Pub Date : 2024-09-10DOI: 10.1177/1721727x241282483
Haopeng Li, Yaru Zu, Qinghua Wang, Tong Zi, Xin Qin, Yan Zhao, Wei Jiang, Xin’an Wang, Chengdang Xu, Xi Chen, Gang Wu
Background: Type 2 diabetes mellitus (T2DM) significantly contributes to sepsis, with patients suffering from both conditions exhibiting greater severity and higher mortality rates compared to those with sepsis alone. Elderly individuals in the intensive care unit (ICU) are particularly prone to these comorbidities. A nomogram prediction model was developed to accurately assess prognosis and guide treatment for elderly patients with sepsis and T2DM. Methods: Data from 1489 patients with sepsis and T2DM in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed and categorized into 28-days survival ( n = 1156) and 28-days death groups ( n = 333). The dataset’s clinical characteristics were employed to create a nomogram predicting 28-days mortality in elderly ICU patients with sepsis and T2DM. The least absolute shrinkage and selection operator (LASSO) regression identified candidate predictors, followed by a multivariate logistic regression analysis incorporating variables with p < .05 into the final model. A nomogram was then constructed using these significant risk predictors. The model’s discriminatory power was evaluated through a receiver operating curve (ROC) and the area under the curve (AUC). Additionally, model performance was assessed using a calibration plot and the Hosmer-Lemeshow goodness-of-fit test (HL test), and clinical utility was examined via decision curve analysis (DCA). Results: Risk factors incorporated into the nomogram included age, ICU length of stay, mean blood pressure (MBP), metastatic solid tumor, Sequential Organ Failure Assessment (SOFA) score, Logistic Organ Dysfunction System (LODS) score, blood urea nitrogen (BUN), and vasopressor use. The predictive model demonstrated robust discrimination, with an AUC of 0.802 (95% CI 0.768–0.835) in the training dataset and 0.753 (95% CI 0.697–0.809) in the validation set. Calibration was confirmed with the HL test ( p > .05), and DCA indicated clinical usefulness. Conclusion: This new nomogram serves as a practical tool for predicting 28-days mortality among elderly ICU patients with sepsis and T2DM. Optimizing treatment strategies based on this model could enhance 28-days survival rates for these patients.
{"title":"Risk factor analysis and nomogram development for predicting 28-day mortality in elderly ICU patients with sepsis and type 2 diabetes mellitus","authors":"Haopeng Li, Yaru Zu, Qinghua Wang, Tong Zi, Xin Qin, Yan Zhao, Wei Jiang, Xin’an Wang, Chengdang Xu, Xi Chen, Gang Wu","doi":"10.1177/1721727x241282483","DOIUrl":"https://doi.org/10.1177/1721727x241282483","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) significantly contributes to sepsis, with patients suffering from both conditions exhibiting greater severity and higher mortality rates compared to those with sepsis alone. Elderly individuals in the intensive care unit (ICU) are particularly prone to these comorbidities. A nomogram prediction model was developed to accurately assess prognosis and guide treatment for elderly patients with sepsis and T2DM. Methods: Data from 1489 patients with sepsis and T2DM in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed and categorized into 28-days survival ( n = 1156) and 28-days death groups ( n = 333). The dataset’s clinical characteristics were employed to create a nomogram predicting 28-days mortality in elderly ICU patients with sepsis and T2DM. The least absolute shrinkage and selection operator (LASSO) regression identified candidate predictors, followed by a multivariate logistic regression analysis incorporating variables with p < .05 into the final model. A nomogram was then constructed using these significant risk predictors. The model’s discriminatory power was evaluated through a receiver operating curve (ROC) and the area under the curve (AUC). Additionally, model performance was assessed using a calibration plot and the Hosmer-Lemeshow goodness-of-fit test (HL test), and clinical utility was examined via decision curve analysis (DCA). Results: Risk factors incorporated into the nomogram included age, ICU length of stay, mean blood pressure (MBP), metastatic solid tumor, Sequential Organ Failure Assessment (SOFA) score, Logistic Organ Dysfunction System (LODS) score, blood urea nitrogen (BUN), and vasopressor use. The predictive model demonstrated robust discrimination, with an AUC of 0.802 (95% CI 0.768–0.835) in the training dataset and 0.753 (95% CI 0.697–0.809) in the validation set. Calibration was confirmed with the HL test ( p > .05), and DCA indicated clinical usefulness. Conclusion: This new nomogram serves as a practical tool for predicting 28-days mortality among elderly ICU patients with sepsis and T2DM. Optimizing treatment strategies based on this model could enhance 28-days survival rates for these patients.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"387 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142179883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1177/1721727x241271668
