Pub Date : 2026-01-15DOI: 10.1016/j.ajt.2025.12.271
Daniel Katz, Shengliang He, Mary Charlton
{"title":"The Impact of Pre-Transplant Mortality Ratio Metric Implementation: A National Survey","authors":"Daniel Katz, Shengliang He, Mary Charlton","doi":"10.1016/j.ajt.2025.12.271","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.271","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"65 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1016/j.ajt.2025.12.255
Sarah Shan, Sophia Diaz, Li Ting Tan, Vina Nguyen, Yusuf Ciftci, Niket Harsh, Maria Parra, Jamal Masri, Lisa Kratz, Shira Ziegler, Daniel Warren, Elizabeth King
{"title":"Ex Vivo Porcine Livers for Treating Maple Syrup Urine Disease: A Pilot Study","authors":"Sarah Shan, Sophia Diaz, Li Ting Tan, Vina Nguyen, Yusuf Ciftci, Niket Harsh, Maria Parra, Jamal Masri, Lisa Kratz, Shira Ziegler, Daniel Warren, Elizabeth King","doi":"10.1016/j.ajt.2025.12.255","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.255","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"12 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1016/j.ajt.2025.12.249
Babawale Oluborode, Lauren Malinzak, Dean Kim, Jason Denny, Shunji Nagai, Marwan Abouljoud, Atsushi Yoshida
{"title":"Beyond the Liver: Factors Associated with Poor Kidney Graft Outcome in Simultaneous Liver-Kidney Transplant Recipients Without Prior Dialysis","authors":"Babawale Oluborode, Lauren Malinzak, Dean Kim, Jason Denny, Shunji Nagai, Marwan Abouljoud, Atsushi Yoshida","doi":"10.1016/j.ajt.2025.12.249","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.249","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"50 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1016/j.ajt.2025.12.256
Ishani Sharma, Marco Diaz-Cordova, William Pascal, Abhay Dhand, Ryosuke Misawa, Gregory Veillette, Seigo Nishida, Kenji Okumura
{"title":"Characteristics and Outcomes of Liver Transplant Recipients with Prior History of Bariatric Surgery","authors":"Ishani Sharma, Marco Diaz-Cordova, William Pascal, Abhay Dhand, Ryosuke Misawa, Gregory Veillette, Seigo Nishida, Kenji Okumura","doi":"10.1016/j.ajt.2025.12.256","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.256","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"2 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1016/j.ajt.2025.12.248
Atsushi Nishimagi, Rikako Oki, Taichi Suzuki, Jack Avedikian, Luckshi Rajendran, Adhnan Mohamed, Ahmed Nassar, Abbas Al-Kurd, Atsushi Yoshida, Marwan Abouljoud, Shunji Nagai
{"title":"The impact of Area Deprivation Index on the conditional post-liver transplant patient survival after 5-year","authors":"Atsushi Nishimagi, Rikako Oki, Taichi Suzuki, Jack Avedikian, Luckshi Rajendran, Adhnan Mohamed, Ahmed Nassar, Abbas Al-Kurd, Atsushi Yoshida, Marwan Abouljoud, Shunji Nagai","doi":"10.1016/j.ajt.2025.12.248","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.248","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"49 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 65-year-old kidney transplant recipient was admitted with isolated fever. Initial tests revealed pancytopenia and elevated C-reactive protein levels but failed to detect any pathogen. A bone marrow aspirate was performed because of signs suggestive of hemophagocytic lymphohistiocytosis (HLH), but results were negative. The patient subsequently developed fulminant hepatitis. Liver biopsy showed severe acute cytolytic hepatitis with a neutrophil-rich infiltrate, suppurative hepatocytic necrosis, and hemophagocytosis. Etoposide, N-acetylcysteine, and piperacillin-tazobactam were initiated. However, the patient died from hemorrhagic complications of the biopsy. Posthumous shotgun metagenomics (SMg) on liver samples identified Spiroplasma ixodetis.
