Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.169098.1216
Shaema Elshemy, Ahmed M. El Minawi, Khaled A. Elsetohy, A. Ali
{"title":"Comparison Between Hysteroscopic Proximal Tubal Occlusion Versus Laparoscopic Salpingectomy on Pregnancy Rates Following Intracytoplasmic Sperm Injection in Infertile Cases of Hydrosalpinx: Controlled Clinical Trial","authors":"Shaema Elshemy, Ahmed M. El Minawi, Khaled A. Elsetohy, A. Ali","doi":"10.21608/ebwhj.2022.169098.1216","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.169098.1216","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"318 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77930693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2023.186709.1230
Hatem Abdel Salam, Samar Mohamed
Background: Inappropriate healing of uterine scar after Cesarean section (CS) delivery is associated with adverse OB/GYN evetns. Recently, it was noticed that the incidence of CS increasing all over the world. Aim of the Work: We aim in our study at comparing two different techniques of uterine closure, one layer versus double-layer using ultrasound and comparing complication rates of CS and other outcomes. Material and Methods: We searched online databases such as (PubMed, Scopus, and WOS) for linked randomized clinical trials (RCTs). We conducted an online screening of the recalled articles, then related studies were incorporated in our meta-analysis (MA). Two types of data were encountered, the continuous type was expressed as mean difference and 95% confidence interval. On the other hand, dichotomous type of data was expressed as relative risk and 95% CI. Analysis done by Review Manager software (Version 5.4). Results: In our research, we used 18 RCTs. regarding myometrial thickness after aperation (MD was (1.15) and the 95% CI was (-1.69, -0.60), with the P-value =0.0001). regarding dys-menorrhea (RR was (1.36), and the 95% CI was (1.02, 1.81), with the P-value = 0.04), our results favored two layer uterine closure, however one layer closure had a shorterduration than two layer closure (MD was (-2.25), and the 95% CI was (-3.29, -1). Regarding uterine dehiscence, our results found that (RR was (1.88), and the 95% CI was (0.63, 5.62), with the P-value = 0.26), healing ratio (MD was (-5.00), and the 95% CI was(-12.40, 2.39), with the P-value = 0.18), maternal infection related morbidity (RR was (0.94), and the 95% CI was (0.66, 1.34), with the P-value equal 0.72), and the duration of hospital stay (MD was (-0.12), and the 95% CI (-0.30, 0.06) were comparable outcomes between the two procedures Conclusion: Two layer closure is superior to one layer closure of cesarean uterine scar in terms of RMT and dysmenorrhea. But one layer closure technique has the advantage over two layer closure in the shorter operation time.
{"title":"One vs Two-Layer Closure of the Uterine Wall Following Cesarean Section: Systematic Review Meta-Analysis of Randomized Control Trials","authors":"Hatem Abdel Salam, Samar Mohamed","doi":"10.21608/ebwhj.2023.186709.1230","DOIUrl":"https://doi.org/10.21608/ebwhj.2023.186709.1230","url":null,"abstract":"Background: Inappropriate healing of uterine scar after Cesarean section (CS) delivery is associated with adverse OB/GYN evetns. Recently, it was noticed that the incidence of CS increasing all over the world. Aim of the Work: We aim in our study at comparing two different techniques of uterine closure, one layer versus double-layer using ultrasound and comparing complication rates of CS and other outcomes. Material and Methods: We searched online databases such as (PubMed, Scopus, and WOS) for linked randomized clinical trials (RCTs). We conducted an online screening of the recalled articles, then related studies were incorporated in our meta-analysis (MA). Two types of data were encountered, the continuous type was expressed as mean difference and 95% confidence interval. On the other hand, dichotomous type of data was expressed as relative risk and 95% CI. Analysis done by Review Manager software (Version 5.4). Results: In our research, we used 18 RCTs. regarding myometrial thickness after aperation (MD was (1.15) and the 95% CI was (-1.69, -0.60), with the P-value =0.0001). regarding dys-menorrhea (RR was (1.36), and the 95% CI was (1.02, 1.81), with the P-value = 0.04), our results favored two layer uterine closure, however one layer closure had a shorterduration than two layer closure (MD was (-2.25), and the 95% CI was (-3.29, -1). Regarding uterine dehiscence, our results found that (RR was (1.88), and the 95% CI was (0.63, 5.62), with the P-value = 0.26), healing ratio (MD was (-5.00), and the 95% CI was(-12.40, 2.39), with the P-value = 0.18), maternal infection related morbidity (RR was (0.94), and the 95% CI was (0.66, 1.34), with the P-value equal 0.72), and the duration of hospital stay (MD was (-0.12), and the 95% CI (-0.30, 0.06) were comparable outcomes between the two procedures Conclusion: Two layer closure is superior to one layer closure of cesarean uterine scar in terms of RMT and dysmenorrhea. But one layer closure technique has the advantage over two layer closure in the shorter operation time.","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89525105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2023.170507.1219
