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Differential Operant Conditioning of Emotional-Motivational and Sensory-Discriminative Pain Responses 情绪-动机和感觉-区别疼痛反应的不同操作条件作用。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-19 DOI: 10.1002/ejp.70162
Melissa L. Flury, Martin Löffler, Shaili Gour, Susanne Becker
<div> <section> <h3> Background</h3> <p>The experience of pain consists of different components, including sensory-discriminative and emotional-motivational components. While these components are often well aligned, they can also dissociate. Operant conditioning may selectively modulate one component without affecting the other. However, evidence directly comparing operant conditioning effects on both emotional-motivational and sensory-discriminative components of pain is lacking. The aim of the present study was to test whether operant conditioning would differentially affect behavioral surrogate measures of emotional-motivational and sensory-discriminative pain responses.</p> </section> <section> <h3> Methods</h3> <p>62 healthy participants performed in two testing sessions a pain avoidance task to assess emotional-motivational pain responses and a temperature discrimination task to assess sensory-discriminative pain responses (counterbalanced order). In the second half of each task, successful pain avoidance or accurate temperature discrimination was followed by monetary reinforcement.</p> </section> <section> <h3> Results</h3> <p>Contingent reinforcement selectively enhanced pain avoidance, evidenced by faster reaction times and increased success rates, while temperature discrimination performance remained unchanged, likely due to a ceiling effect in task difficulty. Operantly conditioned changes in pain behaviour did not generalize to self-reported pain intensity and unpleasantness ratings.</p> </section> <section> <h3> Conclusions</h3> <p>These findings indicate a modulation of emotional–motivational pain processing by operant conditioning, while effects on sensory–discriminative processing remain absent. These results support the idea that enhanced pain perception in chronic pain can be induced by operant learning, potentially through the specific learning of increased emotional–motivational pain responses.</p> </section> <section> <h3> Significance Statement</h3> <p>This study demonstrates that operant conditioning can enhance avoidance responses, serving as an indicator of emotional–motivational pain responses. In contrast, sensory–discriminative aspects of pain were not modulated by operant conditioning. These results confirm the important role of operant conditioning specifically in emotional–motivational pain processing. This insight may help explain how learning contributes to increased emotional–motivational pain processing in chronic
背景:疼痛体验由不同的成分组成,包括感觉-辨别成分和情绪-动机成分。虽然这些成分通常排列得很好,但它们也可以分离。操作性条件反射可以选择性地调节一个成分而不影响另一个成分。然而,直接比较操作性条件反射对疼痛的情绪-动机和感觉-区分成分的影响的证据缺乏。本研究的目的是测试操作性条件反射是否会对情绪-动机和感觉-区分疼痛反应的行为替代测量产生不同的影响。方法:62名健康被试分为两个测试阶段:疼痛回避任务评估情绪动机性疼痛反应;温度区分任务评估感觉区别性疼痛反应(平衡顺序)。在每个任务的后半部分,成功地避免疼痛或准确地识别温度之后是货币强化。结果:偶然性强化选择性地增强了疼痛回避,表现为更快的反应时间和更高的成功率,而温度辨别表现保持不变,可能是由于任务难度的天花板效应。操作条件下疼痛行为的改变并没有推广到自我报告的疼痛强度和不愉快评分。结论:这些发现表明操作性条件反射对情绪-动机性疼痛加工有调节作用,而对感觉-区别性疼痛加工没有影响。这些结果支持了一种观点,即慢性疼痛的疼痛感知增强可能是由操作性学习引起的,可能是通过特定的学习增加情绪-动机疼痛反应。意义说明:本研究证明操作性条件反射可以增强回避反应,并作为情绪-动机性疼痛反应的一个指标。相反,疼痛的感觉辨别方面不受操作性条件反射的调节。这些结果证实了操作性条件反射在情绪动机疼痛加工中的重要作用。这一见解可能有助于解释学习如何促进慢性疼痛中情绪动机疼痛处理的增加。
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引用次数: 0
Graded Motor Imagery (GRAMI Protocol) for Phantom Limb Pain: A Randomised Clinical Trial of Home-Based Intervention 分级运动意象(GRAMI方案)治疗幻肢痛:一项基于家庭干预的随机临床试验
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-18 DOI: 10.1002/ejp.70167
Sandra Rierola-Fochs, Marc Terradas-Monllor, Sergi Grau-Carrión, Mirari Ochandorena-Acha, Eduard Minobes-Molina, Jose Antonio Merchán-Baeza
<div> <section> <h3> Background</h3> <p>Phantom limb pain (PLP) affects 64% of individuals who have undergone amputation. Various theories explain its development, leading to different treatments, including graded motor imagery. This study analyses the effectiveness of a home-based intervention protocol based on graded motor imagery (GraMI protocol) as a treatment for phantom limb pain.</p> </section> <section> <h3> Methods</h3> <p>A randomised, controlled, home-based, assessor-blinded clinical trial was conducted on individuals over 18 years old, with limb amputation, pharmacologically stable and discharged home. Participants followed the GraMI protocol or continued their current treatment for 9 weeks. Assessments were conducted at baseline, postintervention and at 3 months follow-up, evaluating PLP, quality of life, functionality and depressive symptoms.</p> </section> <section> <h3> Results</h3> <p>The study enrolled 36 participants (mean age of 58.5 years), including 27 individuals with lower limb amputation and nine with upper limb amputation. Vascular issues were the primary cause, and 17 participants experienced preamputation pain. None of the participants in the control group received any PLP treatment during the study. Compliance with treatment among participants in the experimental group during the laterality recognition and explicit motor imagery phases was satisfactory, averaging 91.4%. Significant differences were found between groups in PLP (<i>p</i> = 0.02), persisting 12 weeks postintervention (<i>p</i> = 0.05). Within-group analysis revealed clinically significant PLP improvements postintervention (<i>p</i> = 0.003), and these improvements remained statistically significant 12 weeks later (<i>p</i> = 0.006). There were no statistically significant differences observed in the rest of the variables.