Snežana M Jovičić
The manuscript analyzes potential pre-mRNA biomarkers of Myasthenia gravis (MG) in thymoma in silico. GSE11967 data set and platform5188 from the Gene Expression Omnibus database apply for data preprocessing, normalization, and quality control. Quality metrics indicated high overall data integrity, with no significant outliers or batch effects detected. Differential expression analysis (DEG.) uses the limma package in R. We compared thymoma samples to normal thymus tissue to identify DEGs. The significance criteria are adjusted p-value <0.05 and a |log2 fold change| > 1. Functional enrichment and pathway analysis, ontology analysis, and KEGG pathway analysis further investigate the potential underlying biological processes. Despite the extensive use of gene expression profiling for identifying potential biomarkers and therapeutic targets, this study identifies DEGs ENSG00000112345 and ENSG00000234567 and pathways like hsa04110, hsa03013 and hsa04115 in thymoma with MG compared to normal thymus tissue using the GSE11967 dataset Plots like UMAP, Boxplot, Expression density and Mean variance demonstrate differential expression in disease and control group. The GSE11967 data set shows the presence of significant DEG and pathways in thymoma-associated MG tissue, compared to healthy tissue. A broader and integrative approach is needed to understand the complex expression biomarkers in thymoma in MG patients and other regulatory mechanisms that may contribute to the disease by multi-omic approaches.
{"title":"In silico analysis of precursor messenger RNA as a potential biomarker of myasthenia gravis thymoma","authors":"Snežana M Jovičić","doi":"10.1177/1721727x241271668","DOIUrl":"https://doi.org/10.1177/1721727x241271668","url":null,"abstract":"The manuscript analyzes potential pre-mRNA biomarkers of Myasthenia gravis (MG) in thymoma in silico. GSE11967 data set and platform5188 from the Gene Expression Omnibus database apply for data preprocessing, normalization, and quality control. Quality metrics indicated high overall data integrity, with no significant outliers or batch effects detected. Differential expression analysis (DEG.) uses the limma package in R. We compared thymoma samples to normal thymus tissue to identify DEGs. The significance criteria are adjusted p-value <0.05 and a |log2 fold change| > 1. Functional enrichment and pathway analysis, ontology analysis, and KEGG pathway analysis further investigate the potential underlying biological processes. Despite the extensive use of gene expression profiling for identifying potential biomarkers and therapeutic targets, this study identifies DEGs ENSG00000112345 and ENSG00000234567 and pathways like hsa04110, hsa03013 and hsa04115 in thymoma with MG compared to normal thymus tissue using the GSE11967 dataset Plots like UMAP, Boxplot, Expression density and Mean variance demonstrate differential expression in disease and control group. The GSE11967 data set shows the presence of significant DEG and pathways in thymoma-associated MG tissue, compared to healthy tissue. A broader and integrative approach is needed to understand the complex expression biomarkers in thymoma in MG patients and other regulatory mechanisms that may contribute to the disease by multi-omic approaches.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"120 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141936104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ObjectivesHepatitis C virus (HCV) is one of the most global health problems with 2.5% prevalence worldwide. It seems that regulatory T (Treg) cells, which are able to modulate the host immune responses, play a substantial role in the immunopathogenesis of HCV infection. In this study, we evaluated the distribution of Treg cells in HCV-infected patients and its correlation with viral load and clinical manifestations.MethodsPeripheral blood mononuclear cells (PBMCs) were collected from 14 newly diagnosed HCV-infected patients and 23 age- and sex-matched healthy subjects, and the frequency of CD4+CD25+CD127−/low Treg cells was determined by flow cytometry.ResultsOur results showed that the mean level of CD4+CD25+CD127−/low Treg cells in HCV-infected patients was significantly higher than that in healthy control subjects (8.2 ± 1.48% vs 5.4 ± 0.36%, p < .05). However, there was no statistical correlation between Treg cells frequency and viral load or clinical manifestations.ConclusionA higher proportion of Treg cells in HCV-infected patients might indicate their critical role in viral persistence and candidate them as a new target of immunotherapy to improve antiviral immunity.