Hossam H. El Sokkary, R. A. Abo Elwafa
{"title":"Cervical Carcinoma in Shatby University Hospital and its Relation to Human Papilloma Virus","authors":"Hossam H. El Sokkary, R. A. Abo Elwafa","doi":"10.21608/ebwhj.2023.170507.1219","DOIUrl":"https://doi.org/10.21608/ebwhj.2023.170507.1219","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74274124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.158890.1195
M. Kolaib, W. Mohamed, A. Maaty, Raghda Darwish
{"title":"Comparison between Subcuticular Skin Closure by Different Suture Materials in Cesarean Delivery: An Interventional Randomized Controlled Clinical Trial","authors":"M. Kolaib, W. Mohamed, A. Maaty, Raghda Darwish","doi":"10.21608/ebwhj.2022.158890.1195","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.158890.1195","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81309487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.168007.1214
M. Algazzar, W. Tawfik, Mohamed ElHodiby, Ali Bendary
{"title":"Women Undergoing Goal-Directed Fluid Therapy During Pregnancy: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials","authors":"M. Algazzar, W. Tawfik, Mohamed ElHodiby, Ali Bendary","doi":"10.21608/ebwhj.2022.168007.1214","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.168007.1214","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85989333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2023.186446.1228
Mariam A. Dawoud, Doaaa Alaa, M. Elzanaty, A. Eltabakh, Nancy M. Ahmed
{"title":"Efficacy and Safety of the Transracial Approach (TRA) Versus. Transfemoral Approach (TFA) in Uterine Artery Embolization (UAE) for the Management of Uterine Fibroids; A Systematic Review and Meta-Analysis","authors":"Mariam A. Dawoud, Doaaa Alaa, M. Elzanaty, A. Eltabakh, Nancy M. Ahmed","doi":"10.21608/ebwhj.2023.186446.1228","DOIUrl":"https://doi.org/10.21608/ebwhj.2023.186446.1228","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72833240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.161082.1200
M. Ali, Mohamed Abdel Hafeez, Mohamed Khallaf, Shaema Hemida
{"title":"Dual triggering for final oocyte maturation compared to single triggering in GnRH antagonist (IVF-ICSI) protocols","authors":"M. Ali, Mohamed Abdel Hafeez, Mohamed Khallaf, Shaema Hemida","doi":"10.21608/ebwhj.2022.161082.1200","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.161082.1200","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91037514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.158886.1194
H. Haggag, Sherif El Sirgany, Sarah Aboul Gheit, Hasna Kamal, Tarek El husseiny
Objectives: The aim of our study was to perform a comparative evaluation of the uterine and arcuate vessels Doppler indices in four groups of women: Intrauterine contraceptive device (IUCD) users with and without abnormal uterine bleeding (AUB), combined oral contraceptive users and women not using any contraceptive. Materials and Methods: This prospective longitudinal analytic study was conducted in a tertiary university hospital during the period between September 2018 and March 2019. The study included 160 women with ages ranging from 20-35 years enrolled in 4 groups. Group 1: patient on IUCDs with AUB (n=40) Group 2: Patients on IUCD without AUB (n=40) Group 3: Patients on COCPs and without AUB (n=40) Group 4: Women not using aby contraceptive (n=40). The uterine artery and arcuate vessels were identified by transvaginal (TVUS) at the level of the internal os of the cervix. Real-time imaging and pulsed wave transvaginal Doppler assessment of the blood flow was performed to measure the blood flow indices. Results: There was a statistically significant difference between the three patients’ groups and the control group in endometrial thickness ( p=0.004 ), uterine artery PI ( p<0.001 ) , arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ). However there was no significant difference regarding uterine artery RI ( p=0.112 ). Additionally, there was statistically significant difference between endometrial thickness ( p<0.001 ), uterine artery PI ( p=0.036 ), arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ) when comparing the groups IUCD with and without AUB. Yet, there was no statically significant difference regarding uterine artery RI. Finally, ROC curve analysis showed the optimal cutoff values for the uterine artery PI (1.9), the arcuate vessels PI (0.9) and the arcuate vessels RI (0.49) to predict AUB in patients with IUCD. Conclusion : We identified a correlation between increased bleeding and Doppler indices. Most of the uterine artery and arcuate vessels Doppler indices were lower in the group with IUCD and AUB than in non-bleeding group. Thus the blood flow is increased during bleeding in women with IUCD-induced AUB than in those with normal menstruation. This indicates that there is an increase in uterine blood flow occurs in cases of IUCD - induced abnormal uterine bleeding.
