Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.009
Gehan Magdy Yousef, Mahmoud Muhamed Hassanein, Aly Alsaid Zidan, Diaaaldin Taha Zahran
Abstract Aim Evaluation the relationship between the epicardial adipose tissue thickness (EAT), the coronary arteries thrombus burden and the early major adverse cardiovascular events (MACE) in patients presented with STEMI undergoing primary percutaneous coronary intervention. Method The study was prospective and included patients (n = 80) who were referred to the cardiology department in Alexandria University Hospitals with STEMI between the 1st of March 2021 and the last day of August 2022. Patient clinical, laboratory, angiographic and echocardiographic data were described. Patients were put under observation to detect the occurrence of any major adverse cardiovascular events either in hospital or during a period of 30 days follow up. Special concerns for measuring EAT as an echo free space between the myocardium and visceral epicardial and measured perpendicular to the free wall of the right ventricle in parasternal long and short axis views at end diastole and angiographic assessment of thrombus burden was scored as follows: 0 (no thrombus), 1 (possible thrombus), 2 (definite thrombus < 0.5× reference vessel diameter), 3 (definite thrombus 0.5–2× reference vessel diameter), 4 (definite thrombus >2× reference vessel diameter), and 5 (complete vessel occlusion). According to thrombus grade the patients were grouped as low thrombus burden (grades 0–3) and high thrombus burden (grades 4 and 5). Results 25 subjects were in the low thrombus burden group and 55 in the high thrombus burden group. There were no differences in the two groups for age, sex, smoking and drug addiction status, family history of coronary artery disease, diabetes mellitus, hypertension, and total cholesterol, triglyceride, LDL-C and HDL-C, The mean Wall motion score and Wall motion score index. The means levels of high sensitivity troponin I and Creatine Kinase MB are measured higher in the low thrombus burden group with statistically significant difference (P = 0.025) and (P = 0.032). Balloon predilation was statistically significant difference between the two groups (P = 0.006). Thrombus’ aspiration, balloon post dilation of the culprit vessel, GpIIb/IIIa inhibitors, and one stent only were insignificant difference between the two groups. The receiver operating characteristic curve analysis was undergone to determine the cutoff value of EAT to predict the presence of high thrombus burden setting a significance level at P < 0.05. The thickness of 2.48 mm for EAT has 74.55% sensitivity and 72.0% specificity for prediction of the high thrombus burden. The predictors of the high thrombus burden were analyzed by univariate analysis shows EAT, the waist circumference, Wight, the body mass index, and balloon predilation were found as an independent predictors of high thrombus burden. The multivariate analysis shows EAT and balloon predilation were found as an independent predictors of high thrombus burden. The overall MACE at 30 day follows up has statistic
{"title":"Impact of epicardial adipose tissue on coronary arteries thrombus burden and early outcomes in STEMI patients","authors":"Gehan Magdy Yousef, Mahmoud Muhamed Hassanein, Aly Alsaid Zidan, Diaaaldin Taha Zahran","doi":"10.1093/eurheartjsupp/suad113.009","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.009","url":null,"abstract":"Abstract Aim Evaluation the relationship between the epicardial adipose tissue thickness (EAT), the coronary arteries thrombus burden and the early major adverse cardiovascular events (MACE) in patients presented with STEMI undergoing primary percutaneous coronary intervention. Method The study was prospective and included patients (n = 80) who were referred to the cardiology department in Alexandria University Hospitals with STEMI between the 1st of March 2021 and the last day of August 2022. Patient clinical, laboratory, angiographic and echocardiographic data were described. Patients were put under observation to detect the occurrence of any major adverse cardiovascular events either in hospital or during a period of 30 days follow up. Special concerns for measuring EAT as an echo free space between the myocardium and visceral epicardial and measured perpendicular to the free wall of the right ventricle in parasternal long and short axis views at end diastole and angiographic assessment of thrombus burden was scored as follows: 0 (no thrombus), 1 (possible thrombus), 2 (definite thrombus &lt; 0.5× reference vessel diameter), 3 (definite thrombus 0.5–2× reference vessel diameter), 4 (definite thrombus &gt;2× reference vessel diameter), and 5 (complete vessel occlusion). According to thrombus grade the patients were grouped as low thrombus burden (grades 0–3) and high thrombus burden (grades 4 and 5). Results 25 subjects were in the low thrombus burden group and 55 in the high thrombus burden group. There were no differences in the two groups for age, sex, smoking and drug addiction status, family history of coronary artery disease, diabetes mellitus, hypertension, and total cholesterol, triglyceride, LDL-C and HDL-C, The mean Wall motion score and Wall motion score index. The means levels of high sensitivity troponin I and Creatine Kinase MB are measured higher in the low thrombus burden group with statistically significant difference (P = 0.025) and (P = 0.032). Balloon predilation was statistically significant difference between the two groups (P = 0.006). Thrombus’ aspiration, balloon post dilation of the culprit vessel, GpIIb/IIIa inhibitors, and one stent only were insignificant difference between the two groups. The receiver operating characteristic curve analysis was undergone to determine the cutoff value of EAT to predict the presence of high thrombus burden setting a significance level at P &lt; 0.05. The thickness of 2.48 mm for EAT has 74.55% sensitivity and 72.0% specificity for prediction of the high thrombus burden. The predictors of the high thrombus burden were analyzed by univariate analysis shows EAT, the waist circumference, Wight, the body mass index, and balloon predilation were found as an independent predictors of high thrombus burden. The multivariate analysis shows EAT and balloon predilation were found as an independent predictors of high thrombus burden. The overall MACE at 30 day follows up has statistic","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135299072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.008
Amr Setouhi, Hesham Boshra, Hany Askalany, Hazem M A Farrag
Abstract Background Global longitudinal left atrial strain (GLS) has been used as a new assessment tool for left atrial function. Aim To investigate the effect of balloon mitral valvuloplasty (BMV) in patients with severe rheumatic mitral stenosis on GLS and its relation to the mitral valve area achieved after the procedure. Methods The study included 95 patients with severe mitral stenosis who fulfilled the criteria for BMV (case group) and 80 normal healthy subjects (control group). All included participants underwent complete echocardiographic examinations. For the case group, GLS was assessed by 2D speckle-tracking Echocardiography before valvuloplasty, immediately after, within 24 h, at 6 months, and at 12 months, and the results were compared. Results The impaired left-atrium strain in patients with severe mitral stenosis was improved immediately after BMV, and the improvement continued at 6 and 12 months post-BMV (23.1% ± 4.2 vs. 36.0 % ± 4.9, 36.2% ± 4.5, and 40.1% ± 9.5, respectively P < 0.01). After BMV, there was a significant decrease in left atrial volume (76.3 ± 12.4 mL/m2 vs. 68.6 ± 10.4 mL/m2, P < 0.01) and a significant increase in the area occupied by the mitral valve (1.02 ± 0.18 cm2 vs. 1.60 ± 0.31 cm, P < 0.01).The immediate GLS and the mitral valve area were positively correlated (r = 0.64, P < 0.01). Furthermore, the immediate GLS was associated with significantly improved function class (P < 0.01). Conclusion GLS can indicate left atrial function (mainly reservoir function). The improvement observed in patients after BMV may indicate that GLS can be used to evaluate the progress after BMV. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.