{"title":"Evaluation of circulating CD4+CD25+CD127−/low regulatory T cells in newly diagnosed hepatitis C-infected patients","authors":"Morvarid Asadipour, Soolmaz Khansalar, Fatemeh Rezaei Kahmini, Mahsa Eshkevar Vakili, Mohammad Reza Ataollahi, Mohammad Ali-Hassanzadeh, Keivan Shams, Zahra Faghih, Kurosh Kalantar","doi":"10.1177/1721727x241242701","DOIUrl":"https://doi.org/10.1177/1721727x241242701","url":null,"abstract":"ObjectivesHepatitis C virus (HCV) is one of the most global health problems with 2.5% prevalence worldwide. It seems that regulatory T (Treg) cells, which are able to modulate the host immune responses, play a substantial role in the immunopathogenesis of HCV infection. In this study, we evaluated the distribution of Treg cells in HCV-infected patients and its correlation with viral load and clinical manifestations.MethodsPeripheral blood mononuclear cells (PBMCs) were collected from 14 newly diagnosed HCV-infected patients and 23 age- and sex-matched healthy subjects, and the frequency of CD4+CD25+CD127−/low Treg cells was determined by flow cytometry.ResultsOur results showed that the mean level of CD4+CD25+CD127−/low Treg cells in HCV-infected patients was significantly higher than that in healthy control subjects (8.2 ± 1.48% vs 5.4 ± 0.36%, p < .05). However, there was no statistical correlation between Treg cells frequency and viral load or clinical manifestations.ConclusionA higher proportion of Treg cells in HCV-infected patients might indicate their critical role in viral persistence and candidate them as a new target of immunotherapy to improve antiviral immunity.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"18 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease. The effects of emphysema on mortality in IPF remains unclear.MethodsMEDLINE, Embase and Cochrane Library databases were searched. Studies were included if they compared mortality in IPF patients with and without emphysema. In included studies, the diagnosis with IPF or IPF combined emphysema was according to the ATS and ERS statements. From eligible studies, we extracted HR and 95% CI, if HRs were not reported, they were extracted based on Kaplan–Meier curves.ResultsA total of 2605 patients across 15 cohort studies were included in the systematic review and meta-analysis. Emphysema was associated with increased risk of all-cause mortality with a pooled HR 1.37 (95% CI, 1.04-1.80) and I 2 = 64%. However, the level of evidence was ‘very low’ according to GRADE criteria. Subgroup analysis according to IPF with emphysema patients revealed that DLCO%pre<40 (HR 1.75 (95% CI, 1.02-3.01) and I 2 = 74%), FVC%pre<80 (HR 1.81 (95% CI, 1.24-2.64) and I 2 = 61%), location on North America and Europe (HR 2.00 (95% CI, 1.09-3.67) and I 2 = 76%), and Smoking Pack-years<40 (HR 1.38 (95% CI, 1.02-1.87) and I 2 = 15%) were risk factors for all-cause mortality. Sensitivity analysis revealed that one study had a disproportional effect on the pooled rate.ConclusionsOur findings suggested emphysema increased the risk of all-cause mortality in patients with IPF. This conclusion should be re-evaluated by a large-scale randomized controlled trial.Trial RegistrationPROSPERO: CRD42022378699; https://www.crd.york.ac.uk/prospero/ .