{"title":"Uterine Artery and Arcuate Vessels Doppler in Patients with Abnormal Uterine Bleeding Using Copper Intrauterine Contraceptive Device (IUCDs) and Combined Oral Contraceptive Pills (COCPs)","authors":"H. Haggag, Sherif El Sirgany, Sarah Aboul Gheit, Hasna Kamal, Tarek El husseiny","doi":"10.21608/ebwhj.2022.158886.1194","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.158886.1194","url":null,"abstract":"Objectives: The aim of our study was to perform a comparative evaluation of the uterine and arcuate vessels Doppler indices in four groups of women: Intrauterine contraceptive device (IUCD) users with and without abnormal uterine bleeding (AUB), combined oral contraceptive users and women not using any contraceptive. Materials and Methods: This prospective longitudinal analytic study was conducted in a tertiary university hospital during the period between September 2018 and March 2019. The study included 160 women with ages ranging from 20-35 years enrolled in 4 groups. Group 1: patient on IUCDs with AUB (n=40) Group 2: Patients on IUCD without AUB (n=40) Group 3: Patients on COCPs and without AUB (n=40) Group 4: Women not using aby contraceptive (n=40). The uterine artery and arcuate vessels were identified by transvaginal (TVUS) at the level of the internal os of the cervix. Real-time imaging and pulsed wave transvaginal Doppler assessment of the blood flow was performed to measure the blood flow indices. Results: There was a statistically significant difference between the three patients’ groups and the control group in endometrial thickness ( p=0.004 ), uterine artery PI ( p<0.001 ) , arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ). However there was no significant difference regarding uterine artery RI ( p=0.112 ). Additionally, there was statistically significant difference between endometrial thickness ( p<0.001 ), uterine artery PI ( p=0.036 ), arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ) when comparing the groups IUCD with and without AUB. Yet, there was no statically significant difference regarding uterine artery RI. Finally, ROC curve analysis showed the optimal cutoff values for the uterine artery PI (1.9), the arcuate vessels PI (0.9) and the arcuate vessels RI (0.49) to predict AUB in patients with IUCD. Conclusion : We identified a correlation between increased bleeding and Doppler indices. Most of the uterine artery and arcuate vessels Doppler indices were lower in the group with IUCD and AUB than in non-bleeding group. Thus the blood flow is increased during bleeding in women with IUCD-induced AUB than in those with normal menstruation. This indicates that there is an increase in uterine blood flow occurs in cases of IUCD - induced abnormal uterine bleeding.","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"141 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75556190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.21608/ebwhj.2022.170566.1220
Yousef Zaher, Ibrahim Rageh, A. Morsy
Objectives: Evaluation of the relation between plasma lipoprotein(a) (LPA) and serum tumor necrosis factor-α (TNF-α) levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time). Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54 women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples. Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028), high S1 levels of TNF-α (β=0.424, P <0.001), and LPA (β=0.314, P <0.001) as predictors for development of PE as judged by SBP measures at T2 time. Correlation analysis showed a positive significant ( P <0.001) correlation between at-T2-SBP measures with at-T1 BMI and S1 levels of TNF-α and LPA with a positive significant correlation between levels of both variables and with at-T1 BMI. Conclusion: High serum levels of TNF-α and plasma LPA levels early in pregnancy could predict the development of PE and its severity
目的:评价妊娠第6周(GW;T1时间)和诊断时的血压指标判断子痫前期(PE)的发展情况(T2时间)。患者与方法:140例新孕妇在T1时间给予S1样本;怀孕期间,19名妇女发生早发性PE (EOPE), 51名妇女发生晚发性PE (LOPE);16名妇女发展为重度PE (SPE), 54名妇女发展为轻度PE (MPE), 70名妇女在妊娠结束前血压正常(NT)。T2时,所有患者均取S2标本,ELISA法测定两种标本的血浆LPA和血清TNF-α水平。结果:S2组的血清TNF-α和血浆LPA水平均显著高于S1组,PE组的血清TNF-α和血浆LPA水平均显著高于NT组,EOPE组和/或SPE组的血清TNF-α和血浆LPA水平均显著高于LOPE组和/或MPE组。T1数据定义高体质指数的回归分析;BMI (β=0.162, P=0.028)、高S1水平TNF-α (β=0.424, P <0.001)和LPA (β=0.314, P <0.001)是T2时收缩压测量判断PE发展的预测因子。相关分析显示,at-T2-SBP测量值与at-T1 BMI和S1 TNF-α和LPA水平呈正相关(P <0.001),两者水平与at-T1 BMI呈正相关。结论:妊娠早期血清TNF-α和血浆LPA水平升高可预测PE的发展及其严重程度
