In childhood and adolescence cancers; survival rates increase with the use of treatment options such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation. One of the long-term effects of primary disease and cancer treatment is the irreversible damage to gonadal tissues, resulting in impaired fertility. Especially chemotherapeutic drugs; causes germ cell defect, affects the secretion of pituitary hormone, and also damages the anatomical structures of internal genital structures such as the uterus. Gonadal preservation methods are limited in prepubertal male patients. It is a good option to place the testicles in a different area before radiotherapy. Before chemotherapy or whole body irradiation, freezing of testicular tissue and ensuring pregnancy from frozen tissue is still in the experimental stage. After the ejaculation begins, obtaining and storing sperm is successfully done. A limited number of pregnancies were obtained oocytes frozen ovaries in the prepubertal girls. It is possible to freeze oocytes after puberty begins. In addition, recently, as a noninvasive method, gonadotropin-releasing hormone (GnRH) analogues have been used successfully, as it suppresses the hypothalamic-pituitary-gonadal axis and protects germ cells from cytotoxic effects. This article aims to provide information on fertility preservation methods in patients receiving childhood cancer treatment.
{"title":"Fertility Preservation Methods in Childhood and Adolescence Cancers: A Review.","authors":"Ülkü Gül Siraz, N. Hatipoğlu","doi":"10.51271/jpea-2021-0145","DOIUrl":"https://doi.org/10.51271/jpea-2021-0145","url":null,"abstract":"In childhood and adolescence cancers; survival rates increase with the use of treatment options such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation. One of the long-term effects of primary disease and cancer treatment is the irreversible damage to gonadal tissues, resulting in impaired fertility. Especially chemotherapeutic drugs; causes germ cell defect, affects the secretion of pituitary hormone, and also damages the anatomical structures of internal genital structures such as the uterus. Gonadal preservation methods are limited in prepubertal male patients. It is a good option to place the testicles in a different area before radiotherapy. Before chemotherapy or whole body irradiation, freezing of testicular tissue and ensuring pregnancy from frozen tissue is still in the experimental stage. After the ejaculation begins, obtaining and storing sperm is successfully done. A limited number of pregnancies were obtained oocytes frozen ovaries in the prepubertal girls. It is possible to freeze oocytes after puberty begins. In addition, recently, as a noninvasive method, gonadotropin-releasing hormone (GnRH) analogues have been used successfully, as it suppresses the hypothalamic-pituitary-gonadal axis and protects germ cells from cytotoxic effects.\u0000\u0000This article aims to provide information on fertility preservation methods in patients receiving childhood cancer treatment.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130404737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Güven, M. Oflaz, A. Kaya, F. Bolat, Utku Aygüneş, F. D. İçağasıoğlu
Sydenham’s chorea (SC) is common cause of acquired chorea in childhood. SC occurs mainly in children with untreated streptococcal infections. An effective list of therapeutic options has been used to treat this disorder: antiepileptic drugs (valproic acid, carbamazepine etc.), haloperidol, chlorpromazine, amphetamines, steroids, plasma exchange and intravenous immunoglobulins (IVIG). We report a 12-year-old girl with carditis and severely generalized chorea and successfully treated with IVIG. This case report shows that IVIG is an effective treatment for the chorea cases resistant to anticonvulsants, dopamine antagonists and steroids, although larger studies are needed to confirm this conclusion.