背景全局纵向左心房应变(GLS)是一种评价左心房功能的新方法。目的探讨重度风湿性二尖瓣狭窄患者球囊二尖瓣成形术(BMV)对GLS的影响及其与术后二尖瓣面积的关系。方法选取符合BMV标准的重度二尖瓣狭窄患者95例(病例组)和正常健康者80例(对照组)。所有纳入的参与者都进行了完整的超声心动图检查。对于病例组,在瓣膜成形术前、术后立即、24小时内、6个月和12个月时通过二维斑点跟踪超声心动图评估GLS,并对结果进行比较。结果重度二尖瓣狭窄患者左心房应变受损在BMV后立即得到改善,并在BMV后6个月和12个月持续改善(分别为23.1%±4.2∶36.0%±4.9、36.2%±4.5和40.1%±9.5);0.01)。BMV后左房容积显著降低(76.3±12.4 mL/m2 vs. 68.6±10.4 mL/m2), P <0.01),二尖瓣占用面积显著增加(1.02±0.18 cm2 vs. 1.60±0.31 cm, P <0.01)。即时GLS与二尖瓣面积呈正相关(r = 0.64, P <0.01)。此外,即时GLS与显著改善的功能等级(P <0.01)。结论GLS能反映左心房功能(主要是左心房储血功能)。患者在BMV后观察到的改善可能表明GLS可用于评估BMV后的进展。一个作者的视频,伴随着这个摘要可在https://academic.oup.com/eurheartjsupp。请点击“更多内容”旁边的箭头,然后点击“作者视频”。
{"title":"Immediate, short-term, and long-term effects of balloon mitral valvuloplasty on the left atrial global longitudinal strain and its correlation to the outcomes in patients with severe rheumatic mitral stenosis","authors":"Amr Setouhi, Hesham Boshra, Hany Askalany, Hazem M A Farrag","doi":"10.1093/eurheartjsupp/suad113.008","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.008","url":null,"abstract":"Abstract Background Global longitudinal left atrial strain (GLS) has been used as a new assessment tool for left atrial function. Aim To investigate the effect of balloon mitral valvuloplasty (BMV) in patients with severe rheumatic mitral stenosis on GLS and its relation to the mitral valve area achieved after the procedure. Methods The study included 95 patients with severe mitral stenosis who fulfilled the criteria for BMV (case group) and 80 normal healthy subjects (control group). All included participants underwent complete echocardiographic examinations. For the case group, GLS was assessed by 2D speckle-tracking Echocardiography before valvuloplasty, immediately after, within 24 h, at 6 months, and at 12 months, and the results were compared. Results The impaired left-atrium strain in patients with severe mitral stenosis was improved immediately after BMV, and the improvement continued at 6 and 12 months post-BMV (23.1% ± 4.2 vs. 36.0 % ± 4.9, 36.2% ± 4.5, and 40.1% ± 9.5, respectively P &lt; 0.01). After BMV, there was a significant decrease in left atrial volume (76.3 ± 12.4 mL/m2 vs. 68.6 ± 10.4 mL/m2, P &lt; 0.01) and a significant increase in the area occupied by the mitral valve (1.02 ± 0.18 cm2 vs. 1.60 ± 0.31 cm, P &lt; 0.01).The immediate GLS and the mitral valve area were positively correlated (r = 0.64, P &lt; 0.01). Furthermore, the immediate GLS was associated with significantly improved function class (P &lt; 0.01). Conclusion GLS can indicate left atrial function (mainly reservoir function). The improvement observed in patients after BMV may indicate that GLS can be used to evaluate the progress after BMV. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.002
Amr Setouhi, Ashraf Radi, Hany Taha Asklany, Hazem M A Farrag
Abstract Background & objective Recently, the antidiabetic drug sodium-glucose cotransporter type 2 inhibitor (SGLT2i) has been approved among the drugs that reduce mortality in patients with HFrEF. The impact of SGLT2i inhibitors on the left ventricle longitudinal myocardial function in heart failure (HF) patients remained vague. The effect of SGLT2i on left ventricular remodeling and function in patients with HFrEF was studied using STE and traditional echocardiography. Objectives Studying the effects of SGLT2i on left ventricular remodeling and function in HFrEF patients using STE and traditional echocardiography. Methods 300 patients with HFrEF were included.Study design: This prospective observational study involves 300 patients with HFrEF-administered SGLT2i (Empagliflozin & Dapagliflozin) in addition to the classical treatment of heart failure. Then the patients were followed up 2, 4 & 6 months after treatment with laboratory investigations of HbA1C and eGFR, in addition to 2D echo & STE studies. Results Regarding Demographic data, the mean age was 50 ± 9.2 for males and females. The mean weight, height, and body mass index (BMI) were 85.6 ± 8.8 kg, 178.6 ± 7.2 cm, and 26.6 ± 2.9, respectively. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 115.3 ± 5.1 and 75.4 ± 4.5, respectively. The mean heart rate was 79.9 ± 10.2. The mean respiratory rate was15 ± 2.2. Regarding functional NYHA class, 1 (0.2%), 54(12%), 392 (87.1%), and 3 (0.7%) patients were class I, II, III, and IV, respectively. The lab investigations at first presentation were: mean HbA1C was 4.2 ± 0.6, and the mean of eGFR was 66.4 ± 9.3. Concerning Echocardiography data of patients LVEF by 2D echo show significant improvement from 34.73 ± 2.9 at baseline to 34.91 ± 1.2, 35.42 ± 3.5 & 36.54 ± 3.6 at 2, 4 & 6 months (P = 0.001) also GLS A4 showed significant improvement from −15.67 ± 2.74 to −16.5 ± 3.19, −17.32 ± 3.21, −18.03 ± 3.05at 2, 4 & 6 months (P = 0.001), and from −15.66 ± 2.65 to −16.50 ± 3.31, −17.41 ± 3.23 & −17.93 ± 3.32 (P = 0.001) by GLS A2 Regarding dapagliflozin LVEF by 2D echo show significant improvement from 34.87 ± 2.86 at baseline to 34.87 ± 2.86, 35.05 ± 3.01& 37.53 ± 4.1 at 2, 4 & 6 months (P = 0.001) also GLS A2 showed significant improvement from −15.67 ± 2.74 to −16.50 ± 3.31 −17.41 ± 3.23 −17.93 ± 3.32 at 2, 4 & 6 months (P = 0.001), and from −15.54 ± 2.77 to −16.84 ± 3.49, −18.48 ± 2.23 & −19.61 ± 2.98 (P = 0.001) by GLS A4, also E/e′ significantly reduced from 11.2 ± 2.7 to 9.1 ± 2.3 cm/s after administration of empagliflozin and dapagliflozin within 6 months (P = 0.01) also LAVI (ml/m2) improved from 45.6 ± 15.3 to 37.5 ± 6.5 (P = 0.001) after 6 month The results revealed a significant increase of ejection fraction at 4 and 6 months follow-up and a significant improvement of global longitudinal strain at 2, 4 & 6 months follow-up in patients given SGLT2i. Conclusion SGLT2i