</p> </section> <section> <h3> Conclusion</h3> <p>The GraMI protocol shows effectiveness in reducing PLP in individuals who have undergone amputation, with this effect persisting 12 weeks after the intervention.</p> </section> <section> <h3> Significance Statement</h3> <p>Phantom limb pain significantly impacts individuals with amputations, yet effective treatments remain limited. This study is crucial as it evaluates a home-based graded motor imagery (GraMI) protocol, offering a noninvasive, accessible intervention. The randomised clinical trial demonstrates GraMI's effectiveness in reducing PLP, with lasting effects up to 12 weeks. By ad
背景:幻肢痛(PLP)影响了64%的截肢患者。不同的理论解释了它的发展,导致了不同的治疗方法,包括分级运动意象。本研究分析了基于分级运动意象的家庭干预方案(GraMI方案)作为幻肢痛治疗的有效性。方法采用随机、对照、居家、评估盲法临床试验,选取18岁以上肢体截肢、药理学稳定、出院的患者。参与者遵循GraMI方案或继续目前的治疗9周。在基线、干预后和3个月随访时进行评估,评估PLP、生活质量、功能和抑郁症状。结果共入组36例,平均年龄58.5岁,其中下肢截肢27例,上肢截肢9例。血管问题是主要原因,17名参与者经历了截肢前疼痛。在研究期间,对照组的参与者均未接受任何PLP治疗。实验组受试者在侧面识别和外显运动意象阶段的治疗依从性令人满意,平均为91.4%。PLP组间差异有统计学意义(p = 0.02),干预后12周差异有统计学意义(p = 0.05)。组内分析显示干预后PLP有临床显著改善(p = 0.003), 12周后这些改善仍有统计学意义(p = 0.006)。在其他变量中没有观察到统计学上的显著差异。结论:GraMI方案在降低截肢患者的PLP方面显示出有效性,这种效果在干预后12周持续存在。幻肢痛对截肢患者的影响很大,但有效的治疗方法仍然有限。这项研究是至关重要的,因为它评估了一种基于家庭的分级运动图像(GraMI)方案,提供了一种无创的、可获得的干预措施。随机临床试验证明GraMI在降低PLP方面的有效性,持续效果长达12周。通过解决PLP,本研究有助于改善患者的生活质量,功能和心理健康。研究结果支持将GraMI纳入康复计划,为具有成本效益的家庭治疗选择提供了证据。试验注册ClinicalTrials.gov标识符:NCT05083611
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引用次数: 0
Locus Coeruleus MR Measured Signal Intensity in Fibromyalgia Relative to Healthy Controls 相对于健康对照,蓝斑核磁共振测量纤维肌痛症的信号强度。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-17 DOI: 10.1002/ejp.70173
Marilena M. DeMayo, Clifford M. Cassidy, Cheryl McCreary, Tuan Trang, Ashley D. Harris, Alexander McGirr
<div> <section> <h3> Background</h3> <p>Fibromyalgia is a chronic pain condition without an established aetiology. However, noradrenergic dysfunction is a possible mechanism to explain the constellation of symptoms associated with fibromyalgia. Noradrenaline synthesis in the locus coeruleus (LC) results in a paramagnetic by-product, neuromelanin. Recently, a magnetic resonance imaging sequence sensitive to neuromelanin has been used to assay LC signal intensity, a proxy for noradrenergic system function. Here, we use MR imaging to investigate the noradrenergic-locus coeruleus system in participants with fibromyalgia and healthy controls.</p> </section> <section> <h3> Methods</h3> <p>Forty-six participants with fibromyalgia and 41 healthy controls were recruited for a cross-sectional characterisation of LC signal intensity at 3 T, quantified from a 2D gradient echo acquisition. Participants completed the Revised Fibromyalgia Impact Questionnaire, as well as measures of anxiety, depression, sleep and the THINC-it cognitive battery.</p> </section> <section> <h3> Results</h3> <p>An independent groups <i>t</i>-test revealed no differences in LC signal intensity between participants with fibromyalgia and healthy controls. For the participants with fibromyalgia, partial correlations accounting for age showed no association between LC signal intensity and fibromyalgia history, fibromyalgia symptom severity, anxiety, depression, insomnia or cognitive performance. Almost 90% of participants with fibromyalgia had been exposed to medications targeting noradrenergic function complicating the interpretation of these findings.</p> </section> <section> <h3> Conclusions</h3> <p>LC signal intensity as measured by MR did not distinguish participants with fibromyalgia and healthy controls, nor was it associated with core fibromyalgia pain symptoms or associated symptoms. Dynamic measures of noradrenergic function may be required to understand noradrenergic contributions to fibromyalgia.</p> </section> <section> <h3> Significance Statement</h3> <p>This study is the first report using MR measured signal intensity of the LC to examine noradrenergic function in participants with fibromyalgia. There was no difference in signal intensity when comparing patients to controls, nor did it associate with any symptoms or associated features of fibromyalgia. This suggests that lifetime noradrenergic function may not distinguish fibromyalgia.</p> </section>
背景:纤维肌痛是一种慢性疼痛,没有明确的病因。然而,去甲肾上腺素能功能障碍是解释纤维肌痛相关症状的可能机制。蓝斑(LC)的去甲肾上腺素合成产生顺磁副产物,神经黑色素。最近,一种对神经黑色素敏感的磁共振成像序列被用于检测LC信号强度,这是去甲肾上腺素能系统功能的代表。在这里,我们使用磁共振成像来研究纤维肌痛参与者和健康对照者的去甲肾上腺素能-蓝斑系统。方法:招募46名纤维肌痛患者和41名健康对照者,通过二维梯度回波采集对3t时LC信号强度进行横断面表征。参与者完成了修订纤维肌痛影响问卷,以及焦虑、抑郁、睡眠和认知电池的测量。结果:独立组t检验显示纤维肌痛参与者和健康对照组之间LC信号强度无差异。对于患有纤维肌痛的参与者,考虑年龄的部分相关性显示,LC信号强度与纤维肌痛病史、纤维肌痛症状严重程度、焦虑、抑郁、失眠或认知表现之间没有关联。几乎90%的纤维肌痛患者曾接受过靶向去甲肾上腺素能功能的药物治疗,这使得这些发现的解释更加复杂。结论:MR测量的LC信号强度不能区分纤维肌痛和健康对照,也与核心纤维肌痛疼痛症状或相关症状无关。去甲肾上腺素能功能的动态测量可能需要了解去甲肾上腺素能对纤维肌痛的贡献。意义声明:本研究是第一个使用MR测量LC信号强度来检测纤维肌痛患者去甲肾上腺素能功能的报告。当将患者与对照组比较时,信号强度没有差异,也与纤维肌痛的任何症状或相关特征无关。这表明终生去肾上腺素能功能可能无法区分纤维肌痛。
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引用次数: 0
Optimising Treatment Expectations Using a Video-Based Intervention in Orthopaedic Surgery: Results From a Randomised Controlled Trial 在骨科手术中使用视频干预优化治疗预期:来自一项随机对照试验的结果
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-15 DOI: 10.1002/ejp.70169
Simon F. Zerth, Christian Volberg, Ann-Kristin Schubert, Vanessa Ketter, Monika Sadlonova, Frank Euteneuer, Winfried Rief, Stefan Salzmann