{"title":"Spiroplasma infection complicated by macrophage activation syndrome and fulminant hepatitis in a kidney transplanted patient.","authors":"Imane Farhat,Hannah Kaminski,Pierre Louis Woerther,Christophe Rodriguez,Capy Pierre,Justine Cheval,Skander Korbi,Lionel Couzi,Pierre Merville,Frédéric Jambon,Karine Moreau","doi":"10.1016/j.ajt.2026.01.008","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.01.008","url":null,"abstract":"A 65-year-old kidney transplant recipient was admitted with isolated fever. Initial tests revealed pancytopenia and elevated C-reactive protein levels but failed to detect any pathogen. A bone marrow aspirate was performed because of signs suggestive of hemophagocytic lymphohistiocytosis (HLH), but results were negative. The patient subsequently developed fulminant hepatitis. Liver biopsy showed severe acute cytolytic hepatitis with a neutrophil-rich infiltrate, suppurative hepatocytic necrosis, and hemophagocytosis. Etoposide, N-acetylcysteine, and piperacillin-tazobactam were initiated. However, the patient died from hemorrhagic complications of the biopsy. Posthumous shotgun metagenomics (SMg) on liver samples identified Spiroplasma ixodetis.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"147 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.ajt.2025.12.289
Christophe Masset, Olivia Rousseau, Alexandre Walencik, Karine Renaudin, Stéphanie Blandin, Melodie Ambroset, Nathalie Gérard, Marine Lorent, Nicolas Degauque, Sophie Brouard, Richard Danger, Magali Giral, Gilles Blancho, Julien Branchereau, Benoit Mesnard, Diego Cantarovich, Jacques Dantal, for the Nantes DIVAT Consortium, Données Informatisées et VAlidées en Transplantation DIVAT Cohort Collaborators (Medical Doctors Surgeons HLA Biologists), Gilles Blancho, Julien Branchereau, Diego Cantarovich, Agnès Chapelet, Jacques Dantal, Clément Deltombe, Lucile Figueres, Eloise Grenon, Thibault Letellier, Clémence Petit, Claire Garandeau, Magali Giral, Caroline Gourraud-Vercel, Laurent Nicolet, Christine Kandel-Aznar, Ismaël Chelghaf, Benoit Mesnard, Clarisse Kerleau, Christophe Masset, Aurélie Houzet, Karine Renaudin, Simon Ville, Alexandre Walencik
Auto-antibodies targeting the angiotensin-II receptor (AT1R-AA) have been identified as drivers of allograft vascular inflammation in kidney transplantation. We investigated the role of AT1R-AA in pancreas transplantation with focus on rejection and thrombosis. We included all pancreas transplant recipients followed in our center with available pre-transplant sera (Day 0). AT1R-AA levels were assessed and a multivariable cause-specific Cox model was used to examine their association with pancreas rejection and survival. Additionally, pancreatic tissues were analyzed for AT1R expression at molecular and protein level. Among 305 patients, 34 experienced pancreatic rejection and 50 allograft lost at one-year. In multivariable analysis, AT1R-AA titer at transplantation was significantly associated with pancreas survival (adjusted HR = 1.04, CI95% [1.00;1.08], p = 0.0427) and pancreas rejection (adjusted HR = 1.07, CI95% [1.03;1.12], p = 0.0015). AT1R-AA levels were significantly higher in patients with early thrombosis compared to others (10.1 U/ml vs 6.3 U/ml, p < 0.0001). Analysis of tissues from deceased donors and follow-up biopsies revealed wide variation in pancreatic AT1R expression. In conclusion, AT1R-AA were significantly associated with higher risk of pancreatic rejection and allograft failure from complete thrombosis. Variations in pancreatic AT1R expression may contribute to different outcomes among patients with pre-transplant AT1R-AA.