{"title":"The Relation between Deregulated Immune Milieu and Atherogenic Lipids Might Underlie the Development of Pregnancy-induced Hypertensive Disorders","authors":"Yousef Zaher, Ibrahim Rageh, A. Morsy","doi":"10.21608/ebwhj.2022.170566.1220","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.170566.1220","url":null,"abstract":"Objectives: Evaluation of the relation between plasma lipoprotein(a) (LPA) and serum tumor necrosis factor-α (TNF-α) levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time). Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54 women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples. Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028), high S1 levels of TNF-α (β=0.424, P <0.001), and LPA (β=0.314, P <0.001) as predictors for development of PE as judged by SBP measures at T2 time. Correlation analysis showed a positive significant ( P <0.001) correlation between at-T2-SBP measures with at-T1 BMI and S1 levels of TNF-α and LPA with a positive significant correlation between levels of both variables and with at-T1 BMI. Conclusion: High serum levels of TNF-α and plasma LPA levels early in pregnancy could predict the development of PE and its severity","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90910114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.21608/ebwhj.2022.158984.1196
Mahmoud F. Hassan, N. Rund, N. Moussa, M. Moussa
Objectives: Preeclampsia remains a major cause of maternal mortality and morbidity worldwide, with an increased risk of cardiovascular disease later in life. Many previous studies have examined several biomarkers. We aimed to assess the role of Split and hairy-related protein-1 (SHARP1) together with hypoxia-inducible factor-1α (HIF-1α) as biomarkers for the detection of preeclampsia. Materials and Methods: This case-control study included 150 pregnant women, 75 healthy women and 75 with preeclampsia, who were recruited for delivery during the third trimester of pregnancy and subjected to full clinical and laboratory testing. This testing included compete blood analysis, and plasma SHARP1 and HIF-1α measurement using ELISA. The main outcome was the association of SHARP1 and HIF-1α with preeclampsia . Results: A significant decrease in SHARP1 ( P < 0.0001 ) and a significant increase in HIF-1α ( P < 0.0001 ) were observed in patients versus the controls. The SHARP1 and HIF-1α levels were independent indicators of preeclampsia after adjusting for maternal age, body mass index, and parity (the odds ratio for SHARP1 was 0.04, 95% confidence interval 0.321–0.791; P < 0.0001 , and the OR for HIF-1α was 30.222, 95% CI 6.219 – 146.877; P < 0.0001 ). Conclusion : SHARP1 and HIF-1α may have be used as biomarkers for the proper recognition of preeclampsia. The synergistic actions of SHARP1 and HIF-1α might play a key role in the pathogenesis of preeclampsia. Larger studies are likely to help verify the data and justify the wider application of these markers.
{"title":"Maternal serum SHARP1 and hypoxia inducible factor-1α as biomarkers for preeclampsia","authors":"Mahmoud F. Hassan, N. Rund, N. Moussa, M. Moussa","doi":"10.21608/ebwhj.2022.158984.1196","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.158984.1196","url":null,"abstract":"Objectives: Preeclampsia remains a major cause of maternal mortality and morbidity worldwide, with an increased risk of cardiovascular disease later in life. Many previous studies have examined several biomarkers. We aimed to assess the role of Split and hairy-related protein-1 (SHARP1) together with hypoxia-inducible factor-1α (HIF-1α) as biomarkers for the detection of preeclampsia. Materials and Methods: This case-control study included 150 pregnant women, 75 healthy women and 75 with preeclampsia, who were recruited for delivery during the third trimester of pregnancy and subjected to full clinical and laboratory testing. This testing included compete blood analysis, and plasma SHARP1 and HIF-1α measurement using ELISA. The main outcome was the association of SHARP1 and HIF-1α with preeclampsia . Results: A significant decrease in SHARP1 ( P < 0.0001 ) and a significant increase in HIF-1α ( P < 0.0001 ) were observed in patients versus the controls. The SHARP1 and HIF-1α levels were independent indicators of preeclampsia after adjusting for maternal age, body mass index, and parity (the odds ratio for SHARP1 was 0.04, 95% confidence interval 0.321–0.791; P < 0.0001 , and the OR for HIF-1α was 30.222, 95% CI 6.219 – 146.877; P < 0.0001 ). Conclusion : SHARP1 and HIF-1α may have be used as biomarkers for the proper recognition of preeclampsia. The synergistic actions of SHARP1 and HIF-1α might play a key role in the pathogenesis of preeclampsia. Larger studies are likely to help verify the data and justify the wider application of these markers.","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84738291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}