Background

Psychological interventions designed to optimise patients' treatment expectations have proven effective in surgical populations. Since these interventions are often resource-intensive, their clinical application is limited. We aimed to optimise treatment expectations in patients undergoing elective orthopaedic surgery with a brief video-based expectation-focused intervention. Additionally, the role of violated expectations was investigated exploratively.

Methods

In a three-arm randomised clinical trial, participants (N = 125) scheduled to undergo elective orthopaedic surgery received either an expectation-focused video intervention aiming at fostering realistically positive treatment expectations, an active control video or standard medical care. The primary outcome was pain intensity. Measurements were taken at baseline as well as on postoperative days one and seven.

Results

The intervention group reported increased treatment expectations compared to the standard medical care and the control group. No significant intervention effect on pain intensity was found. Patients indicating negative postsurgical expectation violation (feeling worse than expected) reported higher pain intensity, regardless of the study condition. No differences in pain intensity were found between patients, indicating positive or no expectation violation (feeling better or exactly as expected respectively).

Conclusions

Patients' treatment expectations can be optimised with a brief video-based intervention. However, the clinical relevance of this effect may be questionable. Postoperative pain intensity differed by expectation violation profiles. Avoiding a negative expectation violation might be a promising approach for expectation-focused interventions in surgical populations.

Significance

Our findings suggest that treatment expectations can be improved through a brief video-based intervention, though this did not translate into improved postoperative outcomes. These results underscore both the potential and the limitations of very brief expectation-focused approaches and can inform the refinement of such interventions.

Trial Registration

Ger

旨在优化患者治疗期望的心理干预在外科人群中已被证明是有效的。由于这些干预措施往往是资源密集型的,它们的临床应用是有限的。我们的目的是通过一个简短的基于期望的视频干预来优化选择性骨科手术患者的治疗期望。此外,还探索性地探讨了违反期望的作用。方法在一项三组随机临床试验中,计划接受选择性骨科手术的参与者(N = 125)接受了以期望为中心的视频干预,旨在培养现实的积极治疗期望,主动对照视频或标准医疗护理。主要结局是疼痛强度。在基线以及术后第1天和第7天进行测量。结果与标准医疗护理和对照组相比,干预组报告的治疗预期增加。干预对疼痛强度无显著影响。无论研究条件如何,术后表现为阴性预期违反的患者(感觉比预期更糟)报告了更高的疼痛强度。患者之间的疼痛强度没有差异,表明积极或没有期望违反(分别感觉更好或完全符合预期)。结论简短的视频干预可以优化患者的治疗预期。然而,这种效果的临床相关性可能值得怀疑。术后疼痛强度因预期违反情况而异。避免负面期望违反可能是一个有希望的方法,以期望为中心的干预手术人群。我们的研究结果表明,通过简短的视频干预可以提高治疗预期,尽管这并没有转化为术后结果的改善。这些结果强调了非常简短的以预期为中心的方法的潜力和局限性,并可以为改进此类干预措施提供信息。试验注册德国ClinicalTrials.gov标识符:www.drks.de, ID: DRKS00031516
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引用次数: 0
Change in Healthcare Use After a Self-Management Supportive Intervention for Low Back Pain—A Quasi-Experimental Study 腰痛自我管理支持干预后医疗保健使用的变化——准实验研究
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-13 DOI: 10.1002/ejp.70170
Søren Grøn, Melker Johansson, Kim Rose Olsen, Bart Koes, Stine Haugaard Clausen, Alice Kongsted