{"title":"Resistant Chorea Successfully Treated with Intravenous Immunoglobulin: A Case Report","authors":"A. Güven, M. Oflaz, A. Kaya, F. Bolat, Utku Aygüneş, F. D. İçağasıoğlu","doi":"10.51271/jpea-2021-0146","DOIUrl":"https://doi.org/10.51271/jpea-2021-0146","url":null,"abstract":"Sydenham’s chorea (SC) is common cause of acquired chorea in childhood. SC occurs mainly in children with untreated streptococcal infections. An effective list of therapeutic options has been used to treat this disorder: antiepileptic drugs (valproic acid, carbamazepine etc.), haloperidol, chlorpromazine, amphetamines, steroids, plasma exchange and intravenous immunoglobulins (IVIG). We report a 12-year-old girl with carditis and severely generalized chorea and successfully treated with IVIG. This case report shows that IVIG is an effective treatment for the chorea cases resistant to anticonvulsants, dopamine antagonists and steroids, although larger studies are needed to confirm this conclusion.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130510712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Increasing incidence and onset at a younger age has changed the treatment strategy of diabetes mellitus (DM) towards prevention, delaying the onset, and minimizing disease complications. Self-monitoring blood glucose systems and continuous glucose monitoring systems are routinely preferred in diabetic children.Flash glucose monitoring system has come as an entirely new concept in glucose monitoring by providing much greater data than blood glucose testing while being more affordable than the continuous glucose monitors. The FreeStyle Libre provides ‘flash glucose monitoring’ with glucose readings by scanning a sensor rather than pricking the patient’s finger. The sensor measures interstitial tissue glucose levels every minute via a disposable round sensor with a small catheter inserted under the skin that can be worn for up to 14 days. The entire system’s on-body sensor patch worn on the back of the upper arm is disposable. However, the mild erythema may occur on the skin and disappear spontaneously after 24 hours from the detachment of the sensor. Similar skin lesions were observed in diabetic patients, and there was moderate to severe itching in 0.5% of the cases and moderate erythema in 4% of cases
{"title":"Allergic Reaction Following Implantation of a Blood Glucose Sensor.","authors":"M. Atar, Ö. Pirgon, Gülsüm Çetin","doi":"10.51271/jpea-2021-0143","DOIUrl":"https://doi.org/10.51271/jpea-2021-0143","url":null,"abstract":"Increasing incidence and onset at a younger age has changed the treatment strategy of diabetes mellitus (DM) towards prevention, delaying the onset, and minimizing disease complications. Self-monitoring blood glucose systems and continuous glucose monitoring systems are routinely preferred in diabetic children.Flash glucose monitoring system has come as an entirely new concept in glucose monitoring by providing much greater data than blood glucose testing while being more affordable than the continuous glucose monitors. The FreeStyle Libre provides ‘flash glucose monitoring’ with glucose readings by scanning a sensor rather than pricking the patient’s finger. The sensor measures interstitial tissue glucose levels every minute via a disposable round sensor with a small catheter inserted under the skin that can be worn for up to 14 days. The entire system’s on-body sensor patch worn on the back of the upper arm is disposable. However, the mild erythema may occur on the skin and disappear spontaneously after 24 hours from the detachment of the sensor. Similar skin lesions were observed in diabetic patients, and there was moderate to severe itching in 0.5% of the cases and moderate erythema in 4% of cases","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125634828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esra Bağlan, S. Özdel, T. Güngör, D. Karakaya, E. Çelikkaya, F. Yazılıtaş, Evrim Kargın Çakıcı, M. Bülbül
Behçet’s disease (BD) is a multisystemic inflammatory disease with unknown etiology. It is characterized by recurrent oral and genital ulcerations, uveitis, and skin lesions, various musculoskeletal, gastrointestinal, central nervous system, and vascular manifestations. The aim of this study was to analyse the demographic characteristics and clinical features, treatment in Turkish paediatric BD from a single center experience. The records of 36 patients with BD who were diagnosed according to the International Study Group criteria between January 2017 and January 2019 in the department of paediatric rheumatology, were retrospectively reviewed. Data on demographic, clinical features and therapy were collected. A total of 36 (19 male) patients were included in this study. Mean age at disease onset was 9.36±4.45 years and mean age at diagnosis 13.99±2.83 years. The frequencies of signs/symptoms were: recurrent oral aphtosis 100%, genital ulcers 80.6%, musculoskeletal 30.6%, ocular 16.7%, neurological 11.1% and vascular involvement 11.1%, gastrointestinal 2.8%. Colchicine and corticosteroids were the main treatments. In this single-center retrospective study, we analyzed the data of paediatric BD and their treatment from a single center in Turkey. The presented small series and the literature review suggest that paediatric BD is a heterogeneous disease with varied clinical manifestations.
