的血浆十氯酮浓度被用作稳态条件下长期接触十氯酮的代用指标。由于十氯酮的药代动力学过程主要由肝脏决定,因此我们采用了基于人体生理的药代动力学模型来预测肝纤维化引起的稳态血中十氯酮浓度的合理变化。在对开始饮酒后27.1年的中位随访中,我们发现随着血浆十氯酮浓度的增加,晚期肝纤维化的风险显著降低(调整后的危险比=0.56;95%置信区间:最高与最低三等分位数为0.34-0.95,P=0.04)。肝纤维化引起的变化影响了十氯酮的药代动力学处理,导致其稳态血药浓度发生了重大变化。根据这一人类共同暴露于酒精的模型,反向因果关系是血浆中十氯酮浓度与肝纤维化进展之间存在反向联系的最合理解释。这项研究强调,在流行病学研究中,当使用生物标志物来研究环境污染物对肝脏的影响时,必须考虑到环境污染物的药代动力学。ClinicalTrials.gov Identifier:NCT03373396。
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引用次数: 0
Urinary cadmium concentration is associated with the severity and clinical outcomes of COVID-19: a bicenter observational cohort study 尿镉浓度与 COVID-19 的严重程度和临床结果相关:一项双中心观察性队列研究
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-03-19 DOI: 10.1186/s12940-024-01070-6
Li-Chung Chiu, Chung-Shu Lee, Ping-Chih Hsu, Hsin-Hsien Li, Tien-Ming Chan, Ching-Chung Hsiao, Scott Chih-Hsi Kuo, How-Wen Ko, Shu-Min Lin, Chun-Hua Wang, Horng-Chyuan Lin, Pao-Hsien Chu, Tzung-Hai Yen
Cadmium and nickel exposure can cause oxidative stress, induce inflammation, inhibit immune function, and therefore has significant impacts on the pathogenesis and severity of many diseases. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can also provoke oxidative stress and the dysregulation of inflammatory and immune responses. This study aimed to assess the potential associations of cadmium and nickel exposure with the severity and clinical outcomes of patients with coronavirus disease 2019 (COVID-19). We performed a retrospective, observational, bicenter cohort analysis of patients with SARS-CoV-2 infection in Taiwan between June 2022 and July 2023. Cadmium and nickel concentrations in blood and urine were measured within 3 days of the diagnosis of acute SARS-CoV-2 infection, and the severity and clinical outcomes of patients with COVID-19 were analyzed. A total of 574 patients were analyzed and divided into a severe COVID-19 group (hospitalized patients) (n = 252; 43.9%), and non-severe COVID-19 group (n = 322; 56.1%). The overall in-hospital mortality rate was 11.8% (n = 68). The severe COVID-19 patients were older, had significantly more comorbidities, and significantly higher neutrophil/lymphocyte ratio, C-reactive protein, and interleukin-6 than the non-severe COVID-19 patients (all p < 0.05). Blood and urine cadmium and urine nickel concentrations were significantly higher in the severe COVID-19 patients than in the non-severe COVID-19 patients. Among the severe COVID-19 patients, those in higher urine cadmium/creatinine quartiles had a significantly higher risk of organ failure (i.e., higher APACHE II and SOFA scores), higher neutrophil/lymphocyte ratio, lower PaO2/FiO2 requiring higher invasive mechanical ventilation support, higher risk of acute respiratory distress syndrome, and higher 60-, 90-day, and all-cause hospital mortality (all p < 0.05). Multivariable logistic regression models revealed that urine cadmium/creatinine was independently associated with severe COVID-19 (adjusted OR 1.643 [95% CI 1.060–2.547], p = 0.026), and that a urine cadmium/creatinine value > 2.05 μg/g had the highest predictive value (adjusted OR 5.349, [95% CI 1.118–25.580], p = 0.036). Urine cadmium concentration in the early course of COVID-19 could predict the severity and clinical outcomes of patients and was independently associated with the risk of severe COVID-19.