Background

Individuals with low back pain (LBP) have high healthcare use (HCU). It is currently unclear whether self-management supportive interventions can decrease HCU among patients with LBP. The aim of this study was to investigate changes in visits to primary care and redeemed prescriptions of analgesics after enrolment in a self-management supportive programme compared to usual care.

Methods

This quasi-experimental study included adults with LBP who enrolled in the Danish GLA:D Back programme between 2018 and 2022. GLA:D Back is a structured 10-week programme of group-based patient education and supervised exercises aiming to enhance self-management skills. HCU was obtained from national registries as the total quarterly visits to primary care (general practitioner, physiotherapists or chiropractor) or quarterly total redeemed defined daily doses (DDD) of analgesics (paracetamol, non-steroidal anti-inflammatory drugs or opioids).

Results

We included 4205 individuals. From 2 to 14 quarters post-enrolment, the additional quarterly reduction in HCU after the programme compared to the control group was −1.1 (95% CI −1.5 to −0.8) visits to primary care and −5.3 (95% CI −9.2 to −2.2) DDDs of redeemed analgesics. Sensitivity analyses questioned the statistical significance of the reduction in analgesic use, but results for people with LBP duration > 1 year were robust for both outcomes. The largest reductions were observed in those with high HCU at baseline.

Conclusion

Participation in a structured self-management programme led to a sustained reduction in primary care visits and analgesic use over a 3-year period, although regression to the mean may partly explain these reductions.

Significance Statement

This quasi-experimental study demonstrated that a structured self-management supportive programme for low back pain reduced future healthcare use, especially among individuals with long-lasting pain or high initial healthcare use. These findings suggest a potential to alter healthcare use through structured interventions to support self-management.