{"title":"Assessment of cardiac functions using two-dimensional transthoracic and speckle tracking echocardiography after treatment with SGLT2 inhibitors in Patients with HFrEF","authors":"Amr Setouhi, Ashraf Radi, Hany Taha Asklany, Hazem M A Farrag","doi":"10.1093/eurheartjsupp/suad113.002","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.002","url":null,"abstract":"Abstract Background & objective Recently, the antidiabetic drug sodium-glucose cotransporter type 2 inhibitor (SGLT2i) has been approved among the drugs that reduce mortality in patients with HFrEF. The impact of SGLT2i inhibitors on the left ventricle longitudinal myocardial function in heart failure (HF) patients remained vague. The effect of SGLT2i on left ventricular remodeling and function in patients with HFrEF was studied using STE and traditional echocardiography. Objectives Studying the effects of SGLT2i on left ventricular remodeling and function in HFrEF patients using STE and traditional echocardiography. Methods 300 patients with HFrEF were included.Study design: This prospective observational study involves 300 patients with HFrEF-administered SGLT2i (Empagliflozin & Dapagliflozin) in addition to the classical treatment of heart failure. Then the patients were followed up 2, 4 & 6 months after treatment with laboratory investigations of HbA1C and eGFR, in addition to 2D echo & STE studies. Results Regarding Demographic data, the mean age was 50 ± 9.2 for males and females. The mean weight, height, and body mass index (BMI) were 85.6 ± 8.8 kg, 178.6 ± 7.2 cm, and 26.6 ± 2.9, respectively. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 115.3 ± 5.1 and 75.4 ± 4.5, respectively. The mean heart rate was 79.9 ± 10.2. The mean respiratory rate was15 ± 2.2. Regarding functional NYHA class, 1 (0.2%), 54(12%), 392 (87.1%), and 3 (0.7%) patients were class I, II, III, and IV, respectively. The lab investigations at first presentation were: mean HbA1C was 4.2 ± 0.6, and the mean of eGFR was 66.4 ± 9.3. Concerning Echocardiography data of patients LVEF by 2D echo show significant improvement from 34.73 ± 2.9 at baseline to 34.91 ± 1.2, 35.42 ± 3.5 & 36.54 ± 3.6 at 2, 4 & 6 months (P = 0.001) also GLS A4 showed significant improvement from −15.67 ± 2.74 to −16.5 ± 3.19, −17.32 ± 3.21, −18.03 ± 3.05at 2, 4 & 6 months (P = 0.001), and from −15.66 ± 2.65 to −16.50 ± 3.31, −17.41 ± 3.23 & −17.93 ± 3.32 (P = 0.001) by GLS A2 Regarding dapagliflozin LVEF by 2D echo show significant improvement from 34.87 ± 2.86 at baseline to 34.87 ± 2.86, 35.05 ± 3.01& 37.53 ± 4.1 at 2, 4 & 6 months (P = 0.001) also GLS A2 showed significant improvement from −15.67 ± 2.74 to −16.50 ± 3.31 −17.41 ± 3.23 −17.93 ± 3.32 at 2, 4 & 6 months (P = 0.001), and from −15.54 ± 2.77 to −16.84 ± 3.49, −18.48 ± 2.23 & −19.61 ± 2.98 (P = 0.001) by GLS A4, also E/e′ significantly reduced from 11.2 ± 2.7 to 9.1 ± 2.3 cm/s after administration of empagliflozin and dapagliflozin within 6 months (P = 0.01) also LAVI (ml/m2) improved from 45.6 ± 15.3 to 37.5 ± 6.5 (P = 0.001) after 6 month The results revealed a significant increase of ejection fraction at 4 and 6 months follow-up and a significant improvement of global longitudinal strain at 2, 4 & 6 months follow-up in patients given SGLT2i. Conclusion SGLT2i ","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135299069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.018
Mahmoud Tantawy, Sherif Hussien, Sameh Mosaad
Abstract Background True bifurcation lesions are challenging in some special populations like patients with heavily calcified vessels, unprotected left main, and thrombus-containing lesions. Multiple inflations are known to increase the incidence of no-reflow/slow-flow (NR/SL) during primary PCI. The ideal bifurcation stenting strategy during primary PCI is still obscure. Some studies have shown some benefits for deferred stenting in primary PCI but still this area needs more evidence. In our study, we compared deferred stenting for the side branch during primary PCI versus the complete bifurcation stenting strategy during primary PCI. Methods This is prospective observational study included patients who presented with STEMI due to true bifurcation culprit lesion amenable for two stents technique. Group one included patients with provisional stenting and deferred side branch stenting before hospital discharge. Group two included patients with complete two stents bifurcation technique during primary PCI. The technique used was according to operator discretion while patients with immediate indications for two stents strategy during the primary setting were excluded from our study. The primary outcome was MACE till hospital discharge. Secondary outcomes included angiographic outcomes by the end of the bifurcation technique. Results A total of 60 patients met our inclusion criteria, mean age (58.69±9.61), 31.2% women. Twenty-six patients received deferred stenting for side branch, and 34 received complete two stents bifurcation strategy at the primary PCI setting. MACE to hospital discharge was lower in the deferred stenting group without significant difference (21.62% vs 23.64%, P>0.01] compared with the two-stenting approach during primary PCI. Group I (deferred stenting) had significantly superior angiographic outcomes than group II. As regards TIMI II-III flow, 86.2% of patients achieved it in both main vessel and side branch versus 51.1% in group II, CTFC was 8.1 versus 9.6, and in group I, 78% of patients achieved TMPG II-III, compared to 56.7% in group II. Conclusion Deferred stenting for side branch in primary PCI achieved superior angiographic outcomes in the treatment of true bifurcation lesions. However, there was no significant difference in MACE between both strategies.
