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Comparison Between Hysteroscopic Proximal Tubal Occlusion Versus Laparoscopic Salpingectomy on Pregnancy Rates Following Intracytoplasmic Sperm Injection in Infertile Cases of Hydrosalpinx: Controlled Clinical Trial 宫腔镜输卵管近端闭塞与腹腔镜输卵管切除术对输卵管积水不孕症卵胞浆内单精子注射后妊娠率的比较:对照临床试验
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.169098.1216
Shaema Elshemy, Ahmed M. El Minawi, Khaled A. Elsetohy, A. Ali
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引用次数: 0
One vs Two-Layer Closure of the Uterine Wall Following Cesarean Section: Systematic Review Meta-Analysis of Randomized Control Trials 剖宫产术后子宫壁单层闭合vs双层闭合:随机对照试验的系统评价meta分析
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2023.186709.1230
Hatem Abdel Salam, Samar Mohamed
Background: Inappropriate healing of uterine scar after Cesarean section (CS) delivery is associated with adverse OB/GYN evetns. Recently, it was noticed that the incidence of CS increasing all over the world. Aim of the Work: We aim in our study at comparing two different techniques of uterine closure, one layer versus double-layer using ultrasound and comparing complication rates of CS and other outcomes. Material and Methods: We searched online databases such as (PubMed, Scopus, and WOS) for linked randomized clinical trials (RCTs). We conducted an online screening of the recalled articles, then related studies were incorporated in our meta-analysis (MA). Two types of data were encountered, the continuous type was expressed as mean difference and 95% confidence interval. On the other hand, dichotomous type of data was expressed as relative risk and 95% CI. Analysis done by Review Manager software (Version 5.4). Results: In our research, we used 18 RCTs. regarding myometrial thickness after aperation (MD was (1.15) and the 95% CI was (-1.69, -0.60), with the P-value =0.0001). regarding dys-menorrhea (RR was (1.36), and the 95% CI was (1.02, 1.81), with the P-value = 0.04), our results favored two layer uterine closure, however one layer closure had a shorterduration than two layer closure (MD was (-2.25), and the 95% CI was (-3.29, -1). Regarding uterine dehiscence, our results found that (RR was (1.88), and the 95% CI was (0.63, 5.62), with the P-value = 0.26), healing ratio (MD was (-5.00), and the 95% CI was(-12.40, 2.39), with the P-value = 0.18), maternal infection related morbidity (RR was (0.94), and the 95% CI was (0.66, 1.34), with the P-value equal 0.72), and the duration of hospital stay (MD was (-0.12), and the 95% CI (-0.30, 0.06) were comparable outcomes between the two procedures Conclusion: Two layer closure is superior to one layer closure of cesarean uterine scar in terms of RMT and dysmenorrhea. But one layer closure technique has the advantage over two layer closure in the shorter operation time.
背景:剖宫产术后子宫瘢痕愈合不当与妇产科不良事件相关。近年来,人们注意到CS的发病率在世界范围内呈上升趋势。工作目的:我们的研究目的是比较两种不同的子宫关闭技术,超声单层和双层,比较CS的并发症发生率和其他结果。材料和方法:我们在PubMed、Scopus和WOS等在线数据库中检索相关随机临床试验(rct)。我们对召回的文章进行了在线筛选,然后将相关研究纳入我们的荟萃分析(MA)。遇到两类数据,连续型用均值差和95%置信区间表示。另一方面,二分型数据用相对危险度和95% CI表示。由Review Manager软件(版本5.4)完成的分析。结果:在我们的研究中,我们使用了18个随机对照试验。术后肌层厚度差异(MD为(1.15),95% CI为(-1.69,-0.60),p值=0.0001)。对于痛经(RR为(1.36),95% CI为(1.02,1.81),p值= 0.04),我们的结果倾向于两层子宫关闭,但一层子宫关闭的持续时间短于两层子宫关闭(MD为(-2.25),95% CI为(-3.29,-1)。对于子宫裂,我们的结果发现(RR为(1.88),95% CI为(0.63,5.62),p值= 0.26),愈合率(MD为(-5.00),95% CI为(-12.40,2.39),p值= 0.18),产妇感染相关发病率(RR为(0.94),95% CI为(0.66,1.34),p值= 0.72),住院时间(MD为(-0.12),95% CI为(-0.30,0.06)是两种手术的可比结果。两层缝合术在RMT和痛经方面优于一层缝合术。但单层封闭技术比双层封闭技术在更短的操作时间内具有优势。
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引用次数: 0
Cervical Carcinoma in Shatby University Hospital and its Relation to Human Papilloma Virus 沙比大学医院宫颈癌与人乳头瘤病毒的关系
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2023.170507.1219
Hossam H. El Sokkary, R. A. Abo Elwafa
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引用次数: 0
Comparison between Subcuticular Skin Closure by Different Suture Materials in Cesarean Delivery: An Interventional Randomized Controlled Clinical Trial 一项介入性随机对照临床试验:不同缝线材料对剖宫产术中皮下闭合效果的比较
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.158890.1195
M. Kolaib, W. Mohamed, A. Maaty, Raghda Darwish
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引用次数: 0