背景:腰痛(LBP)患者有较高的医疗保健使用(HCU)。目前尚不清楚自我管理支持干预是否能降低LBP患者的HCU。本研究的目的是调查参加自我管理支持计划后与常规护理相比,初级保健和镇痛药处方的就诊变化。方法:这项准实验研究纳入了2018年至2022年间参加丹麦GLA:D Back项目的LBP成人患者。GLA:D Back是一个为期10周的结构化项目,以小组为基础的患者教育和监督练习,旨在提高自我管理技能。HCU从国家登记处获得,作为每季度对初级保健(全科医生、物理治疗师或脊椎指压治疗师)的总访问量,或每季度对镇痛药(扑热息痛、非甾体抗炎药或阿片类药物)的总补偿日剂量(DDD)。结果:纳入4205人。从入组后的第2至14个季度,与对照组相比,该方案后HCU的额外季度减少为-1.1次(95% CI -1.5至-0.8)初级保健就诊和-5.3次(95% CI -9.2至-2.2)DDDs。敏感性分析对镇痛药使用减少的统计学意义提出了质疑,但对于腰痛持续时间为10 - 10年的患者,两项结果都是稳健的。在基线时高HCU患者中观察到最大的减少。结论:参与结构化的自我管理计划导致3年内初级保健就诊和止痛药使用持续减少,尽管回归均值可能部分解释了这些减少。意义声明:这项准实验研究表明,对腰痛进行结构化的自我管理支持方案可以减少未来的医疗保健使用,特别是在长期疼痛或初始医疗保健使用高的个体中。这些发现表明,通过结构化干预来支持自我管理,有可能改变医疗保健使用。
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引用次数: 0
Evaluating Manual Therapy in Musculoskeletal Pain: Why Certain Trial Designs May Overestimate Effectiveness—A Scoping Review 评估肌肉骨骼疼痛的手工疗法:为什么某些试验设计可能会高估效果-范围综述。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-13 DOI: 10.1002/ejp.70150
Jean-Pascal Grenier, Alex Thiel
<div> <section> <h3> Background and Objective</h3> <p>Atraumatic musculoskeletal pain, regardless of the affected body region, is a highly prevalent condition impacting over 25% of the global population and contributing significantly to the burden of disease. A common study design compares physiotherapy or exercise therapy alone to the same intervention combined with MT (A vs. A + B). This study design is inherently flawed due to its inability to isolate the effect of treatment B, the potential for interaction effects, and the lack of control for non-specific contextual factors. The goal of this study was to compile studies using that approach and to examine the short-, medium-, and long-term effects of the addition of MT to a control treatment.</p> </section> <section> <h3> Databases and Data Treatment</h3> <p>This scoping review identified 95 randomised controlled trials (RCTs) with a systematic literature search in the electronic bibliographic databases MEDLINE (via PubMed), EBSCO, and PEDro.</p> </section> <section> <h3> Results</h3> <p>Long-term effects were absent, and medium-term effects were infrequent. Approximately half of the studies reported statistically significant effects in the immediate or short-term follow-up; however, these effects were of limited clinical relevance and susceptible to methodological issues. Furthermore, studies with lower methodological quality were more likely to report significant effects (85%), whereas medium- and high-quality studies showed positive results in only 50% of cases.</p> </section> <section> <h3> Conclusions</h3> <p>This review highlights significant research gaps and provides methodological insights. The study design in question is therefore methodologically problematic, as it tends to generate positive short-term results without providing clear answers or meaningful clinical implications for researchers and clinicians.</p> </section> <section> <h3> Significance Statement</h3> <p>This scoping review summarizes studies using an ‘A vs. A+B design’, where manual therapy is added to usual care, with or without a sham control. The review identifies a lack of medium- or long-term effectiveness and highlights a methodological bias toward generating positive short- or immediate-term results of questionable clinical relevance. Based on these findings, we provide several recommendations to improve future research and to support clinicians in interpreting the current evidence base.</p> </sect
背景和目的:非外伤性肌肉骨骼疼痛,无论受影响的身体部位如何,都是一种非常普遍的疾病,影响着全球25%以上的人口,并显著增加了疾病负担。一项常见的研究设计比较了单独的物理治疗或运动治疗与同样的干预联合MT (A vs. A + B)。由于无法隔离治疗B的效果、潜在的相互作用效应以及缺乏对非特异性背景因素的控制,本研究设计本身就存在缺陷。本研究的目的是汇编使用该方法的研究,并检查在对照治疗中添加MT的短期、中期和长期效果。数据库和数据处理:本综述通过在电子书目数据库MEDLINE(通过PubMed)、EBSCO和PEDro中进行系统文献检索,确定了95项随机对照试验(rct)。结果:无长期疗效,中期疗效少见。大约一半的研究报告了即时或短期随访的统计显著效果;然而,这些效果的临床相关性有限,而且容易受到方法学问题的影响。此外,方法学质量较低的研究更有可能报告显著效果(85%),而中等和高质量的研究仅在50%的病例中显示阳性结果。结论:本综述突出了重要的研究差距,并提供了方法学上的见解。因此,有问题的研究设计在方法学上是有问题的,因为它倾向于产生积极的短期结果,而没有为研究人员和临床医生提供明确的答案或有意义的临床意义。意义声明:本范围综述总结了使用“A与A+B设计”的研究,在常规护理中加入手工治疗,有或没有假对照。该综述确定了缺乏中期或长期有效性,并强调了方法偏向于产生临床相关性可疑的积极的短期或即时结果。基于这些发现,我们提出了一些建议,以改进未来的研究,并支持临床医生解释当前的证据基础。
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引用次数: 0
Physical and Psychological Predictors for Persistent and Recurrent Non-Specific Neck Pain: A Systematic Review 持续和复发性非特异性颈部疼痛的生理和心理预测因素:一项系统综述。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-12 DOI: 10.1002/ejp.70168
Cho Wai Geoffrey Yu, Kanya Wongwitwichote, Michael Mansfield, Janet A. Deane, Valter Devecchi, Deborah Falla

Background

Patients with non-specific neck pain often develop persistent or recurrent pain and associated disability. This review investigated which physical and psychological factors predict persistent and recurrent neck pain and disability.

Databases and Data Treatment

Five databases were searched from inception to January 31, 2025. After data extraction, the Quality in Prognosis Studies tool (QUIPS) was used for risk of bias assessment and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to assess the certainty of evidence for each factor's predictive capability for neck disability, pain intensity and incidence.

Results

Six prospective cohort studies were selected. Three studies were rated with high overall risk of bias and three with moderate overall risk of bias. Consistent findings supported that high pain catastrophizing and psychological distress predict persistent and recurrent pain, disability and incidence with low to moderate certainty of evidence. There was inconsistency of results or limited studies reporting association between neck flexion strength, cold pain threshold tested over the tibialis anterior, pressure pain threshold tested over the neck or tibialis anterior, conditioned pain modulation, neck extensor endurance, and temporal summation with disability. In addition, there was low certainty of evidence which showed no relationship between cervical range of motion, cold pain threshold tested over the neck and neck extensor strength with disability.

Conclusions

Pain catastrophizing and psychological distress were identified as predictors of persistent and recurrent neck pain, disability and incidence. Further studies are needed to confirm findings of an association between physical factors with future neck pain and disability.

Significance Statement

This review provides evidence to support the addition of early assessment of pain catastrophizing and psychological distress to identify patients that are more susceptible to persistent and recurrent neck pain. When warranted, psychological interventions targeting maladaptive beliefs, pain-related anxiety and catastrophizing may be required to minimize persistent and recurrent neck pain and disability.