在一些特殊人群中,如血管严重钙化、左主干未受保护和含血栓病变的患者,真正的分叉病变是具有挑战性的。多次充气已知会增加初次PCI期间无回流/慢流(NR/SL)的发生率。理想的分岔支架术在初级PCI仍然是模糊的策略。一些研究显示延迟支架置入术在初次PCI中有一些益处,但这一领域仍需要更多的证据。在我们的研究中,我们比较了初次PCI期间侧支延期支架置入与初次PCI期间完全分岔支架置入策略。方法:这是一项前瞻性观察性研究,纳入了因真分叉罪魁祸首病变可适用双支架技术而出现STEMI的患者。第一组包括出院前行临时支架术和延期侧支支架术的患者。第二组包括在初次PCI中采用完全双支架分岔技术的患者。所使用的技术是根据操作者的判断,而在最初设置时立即有两个支架策略指征的患者被排除在我们的研究之外。出院前主要观察指标为MACE。次要结果包括分岔技术结束时的血管造影结果。结果共60例患者符合纳入标准,平均年龄(58.69±9.61)岁,女性31.2%。26例患者接受了侧支延期支架术,34例患者在初次PCI设置时接受了完整的双支架术。初次PCI时延期支架置入组与双支架置入组相比,MACE较低,但无显著差异(21.62% vs 23.64%, P>0.01)。I组(延期支架置入术)的血管造影结果明显优于II组。关于TIMI II- iii型血流,86.2%的患者在主血管和侧支均达到,而II组为51.1%,CTFC为8.1比9.6,在I组中,78%的患者达到TMPG II- iii型,而II组为56.7%。结论原发性PCI侧支延期支架术治疗真分叉病变具有较好的血管造影效果。然而,两种策略间的MACE无显著差异。
{"title":"Deferred Stenting for Side Branch in STEMI Patients Presented by Bifurcation Culprit Lesion","authors":"Mahmoud Tantawy, Sherif Hussien, Sameh Mosaad","doi":"10.1093/eurheartjsupp/suad113.018","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.018","url":null,"abstract":"Abstract Background True bifurcation lesions are challenging in some special populations like patients with heavily calcified vessels, unprotected left main, and thrombus-containing lesions. Multiple inflations are known to increase the incidence of no-reflow/slow-flow (NR/SL) during primary PCI. The ideal bifurcation stenting strategy during primary PCI is still obscure. Some studies have shown some benefits for deferred stenting in primary PCI but still this area needs more evidence. In our study, we compared deferred stenting for the side branch during primary PCI versus the complete bifurcation stenting strategy during primary PCI. Methods This is prospective observational study included patients who presented with STEMI due to true bifurcation culprit lesion amenable for two stents technique. Group one included patients with provisional stenting and deferred side branch stenting before hospital discharge. Group two included patients with complete two stents bifurcation technique during primary PCI. The technique used was according to operator discretion while patients with immediate indications for two stents strategy during the primary setting were excluded from our study. The primary outcome was MACE till hospital discharge. Secondary outcomes included angiographic outcomes by the end of the bifurcation technique. Results A total of 60 patients met our inclusion criteria, mean age (58.69±9.61), 31.2% women. Twenty-six patients received deferred stenting for side branch, and 34 received complete two stents bifurcation strategy at the primary PCI setting. MACE to hospital discharge was lower in the deferred stenting group without significant difference (21.62% vs 23.64%, P&gt;0.01] compared with the two-stenting approach during primary PCI. Group I (deferred stenting) had significantly superior angiographic outcomes than group II. As regards TIMI II-III flow, 86.2% of patients achieved it in both main vessel and side branch versus 51.1% in group II, CTFC was 8.1 versus 9.6, and in group I, 78% of patients achieved TMPG II-III, compared to 56.7% in group II. Conclusion Deferred stenting for side branch in primary PCI achieved superior angiographic outcomes in the treatment of true bifurcation lesions. However, there was no significant difference in MACE between both strategies.","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.015
Kawkab Khedr, Eman Elsharkawy, Hoda Shehata, Bassant Mowafy
Abstract Background The global burden of atrial fibrillation (AF) is enormous for healthcare systems. AF is typically classified into five distinct patterns depending on the onset, progression, and resolution of AF episodes, first diagnosed AF, paroxysmal AF, persistent AF, long-standing persistent AF& permanent AF. Atrial structural remodeling or exacerbation of atrial cardiomyopathy are generally defining features of the transition from paroxysmal to non-paroxysmal AF. The duration of rhythm monitoring and the presence of a substrate are both important factors in determining the rate of AF development. In the existence of a structurally normal valve, functional MR develops when there is a mismatch between the tethering forces exerted by the heart & the closing forces exerted by the heart. In the context of functional MR annular dilation alone, can constitute a separate etiology of MR (atrial functional MR). TEE provides supplementary imaging, particularly if TTE windows are technically challenging, making it a useful tool even if TTE is the primary technique for assessing and quantifying mitral valve disease. 3DE data sets can be acquired from either TTE or TEE approach, allowing real-time visualization of the cardiac structures, it is superior to 2DE in quantification of cardiac chamber volumes and function, assessment of the mechanisms and severity of heart valve diseases, evaluation of cardiac complex anatomy. Aim of the work To study mitral valve apparatus remodeling in patients with atrial functional mitral valve regurgitation using three-dimensional echocardiography. Methods This study included a total of 30 patients with diagnosis of atrial fibrillation divided in to two groups, 15 patients having no/ mild mitral regurgitation while 15 patients having moderate/severe mitral regurgitation, they were subjected to 2D and 3D TEE echocardiographic assessment of MR degree, LA volumes, mitral leaflets and mitral annulus parameters. Results There was statistically significant difference between the two groups as regard the posterior leaflet area as larger area was estimated in (Mod/severe MR) group compared to (No/ mild MR) group, with mean posterior leaflet area in group I was (8.96 ± 2.60) and (7.30 ± 2.17) in group II with (P value = 0.029) as well as there was statistically significant difference between the two groups as regard total leaflet area/Mitral annular area ratio as smaller ratio was estimated in (Mod/severe MR) group as compared to (No/mild MR) group, with the mean total leaflet area /mitral annular area ratio in group I was (1.22 ± 0.04) and (1.26 ± 0.04) in group II with (P value = 0.008). Conclusion Isolated annular dilatation can cause significant functional atrial mitral regurgitation while mitral leaflet area increases in AF as the annulus dilates, but this adaptation may plateau at larger annular areas, with the resulting leaflet deficiency causing functional atrial mitral regurgitation. Additional Content An author