{"title":"Paediatric Behçet’s Disease: Data From A Single Center Experience in Turkey.","authors":"Esra Bağlan, S. Özdel, T. Güngör, D. Karakaya, E. Çelikkaya, F. Yazılıtaş, Evrim Kargın Çakıcı, M. Bülbül","doi":"10.51271/jpea-2021-0138","DOIUrl":"https://doi.org/10.51271/jpea-2021-0138","url":null,"abstract":"Behçet’s disease (BD) is a multisystemic inflammatory disease with unknown etiology. It is characterized by recurrent oral and genital ulcerations, uveitis, and skin lesions, various musculoskeletal, gastrointestinal, central nervous system, and vascular manifestations. The aim of this study was to analyse the demographic characteristics and clinical features, treatment in Turkish paediatric BD from a single center experience. The records of 36 patients with BD who were diagnosed according to the International Study Group criteria between January 2017 and January 2019 in the department of paediatric rheumatology, were retrospectively reviewed. Data on demographic, clinical features and therapy were collected. A total of 36 (19 male) patients were included in this study. Mean age at disease onset was 9.36±4.45 years and mean age at diagnosis 13.99±2.83 years. The frequencies of signs/symptoms were: recurrent oral aphtosis 100%, genital ulcers 80.6%, musculoskeletal 30.6%, ocular 16.7%, neurological 11.1% and vascular involvement 11.1%, gastrointestinal 2.8%. Colchicine and corticosteroids were the main treatments. In this single-center retrospective study, we analyzed the data of paediatric BD and their treatment from a single center in Turkey. The presented small series and the literature review suggest that paediatric BD is a heterogeneous disease with varied clinical manifestations.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124543675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Coronavirus disease (COVID-19) rapidly spread all around the world and was declared a worldwide pandemic by World Health Organization in March 2020. We aimed to investigate the clinical, demographic and laboratory characteristics of COVID-19 in children admitted to the pediatric emergency triage. Epidemiological, clinical, laboratory, and radiological data of children were collected retrospectively and analyzed to compare by symptoms. A total of 213 pediatric cases with COVID-19 were included. Most of the patients were asymptomatic (63.8%). The main clinical features were mild symptoms including fever (7.5%), cough (6.5%), myalgia (6.3%) or no (63.8%). Of the patients who had CT scan, 25% had specific findings of COVID-19. Ground-like opacities were common radiological findings (25%). Symptomatic patients had higher lymphopenia rate (p=0.03), higher CRP and procalcitonin (PCT) values (p=0.04, p=0.04), lower age (p<0.001) and lower neutrophil count (p=0.01). The rate of neutropenia and leukopenia were higher in asymptomatic patients (p=0.15, p=0.05, respectively). The most common cause of transmission in children is family contact. Home isolation was recommended for 89.6% of the patients, 10.3% were hospitalized, 2.3% needed an intensive care unit (ICU). Only one death was reported. We found found that children with COVID-19 are generally mild severe or asymptomatic clinic. Young children were relatively more symptomatic than older children, and those with underlying diseases often needed intensive care unit. The most important laboratory findings difference between symptomatic and asymptomatic patients are lymphopenia, increased CRP and PCT values (p=0.04 for all three parameter).
{"title":"Evaluation of COVID-19 Patients Admitted to Pediatric Emergency Department","authors":"M. Dogan, Binnaz Çelik","doi":"10.51271/jpea-2021-128","DOIUrl":"https://doi.org/10.51271/jpea-2021-128","url":null,"abstract":"The Coronavirus disease (COVID-19) rapidly spread all around the world and was declared a worldwide pandemic by World Health Organization in March 2020. We aimed to investigate the clinical, demographic and laboratory characteristics of COVID-19 in children admitted to the pediatric emergency triage. Epidemiological, clinical, laboratory, and radiological data of children were collected retrospectively and analyzed to compare by symptoms. A total of 213 pediatric cases with COVID-19 were included. Most of the patients were asymptomatic (63.8%). The main clinical features were mild symptoms including fever (7.5%), cough (6.5%), myalgia (6.3%) or no (63.8%). Of the patients who had CT scan, 25% had specific findings of COVID-19. Ground-like opacities were common radiological findings (25%). Symptomatic patients had higher lymphopenia rate (p=0.03), higher CRP and procalcitonin (PCT) values (p=0.04, p=0.04), lower age (p<0.001) and lower neutrophil count (p=0.01). The rate of neutropenia and leukopenia were higher in asymptomatic patients (p=0.15, p=0.05, respectively). The most common cause of transmission in children is family contact. Home isolation was recommended for 89.6% of the patients, 10.3% were hospitalized, 2.3% needed an intensive care unit (ICU). Only one death was reported. We found found that children with COVID-19 are generally mild severe or asymptomatic clinic. Young children were relatively more symptomatic than older children, and those with underlying diseases often needed intensive care unit. The most important laboratory findings difference between symptomatic and asymptomatic patients are lymphopenia, increased CRP and PCT values (p=0.04 for all three parameter).","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114964564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A complete or partial involuntary erection that occurs in absence of a sexual stimulation and lasts longer than four hours is defined as priapism. Etiology usually includes sickle cell disease or hematologic malignancies. Less common causes include trauma, spinal cord injury, medications, congenital syphilis, parotitis, Fabry’s disease and retroperitoneal sarcoma. Priapism is a urologic emergency that varies by ischemic and non-ischemic episodes. Ischemic injury to cavernous tissues leads to erectile dysfunction. Early recognition of priapism, determination of the type and the treatment are crucial in preventing potential long-term complications caused by priapism. With this case of priapism caused by a treatment with valproic acid, it was aimed to point out priapism which is a urologic emergency.
