Background: Recent demonstration of opioid receptors along peripheral sensory nerves especially after painful inflammatory conditions forms the basis of peripheral opioid analgesia. This form of opioid antinociception has the potential to help overcome one of the disadvantages of intravenous regional anesthesia (IVRA) that is lack of postoperative analgesia. The aim of the study was to assess the efficacy of Buprenorphine as an adjunct to Lignocaine in (IVRA) for postoperative analgesia. Methods: Seventy-five consenting patients undergoing hand and forearm surgery were randomly allocated into three groups of twenty-five each: group A received 0.5% 40 ml Lignocaine for IVRA, group B received 0.5% 40 ml Lignocaine for IVRA and Buprenorphine 0.3 mg intramuscularly and group C received 0.5% 40 ml Lignocaine with Buprenorphine 0.3 mg for IVRA. Postoperative analgesia was assessed using visual analog scale (VAS) on a 0 to 100 mm scale in the immediate postoperative period and 1 hourly thereafter for 24 hours. Patients were given Declofenac 1 mg/kg orally whenever VAS score exceeded 25 or patient demanded analgesic. Results: Onset time for sensory block was longer in group C as compared to group A and B (5.0±1.0 min versus 4.0±0.6 and 4.0±0.4) whereas motor block onset time was comparable in all the three groups. Quality of sensory and motor block was similar in all the groups. Duration of postoperative analgesia was significantly longer in group C (1200 ±120 min.) as compared to 42±12 and 420±36 minutes for group A and B respectively (p=0.001). Analgesic consumption was also significantly lower in group C (56±9 mg versus 201±27 and 120±24 mg for group A and B respectively (p=0.001). Incidence of nausea/vomiting and sedation was much higher in group B as compared to other groups (p=0.002).Conclusion: We concluded that addition of Buprenorphine 0.3 mg to Lignocaine for IVRA significantly prolongs analgesia without causing systemic side effects.
{"title":"Peripheral opioid receptor mediated enhancement of analgesia by buprenorphine in intravenous regional anaesthesia","authors":"Nikhil Swarnkar, Anshul Yadav","doi":"10.26611/101511215","DOIUrl":"https://doi.org/10.26611/101511215","url":null,"abstract":"Background: Recent demonstration of opioid receptors along peripheral sensory nerves especially after painful inflammatory conditions forms the basis of peripheral opioid analgesia. This form of opioid antinociception has the potential to help overcome one of the disadvantages of intravenous regional anesthesia (IVRA) that is lack of postoperative analgesia. The aim of the study was to assess the efficacy of Buprenorphine as an adjunct to Lignocaine in (IVRA) for postoperative analgesia. Methods: Seventy-five consenting patients undergoing hand and forearm surgery were randomly allocated into three groups of twenty-five each: group A received 0.5% 40 ml Lignocaine for IVRA, group B received 0.5% 40 ml Lignocaine for IVRA and Buprenorphine 0.3 mg intramuscularly and group C received 0.5% 40 ml Lignocaine with Buprenorphine 0.3 mg for IVRA. Postoperative analgesia was assessed using visual analog scale (VAS) on a 0 to 100 mm scale in the immediate postoperative period and 1 hourly thereafter for 24 hours. Patients were given Declofenac 1 mg/kg orally whenever VAS score exceeded 25 or patient demanded analgesic. Results: Onset time for sensory block was longer in group C as compared to group A and B (5.0±1.0 min versus 4.0±0.6 and 4.0±0.4) whereas motor block onset time was