{"title":"Study of mitral valve remodling in patients with atrial functional mitral valve regurgitation using three-dimensional echocardiography","authors":"Kawkab Khedr, Eman Elsharkawy, Hoda Shehata, Bassant Mowafy","doi":"10.1093/eurheartjsupp/suad113.015","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.015","url":null,"abstract":"Abstract Background The global burden of atrial fibrillation (AF) is enormous for healthcare systems. AF is typically classified into five distinct patterns depending on the onset, progression, and resolution of AF episodes, first diagnosed AF, paroxysmal AF, persistent AF, long-standing persistent AF& permanent AF. Atrial structural remodeling or exacerbation of atrial cardiomyopathy are generally defining features of the transition from paroxysmal to non-paroxysmal AF. The duration of rhythm monitoring and the presence of a substrate are both important factors in determining the rate of AF development. In the existence of a structurally normal valve, functional MR develops when there is a mismatch between the tethering forces exerted by the heart & the closing forces exerted by the heart. In the context of functional MR annular dilation alone, can constitute a separate etiology of MR (atrial functional MR). TEE provides supplementary imaging, particularly if TTE windows are technically challenging, making it a useful tool even if TTE is the primary technique for assessing and quantifying mitral valve disease. 3DE data sets can be acquired from either TTE or TEE approach, allowing real-time visualization of the cardiac structures, it is superior to 2DE in quantification of cardiac chamber volumes and function, assessment of the mechanisms and severity of heart valve diseases, evaluation of cardiac complex anatomy. Aim of the work To study mitral valve apparatus remodeling in patients with atrial functional mitral valve regurgitation using three-dimensional echocardiography. Methods This study included a total of 30 patients with diagnosis of atrial fibrillation divided in to two groups, 15 patients having no/ mild mitral regurgitation while 15 patients having moderate/severe mitral regurgitation, they were subjected to 2D and 3D TEE echocardiographic assessment of MR degree, LA volumes, mitral leaflets and mitral annulus parameters. Results There was statistically significant difference between the two groups as regard the posterior leaflet area as larger area was estimated in (Mod/severe MR) group compared to (No/ mild MR) group, with mean posterior leaflet area in group I was (8.96 ± 2.60) and (7.30 ± 2.17) in group II with (P value = 0.029) as well as there was statistically significant difference between the two groups as regard total leaflet area/Mitral annular area ratio as smaller ratio was estimated in (Mod/severe MR) group as compared to (No/mild MR) group, with the mean total leaflet area /mitral annular area ratio in group I was (1.22 ± 0.04) and (1.26 ± 0.04) in group II with (P value = 0.008). Conclusion Isolated annular dilatation can cause significant functional atrial mitral regurgitation while mitral leaflet area increases in AF as the annulus dilates, but this adaptation may plateau at larger annular areas, with the resulting leaflet deficiency causing functional atrial mitral regurgitation. Additional Content An author","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.012
Hesham S Taha, Ghada Youssef, Mirna M Shaker, Mohamed Ghalab, Hadeer G Sayed, Suzan H Abdullah, Mohamed A Thabet, Amir Mostafa
Abstract Background Fasting Ramadan has been linked to favorable health profile, yet some unhealthy behaviors were shown to affect the progression of cardiovascular diseases during the holy month. Purpose To detect the prevalent diagnoses of cardiovascular admissions during the month of Ramadan and to compare them to the admission diagnoses during the rest of the year. Methods This retrospective observational study included all patients who were admitted to the Cardiology department and the Coronary Care Unit from April 2019 to May 2022, with 4 Ramadan months included. The median number of specific cardiac admission diagnoses during Ramadan months were compared to the median number of similar admission diagnoses during the other months of the year. Results The number of patients admitted during the 4 year-study period were 8170 patients, 14.6% of them (n = 1194 patients) were admitted during the 4 Ramadan months. All cardiovascular diagnoses were comparable during Ramadan admissions as compared to the rest of the year, Table. There was a trend towards higher cardiovascular admission rates during Ramadan in almost all diagnoses except for unstable angina, infective endocarditis and pericardial diseases. Conclusions The pattern of specific cardiovascular disease admission during Ramadan was not different from the pattern of admission during the rest of the year. Yet, there were numerically higher cardiovascular admissions during the 4 Ramadan months. Table Comparison of the median number of admission diagnoses in the 4 Ramadan months and the monthly average of the 4 years Ramadan months Median (range) Monthly average of the 4 years Median (range) P value IHD 145.5 (63) 106 (74) 0.486 * CCS 39.5 (35) 17 (11) 0.057 * ACS 107.5 (71) 89 (83) 0.686 - STEMI 49.5 (34) 39 (24) 0.343 - NSTEMI 41 (46) 39.5 (56) 1.0 - UA 8.5 (8) 10 (4) 0.686 ADHF & cardiogenic shock 113.5 (111) 56 (37) 0.486 Arrhythmia 43.5 (39) 34 (10) 0.343 - AF 18.5 (22) 22.5 (5) 0.686 - SVT 9.5 (15) 6 (9) 0.486 - AFL 6 (12) 2.5 (2) 0.2 - CHB 4 (5) 3.5 (3) 0.686 IE 10.5 (7) 14 (6) 0.2 PE 3 (11) 2.5 (1) 0.686 Pericardial disease 2 (6) 6 (11) 0.2 Hypertensive urgency & emergency 12 (23) 9.5 (7) 1.0 IHD, ischemic heart disease; CCS, chronic coronary syndrome; ACS, acute coronary syndrome; STEMI, ST elevation myocardial infarction; NSTEMI, non-ST elevation myocardial infarction; UA, unstable angina; ADHF, acute decompensated heart failure; AF, atrial fibrillation; SVT, supraventricular tachycardia; AFL, atrial flutter; CHD, complete heart block; IE, infective endocarditis; PE, pulmonary embolism. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.