针对血管紧张素- ii受体（AT1R-AA）的自身抗体已被确定为肾移植中异体移植血管炎症的驱动因素。我们研究了AT1R-AA在胰腺移植中的作用，重点是排斥反应和血栓形成。我们纳入了所有胰腺移植受者，并在本中心随访了移植前血清（第0天）。评估AT1R-AA水平，并使用多变量病因特异性Cox模型来检查其与胰腺排斥反应和生存的关系。此外，在分子和蛋白水平上分析胰腺组织中AT1R的表达。在305例患者中，34例出现胰腺排斥反应，50例异体移植在一年内丢失。在多变量分析中，移植时AT1R-AA滴度与胰腺生存（校正HR = 1.04, CI95% [1.00;1.08], p = 0.0427）和胰腺排斥反应（校正HR = 1.07, CI95% [1.03;1.12], p = 0.0015）显著相关。早期血栓患者的AT1R-AA水平明显高于其他患者（10.1 U/ml vs 6.3 U/ml, p < 0.0001）。死亡供体组织分析和后续活检显示胰腺AT1R表达存在广泛差异。总之，AT1R-AA与胰腺排斥反应和完全血栓形成的同种异体移植失败的高风险显著相关。胰腺AT1R表达的变化可能导致移植前AT1R- aa患者的不同预后。
{"title":"Anti-AT1R Autoantibodies in pancreas transplantation","authors":"Christophe Masset, Olivia Rousseau, Alexandre Walencik, Karine Renaudin, Stéphanie Blandin, Melodie Ambroset, Nathalie Gérard, Marine Lorent, Nicolas Degauque, Sophie Brouard, Richard Danger, Magali Giral, Gilles Blancho, Julien Branchereau, Benoit Mesnard, Diego Cantarovich, Jacques Dantal, for the Nantes DIVAT Consortium, Données Informatisées et VAlidées en Transplantation DIVAT Cohort Collaborators (Medical Doctors Surgeons HLA Biologists), Gilles Blancho, Julien Branchereau, Diego Cantarovich, Agnès Chapelet, Jacques Dantal, Clément Deltombe, Lucile Figueres, Eloise Grenon, Thibault Letellier, Clémence Petit, Claire Garandeau, Magali Giral, Caroline Gourraud-Vercel, Laurent Nicolet, Christine Kandel-Aznar, Ismaël Chelghaf, Benoit Mesnard, Clarisse Kerleau, Christophe Masset, Aurélie Houzet, Karine Renaudin, Simon Ville, Alexandre Walencik","doi":"10.1016/j.ajt.2025.12.289","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.12.289","url":null,"abstract":"Auto-antibodies targeting the angiotensin-II receptor (AT1R-AA) have been identified as drivers of allograft vascular inflammation in kidney transplantation. We investigated the role of AT1R-AA in pancreas transplantation with focus on rejection and thrombosis. We included all pancreas transplant recipients followed in our center with available pre-transplant sera (Day 0). AT1R-AA levels were assessed and a multivariable cause-specific Cox model was used to examine their association with pancreas rejection and survival. Additionally, pancreatic tissues were analyzed for AT1R expression at molecular and protein level. Among 305 patients, 34 experienced pancreatic rejection and 50 allograft lost at one-year. In multivariable analysis, AT1R-AA titer at transplantation was significantly associated with pancreas survival (adjusted HR = 1.04, CI95% [1.00;1.08], p = 0.0427) and pancreas rejection (adjusted HR = 1.07, CI95% [1.03;1.12], p = 0.0015). AT1R-AA levels were significantly higher in patients with early thrombosis compared to others (10.1 U/ml vs 6.3 U/ml, p < 0.0001). Analysis of tissues from deceased donors and follow-up biopsies revealed wide variation in pancreatic AT1R expression. In conclusion, AT1R-AA were significantly associated with higher risk of pancreatic rejection and allograft failure from complete thrombosis. Variations in pancreatic AT1R expression may contribute to different outcomes among patients with pre-transplant AT1R-AA.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"57 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145956673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.ajt.2026.01.009
Alexandra F Sharland,Natasha M Rogers
{"title":"Rewriting the rule of alloimmunity: a blueprint for B cell-driven transplant outcomes.","authors":"Alexandra F Sharland,Natasha M Rogers","doi":"10.1016/j.ajt.2026.01.009","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.01.009","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"84 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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