comparable in all the three groups. Quality of sensory and motor block was similar in all the groups. Duration of postoperative analgesia was significantly longer in group C (1200 ±120 min.) as compared to 42±12 and 420±36 minutes for group A and B respectively (p=0.001). Analgesic consumption was also significantly lower in group C (56±9 mg versus 201±27 and 120±24 mg for group A and B respectively (p=0.001). Incidence of nausea/vomiting and sedation was much higher in group B as compared to other groups (p=0.002).Conclusion: We concluded that addition of Buprenorphine 0.3 mg to Lignocaine for IVRA significantly prolongs analgesia without causing systemic side effects.","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129338833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of preoperative assessment of geriatric patients of Telangana","authors":"Swapna T, G. Reddy","doi":"10.26611/101511219","DOIUrl":"https://doi.org/10.26611/101511219","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122739111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Patel, India. Nagar Haveli, Rajesh K Pargi, B. Butala
{"title":"Study of two doses of intranasal dexmedetomidine (1mcg vs. 2mcg) for premedication in children","authors":"H. Patel, India. Nagar Haveli, Rajesh K Pargi, B. Butala","doi":"10.26611/10151115","DOIUrl":"https://doi.org/10.26611/10151115","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130823703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Day-care surgery, it is the patient being discharged from the hospital on the same day of surgical procedure, has become immensely popular modality of treatment throughout the globe. Aims and Objectives: To compare the efficacy of intrathecal (1%) 2-Chloroprocaine and intrathecal (0.5%) sensorcaine for day care infraumbilical surgeries. Methodology: This was a prospective, randomized study carried out in the patients undergoing the various infraumbilical day care surgeries under spinal anaesthesia at tertiary health care centre. After the ethical permission, the written informed consent was obtained from 70 patients and was enrolled in the study. Out of 70 patients, 35 patients were enrolled to Group A i.e. Chloroprocaine Group and 35 patient in Group B i.e. Sensorcaine Group The patients were randomly allocated in to the groups by computer generated random numbers. . The subarachonoid block was given to the patients in Group A with (1% ) 50 mg chlorprocaine and in Group B with( 0.5% ) 15 mg sensorcaine. The data was then analyzed by unpaired t-test and chi-square test by SPSS 19 version software. Results: The mean age in both the groups were comparable i.e. 34 ± 4.65 35± 3.97 (t=0.76,df=48,P>0.05) and the Male to Female ratio was also comparable i.e. 2.5 :1 and 1.67:1 (X2=0.35,df=1,p>0.05). Time for onset of Sensory block(min) was comparable in both the groups was 2.45 ± 1.03 and 2.29 ± 0.93 (P>0.05,t=0.72,df=68); Time for onset of Motor block (min) was comparable i.e. 3.1± 0.34 and 2.84 ± 1.04 (P >0.05,t=0.92,df=68); Total duration of sensory block (min) was significantly higher in group B ( 167 ±43.87) than Group A (105.62±30.56), (P<0.05,t=4.92,df=68); Total duration of motor block (min) was significantly greater in Group B(135±54.32) than Group A (95.73± 30.76), (P<0.05,t=1.02,df=68). Conclusion: It can be concluded from this study that sensorcaine was superior to chloroprocaine with respect to sensory motor blockade otherwise it was comparable in all the other characteristics of anaesthesia.