{"title":"Impact of emphysema on mortality in idiopathic pulmonary fibrosis: A systematic review and meta-analysis","authors":"Yanhong Wang, Ruyi Zou, Yu Yao, Cheng Tang, Jing Luo, Minjie Lin","doi":"10.1177/1721727x241258923","DOIUrl":"https://doi.org/10.1177/1721727x241258923","url":null,"abstract":"BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease. The effects of emphysema on mortality in IPF remains unclear.MethodsMEDLINE, Embase and Cochrane Library databases were searched. Studies were included if they compared mortality in IPF patients with and without emphysema. In included studies, the diagnosis with IPF or IPF combined emphysema was according to the ATS and ERS statements. From eligible studies, we extracted HR and 95% CI, if HRs were not reported, they were extracted based on Kaplan–Meier curves.ResultsA total of 2605 patients across 15 cohort studies were included in the systematic review and meta-analysis. Emphysema was associated with increased risk of all-cause mortality with a pooled HR 1.37 (95% CI, 1.04-1.80) and I<jats:sup> 2</jats:sup> = 64%. However, the level of evidence was ‘very low’ according to GRADE criteria. Subgroup analysis according to IPF with emphysema patients revealed that DL<jats:sub>CO</jats:sub>%pre<40 (HR 1.75 (95% CI, 1.02-3.01) and I<jats:sup> 2</jats:sup> = 74%), FVC%pre<80 (HR 1.81 (95% CI, 1.24-2.64) and I<jats:sup> 2</jats:sup> = 61%), location on North America and Europe (HR 2.00 (95% CI, 1.09-3.67) and I<jats:sup> 2</jats:sup> = 76%), and Smoking Pack-years<40 (HR 1.38 (95% CI, 1.02-1.87) and I<jats:sup> 2</jats:sup> = 15%) were risk factors for all-cause mortality. Sensitivity analysis revealed that one study had a disproportional effect on the pooled rate.ConclusionsOur findings suggested emphysema increased the risk of all-cause mortality in patients with IPF. This conclusion should be re-evaluated by a large-scale randomized controlled trial.Trial RegistrationPROSPERO: CRD42022378699; https://www.crd.york.ac.uk/prospero/ .","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"69 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141190939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29DOI: 10.1177/1721727x241258929
Canser Yilmaz Demir, Nazim Bozan
Objective: Deep neck space abscess (DNSA) is a serious infection associated with immune response. Magnesium has fundamental multifunctions in the body. Its insufficiency is involved in immüne weakness and susceptibility to infectious diseases. The present study addressed serum magnesium status in patients with DNSA. Herein, we hypothesized that patients with DNSA may have decreased serum magnesium concentration.Materials and Methods: In the study, 23 patients with DNSA and 23 matched healthy individuals were included. The atomic absorption spectrometry was used to measure serum magnesium concentration. The groups were compared statistically for demographics and serum magnesium concentration.Results: Patients with DNSA and healthy controls were statistically similar in age ( p = .625), gender ( p = 1.0), and smoking status ( p = 1.0). However, patients with DNSA had significantly decreased serum magnesium concentration (µg/dL) than healthy controls [25.23 ± 4.98 (19.9-42.2) versus 31.98 ± 5.36 (26.8-40.8)], ( p < .001).Conclusion: This study demonstrated that decreased serum magnesium concentration is associated with DNSA. It is the first report on the research topic, and may inspire future studies.
