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European journal of anaesthesiology. Supplement最新文献

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Euro-Neuro 2000: 2nd International Update on Neuro-Anaesthesia and Neuro-Intensive Care. Genk, Belgium, 2-5 February 2000. Abstracts. Euro-Neuro 2000:第二届神经麻醉和神经重症监护国际更新。Genk，比利时，2000年2月2-5日。摘要。
European journal of anaesthesiology. Supplement
Pub Date : 2000-01-01
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引用次数: 0
European Society of Anaesthesiologists 8th annual meeting with the Austrian International Congress. Vienna, Austria, 1-4 April 2000. Abstracts. 欧洲麻醉师协会第八届年会与奥地利国际大会。奥地利维也纳，2000年4月1日至4日。摘要。
European journal of anaesthesiology. Supplement
Pub Date : 2000-01-01
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引用次数: 0
3rd Meeting of the International Society for Medical Gases (ISMG). Heidelberg, Germany, 29 September-1 October 1999. Abstracts. 国际医用气体学会(ISMG)第三次会议。1999年9月29日至10月1日，德国海德堡。摘要。
European journal of anaesthesiology. Supplement
Pub Date : 2000-01-01
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引用次数: 0
Euro-Neuro '98: 1st International update on Neuro-Anaesthesia and Neuro-Intensive Care. Genk, Belgium, 5-7 February 1998. Abstracts. Euro-Neuro '98:第一次国际更新的神经麻醉和神经重症监护。1998年2月5日至7日，比利时根克。摘要。
European journal of anaesthesiology. Supplement
Pub Date : 1998-01-01
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引用次数: 0
Near-infrared spectroscopy 近红外光谱
European journal of anaesthesiology. Supplement
Pub Date : 1998-01-01 DOI: 10.1097/00003643-199801001-00043
D. Prough
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引用次数: 1
Cerebral blood flow thermodilution measurements 脑血流热稀释测量
European journal of anaesthesiology. Supplement
Pub Date : 1998-01-01 DOI: 10.1097/00003643-199801001-00040
J. Berré, C. Mélot, J. Moraine
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引用次数: 0
6th International Neuromuscular Meeting. Paris, France, 22-24 August 1997. Abstracts. 第六届国际神经肌肉会议。1997年8月22日至24日，法国巴黎。摘要。
European journal of anaesthesiology. Supplement
Pub Date : 1997-09-01
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引用次数: 0
Target-controlled anaesthesia: concepts and first clinical experiences. 靶控麻醉:概念和初步临床经验。
European journal of anaesthesiology. Supplement
Pub Date : 1997-05-01 DOI: 10.1097/00003643-199705001-00006
G N Kenny

Propofol has a favourable pharmacokinetic profile for total intravenous anaesthesia and several manual infusion schemes have been proposed to maintain a constant blood concentration during anaesthesia. However, such schemes cannot respond predictably to changing surgical and anaesthetic requirements. A pharmacokinetic model for propofol has been incorporated into a target-controlled infusion system. This allows the desired target blood concentration appropriate for any individual patient and level of surgical stimulation to be achieved and maintained at any time. There is no single blood concentration of an anaesthetic agent which will result in satisfactory anaesthesia for all patients and all surgical conditions. It is necessary to titrate the target concentration against each patient's clinical response. Target-controlled systems provide the best estimate of the blood concentration at any time and permit the required target concentration to be achieved as accurately and as rapidly as possible.

异丙酚在全静脉麻醉中具有良好的药代动力学特征，并且已经提出了几种手动输注方案，以在麻醉期间保持恒定的血药浓度。然而，这种方案不能对不断变化的手术和麻醉需求做出可预测的反应。异丙酚的药代动力学模型已被纳入目标控制输注系统。这样就可以在任何时候达到并维持适合任何个体患者和手术刺激水平的理想目标血药浓度。没有一种麻醉药的单一血药浓度能对所有病人和所有手术条件产生满意的麻醉效果。有必要根据每个病人的临床反应来滴定目标浓度。目标控制系统可在任何时间提供最佳的血液浓度估计，并允许尽可能准确和快速地达到所需的目标浓度。
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引用次数: 14
Neuromuscular blockade: is it still useful in the ICU? 神经肌肉阻滞:在ICU仍然有用吗?
European journal of anaesthesiology. Supplement
Pub Date : 1997-05-01 DOI: 10.1097/00003643-199705001-00011
C Meistelman, B Plaud

Neuromuscular relaxants may be administered to ICU patients for days or weeks. The most frequent indications are facilitation of mechanical ventilation and management of neurosurgical patients after severe head injury. Tachyphylaxis can be observed in ICU patients but the major problem remains the prolonged weakness which can occur after long-term administration of muscle relaxants. The mechanisms are still poorly understood and under investigation. Although neuromuscular monitoring provides guidelines for the administration of muscle relaxants in critically ill patients, it does not prevent the development of a myopathy.

神经肌肉松弛剂可给予ICU患者数天或数周。最常见的适应症是重型颅脑损伤后的机械通气和神经外科患者的处理。在ICU患者中可以观察到快速反应，但主要问题仍然是长期服用肌肉松弛剂后可能出现的长期无力。人们对其机制仍知之甚少，尚在调查中。虽然神经肌肉监测为危重病人使用肌肉松弛剂提供指导，但它并不能预防肌病的发展。
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引用次数: 7
Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs. 阿片类药物和非甾体抗炎药的作用机制。
European journal of anaesthesiology. Supplement
Pub Date : 1997-05-01 DOI: 10.1097/00003643-199705001-00003
J G Bovill

Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are the commonest drugs used to treat pain. Opioids mimic the actions of endogenous opioid peptides by interacting with mu, delta or kappa opioid receptors. The opioid receptors are coupled to G1 proteins and the actions of the opioids are mainly inhibitory. They close N-type voltage-operated calcium channels and open calcium-dependent inwardly-rectifying potassium channels. This results in hyperpolarization and a reduction in neuronal excitability. They also decrease intracellular cAMP which modulates the release of nociceptive neurotransmitters (e.g. substance P). Inhibition of prostaglandin synthesis by cyclooxygenase is the principal mode of the analgesic and anti-inflammatory actions of NSAIDs. Cyclo-oxygenase is inhibited irreversibly by aspirin and reversibly by other NSAIDs. The widespread inhibition of cyclo-oxygenase is responsible for many of the adverse effects of these drugs. NSAIDs also reduce prostaglandin production within the CNS. This is the main action of paracetamol.

阿片类药物和非甾体抗炎药(NSAIDs)是最常用的治疗疼痛的药物。阿片通过与mu, delta或kappa阿片受体相互作用来模拟内源性阿片肽的作用。阿片受体与G1蛋白偶联，其作用主要是抑制性的。它们关闭了n型电压控制的钙通道，打开了钙依赖的内整流钾通道。这导致了超极化和神经元兴奋性的降低。它们还降低细胞内cAMP, cAMP调节伤害性神经递质(如P物质)的释放。环加氧酶抑制前列腺素的合成是非甾体抗炎药镇痛和抗炎作用的主要模式。阿司匹林对环加氧酶有不可逆的抑制作用，其他非甾体抗炎药对环加氧酶有可逆的抑制作用。环加氧酶的广泛抑制是这些药物的许多不良反应的原因。非甾体抗炎药也能减少中枢神经系统内前列腺素的产生。这是扑热息痛的主要作用。
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引用次数: 43
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