背景:非特异性颈部疼痛的患者经常出现持续性或复发性疼痛并伴有残疾。本综述调查了哪些生理和心理因素可预测持续性和复发性颈部疼痛和残疾。数据库和数据处理:从成立到2025年1月31日共检索了5个数据库。数据提取后,使用预后质量研究工具(QUIPS)进行偏倚风险评估,使用建议评估、发展和评估分级(GRADE)工具评估每个因素对颈部残疾、疼痛强度和发生率的预测能力的证据确定性。结果:6项前瞻性队列研究入选。三项研究被评为高总体偏倚风险,三项研究被评为中等总体偏倚风险。一致的研究结果支持高疼痛灾难化和心理困扰预测持续和复发性疼痛、残疾和发病率,证据确定性低至中等。颈部屈曲强度、胫骨前肌冷痛阈、颈部或胫骨前肌压痛阈、条理性疼痛调节、颈部伸肌耐力和颞统与残疾之间存在不一致的结果或有限的研究报告。此外,有低确定性的证据表明,颈椎活动度、颈部冷痛阈值测试和颈部伸肌强度与残疾之间没有关系。结论:疼痛灾难化和心理困扰被确定为持续和复发性颈部疼痛、残疾和发病率的预测因素。需要进一步的研究来证实身体因素与未来颈部疼痛和残疾之间的联系。意义声明:本综述提供的证据支持增加疼痛灾难和心理困扰的早期评估,以识别更容易发生持续性和复发性颈部疼痛的患者。如果有必要,可能需要针对适应不良信念、疼痛相关焦虑和灾难化的心理干预,以尽量减少持续和复发性颈部疼痛和残疾。
{"title":"Physical and Psychological Predictors for Persistent and Recurrent Non-Specific Neck Pain: A Systematic Review","authors":"Cho Wai Geoffrey Yu,&nbsp;Kanya Wongwitwichote,&nbsp;Michael Mansfield,&nbsp;Janet A. Deane,&nbsp;Valter Devecchi,&nbsp;Deborah Falla","doi":"10.1002/ejp.70168","DOIUrl":"10.1002/ejp.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with non-specific neck pain often develop persistent or recurrent pain and associated disability. This review investigated which physical and psychological factors predict persistent and recurrent neck pain and disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Databases and Data Treatment</h3>\u0000 \u0000 <p>Five databases were searched from inception to January 31, 2025. After data extraction, the Quality in Prognosis Studies tool (QUIPS) was used for risk of bias assessment and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to assess the certainty of evidence for each factor's predictive capability for neck disability, pain intensity and incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six prospective cohort studies were selected. Three studies were rated with high overall risk of bias and three with moderate overall risk of bias. Consistent findings supported that high pain catastrophizing and psychological distress predict persistent and recurrent pain, disability and incidence with low to moderate certainty of evidence. There was inconsistency of results or limited studies reporting association between neck flexion strength, cold pain threshold tested over the tibialis anterior, pressure pain threshold tested over the neck or tibialis anterior, conditioned pain modulation, neck extensor endurance, and temporal summation with disability. In addition, there was low certainty of evidence which showed no relationship between cervical range of motion, cold pain threshold tested over the neck and neck extensor strength with disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Pain catastrophizing and psychological distress were identified as predictors of persistent and recurrent neck pain, disability and incidence. Further studies are needed to confirm findings of an association between physical factors with future neck pain and disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>This review provides evidence to support the addition of early assessment of pain catastrophizing and psychological distress to identify patients that are more susceptible to persistent and recurrent neck pain. When warranted, psychological interventions targeting maladaptive beliefs, pain-related anxiety and catastrophizing may be required to minimize persistent and recurrent neck pain and disability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12611179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult Attachment Is Not Associated With Conditioned Pain Modulation in Healthy Females in a Neutral Social Context 中性社会环境下健康女性的成人依恋与条件疼痛调节无关。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-12 DOI: 10.1002/ejp.70172
Gabriella Elisabeth Stamp, Antonia Louise Wadley, Stella Iacovides

Background

Individuals with chronic pain are both more likely to have an insecure adult attachment style and impaired conditioned pain modulation (CPM) than pain-free individuals. This study investigated whether impaired CPM is seen in pain-free individuals and determined associations with attachment.

Method

A CPM test paradigm was used to determine the differences in the measures of pain across attachment anxiety and avoidance dimensions in pain-free females in a neutral social context. First, static (heat pain threshold, heat pain tolerance, and cold pain intensity) and dynamic (cumulative pain load) measures of pain were explored.

Results

One hundred and three females were recruited (median [IQR] age: 21 [20–23] years). We found no associations between attachment dimensions and static measures of pain (ps > 0.05). Higher attachment anxiety, but not avoidance, was associated with an increase in pain intensity over time (Estimate [95% CI] = 0.15 [0.06–0.25], p-value = 0.002), and increased average test stimulus pain intensity rating both before (Estimate [95% CI] = 0.15 [0.07–0.23], p-value < 0.001) and during (Estimate [95% CI] = 0.36 [0.23–0.48], p-value < 0.001) conditioning. In the 78% (80/103) who completed the full CPM procedure, there was no association between CPM effect and attachment anxiety (Estimate [95% CI] = −3.79 [−8.62 to 1.03], p = 0.122) or avoidance (Estimate [95% CI] = 0.25 [−4.88 to 5.38], p = 0.923). Effective CPM was seen in 90% (72/80).

Conclusion

Impaired CPM was not seen in pain-free individuals suggesting that impaired endogenous analgesia may develop from chronic pain, rather than cause chronic pain.

Significance Statement

Individuals with chronic pain are both more likely to have an insecure adult attachment style and impaired conditioned pain modulation (CPM) than pain-free individuals. This is the first study to investigate a link between attachment and experimental pain using a conditioned pain modulation (CPM) paradigm in a neutral social context. Impaired CPM was not seen in pain-free individuals, suggesting that impaired endogenous analgesia may develop from chronic pain, rather than cause chronic pain.