{"title":"Serum magnesium levels in patients with deep neck space abscess: A case-control study","authors":"Canser Yilmaz Demir, Nazim Bozan","doi":"10.1177/1721727x241258929","DOIUrl":"https://doi.org/10.1177/1721727x241258929","url":null,"abstract":"Objective: Deep neck space abscess (DNSA) is a serious infection associated with immune response. Magnesium has fundamental multifunctions in the body. Its insufficiency is involved in immüne weakness and susceptibility to infectious diseases. The present study addressed serum magnesium status in patients with DNSA. Herein, we hypothesized that patients with DNSA may have decreased serum magnesium concentration.Materials and Methods: In the study, 23 patients with DNSA and 23 matched healthy individuals were included. The atomic absorption spectrometry was used to measure serum magnesium concentration. The groups were compared statistically for demographics and serum magnesium concentration.Results: Patients with DNSA and healthy controls were statistically similar in age ( p = .625), gender ( p = 1.0), and smoking status ( p = 1.0). However, patients with DNSA had significantly decreased serum magnesium concentration (µg/dL) than healthy controls [25.23 ± 4.98 (19.9-42.2) versus 31.98 ± 5.36 (26.8-40.8)], ( p < .001).Conclusion: This study demonstrated that decreased serum magnesium concentration is associated with DNSA. It is the first report on the research topic, and may inspire future studies.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"51 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141190944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosacea, a common and chronic skin disorder, presents with various cutaneous manifestations. The phenotype of rosacea determines the approach to treatment. Refractory rosacea with persistent erythema invariably necessitates pharmacologic agents. Herein, we report a case series on three female patients with persistent erythema of rosacea treated by abrocitinib, a JAK-1 inhibitor.
{"title":"Real-life experience of abrocitinib for the treatment of female patients with persistent erythema of rosacea","authors":"Yan Teng, Huiting Zhong, Youming Huang, Xiaohua Tao, Yibin Fan, Yong Yu","doi":"10.1177/1721727x241258794","DOIUrl":"https://doi.org/10.1177/1721727x241258794","url":null,"abstract":"Rosacea, a common and chronic skin disorder, presents with various cutaneous manifestations. The phenotype of rosacea determines the approach to treatment. Refractory rosacea with persistent erythema invariably necessitates pharmacologic agents. Herein, we report a case series on three female patients with persistent erythema of rosacea treated by abrocitinib, a JAK-1 inhibitor.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"45 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141165735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the ability of the 35 kDa low-molecular-weight hyaluronan fragment (HA35) to relieve neuropathic and inflammatory pain, including postherpetic neuralgia and shoulder, neck, back and temporomandibular pain. Ten patients with postherpetic neuralgia and 26 patients with shoulder, neck, back or temporomandibular pain were studied and assessed. The 35 kDa hyaluronan fragment (HA35) was prepared by mixing hyaluronidase and 100 mg of high-molecular-weight HA at room temperature for 20 mins. This mixture was locally injected once at the pain point or where the nerve trunk innervated the pain point. Patients scored their pain and comfort on the numerical pain rating scale (NPRS) and the General Comfort Questionnaire (GCQ). After treatment, the NPRS scores and GCQ scores improved. Patients with postherpetic neuralgia and shoulder, neck, back or temporomandibular pain had significantly lower NPRS scores at 30 min to 180 min after injection, especially at 180 min ( p < .001). The GCQ scores after treatment for 24 h was significantly greater than that before treatment ( p < .01). No adverse reactions occurred. The 35 kDa hyaluronan fragment (HA35) effectively relieved postherpetic neuralgia-induced neuropathic pain and shoulder, neck, back and temporomandibular inflammatory pain.Clinical Trial Registration: NCT05809700 at https://www.clinicaltrials.gov .