{"title":"Valproic Acid-Induced Priapism in a Child","authors":"Esra Türe, A. Yazar, F. Akın, A. Kılıç","doi":"10.51271/jpea-2021-0109","DOIUrl":"https://doi.org/10.51271/jpea-2021-0109","url":null,"abstract":"A complete or partial involuntary erection that occurs in absence of a sexual stimulation and lasts longer than four hours is defined as priapism. Etiology usually includes sickle cell disease or hematologic malignancies. Less common causes include trauma, spinal cord injury, medications, congenital syphilis, parotitis, Fabry’s disease and retroperitoneal sarcoma. Priapism is a urologic emergency that varies by ischemic and non-ischemic episodes. Ischemic injury to cavernous tissues leads to erectile dysfunction. Early recognition of priapism, determination of the type and the treatment are crucial in preventing potential long-term complications caused by priapism. With this case of priapism caused by a treatment with valproic acid, it was aimed to point out priapism which is a urologic emergency.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114796524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phenylketonuria is treated either with tetrahydrobiopterin (BH4) or with a phenylalanine-restricted diet. Patients in the diet group may tend to consume carbohydrate-rich foods which have a risk for obesity. In this study, the prevalence of obesity+overweight among phenylketonuria patients either treated with phenylalanine-restricted diet or with BH4 were compared.Patients with phenylketonuria were divided into two groups on dietary treatment and BH4 treatment. Body mass index (BMI), BMI-percentile, and z-score values of patients were calculated and classified as underweight, normal-weight, overweight, and obese according to their nutritional status. The annual mean phenylalanine level of each patient is also evaluated. The study was done retrospectively.A total of 130 patients was included. 77 were receiving diet (female (n,%):37, 48.1%; male (n,%):40, 51.9%) and 53 were receiving BH4 (female (n,%):33, 62.3%; male (n,%):20, 37.7%) respectively. According to BMI-z-score, the sum of the ratio of obesity+overweight was found to be 35.1% in the diet group, 16.9% in the BH4 group. Ratio was significantly higher in diet group (p=0.02). When obesity+overweight ratios were examined in terms of female/male distribution, no significant difference was found. Considering the correlation of obesity+overweight ratios with age in two groups, the median age of the patients with normal weight+underweight in the BH4 group were found as 46-months, and the median age of obese+overweight patients was 137-months (p=0.001). For the same situation, there was no significant difference in the dietary treatment group (p=0.92). Mean annual phenylalanine levels were significantly higher in obese+overweight patients (p=0.047) in the BH4 treatment group but this difference was not significant in the diet group (p=0.051).Patients on the phenylalanine-restricted diet have a risk of obesity or overweight. Therefore, attention should be paid not only to the phenylalanine levels of these patients but also to their weight control and dietary content
{"title":"Does Dietary Treatment Cause Obesity in Phenylketonuria? Comparison of Obesity Ratios of Patients Receiving Dietary Treatment and Tetrahydrobiopterin Treatment","authors":"Banu Kadıoğlu Yılmaz, F. Kardaş, M. Kendirci","doi":"10.51271/jpea-2021-0098","DOIUrl":"https://doi.org/10.51271/jpea-2021-0098","url":null,"abstract":"Phenylketonuria is treated either with tetrahydrobiopterin (BH4) or with a phenylalanine-restricted diet. Patients in the diet group may tend to consume carbohydrate-rich foods which have a risk for obesity. In this study, the prevalence of obesity+overweight among phenylketonuria patients either treated with phenylalanine-restricted diet or with BH4 were compared.Patients with phenylketonuria were divided into two groups on dietary treatment and BH4 treatment. Body mass index (BMI), BMI-percentile, and z-score values of patients were calculated and classified as underweight, normal-weight, overweight, and obese according to their nutritional status. The annual mean phenylalanine level of each patient is also evaluated. The study was done retrospectively.A total of 130 patients was included. 