Women Undergoing Goal-Directed Fluid Therapy During Pregnancy: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials 妇女在怀孕期间接受定向液体治疗:已发表的随机对照试验的系统回顾和荟萃分析
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.168007.1214
M. Algazzar, W. Tawfik, Mohamed ElHodiby, Ali Bendary
{"title":"Women Undergoing Goal-Directed Fluid Therapy During Pregnancy: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials","authors":"M. Algazzar, W. Tawfik, Mohamed ElHodiby, Ali Bendary","doi":"10.21608/ebwhj.2022.168007.1214","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.168007.1214","url":null,"abstract":"","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85989333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of the Transracial Approach (TRA) Versus. Transfemoral Approach (TFA) in Uterine Artery Embolization (UAE) for the Management of Uterine Fibroids; A Systematic Review and Meta-Analysis 跨种族治疗方法(TRA)的有效性和安全性。经股动脉栓塞术治疗子宫肌瘤系统回顾和荟萃分析
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2023.186446.1228
Mariam A. Dawoud, Doaaa Alaa, M. Elzanaty, A. Eltabakh, Nancy M. Ahmed
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引用次数: 0
Dual triggering for final oocyte maturation compared to single triggering in GnRH antagonist (IVF-ICSI) protocols 与GnRH拮抗剂(IVF-ICSI)方案中的单触发相比,双触发最终卵母细胞成熟
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.161082.1200
M. Ali, Mohamed Abdel Hafeez, Mohamed Khallaf, Shaema Hemida
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引用次数: 0
Uterine Artery and Arcuate Vessels Doppler in Patients with Abnormal Uterine Bleeding Using Copper Intrauterine Contraceptive Device (IUCDs) and Combined Oral Contraceptive Pills (COCPs) 铜质宫内节育器联合口服避孕药治疗子宫异常出血的子宫动脉、弓形血管多普勒分析
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.158886.1194
H. Haggag, Sherif El Sirgany, Sarah Aboul Gheit, Hasna Kamal, Tarek El husseiny
Objectives: The aim of our study was to perform a comparative evaluation of the uterine and arcuate vessels Doppler indices in four groups of women: Intrauterine contraceptive device (IUCD) users with and without abnormal uterine bleeding (AUB), combined oral contraceptive users and women not using any contraceptive. Materials and Methods: This prospective longitudinal analytic study was conducted in a tertiary university hospital during the period between September 2018 and March 2019. The study included 160 women with ages ranging from 20-35 years enrolled in 4 groups. Group 1: patient on IUCDs with AUB (n=40) Group 2: Patients on IUCD without AUB (n=40) Group 3: Patients on COCPs and without AUB (n=40) Group 4: Women not using aby contraceptive (n=40). The uterine artery and arcuate vessels were identified by transvaginal (TVUS) at the level of the internal os of the cervix. Real-time imaging and pulsed wave transvaginal Doppler assessment of the blood flow was performed to measure the blood flow indices. Results: There was a statistically significant difference between the three patients’ groups and the control group in endometrial thickness ( p=0.004 ), uterine artery PI ( p<0.001 ) , arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ). However there was no significant difference regarding uterine artery RI ( p=0.112 ). Additionally, there was statistically significant difference between endometrial thickness ( p<0.001 ), uterine artery PI ( p=0.036 ), arcuate vessel PI ( p<0.001 ) and arcuate vessel RI ( p<0.001 ) when comparing the groups IUCD with and without AUB. Yet, there was no statically significant difference regarding uterine artery RI. Finally, ROC curve analysis showed the optimal cutoff values for the uterine artery PI (1.9), the arcuate vessels PI (0.9) and the arcuate vessels RI (0.49) to predict AUB in patients with IUCD. Conclusion : We identified a correlation between increased bleeding and Doppler indices. Most of the uterine artery and arcuate vessels Doppler indices were lower in the group with IUCD and AUB than in non-bleeding group. Thus the blood flow is increased during bleeding in women with IUCD-induced AUB than in those with normal menstruation. This indicates that there is an increase in uterine blood flow occurs in cases of IUCD - induced abnormal uterine bleeding.