{"title":"Local injection of a freshly manufactured 35 kDa hyaluronan fragment reduces neuropathic and inflammatory pain: A clinical study","authors":"FengHe Xu, Dylan Treger, Xinyue Ma, XiaoXiao Jia, Joshua H Shofaro, Taivanbat Ganbaatar, Munkh-Amgalan Gantumur, Jessica Hui, Mizhou Hui, Chao Meng","doi":"10.1177/1721727x241258268","DOIUrl":"https://doi.org/10.1177/1721727x241258268","url":null,"abstract":"To investigate the ability of the 35 kDa low-molecular-weight hyaluronan fragment (HA35) to relieve neuropathic and inflammatory pain, including postherpetic neuralgia and shoulder, neck, back and temporomandibular pain. Ten patients with postherpetic neuralgia and 26 patients with shoulder, neck, back or temporomandibular pain were studied and assessed. The 35 kDa hyaluronan fragment (HA35) was prepared by mixing hyaluronidase and 100 mg of high-molecular-weight HA at room temperature for 20 mins. This mixture was locally injected once at the pain point or where the nerve trunk innervated the pain point. Patients scored their pain and comfort on the numerical pain rating scale (NPRS) and the General Comfort Questionnaire (GCQ). After treatment, the NPRS scores and GCQ scores improved. Patients with postherpetic neuralgia and shoulder, neck, back or temporomandibular pain had significantly lower NPRS scores at 30 min to 180 min after injection, especially at 180 min ( p < .001). The GCQ scores after treatment for 24 h was significantly greater than that before treatment ( p < .01). No adverse reactions occurred. The 35 kDa hyaluronan fragment (HA35) effectively relieved postherpetic neuralgia-induced neuropathic pain and shoulder, neck, back and temporomandibular inflammatory pain.Clinical Trial Registration: NCT05809700 at https://www.clinicaltrials.gov .","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"38 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141150153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.1177/1721727x241252959
Shuo Huang, Fang Guo, Ning Liu, Kaijin Hu, Changkui Liu
Investigating the role of surface-modified 3D printed titanium implants in modulating oral soft tissue closure and antimicrobial properties. Eighteen 6-month-old healthy adult New Zealand White rabbits were selected as experimental animals, the left and right mandibular teeth of each experimental animal were randomly divided into two groups, and the bilateral first premolar teeth were extracted after general anesthesia, and one implant was implanted into each of the magnesium/zinc ionized surface-treated group (experimental group) and the surface-untreated group (control group), with a total of 36 implants, i.e., 18 implants for the experimental group and 18 implants for the control group. Bilateral mandibular samples from both groups were removed after 2 and 4 weeks of implantation to investigate the attachment and spreading of human gingival fibroblasts (HGFs) on the surface of the samples, their proliferative and migratory behaviors as well as the expression levels of related gene proteins (CoL-1 and TGF-β), and HE staining of the soft tissues of the samples and inflammatory cell counts. After 2 and 4 weeks of implantation, the experimental group’s HGFs adhesion and spreading were significantly better than that of the control group, the migration and proliferation of HGFs were significantly greater than that of the control group ( p < .05), and the expression of CoL-1 and TGF-β genes was significantly higher than that of the control group ( p < .05), and the inflammatory cell count was significantly smaller than that of the control group ( p < .05). Surface modification by magnesium and zinc ions enhances the sealing performance and antimicrobial performance of 3D printed titanium implants in oral soft tissues, with significant effects.
{"title":"Cellular experimental study and mechanism of surface modification of 3D printed titanium materials to modulate the sealing and antimicrobial properties of oral implants","authors":"Shuo Huang, Fang Guo, Ning Liu, Kaijin Hu, Changkui Liu","doi":"10.1177/1721727x241252959","DOIUrl":"https://doi.org/10.1177/1721727x241252959","url":null,"abstract":"Investigating the role of surface-modified 3D printed titanium implants in modulating oral soft tissue closure and antimicrobial properties. Eighteen 6-month-old healthy adult New Zealand White rabbits were selected as experimental animals, the left and right mandibular teeth of each experimental animal were randomly divided into two groups, and the bilateral first premolar teeth were extracted after general anesthesia, and one implant was implanted into each of the magnesium/zinc ionized surface-treated group (experimental group) and the surface-untreated group (control group), with a total of 36 implants, i.e., 18 implants for the experimental group and 18 implants for the control group. Bilateral mandibular samples from both groups were removed after 2 and 4 weeks of implantation to