77 were receiving diet (female (n,%):37, 48.1%; male (n,%):40, 51.9%) and 53 were receiving BH4 (female (n,%):33, 62.3%; male (n,%):20, 37.7%) respectively. According to BMI-z-score, the sum of the ratio of obesity+overweight was found to be 35.1% in the diet group, 16.9% in the BH4 group. Ratio was significantly higher in diet group (p=0.02). When obesity+overweight ratios were examined in terms of female/male distribution, no significant difference was found. Considering the correlation of obesity+overweight ratios with age in two groups, the median age of the patients with normal weight+underweight in the BH4 group were found as 46-months, and the median age of obese+overweight patients was 137-months (p=0.001). For the same situation, there was no significant difference in the dietary treatment group (p=0.92). Mean annual phenylalanine levels were significantly higher in obese+overweight patients (p=0.047) in the BH4 treatment group but this difference was not significant in the diet group (p=0.051).Patients on the phenylalanine-restricted diet have a risk of obesity or overweight. Therefore, attention should be paid not only to the phenylalanine levels of these patients but also to their weight control and dietary content","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117181985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Yılmaz, Büşra Özyalvaç, Gökçe Ünal, S. Pekcan, O. Eğil, Ş. Yosunkaya
Cystic fibrosis (CF) is a chronic disease with autosomal recessive inheritance, chlorine duct defect, and multisystemic involvement. In this study, we evaluated the problems of our adolescent and adult patients with CF who were followed up in our unit to determine their problems at the regional level, to better observe their treatments, and to offer solutions for complications that occurred during their follow-up. Sixty-five patients with CF (50 adolescents and 15 adults) who consulted our clinic between September 2008 and November 2020 were included in this study, and their retrospective data were reviewed and saved. The mean age of the patients was 17.2±6.21 years, and the mean age at diagnosis was 7.1 years. Nearly three-quarters (73.8%) of the patients were adolescents, 26.2% were adults. Their mean body mass index (BMI) was 18.81±4.06 kg/m2. The mean FEV1 was 82.94±25.22% in the adolescent group and 64.47 ±28.47% in the adult group. Pseudo-Bartter syndrome was the most common clinical presentation in adolescents (44%) and productive cough 28.6% was most common in adults. The rate of bronchiectasis was 73.6% in the adults and 29.2% in the adolescents. CF-related diabetes was seen in 33.3% of the adults and 8.3% of the adolescents. Gastroesophageal reflux disease was present in 25.5% of the adolescents, but it was not seen in the adults. Mortality was 20.0% in the adult group and 4.1% in the adolescents. There was no significant difference between the groups regarding BMI, chronic pseudomonas colonization, and pulmonary exacerbation. In both groups, the most common allele (21.8%) was delf508. We saw that the disease complications were less in the adolescent group. We thought that early diagnosis and treatment were related to this condition
{"title":"Long-term Follow-up Of Adolescent And Adult Patients With Cystic Fibrosis: A Single Center's Experience","authors":"A. Yılmaz, Büşra Özyalvaç, Gökçe Ünal, S. Pekcan, O. Eğil, Ş. Yosunkaya","doi":"10.51271/jpea-2021-0114","DOIUrl":"https://doi.org/10.51271/jpea-2021-0114","url":null,"abstract":"Cystic fibrosis (CF) is a chronic disease with autosomal recessive inheritance, chlorine duct defect, and multisystemic involvement. In this study, we evaluated the problems of our adolescent and adult patients with CF who were followed up in our unit to determine their problems at the regional level, to better observe their treatments, and to offer solutions for complications that occurred during their follow-up. Sixty-five patients with CF (50 adolescents and 15 adults) who consulted our clinic between September 2008 and November 2020 were included in this study, and their retrospective data were reviewed and saved. The mean age of the patients was 17.2±6.21 years, and the mean age at diagnosis was 7.1 years. Nearly three-quarters (73.8%) of the patients were adolescents, 26.2% were adults. Their mean body mass index (BMI) was 18.81±4.06 kg/m2. The mean FEV1 was 82.94±25.22% in the adolescent group and 64.47 ±28.47% in the adult