目的:本研究的目的是比较评价四组妇女的子宫和弓形血管多普勒指数:宫内节育器(IUCD)使用者有和没有子宫异常出血(AUB),联合口服避孕药使用者和未使用任何避孕药的妇女。材料与方法:本前瞻性纵向分析研究于2018年9月至2019年3月在某三级大学医院进行。该研究包括160名年龄在20-35岁之间的女性,分为4组。第1组:IUCD合并AUB患者(n=40)第2组:IUCD合并AUB患者(n=40)第3组:cops合并AUB患者(n=40)第4组:未使用避孕措施的女性(n=40)。子宫动脉和弓状血管经阴道(TVUS)识别在宫颈内os水平。实时显像及经阴道多普勒血流评估,测量血流指标。结果:三组患者子宫内膜厚度(p=0.004)、子宫动脉PI (p<0.001)、弓形血管PI (p<0.001)、弓形血管RI (p<0.001)与对照组比较,差异均有统计学意义。子宫动脉RI无显著差异(p=0.112)。IUCD合并AUB组与不合并AUB组比较,子宫内膜厚度(p<0.001)、子宫动脉PI (p=0.036)、弓形血管PI (p<0.001)、弓形血管RI (p<0.001)差异有统计学意义。而子宫动脉RI差异无统计学意义。最后,ROC曲线分析显示子宫动脉PI(1.9)、弓形血管PI(0.9)和弓形血管RI(0.49)预测IUCD患者AUB的最佳截止值。结论:我们确定了出血增加与多普勒指数之间的相关性。宫内节育器组和AUB组大部分子宫动脉和弓形血管多普勒指数均低于未出血组。因此,与月经正常的妇女相比,宫内节育器诱发AUB的妇女出血时血流量增加。这表明在宫内节育器引起的子宫异常出血的情况下,子宫血流量增加。
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引用次数: 0
The Relation between Deregulated Immune Milieu and Atherogenic Lipids Might Underlie the Development of Pregnancy-induced Hypertensive Disorders 解除调节的免疫环境与动脉粥样硬化性脂质的关系可能是妊娠高血压疾病发展的基础
Pub Date : 2023-02-01 DOI: 10.21608/ebwhj.2022.170566.1220
Yousef Zaher, Ibrahim Rageh, A. Morsy
Objectives: Evaluation of the relation between plasma lipoprotein(a) (LPA) and serum tumor necrosis factor-α (TNF-α) levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time). Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54 women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples. Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028), high S1 levels of TNF-α (β=0.424, P <0.001), and LPA (β=0.314, P <0.001) as predictors for development of PE as judged by SBP measures at T2 time. Correlation analysis showed a positive significant ( P <0.001) correlation between at-T2-SBP measures with at-T1 BMI and S1 levels of TNF-α and LPA with a positive significant correlation between levels of both variables and with at-T1 BMI. Conclusion: High serum levels of TNF-α and plasma LPA levels early in pregnancy could predict the development of PE and its severity
目的:评价妊娠第6周(GW;T1时间)和诊断时的血压指标判断子痫前期(PE)的发展情况(T2时间)。患者与方法:140例新孕妇在T1时间给予S1样本;怀孕期间,19名妇女发生早发性PE (EOPE), 51名妇女发生晚发性PE (LOPE);16名妇女发展为重度PE (SPE), 54名妇女发展为轻度PE (MPE), 70名妇女在妊娠结束前血压正常(NT)。T2时,所有患者均取S2标本,ELISA法测定两种标本的血浆LPA和血清TNF-α水平。结果:S2组的血清TNF-α和血浆LPA水平均显著高于S1组,PE组的血清TNF-α和血浆LPA水平均显著高于NT组,EOPE组和/或SPE组的血清TNF-α和血浆LPA水平均显著高于LOPE组和/或MPE组。T1数据定义高体质指数的回归分析;BMI (β=0.162, P=0.028)、高S1水平TNF-α (β=0.424, P <0.001)和LPA (β=0.314, P <0.001)是T2时收缩压测量判断PE发展的预测因子。相关分析显示,at-T2-SBP测量值与at-T1 BMI和S1 TNF-α和LPA水平呈正相关(P <0.001),两者水平与at-T1 BMI呈正相关。结论:妊娠早期血清TNF-α和血浆LPA水平升高可预测PE的发展及其严重程度
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引用次数: 0
Maternal serum SHARP1 and hypoxia inducible factor-1α as biomarkers for preeclampsia 母体血清SHARP1和缺氧诱导因子-1α作为子痫前期的生物标志物
Pub Date : 2022-11-01 DOI: 10.21608/ebwhj.2022.158984.1196
Mahmoud F. Hassan, N. Rund, N. Moussa, M. Moussa
Objectives: Preeclampsia remains a major cause of maternal mortality and morbidity worldwide, with an increased risk of cardiovascular disease later in life. Many previous studies have examined several biomarkers. We aimed to assess the role of Split and hairy-related protein-1 (SHARP1) together with hypoxia-inducible factor-1α (HIF-1α) as biomarkers for the detection of preeclampsia. Materials and Methods: This case-control study included 150 pregnant women, 75 healthy women and 75 with preeclampsia, who were recruited for delivery during the third trimester of pregnancy and subjected to full clinical and laboratory testing. This testing included compete blood analysis, and plasma SHARP1 and HIF-1α measurement using ELISA. The main outcome was the association of SHARP1 and HIF-1α with preeclampsia . Results: A significant decrease in SHARP1 ( P < 0.0001 ) and a significant increase in HIF-1α ( P < 0.0001 ) were observed in patients versus the controls. The SHARP1 and HIF-1α levels were independent indicators of preeclampsia after adjusting for maternal age, body mass index, and parity (the odds ratio for SHARP1 was 0.04, 95% confidence interval 0.321–0.791; P < 0.0001 , and the OR for HIF-1α was 30.222, 95% CI 6.219 – 146.877; P < 0.0001 ). Conclusion : SHARP1 and HIF-1α may have be used as biomarkers for the proper recognition of preeclampsia. The synergistic actions of SHARP1 and HIF-1α might play a key role in the pathogenesis of preeclampsia. Larger studies are likely to help verify the data and justify the wider application of these markers.