investigate the attachment and spreading of human gingival fibroblasts (HGFs) on the surface of the samples, their proliferative and migratory behaviors as well as the expression levels of related gene proteins (CoL-1 and TGF-β), and HE staining of the soft tissues of the samples and inflammatory cell counts. After 2 and 4 weeks of implantation, the experimental group’s HGFs adhesion and spreading were significantly better than that of the control group, the migration and proliferation of HGFs were significantly greater than that of the control group ( p < .05), and the expression of CoL-1 and TGF-β genes was significantly higher than that of the control group ( p < .05), and the inflammatory cell count was significantly smaller than that of the control group ( p < .05). Surface modification by magnesium and zinc ions enhances the sealing performance and antimicrobial performance of 3D printed titanium implants in oral soft tissues, with significant effects.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"111 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140934541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.1177/1721727x241249434
Hamid Chegni, Hadise Babaii, Fatemeh Pouran
Introduction: The anti-idiotype network was introduced in 1974 by Niels Jerne. One of the factors that reduces the effectiveness of the vaccines is the anti-idiotype network. It should be noted that the Anti-idiotype of the antibody has the ability to bind to the receptors of the body cells to which the antigen of the first antibody binds; this causes pathological complications, especially after a longer period of time. In this study, we aim to be the first to study the presence of Anti-idiotype antibodies and ANA in people who have received three doses of the COVID-19 vaccine and check that at least 4 months have passed since the injection of their third dose.Materials and Methods: This study was conducted on 180 people and measuring amount of Anti-RBD Anti-idiotype, Anti-Nuclear Antibody (IgG antibodies against RNP, sm RNP, smSSB/La, SSA/Ro, scl 70, centromere B, Jo1, and dsDNA antigens) and SARS-COV-Anti IgG RBD in serum by ELISA methods.Results: In the measurement of Anti-RBD Anti-idiotype, it was found that 14 people (7.7%) of the studied subjects had Anti-idiotype antibodies and 166 (92.3%) lacked this antibody. It was found that five of the studied subjects (2.7%) had positive values for ANA (above 50 RU/ML; in 175 people (97.3), the ANA value was negative (less than 50 RU/ML). In the examination of the results related to the measurement of the quantitative amount of SARS-COV-Anti IgG RBD, it was found that all 180 people included in the study (100%) had a detectable titer of Anti-RBD antibody.Conclusion: Many studies have shown an association between autoimmune diseases and SARS-COV-2 and MERS-CoV. Nevertheless, no studies have investigated autoantibodies in people who have injected three doses of the COVID-19 vaccine. further studies are warranted to confirm and find the causes of this difference.
{"title":"The study of anti-idiotype antibody and antinuclear antibodies (ANA) in people receiving three doses of the COVID-19 vaccine","authors":"Hamid Chegni, Hadise Babaii, Fatemeh Pouran","doi":"10.1177/1721727x241249434","DOIUrl":"https://doi.org/10.1177/1721727x241249434","url":null,"abstract":"Introduction: The anti-idiotype network was introduced in 1974 by Niels Jerne. One of the factors that reduces the effectiveness of the vaccines is the anti-idiotype network. It should be noted that the Anti-idiotype of the antibody has the ability to bind to the receptors of the body cells to which the antigen of the first antibody binds; this causes pathological complications, especially after a longer period of time. In this study, we aim to be the first to study the presence of Anti-idiotype antibodies and ANA in people who have received three doses of the COVID-19 vaccine and check that at least 4 months have passed since the injection of their third dose.Materials and Methods: This study was conducted on 180 people and measuring amount of Anti-RBD Anti-idiotype, Anti-Nuclear Antibody (IgG antibodies against RNP, sm RNP, smSSB/La, SSA/Ro, scl 70, centromere B, Jo1, and dsDNA antigens) and SARS-COV-Anti IgG RBD in serum by ELISA methods.Results: In the measurement of Anti-RBD Anti-idiotype, it was found that 14 people (7.7%) of the studied subjects had Anti-idiotype antibodies and 166 (92.3%) lacked this antibody. It was found that five of the studied subjects (2.7%) had positive values for ANA (above 50 RU/ML; in 175 people (97.3), the ANA value was negative (less than 50 RU/ML). In the examination of the results related to the measurement of the quantitative amount of SARS-COV-Anti IgG RBD, it was found that all 180 people included in the study (100%) had a detectable titer of Anti-RBD antibody.Conclusion: Many studies have shown an association between autoimmune diseases and SARS-COV-2 and MERS-CoV. Nevertheless, no studies have investigated autoantibodies in people who have injected three doses of the COVID-19 vaccine. further studies are warranted to confirm and find the causes of this difference.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"15 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140883434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-29DOI: 10.1177/1721727x241250289