{"title":"Comparative study of intrathecal (1%) 2-Chloroprocaine Vs intrathecal (0.5%) Sensorcaine for day care surgeries","authors":"Y. Anarase, A. Bhalerao","doi":"10.26611/101511211","DOIUrl":"https://doi.org/10.26611/101511211","url":null,"abstract":"Background: Day-care surgery, it is the patient being discharged from the hospital on the same day of surgical procedure, has become immensely popular modality of treatment throughout the globe. Aims and Objectives: To compare the efficacy of intrathecal (1%) 2-Chloroprocaine and intrathecal (0.5%) sensorcaine for day care infraumbilical surgeries. Methodology: This was a prospective, randomized study carried out in the patients undergoing the various infraumbilical day care surgeries under spinal anaesthesia at tertiary health care centre. After the ethical permission, the written informed consent was obtained from 70 patients and was enrolled in the study. Out of 70 patients, 35 patients were enrolled to Group A i.e. Chloroprocaine Group and 35 patient in Group B i.e. Sensorcaine Group The patients were randomly allocated in to the groups by computer generated random numbers. . The subarachonoid block was given to the patients in Group A with (1% ) 50 mg chlorprocaine and in Group B with( 0.5% ) 15 mg sensorcaine. The data was then analyzed by unpaired t-test and chi-square test by SPSS 19 version software. Results: The mean age in both the groups were comparable i.e. 34 ± 4.65 35± 3.97 (t=0.76,df=48,P>0.05) and the Male to Female ratio was also comparable i.e. 2.5 :1 and 1.67:1 (X2=0.35,df=1,p>0.05). Time for onset of Sensory block(min) was comparable in both the groups was 2.45 ± 1.03 and 2.29 ± 0.93 (P>0.05,t=0.72,df=68); Time for onset of Motor block (min) was comparable i.e. 3.1± 0.34 and 2.84 ± 1.04 (P >0.05,t=0.92,df=68); Total duration of sensory block (min) was significantly higher in group B ( 167 ±43.87) than Group A (105.62±30.56), (P<0.05,t=4.92,df=68); Total duration of motor block (min) was significantly greater in Group B(135±54.32) than Group A (95.73± 30.76), (P<0.05,t=1.02,df=68). Conclusion: It can be concluded from this study that sensorcaine was superior to chloroprocaine with respect to sensory motor blockade otherwise it was comparable in all the other characteristics of anaesthesia.","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126942234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combined spinal-epidural is superior to epidural block for total abdominal hysterectomy in terms of surgeon and patient satisfaction","authors":"Nikhil Swarnkar, Alok Ghosh, Anshul Yadav","doi":"10.26611/101511218","DOIUrl":"https://doi.org/10.26611/101511218","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"299 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124279653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandip R. Baheti, Kaushik Cherukuri, P. Sathe, S. Gaur, Tanya Gulia, N. Baheti
{"title":"Comparing the incidence of sore throat between awake nasogastric tube insertion and nasogastric tube insertion after general anaesthesia with endotracheal intubation","authors":"Sandip R. Baheti, Kaushik Cherukuri, P. Sathe, S. Gaur, Tanya Gulia, N. Baheti","doi":"10.26611/101512227","DOIUrl":"https://doi.org/10.26611/101512227","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122069919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Suganthi, M. Swathi, Jayaraman, V. Sathyamoorthy, Chennai Tamil Nadu India. Children
{"title":"Comparison of 0.25% bupivacaine and 0.375% ropivacaine in combination with fentanyl for modified radical mastectomy under cervical epidural Anaesthesia","authors":"C. Suganthi, M. Swathi, Jayaraman, V. Sathyamoorthy, Chennai Tamil Nadu India. Children","doi":"10.26611/101511316","DOIUrl":"https://doi.org/10.26611/101511316","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"88 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123083291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of oral premedication of melatonin on anxiety and sedation in preoperative period before induction of general Anaesthesia","authors":"K. Bhaskar, K. Suma, Tanuja, K. Srinivasan","doi":"10.26611/10151118","DOIUrl":"https://doi.org/10.26611/10151118","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114937818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anaesthetic challenges in a patient with Glucose-6-Phosphate dehydrogenase deficiency: A case study","authors":"Megha Wadhwani, J. Tharion, Rajat Gupta","doi":"10.26611/10151133","DOIUrl":"https://doi.org/10.26611/10151133","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116746813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A study to compare the heamo dynamic changes among mother and fetus with bupivacaine and bupivacaine with clonidine as analgesic during labour","authors":"M. Asif, S. Agnihotri, P. Chougule","doi":"10.26611/101511310","DOIUrl":"https://doi.org/10.26611/101511310","url":null,"abstract":"","PeriodicalId":118187,"journal":{"name":"MedPulse International Journal of Anesthesology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125823449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：