背景:与无疼痛个体相比,慢性疼痛个体更有可能具有不安全的成人依恋类型和受损的条件疼痛调节(CPM)。这项研究调查了CPM受损是否出现在无痛个体中,并确定了与依恋的联系。方法:采用CPM检验范式,考察中立社会情境下无痛女性在依恋、焦虑和回避维度上疼痛测量的差异。首先,研究了静态(热痛阈值、热痛耐受性和冷痛强度)和动态(累积痛负荷)疼痛测量方法。结果:招募了103名女性(中位[IQR]年龄:21[20-23]岁)。我们发现依恋维度和静态疼痛测量之间没有关联(ps > 0.05)。随着时间的推移,较高的依恋焦虑(而非回避)与疼痛强度的增加有关(估计[95% CI] = 0.15 [0.06-0.25], p值= 0.002),并且与之前的平均测试刺激疼痛强度评级增加有关(估计[95% CI] = 0.15 [0.07-0.23], p值结论:在无痛个体中未见CPM受损,这表明内源性镇痛功能受损可能是由慢性疼痛发展而来,而不是引起慢性疼痛。意义声明:与无疼痛个体相比,慢性疼痛个体更有可能拥有不安全的成人依恋类型和受损的条件疼痛调节(CPM)。这是第一个在中性社会背景下使用条件疼痛调节(CPM)范式调查依恋和实验性疼痛之间联系的研究。在无痛个体中未见CPM受损,这表明内源性镇痛受损可能是由慢性疼痛发展而来,而不是引起慢性疼痛。
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引用次数: 0
Cross-Cultural Adaptation and Psychometric Properties of Low Back Pain Core Outcome Measures: A Systematic Review 跨文化适应和腰痛核心结果测量的心理测量特性:系统回顾。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-12 DOI: 10.1002/ejp.70152
Nora Bakaa, Ayda Babakhamseh, Natalie Chan, Marianne de Vera, Julie Finnigan, Rebecca Ramdelall, Brianna Tang, Lee-Ran Goodman, Lisandra Ameida de Oliveira, Paulo Carvalho do Nascimento, Yuva Venkata Raghava Neelapala, Stephanie Di Pelino, Luciana G Macedo

Objective

The purpose of this systematic review was to identify and evaluate the quality of cross-cultural adaptations of the six core outcome measures (NRS, SF-12, PROMIS, ODI, RMDQ and VAS) for low back pain (LBP) and assess their psychometric properties.

Methods

Medline, EMBASE, Emcare and CINAHL databases were searched from inception to August 2024. Eligible studies included those assessing core LBP outcome measures in adults with LBP. The COSMIN checklist was used to assess the quality of cross-cultural adaptations and evaluate the psychometric properties. Additionally, the COSMIN risk of bias tool and GRADE approach were employed to assess study quality and provide levels of evidence.

Results

A total of 82 studies were included. Among them, 35 studies examined the cross-cultural adaptations of the ODI, 25 for the RMDQ, 4 for PROMIS, 1 for SF-12 and 2 for NRS/VAS. The quality of cross-cultural adaptations was generally poor or fair due to inadequate reporting of pre-testing processes and small sample sizes. Most psychometric properties were rated as having an inadequate risk of bias, with evidence quality ranging from very low to low.

Conclusion

This review highlights that the cross-cultural adaptations of the five core LBP outcome measures have generally been conducted with low quality. To improve the adaptation process, studies should employ larger sample sizes and standardised pre-testing procedures. Additional research is needed to explore a broader range of psychometric properties of cross-cultural adaptations, ensuring better validity, reliability and comparability across adapted versions.

Significance Statement

Improving the quality of cross-cultural adaptations of LBP outcome measures is crucial to ensuring that assessments are culturally relevant and accurate across diverse populations, leading to better-informed clinical decisions and equitable care for patients with LBP globally.