Juan Shao, Xin Wang, Zhongwen Zhang, Linfeng Li
Introduction: Bacterial infection secondary to eczema and dermatitis occurs frequently. However, due to the inconvenience of clinical bacterial culture procedure, clinical diagnosis of bacterial infection following eczema is typically based on the appearance of skin lesions. To date, no surveys on the use of topical antibiotics for treating eczema and dermatitis in China have been carried out. Methods: The present study investigated the factors influencing the use of topical antibiotics to treat eczema and dermatitis in China. Logistic regression model and chi-square test were employed to examine whether topical antibiotics cause contact irritation. Results: It was found that the proportion of patients with eczema and dermatitis who were previously treated with topical antibiotics was 72.40%. The patients’ residence regions (southern vs northern territories, p < .001), hospital levels (secondary-level and below vs third-level hospitals, p = .004), itching degrees (no itching, itching does not require scratching, itching requires scratching, and scratching affects sleep and life quality, p < .001), skin infection status (no obvious infection phenomenon, possible infection, and clear infection, p = .001), and skin lesion infection severity (mild, moderate, and severe, p < .001) all showed statistically significant differences in the univariate analysis of antibiotic ointment treatment factors. The percentage of patients experiencing contact irritation reactions resulting from the use of topical antibiotics was 2.60%. The incidence of exposure to irritation was higher in patients who used more than two types of topical antibiotics compared to patients treated with only one type of topical antibiotic (% vs %, chi-square test, p < .001). Conclusion: The number of individuals who used topical antibiotics for eczema and dermatitis was relatively high in China. The degree of itching, infection possibility, and degree of skin lesion infection were positively correlated with the patients’ previous topical antibiotic treatment.
{"title":"An investigation on the use of topical antibiotics for treating eczema and dermatitis in China","authors":"Juan Shao, Xin Wang, Zhongwen Zhang, Linfeng Li","doi":"10.1177/1721727x241250289","DOIUrl":"https://doi.org/10.1177/1721727x241250289","url":null,"abstract":"Introduction: Bacterial infection secondary to eczema and dermatitis occurs frequently. However, due to the inconvenience of clinical bacterial culture procedure, clinical diagnosis of bacterial infection following eczema is typically based on the appearance of skin lesions. To date, no surveys on the use of topical antibiotics for treating eczema and dermatitis in China have been carried out. Methods: The present study investigated the factors influencing the use of topical antibiotics to treat eczema and dermatitis in China. Logistic regression model and chi-square test were employed to examine whether topical antibiotics cause contact irritation. Results: It was found that the proportion of patients with eczema and dermatitis who were previously treated with topical antibiotics was 72.40%. The patients’ residence regions (southern vs northern territories, p < .001), hospital levels (secondary-level and below vs third-level hospitals, p = .004), itching degrees (no itching, itching does not require scratching, itching requires scratching, and scratching affects sleep and life quality, p < .001), skin infection status (no obvious infection phenomenon, possible infection, and clear infection, p = .001), and skin lesion infection severity (mild, moderate, and severe, p < .001) all showed statistically significant differences in the univariate analysis of antibiotic ointment treatment factors. The percentage of patients experiencing contact irritation reactions resulting from the use of topical antibiotics was 2.60%. The incidence of exposure to irritation was higher in patients who used more than two types of topical antibiotics compared to patients treated with only one type of topical antibiotic (% vs %, chi-square test, p < .001). Conclusion: The number of individuals who used topical antibiotics for eczema and dermatitis was relatively high in China. The degree of itching, infection possibility, and degree of skin lesion infection were positively correlated with the patients’ previous topical antibiotic treatment.","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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