group. Pseudo-Bartter syndrome was the most common clinical presentation in adolescents (44%) and productive cough 28.6% was most common in adults. The rate of bronchiectasis was 73.6% in the adults and 29.2% in the adolescents. CF-related diabetes was seen in 33.3% of the adults and 8.3% of the adolescents. Gastroesophageal reflux disease was present in 25.5% of the adolescents, but it was not seen in the adults. Mortality was 20.0% in the adult group and 4.1% in the adolescents. There was no significant difference between the groups regarding BMI, chronic pseudomonas colonization, and pulmonary exacerbation. In both groups, the most common allele (21.8%) was delf508. We saw that the disease complications were less in the adolescent group. We thought that early diagnosis and treatment were related to this condition","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"1193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121045272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
15-year-old female patient, who had no previous history of illness, had the complaint of intermittent cough and chest pain for 2 months. Two days ago, she applied to the hospital with difficulty in breathing added to her complaints. Tomography was planned due to the presence of pneumonic infiltration in the left lung in the chest radiography of the patient who was hospitalized in the intensive care unit due to respiratory distress.
{"title":"A Case of Pulmonary Tuberculosis Detected While Being Investigated with a Preliminary Diagnosis of Covid-19 Infection","authors":"Taylan Çelik, Tayyar Ayberk Borak, Ender Ekin","doi":"10.51271/pea-2021-0122","DOIUrl":"https://doi.org/10.51271/pea-2021-0122","url":null,"abstract":"15-year-old female patient, who had no previous history of illness, had the complaint of intermittent cough and chest pain for 2 months. Two days ago, she applied to the hospital with difficulty in breathing added to her complaints. Tomography was planned due to the presence of pneumonic infiltration in the left lung in the chest radiography of the patient who was hospitalized in the intensive care unit due to respiratory distress.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115059345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MonitorizationNon-invasive methods have replaced invasive methods in line with developments in pediatric intensive care units. (Especially methods that enable continuous monitoring) Although arterial carbon dioxide measurement is still the gold standard for the evaluation of alveolar ventilation, the need for continuous monitoring of PaCO2 and the invasive nature of this method have led to the investigation of alternative methods. To evaluate the correlation of transcutaneous CO2 (TcCO2) monitoring with PaCO2 and ETCO2 in mechanically ventilated patients in peditaric intensive care units. Single-center, prospective, observational cohort study. We enrolled 60 patients between the age of 1 month-18 years who were mechanically ventilated in pediatric intensive care unit for this single-center, prospective, observational cohort study from February 2019 through March 2019. Correlation analysis was performed for arterial PaCO2, end-tidal CO2, TcCO2 parameters. P<0.05 values were considered significant. The Bland-Altman plot was created for determining the agreement between the methods. The correlation of transcutaneous CO2 and end-tidal CO2 with arterial PaCO2 was evaluated, both parameters were found to be positively and highly correlated (r=0.864, p<0.001, r:0.962, p<0.001, respectively). The mean bias between the arterial carbondioxide mesaurement and transcutaneous measurement was 5.5, and limits of agreement (bias ±1.96 SD) ranged from -13.9 to 2.9. The mean bias between the arterial carbondioxide mesaurement and end-tidal carbondioxide measurement was 2.3, and limits of agreement (bias ±1.96 SD) ranged from -4.1 to 8.6. In 44 measurements (88%), the TcCO2 was ±7.5 mm Hg of the PaCO2. TcCO2 seems to be a good alternative for carbon dioxide measurement, as it is non-invasive and allows continuous monitoring in view of today's intensive care conditions, but arterial PaCO2 measurement is still the gold standard method. Continuous TcCO2 monitoring provides a promising alternative to repeated blood sampling in subjects requiring mechanical ventilation for critically ill children.