镉和镍的暴露可导致氧化应激、诱发炎症、抑制免疫功能,因此对许多疾病的发病机制和严重程度有重大影响。严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染也会引起氧化应激以及炎症和免疫反应失调。本研究旨在评估镉和镍暴露与 2019 年冠状病毒病(COVID-19)患者的严重程度和临床结果之间的潜在关联。我们对2022年6月至2023年7月期间在台湾感染SARS-CoV-2的患者进行了一项回顾性、观察性、双中心队列分析。在确诊急性 SARS-CoV-2 感染后 3 天内测量了血液和尿液中的镉和镍浓度,并分析了 COVID-19 患者的严重程度和临床结果。共对 574 名患者进行了分析,并将其分为严重 COVID-19 组(住院患者)(n = 252;43.9%)和非严重 COVID-19 组(n = 322;56.1%)。住院总死亡率为 11.8%(n = 68)。与非重度 COVID-19 患者相比,重度 COVID-19 患者年龄更大,合并症明显增多,中性粒细胞/淋巴细胞比率、C 反应蛋白和白细胞介素-6 明显更高(均 p 2.05),μg/g 的预测值最高(调整 OR 5.349,[95% CI 1.118-25.580],p = 0.036)。COVID-19早期尿镉浓度可预测患者病情的严重程度和临床结局,并与严重COVID-19的风险独立相关。
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引用次数: 0
Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study 有机氯杀虫剂与美国军人罹患甲状腺乳头状癌的风险:一项巢式病例对照研究
IF 6 2区 环境科学与生态学 Q1 Medicine Pub Date : 2024-03-19 DOI: 10.1186/s12940-024-01068-0
Jennifer A. Rusiecki, Jordan McAdam, Hristina Denic-Roberts, Andreas Sjodin, Mark Davis, Richard Jones, Thanh D. Hoang, Mary H. Ward, Shuangge Ma, Yawei Zhang
The effects of organochlorine pesticide (OCP) exposure on the development of human papillary thyroid cancer (PTC) are not well understood. A nested case-control study was conducted with data from the U.S. Department of Defense Serum Repository (DoDSR) cohort between 2000 and 2013 to assess associations of individual OCPs serum concentrations with PTC risk. This study included 742 histologically confirmed PTC cases (341 females, 401 males) and 742 individually-matched controls with pre-diagnostic serum samples selected from the DoDSR. Associations between categories of lipid-corrected serum concentrations of seven OCPs and PTC risk were evaluated for classical PTC and follicular PTC using conditional logistic regression, adjusted for body mass index category and military branch to compute odds ratios (OR) and 95% confidence intervals (CIs). Effect modification by sex, birth cohort, and race was examined. There was no evidence of associations between most of the OCPs and PTC, overall or stratified by histological subtype. Overall, there was no evidence of an association between hexachlorobenzene (HCB) and PTC, but stratified by histological subtype HCB was associated with significantly increased risk of classical PTC (third tertile above the limit of detection (LOD) vs.
有机氯杀虫剂(OCP)暴露对人类甲状腺乳头状癌(PTC)发病的影响尚不十分清楚。我们利用美国国防部血清库(DoDSR)队列中 2000 年至 2013 年期间的数据开展了一项嵌套病例对照研究,以评估单个 OCP 血清浓度与 PTC 风险之间的关联。这项研究包括 742 例经组织学确诊的 PTC 病例(女性 341 例,男性 401 例)和 742 例单独匹配的对照组,其诊断前血清样本选自 DoDSR。利用条件逻辑回归评估了经典 PTC 和滤泡型 PTC 的七种 OCPs 脂质校正血清浓度类别与 PTC 风险之间的关系,并根据体重指数类别和军种进行了调整,计算出了几率比 (OR) 和 95% 置信区间 (CI)。研究还考察了性别、出生队列和种族对效果的影响。没有证据表明大多数 OCPs 与 PTC 之间存在关联,无论是总体关联还是按组织学亚型分层关联。总体而言,没有证据表明六氯苯(HCB)与 PTC 存在关联,但按组织学亚型分层,六氯苯与经典 PTC 风险显著增加有关(高于检测限 (LOD) 的第三三元组与低于检测限的第三三元组相比,OR = 1.5)。
{"title":"Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study","authors":"Jennifer A. Rusiecki, Jordan McAdam, Hristina Denic-Roberts, Andreas Sjodin, Mark Davis, Richard Jones, Thanh D. Hoang, Mary H. Ward, Shuangge Ma, Yawei Zhang","doi":"10.1186/s12940-024-01068-0","DOIUrl":"https://doi.org/10.1186/s12940-024-01068-0","url":null,"abstract":"The effects of organochlorine pesticide (OCP) exposure on the development of human papillary thyroid cancer (PTC) are not well understood. A nested case-control study was conducted with data from the U.S. Department of Defense Serum Repository (DoDSR) cohort between 2000 and 2013 to assess associations of individual OCPs serum concentrations with PTC risk. This study included 742 histologically confirmed PTC cases (341 females, 401 males) and 742 individually-matched controls with pre-diagnostic serum samples selected from the DoDSR. Associations between categories of lipid-corrected serum concentrations of seven OCPs and PTC risk were evaluated for classical PTC and follicular PTC using conditional logistic regression, adjusted for body mass index category and military branch to compute odds ratios (OR) and 95% confidence intervals (CIs). Effect modification by sex, birth cohort, and race was examined. There was no evidence of associations between most of the OCPs and PTC, overall or stratified by histological subtype. Overall, there was no evidence of an association between hexachlorobenzene (HCB) and PTC, but stratified by histological subtype HCB was associated with significantly increased risk of classical PTC (third tertile above the limit of detection (LOD) vs. <LOD, OR = 1.61, 95% CI, 1.09, 2.38; p for trend = 0.05) and significantly decreased risk of follicular variant PTC (third tertile above the limit of detection (LOD) vs. <LOD, OR = 0.38, 95% CI, 0.16, 0.91; p for trend = 0.04). Further stratified by sex, risk of classical PTC was higher for females (third tertile above LOD vs. <LOD, OR = 2.23, 95% CI: 1.23, 4.06; p-trend = 0.02) than for males (OR = 1.22, 95%CI: 0.72–2.08; p-trend = 0.56), though the test for interaction by sex was not statistically significant (p-interaction = 0.30). Similarly, β-hexachlorocyclohexane (β-HCCH) was associated with a higher risk for classical PTC for women with concentrations ≥LOD versus <LOD (OR = 1.76, 95% CI: 1.07, 2.89), while the effects were null for men. There were no consistent trends when stratified by race or birth year. The U.S. Environmental Protection Agency has classified HCB and other OCPs we studied here as probable human carcinogens. Our findings of increased risks for classical PTC associated with increased concentrations of HCB and β-HCCH, which were stronger among females, should be replicated in future studies of other populations.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Environmental Health
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