{"title":"Pattern of cardiovascular admission diagnoses during the month of Ramadan: a single center experience","authors":"Hesham S Taha, Ghada Youssef, Mirna M Shaker, Mohamed Ghalab, Hadeer G Sayed, Suzan H Abdullah, Mohamed A Thabet, Amir Mostafa","doi":"10.1093/eurheartjsupp/suad113.012","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.012","url":null,"abstract":"Abstract Background Fasting Ramadan has been linked to favorable health profile, yet some unhealthy behaviors were shown to affect the progression of cardiovascular diseases during the holy month. Purpose To detect the prevalent diagnoses of cardiovascular admissions during the month of Ramadan and to compare them to the admission diagnoses during the rest of the year. Methods This retrospective observational study included all patients who were admitted to the Cardiology department and the Coronary Care Unit from April 2019 to May 2022, with 4 Ramadan months included. The median number of specific cardiac admission diagnoses during Ramadan months were compared to the median number of similar admission diagnoses during the other months of the year. Results The number of patients admitted during the 4 year-study period were 8170 patients, 14.6% of them (n = 1194 patients) were admitted during the 4 Ramadan months. All cardiovascular diagnoses were comparable during Ramadan admissions as compared to the rest of the year, Table. There was a trend towards higher cardiovascular admission rates during Ramadan in almost all diagnoses except for unstable angina, infective endocarditis and pericardial diseases. Conclusions The pattern of specific cardiovascular disease admission during Ramadan was not different from the pattern of admission during the rest of the year. Yet, there were numerically higher cardiovascular admissions during the 4 Ramadan months. Table Comparison of the median number of admission diagnoses in the 4 Ramadan months and the monthly average of the 4 years Ramadan months Median (range) Monthly average of the 4 years Median (range) P value IHD 145.5 (63) 106 (74) 0.486 * CCS 39.5 (35) 17 (11) 0.057 * ACS 107.5 (71) 89 (83) 0.686 - STEMI 49.5 (34) 39 (24) 0.343 - NSTEMI 41 (46) 39.5 (56) 1.0 - UA 8.5 (8) 10 (4) 0.686 ADHF & cardiogenic shock 113.5 (111) 56 (37) 0.486 Arrhythmia 43.5 (39) 34 (10) 0.343 - AF 18.5 (22) 22.5 (5) 0.686 - SVT 9.5 (15) 6 (9) 0.486 - AFL 6 (12) 2.5 (2) 0.2 - CHB 4 (5) 3.5 (3) 0.686 IE 10.5 (7) 14 (6) 0.2 PE 3 (11) 2.5 (1) 0.686 Pericardial disease 2 (6) 6 (11) 0.2 Hypertensive urgency & emergency 12 (23) 9.5 (7) 1.0 IHD, ischemic heart disease; CCS, chronic coronary syndrome; ACS, acute coronary syndrome; STEMI, ST elevation myocardial infarction; NSTEMI, non-ST elevation myocardial infarction; UA, unstable angina; ADHF, acute decompensated heart failure; AF, atrial fibrillation; SVT, supraventricular tachycardia; AFL, atrial flutter; CHD, complete heart block; IE, infective endocarditis; PE, pulmonary embolism. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.003
Aya Tarek Elsayegh, Osama Mohameden Mohamed Asous, Ahmed Mohamed El misiri
Abstract Introduction The left atrium (LA)’s essential function is modulating left ventricular (LV) filling via its different reservoir, conduit, and contractile functions. This could be accurately achieved now by dedicated speckle-tracking echocardiography software. Methodology We included in this prospective cohort study 200 subjects with structurally normal hearts, who present for elective echocardiography, routine echocardiography was performed in addition to left atrial strain analysis by 2D speckle tracking echocardiography. Aim of work To study the effect of different variables on left atrial reservoir strain. Results The study population consisted of 134 males and 66 females, age range between 20 and 69 years of age. linear regression analysis was performed to examine the contributions of different variables as predictors in explaining the variance. S-R (strain reservoir) was significantly affected by age in a negative correlation with P = 0.032. Body weight, height, BMI (body mass index), lipid profile and HbA1C (glycosylated hemoglobin) had no significant impact on S-R left atrial function. All echocardiographic parameters of diastolic function including E/A ratio, Septal E′, Lateral E′, E/E′ and TR jet velocity had no significant impact on S-R left atrial function. Maximum and minimum indexed left atrial volumes, indexed LV systolic and diastolic volumes measured by Simpson’s method had no significant effect on S-R left atrial function. Conclusion Left atrial stiffness increases with age. Obesity, dyslipidemia, impaired glucose tolerance and diastolic dysfunction have no significant effect on the S-R of the left atrium. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.
{"title":"Determinants of left atrial stiffness by reservoir strain using 2D speckle tracking echocardiography in structurally normal heart","authors":"Aya Tarek Elsayegh, Osama Mohameden Mohamed Asous, Ahmed Mohamed El misiri","doi":"10.1093/eurheartjsupp/suad113.003","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.003","url":null,"abstract":"Abstract Introduction The left atrium (LA)’s essential function is modulating left ventricular (LV) filling via its different reservoir, conduit, and contractile functions. This could be accurately achieved now by dedicated speckle-tracking echocardiography software. Methodology We included in this prospective cohort study 200 subjects with structurally normal hearts, who present for elective echocardiography, routine echocardiography was performed in addition to left atrial strain analysis by 2D speckle tracking echocardiography. Aim of work To study the effect of different variables on left atrial reservoir strain. Results The study population consisted of 134 males and 66 females, age range between 20 and 69 years of age. linear regression analysis was performed to examine the contributions of different variables as predictors in explaining the variance. S-R (strain reservoir) was significantly affected by age in a negative correlation with P = 0.032. Body weight, height, BMI (body mass index), lipid profile and HbA1C (glycosylated hemoglobin) had no significant impact on S-R left atrial function. All echocardiographic parameters of diastolic function including E/A ratio, Septal E′, Lateral E′, E/E′ and TR jet velocity had no significant impact on S-R left atrial function. Maximum and minimum indexed left atrial volumes, indexed LV systolic and diastolic volumes measured by Simpson’s method had no significant effect on S-R left atrial function. Conclusion Left atrial stiffness increases with age. Obesity, dyslipidemia, impaired glucose tolerance and diastolic dysfunction have no significant effect on the S-R of the left atrium. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.010
Reham M Nagaty, Mona Hassan Ahmed, Amany M Seddik, Ahmed Abdelaty, Laila Mohamed Hamed Nofal
Abstract Methods A cross sectional study was conducted among 200 heart failure patients selected from two hospitals in Alexandria governate. The HLS-EU-Q16 survey to assess HL, SF-12 health survey questionnaire to assess QoL, record review, and interviewing the patients were used to collect the required data. Linear and logistic regression models were used to explore the relation between health literacy and the QoL then comparing between the two models. Results Forty-six and half percent of HF patients had sufficient HL while 53.5% had insufficient HL. Patients showed low mean score of 34.16 ± 10.43 for the physical dimension of the SF-12 questionnaire (PCS-12), while the mental dimension (MCS-12) displayed good mean score of 41.87 ± 14.34. For the linear regression regarding PCS-12, HL was statistically significant and an independent predictor of PCS-12 in patients with HF, both before and after adjustment for the personal and clinical characteristics. Concerning MCS-12, we found that HL was statistically significant and an independent predictor of MCS-12 only before adjustment. While in logistic regression, considering PCS-12, analysis revealed that HL was not statistically significant predictor of the median-split dichotomized PCS-12 in both before and after adjustments for covariates. Regarding MCS-12, it was found that HL was statistically significant and an independent predictor of the median-split dichotomized MCS-12 only before adjustment for personal and clinical characteristics. The correct prediction percent in the logistic model of PCS-12 (70%) was higher than the linear model (53.5%). Similarly, the correct prediction percent in the logistic model of MCS-12 (68.5%) was higher than the linear model (57.5%). Conclusion It has been explained that HL is a statistically significant independent predictor of only the PCS-12 of SF-12 in the linear regression model but not for MCS-12, while it was not statistically significant predictor in the logistic models for the two dimensions of SF-12. However, each of the two models, linear regression model and logistic regression model, has its advantages and disadvantages.