随着儿科重症监护病房的发展，非侵入性方法已经取代了侵入性方法。尽管动脉二氧化碳测量仍然是评估肺泡通气的金标准，但由于PaCO2持续监测的需要以及该方法的侵入性，人们开始研究替代方法。目的探讨儿科重症监护病房机械通气患者经皮CO2 (TcCO2)监测与PaCO2、ETCO2的相关性。单中心、前瞻性、观察队列研究。2019年2月至2019年3月，我们招募了60名年龄在1个月至18岁之间、在儿科重症监护病房接受机械通气的患者，进行这项单中心、前瞻性、观察性队列研究。对动脉血PaCO2、末潮CO2、TcCO2参数进行相关性分析。P<0.05认为差异有统计学意义。Bland-Altman图是为了确定方法之间的一致性而创建的。经皮CO2和尾潮CO2与动脉血PaCO2的相关性分析，两者呈正相关和高度相关(r=0.864, p<0.001, r:0.962, p<0.001)。动脉二氧化碳测量与经皮测量之间的平均偏差为5.5，一致性限(偏差±1.96 SD)范围为-13.9至2.9。动脉二氧化碳测量和潮汐末二氧化碳测量之间的平均偏差为2.3，一致性限(偏差±1.96 SD)范围为-4.1至8.6。在44次(88%)测量中，TcCO2为PaCO2的±7.5 mm Hg。TcCO2似乎是二氧化碳测量的一个很好的替代方案，因为它是非侵入性的，并且考虑到今天的重症监护条件，可以连续监测，但动脉PaCO2测量仍然是金标准方法。对于需要机械通气的危重儿童，连续TcCO2监测为重复采血提供了一个有希望的替代方案。
{"title":"Evaluation of the Relationship between Transcutaneous Carbondioxide Monitorization and End-tidal Carbondioxide and Partial Carbondioxide Monitorization","authors":"Serkan Özsoylu, B. Akyıldız, A. Dursun, A. Baykan","doi":"10.51271/jpea-2021-0118","DOIUrl":"https://doi.org/10.51271/jpea-2021-0118","url":null,"abstract":"MonitorizationNon-invasive methods have replaced invasive methods in line with developments in pediatric intensive care units. (Especially methods that enable continuous monitoring) Although arterial carbon dioxide measurement is still the gold standard for the evaluation of alveolar ventilation, the need for continuous monitoring of PaCO2 and the invasive nature of this method have led to the investigation of alternative methods. To evaluate the correlation of transcutaneous CO2 (TcCO2) monitoring with PaCO2 and ETCO2 in mechanically ventilated patients in peditaric intensive care units. Single-center, prospective, observational cohort study. We enrolled 60 patients between the age of 1 month-18 years who were mechanically ventilated in pediatric intensive care unit for this single-center, prospective, observational cohort study from February 2019 through March 2019. Correlation analysis was performed for arterial PaCO2, end-tidal CO2, TcCO2 parameters. P<0.05 values were considered significant. The Bland-Altman plot was created for determining the agreement between the methods. The correlation of transcutaneous CO2 and end-tidal CO2 with arterial PaCO2 was evaluated, both parameters were found to be positively and highly correlated (r=0.864, p<0.001, r:0.962, p<0.001, respectively). The mean bias between the arterial carbondioxide mesaurement and transcutaneous measurement was 5.5, and limits of agreement (bias ±1.96 SD) ranged from -13.9 to 2.9. The mean bias between the arterial carbondioxide mesaurement and end-tidal carbondioxide measurement was 2.3, and limits of agreement (bias ±1.96 SD) ranged from -4.1 to 8.6. In 44 measurements (88%), the TcCO2 was ±7.5 mm Hg of the PaCO2. TcCO2 seems to be a good alternative for carbon dioxide measurement, as it is non-invasive and allows continuous monitoring in view of today's intensive care conditions, but arterial PaCO2 measurement is still the gold standard method. Continuous TcCO2 monitoring provides a promising alternative to repeated blood sampling in subjects requiring mechanical ventilation for critically ill children.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123379651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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