目的:先兆子痫仍然是全世界孕产妇死亡和发病的主要原因,并且在以后的生活中患心血管疾病的风险增加。许多先前的研究已经检查了几种生物标志物。我们的目的是评估分裂和毛发相关蛋白-1 (SHARP1)和缺氧诱导因子-1α (HIF-1α)作为检测子痫前期的生物标志物的作用。材料和方法:本病例对照研究包括150名孕妇,75名健康妇女和75名先兆子痫妇女,这些妇女在妊娠晚期分娩,并进行了全面的临床和实验室检测。该检测包括竞争性血液分析,ELISA检测血浆SHARP1和HIF-1α。主要结局是SHARP1和HIF-1α与先兆子痫的相关性。结果:与对照组相比,患者SHARP1显著降低(P < 0.0001), HIF-1α显著升高(P < 0.0001)。在调整母亲年龄、体重指数和胎次后,SHARP1和HIF-1α水平是子痫前期的独立指标(SHARP1的优势比为0.04,95%可信区间为0.321-0.791;P < 0.0001, HIF-1α OR为30.222,95% CI为6.219 ~ 146.877;P < 0.0001)。结论:SHARP1和HIF-1α可能是正确识别子痫前期的生物标志物。SHARP1和HIF-1α的协同作用可能在子痫前期的发病机制中起关键作用。更大规模的研究可能有助于验证这些数据,并证明这些标记物的广泛应用是合理的。
{"title":"Maternal serum SHARP1 and hypoxia inducible factor-1α as biomarkers for preeclampsia","authors":"Mahmoud F. Hassan, N. Rund, N. Moussa, M. Moussa","doi":"10.21608/ebwhj.2022.158984.1196","DOIUrl":"https://doi.org/10.21608/ebwhj.2022.158984.1196","url":null,"abstract":"Objectives: Preeclampsia remains a major cause of maternal mortality and morbidity worldwide, with an increased risk of cardiovascular disease later in life. Many previous studies have examined several biomarkers. We aimed to assess the role of Split and hairy-related protein-1 (SHARP1) together with hypoxia-inducible factor-1α (HIF-1α) as biomarkers for the detection of preeclampsia. Materials and Methods: This case-control study included 150 pregnant women, 75 healthy women and 75 with preeclampsia, who were recruited for delivery during the third trimester of pregnancy and subjected to full clinical and laboratory testing. This testing included compete blood analysis, and plasma SHARP1 and HIF-1α measurement using ELISA. The main outcome was the association of SHARP1 and HIF-1α with preeclampsia . Results: A significant decrease in SHARP1 ( P < 0.0001 ) and a significant increase in HIF-1α ( P < 0.0001 ) were observed in patients versus the controls. The SHARP1 and HIF-1α levels were independent indicators of preeclampsia after adjusting for maternal age, body mass index, and parity (the odds ratio for SHARP1 was 0.04, 95% confidence interval 0.321–0.791; P < 0.0001 , and the OR for HIF-1α was 30.222, 95% CI 6.219 – 146.877; P < 0.0001 ). Conclusion : SHARP1 and HIF-1α may have be used as biomarkers for the proper recognition of preeclampsia. The synergistic actions of SHARP1 and HIF-1α might play a key role in the pathogenesis of preeclampsia. Larger studies are likely to help verify the data and justify the wider application of these markers.","PeriodicalId":12080,"journal":{"name":"Evidence Based Women's Health Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84738291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Evidence Based Women's Health Journal
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