{"title":"Logistic regression vs. linear regression in exploring the importance of health literacy for the quality of life of patients with heart failure","authors":"Reham M Nagaty, Mona Hassan Ahmed, Amany M Seddik, Ahmed Abdelaty, Laila Mohamed Hamed Nofal","doi":"10.1093/eurheartjsupp/suad113.010","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.010","url":null,"abstract":"Abstract Methods A cross sectional study was conducted among 200 heart failure patients selected from two hospitals in Alexandria governate. The HLS-EU-Q16 survey to assess HL, SF-12 health survey questionnaire to assess QoL, record review, and interviewing the patients were used to collect the required data. Linear and logistic regression models were used to explore the relation between health literacy and the QoL then comparing between the two models. Results Forty-six and half percent of HF patients had sufficient HL while 53.5% had insufficient HL. Patients showed low mean score of 34.16 ± 10.43 for the physical dimension of the SF-12 questionnaire (PCS-12), while the mental dimension (MCS-12) displayed good mean score of 41.87 ± 14.34. For the linear regression regarding PCS-12, HL was statistically significant and an independent predictor of PCS-12 in patients with HF, both before and after adjustment for the personal and clinical characteristics. Concerning MCS-12, we found that HL was statistically significant and an independent predictor of MCS-12 only before adjustment. While in logistic regression, considering PCS-12, analysis revealed that HL was not statistically significant predictor of the median-split dichotomized PCS-12 in both before and after adjustments for covariates. Regarding MCS-12, it was found that HL was statistically significant and an independent predictor of the median-split dichotomized MCS-12 only before adjustment for personal and clinical characteristics. The correct prediction percent in the logistic model of PCS-12 (70%) was higher than the linear model (53.5%). Similarly, the correct prediction percent in the logistic model of MCS-12 (68.5%) was higher than the linear model (57.5%). Conclusion It has been explained that HL is a statistically significant independent predictor of only the PCS-12 of SF-12 in the linear regression model but not for MCS-12, while it was not statistically significant predictor in the logistic models for the two dimensions of SF-12. However, each of the two models, linear regression model and logistic regression model, has its advantages and disadvantages.","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.013
Samir Rafla, Amr Zaki, Mohamed Loutfi, Mohamed Ahmed Sadaka, Moataz Shebl
Abstract Background New imaging modalities such as IVUS had improved results of Stenting of the unprotected left main coronary artery (UPLM). The results of stenting UPLM without these new modalities but with meticulous care need to be studied more. Methods This prospective and retrospective study was performed in multiple local centers. The local ethics committee approved the study, and the patients signed informed consent. In addition, the local heart team, including a cardiac surgeon, was consulted for a joint decision agreement. In the last five years, one hundred twenty patients with left main disease >50% were subjected to stenting with drug- eluted stents.All patients were subjected to detailed history taking with particular emphasis on acute coronary syndrome, angina duration, class, previous coronary interventions, and medications. In addition, 12 lead ECGs were revised with an evaluation of ST/T changes and any old infarction. An echocardiographic examination was done on all patients. Relevant laboratory tests were done.Risk assessment was calculated for every patient, including Euro SCORE and Syntax score. Patient selection: Consecutive patients arriving for primary Stenting or acute coronary episode were included. Medications: All patients received clopidogrel and aspirin before the planned procedure. Anticoagulation with unfractionated heparin in a dose of 10000 IU was given at the beginning of the PCI. Post PCI, all patients received B blockers, ACE inhibitors, statins, and dual antiplatelets in the guidelines recommended doses. Calcification was assessed by angiographic imaging only. We estimated the vessel diameter as 2/3 diameter of the branches. PCI technique: A steerable guidewire was advanced in LAD, followed by PCI with pre-dilatation or direct Stenting according to the operator’s discretion. One or two stent strategy was utilized according to the situation of the lesions. Results 92 patients (77.3%) presented with ACS, of which 65 patients (54.6%) had no Previous Intervention, and 27 patients (22.7%) had a previous PCI. Left ventricular ejection fraction significantly correlates with the complication at six months follow-up; all 16 patients with reported complications (100%) had baseline LVEF of <40% (P-value = 0.023). Syntax score 11 patients (55%) with a high score of more than 32 had adverse events, P = 0.004. Residual syntax shows a less significant correlation with a mean value of 7.3 in the complication group vs. 4.9 in the other group (P = 0.016). Final kissing balloon inflation shows no statistically significant difference. Conclusions PCI in UPLM is a safe, feasible option with a high technical success rate and acceptable outcome at follow-up, even without the utilization of IVUS
{"title":"Stenting the unprotected left main coronary artery- mid-term outcomes of the observational registry","authors":"Samir Rafla, Amr Zaki, Mohamed Loutfi, Mohamed Ahmed Sadaka, Moataz Shebl","doi":"10.1093/eurheartjsupp/suad113.013","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.013","url":null,"abstract":"Abstract Background New imaging modalities such as IVUS had improved results of Stenting of the unprotected left main coronary artery (UPLM). The results of stenting UPLM without these new modalities but with meticulous care need to be studied more. Methods This prospective and retrospective study was performed in multiple local centers. The local ethics committee approved the study, and the patients signed informed consent. In addition, the local heart team, including a cardiac surgeon, was consulted for a joint decision agreement. In the last five years, one hundred twenty patients with left main disease &gt;50% were subjected to stenting with drug- eluted stents.All patients were subjected to detailed history taking with particular emphasis on acute coronary syndrome, angina duration, class, previous coronary interventions, and medications. In addition, 12 lead ECGs were revised with an evaluation of ST/T changes and any old infarction. An echocardiographic examination was done on all patients. Relevant laboratory tests were done.Risk assessment was calculated for every patient, including Euro SCORE and Syntax score. Patient selection: Consecutive patients arriving for primary Stenting or acute coronary episode were included. Medications: All patients received clopidogrel and aspirin before the planned procedure. Anticoagulation with unfractionated heparin in a dose of 10000 IU was given at the beginning of the PCI. Post PCI, all patients received B blockers, ACE inhibitors, statins, and dual antiplatelets in the guidelines recommended doses. Calcification was assessed by angiographic imaging only. We estimated the vessel diameter as 2/3 diameter of the branches. PCI technique: A steerable guidewire was advanced in LAD, followed by PCI with pre-dilatation or direct Stenting according to the operator’s discretion. One or two stent strategy was utilized according to the situation of the lesions. Results 92 patients (77.3%) presented with ACS, of which 65 patients (54.6%) had no Previous Intervention, and 27 patients (22.7%) had a previous PCI. Left ventricular ejection fraction significantly correlates with the complication at six months follow-up; all 16 patients with reported complications (100%) had baseline LVEF of &lt;40% (P-value = 0.023). Syntax score 11 patients (55%) with a high score of more than 32 had adverse events, P = 0.004. Residual syntax shows a less significant correlation with a mean value of 7.3 in the complication group vs. 4.9 in the other group (P = 0.016). Final kissing balloon inflation shows no statistically significant difference. Conclusions PCI in UPLM is a safe, feasible option with a high technical success rate and acceptable outcome at follow-up, even without the utilization of IVUS","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135299051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1093/eurheartjsupp/suad113.006