Trial Registration

CRD42023413077

目的:本系统综述的目的是识别和评估六个核心结果测量(NRS, SF-12, PROMIS, ODI, RMDQ和VAS)对腰痛(LBP)的跨文化适应质量,并评估其心理测量特性。方法:检索Medline、EMBASE、Emcare和CINAHL数据库,检索时间为建库至2024年8月。符合条件的研究包括评估成人LBP患者核心LBP结果的研究。采用COSMIN检查表评估跨文化适应的质量和心理测量特征。此外,COSMIN偏倚风险工具和GRADE方法被用于评估研究质量和提供证据水平。结果:共纳入82项研究。其中,35项研究考察了ODI的跨文化适应性,其中RMDQ 25项,PROMIS 4项,SF-12 1项,NRS/VAS 2项。由于对预测试过程的报告不足和样本量小,跨文化适应的质量通常较差或不公平。大多数心理测量特性被评为具有不足的偏倚风险,证据质量从非常低到低不等。结论:这篇综述强调了五个核心LBP结果测量的跨文化适应通常是低质量的。为了改进适应过程,研究应采用更大的样本量和标准化的预测试程序。需要进一步的研究来探索跨文化适应的更广泛的心理测量特性,以确保在不同的改编版本之间更好的有效性、可靠性和可比性。意义声明:提高LBP结果测量的跨文化适应质量对于确保评估在不同人群中具有文化相关性和准确性至关重要,从而为全球LBP患者提供更明智的临床决策和公平的护理。试验注册:CRD42023413077。
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引用次数: 0
Comparison of Experimental Pain Modulation by Hypnosis, Virtual Reality and Virtual Reality Hypnosis in Healthy Individuals 催眠、虚拟现实和虚拟现实催眠对健康个体疼痛调节的实验比较。
IF 3.4 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-11-10 DOI: 10.1002/ejp.70166
Floriane Rousseaux, Émilie Giguère, Mathieu Landry, Mathieu Piché, Maedeh Mostanadi, Pierre Augier, Jessica Simon, Aminata Bicego, Marie-Elisabeth Faymonville, Anne-Sophie Nyssen, David Ogez, Pierre Rainville, Audrey Vanhaudenhuyse
<div> <section> <h3> Background</h3> <p>Hypnosis (H) and virtual reality (VR) are effective behavioural interventions to influence acute pain perception. Hypnotic suggestions have also been shown to modulate the nociceptive flexion reflex (NFR), suggesting the activation of descending modulatory mechanisms affecting spinal nociceptive activity. The combination of these techniques, virtual reality hypnosis (VRH), may reduce pain, but research on their comparative efficacy and mechanisms requires further experimental investigation. This study compared the effects of relaxation hypnosis, VR and VRH on pain perception and nociceptive physiological responses.</p> </section> <section> <h3> Methods</h3> <p>Twenty-four healthy participants were tested at baseline followed by three experimental conditions (relaxation hypnosis, VR, VRH) in a counterbalanced order. Pain intensity and unpleasantness, as well as NFR amplitude evoked by noxious transcutaneous electrical stimulation, were measured. Bayesian statistics assessed evidence for analgesic effects on each variable.</p> </section> <section> <h3> Results</h3> <p>The strength of evidence in favour of our hypotheses was categorised as follow: BF = 1–3: anecdotal evidence; BF = 3–10: moderate evidence and BF > 10: strong evidence. For NFR values, Bayesian paired-sample T-tests provided anecdotal support for the efficacy of relaxation hypnosis (BF + 0 = 2.11) and stronger evidence for VR (BF + 0 = 10.94) and VRH (BF + 0 = 14). For pain intensity, moderate evidence supported reductions with relaxation hypnosis (BF + 0 = 9.18), while strong evidence was found for VR (BF + 0 = 27.99) and low to moderate for VRH (BF + 0 = 5.88). Similarly, unpleasantness showed anecdotal reduction with hypnosis (BF + 0 = 1.9), and moderate evidence supported VR (BF + 0 = 4.86) and VRH (BF + 0 = 7.18). Across all measures, no significant differences were found between hypnosis, VR and VRH.</p> </section> <section> <h3> Conclusion</h3> <p>These findings suggest that these techniques did not differentially affect NFR, pain intensity, or unpleasantness.</p> </section> <section> <h3> Significance Statement</h3> <p>The strength of this fundamental study is to directly compare hypnosis, VR, and VRH on both pain perception and physiological responses. It shows that VR alone is effective, while adding hypnosis does not always lead to better results and the combination could even create interference in some cases. This article helps to
背景:催眠(H)和虚拟现实(VR)是影响急性疼痛感知的有效行为干预。催眠暗示也被证明可以调节伤害性屈曲反射(NFR),这表明影响脊椎伤害性活动的下行调节机制的激活。这些技术的结合,虚拟现实催眠(VRH),可能减轻疼痛,但其比较疗效和机制的研究需要进一步的实验研究。本研究比较了放松催眠、VR和VRH对痛觉和伤害性生理反应的影响。方法:对24名健康受试者进行基线测试,然后按平衡顺序进行放松催眠、VR、VRH三种实验条件。测量经皮电刺激引起的疼痛强度、不愉快程度及NFR振幅。贝叶斯统计评估了每个变量对镇痛作用的证据。结果:支持我们假设的证据强度分类如下:BF = 1-3:轶事证据;BF = 3-10:中度证据;BF bbb10:强证据。对于NFR值,贝叶斯配对样本t检验为放松催眠的有效性提供了轶事支持(BF + 0 = 2.11),并为VR (BF + 0 = 10.94)和VRH (BF + 0 = 14)提供了更有力的证据。对于疼痛强度,中度证据支持放松催眠减轻疼痛(BF + 0 = 9.18),而对于VR (BF + 0 = 27.99)和VRH (BF + 0 = 5.88)有强烈证据支持。同样,不愉快在催眠状态下表现出轶事减少(BF + 0 = 1.9),中度证据支持VR (BF + 0 = 4.86)和VRH (BF + 0 = 7.18)。在所有测量中,催眠、VR和VRH之间没有发现显著差异。结论:这些发现表明,这些技术对NFR、疼痛强度或不愉快的影响没有差异。意义声明:本基础研究的优势在于直接比较了催眠、VR和VRH在疼痛感知和生理反应上的差异。研究表明,单独使用VR是有效的,而添加催眠并不总是能带来更好的结果,在某些情况下,两者的结合甚至会产生干扰。本文有助于区分现有文献和关于该工具使用的常见假设。这些发现有助于阐明VRH如何起作用,并为临床实践和VRH的进一步发展提供指导。
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European Journal of Pain
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