Mohamed El-Khatib, Ibrahim Helmy
Abstract Introduction Professional electronic portfolios are becoming increasingly popular among nurses as a means of documenting their lifelong learning and self-reflection, as well as proving that they have fulfilled all of their licensure and certification criteria. An e-Portfolio can help nurses keep track of their renewal and registration paperwork in one location so that they can be updated and used in performance assessments and job applications. All nurses are obliged to participate in continuing professional development activities in order to maintain, update, and to improve their knowledge and practice. In addition, e-Portfolios allow nurses to assess their strengths and weaknesses. Also, establishing an e-Portfolio can help nurses develop a learning strategy to meet those needs. Aim To assess the nurses' feedback after developing their professional e-Portfolio. Process As part of their professional development, nurses at the Aswan Heart Centre were required to compile their professional development records. Even the most recent curriculum vitae (CV) was difficult for most nurses to locate.Using Google sites as the e-platform, the nursing education department established a method for generating the e-Portfolio in a systematic manner. The e-Portfolio contained all of the following dataset (Biography—CV—Nursing, leadership, or teaching philosophy—Teaching Perspective Inventory Result—Learning Style Result—Personality Type—Conflict Style—Strength, Weaknesses, Opportunities, and Threats (SWOT) Analysis—Learning Action Plan—Professional Certificates—Research Activities).A brief guide was developed to assist nurses in developing the e-Portfolio to the same criteria. In addition, short courses were designed to assist them in creating a SWOT analysis and learning action plan. Survey Result There were 130 nurses who joined the process, and 70 nurses filled out the survey. What was the best part of creating your e-Portfolio?The majority of the staff members responded that they do collect their professional development records.What was the worst part of creating your e-Portfolio?The staff's biggest challenge during the platform’s development was time. Data Analysis Participants responded that use of the e-portfolio was a way to keep track of their own professional growth and gain a better understanding of who they are as well as help develop their professional identity as lifelong learners by approximately 70%.According to the responses from the participants, using the e-portfolio was a technique to boost their level of creativity as well as their level of proficiency with computer skills by around 65%. Recommendations Building and maintaining an e-Portfolio can also provide nurses with the ability to assess their skills and determine areas in which they require additional training, as well as to create a lifelong learning plan to meet these needs. Additional Content An author video to accompany this abstract is available on https://academic.oup.c
{"title":"Effects of e-portfolios on developing professional awareness for cardiac nurses","authors":"Mohamed El-Khatib, Ibrahim Helmy","doi":"10.1093/eurheartjsupp/suad113.006","DOIUrl":"https://doi.org/10.1093/eurheartjsupp/suad113.006","url":null,"abstract":"Abstract Introduction Professional electronic portfolios are becoming increasingly popular among nurses as a means of documenting their lifelong learning and self-reflection, as well as proving that they have fulfilled all of their licensure and certification criteria. An e-Portfolio can help nurses keep track of their renewal and registration paperwork in one location so that they can be updated and used in performance assessments and job applications. All nurses are obliged to participate in continuing professional development activities in order to maintain, update, and to improve their knowledge and practice. In addition, e-Portfolios allow nurses to assess their strengths and weaknesses. Also, establishing an e-Portfolio can help nurses develop a learning strategy to meet those needs. Aim To assess the nurses' feedback after developing their professional e-Portfolio. Process As part of their professional development, nurses at the Aswan Heart Centre were required to compile their professional development records. Even the most recent curriculum vitae (CV) was difficult for most nurses to locate.Using Google sites as the e-platform, the nursing education department established a method for generating the e-Portfolio in a systematic manner. The e-Portfolio contained all of the following dataset (Biography—CV—Nursing, leadership, or teaching philosophy—Teaching Perspective Inventory Result—Learning Style Result—Personality Type—Conflict Style—Strength, Weaknesses, Opportunities, and Threats (SWOT) Analysis—Learning Action Plan—Professional Certificates—Research Activities).A brief guide was developed to assist nurses in developing the e-Portfolio to the same criteria. In addition, short courses were designed to assist them in creating a SWOT analysis and learning action plan. Survey Result There were 130 nurses who joined the process, and 70 nurses filled out the survey. What was the best part of creating your e-Portfolio?The majority of the staff members responded that they do collect their professional development records.What was the worst part of creating your e-Portfolio?The staff's biggest challenge during the platform’s development was time. Data Analysis Participants responded that use of the e-portfolio was a way to keep track of their own professional growth and gain a better understanding of who they are as well as help develop their professional identity as lifelong learners by approximately 70%.According to the responses from the participants, using the e-portfolio was a technique to boost their level of creativity as well as their level of proficiency with computer skills by around 65%. Recommendations Building and maintaining an e-Portfolio can also provide nurses with the ability to assess their skills and determine areas in which they require additional training, as well as to create a lifelong learning plan to meet these needs. Additional Content An author video to accompany this abstract is available on https://academic.oup.c","PeriodicalId":11956,"journal":{"name":"European Heart Journal Supplements","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}