Pub Date : 2024-05-14eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0219
Joe Rassi, Stephanie Khazaka, Sani Hlais, Stephanie Rassi, Mohammad Daher, Toufic Samaha
Aim: The purpose of this study is to analyze the different characteristics of gabapentinoids prescription by Lebanese orthopedics surgeons. Methods: This is an observational, cross-sectional study using a survey which was carried out in collaboration with the Lebanese Orthopedic Society over a 3-month period. Results: Forty-two orthopedic surgeons responded, most of them prescribing gabapentinoids in their daily practice with only half of the patients feeling relief after taking them. Furthermore, most of the surgeons prescribed these drugs for patients above 18 years old and for both acute and chronic pain. Conclusion: Even though almost half of the patients do not experience relief after taking gabapentinoids, these drugs are becoming more and more prescribed.
{"title":"Gabapentinoid prescriptions for neuropathic and musculoskeletal pain in Lebanon.","authors":"Joe Rassi, Stephanie Khazaka, Sani Hlais, Stephanie Rassi, Mohammad Daher, Toufic Samaha","doi":"10.2144/fsoa-2023-0219","DOIUrl":"10.2144/fsoa-2023-0219","url":null,"abstract":"<p><p><b>Aim:</b> The purpose of this study is to analyze the different characteristics of gabapentinoids prescription by Lebanese orthopedics surgeons. <b>Methods:</b> This is an observational, cross-sectional study using a survey which was carried out in collaboration with the Lebanese Orthopedic Society over a 3-month period. <b>Results:</b> Forty-two orthopedic surgeons responded, most of them prescribing gabapentinoids in their daily practice with only half of the patients feeling relief after taking them. Furthermore, most of the surgeons prescribed these drugs for patients above 18 years old and for both acute and chronic pain. <b>Conclusion:</b> Even though almost half of the patients do not experience relief after taking gabapentinoids, these drugs are becoming more and more prescribed.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO960"},"PeriodicalIF":2.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0185
Mohamed S Jarrar, Malek Barka, Mehdi Chahed, Radhouane Toumi, Ameni Beizig, Mohamed H Mraidha, Fehmi Hamila, Sabri Youssef
Aim: The aim is to evaluate laparoscopic cholecystectomy safety based on American Society of Anesthesiologists score for acute cholecystitis in patients with comorbidities. Patients & methods: This is retrospective study of patients who underwent laparoscopic cholecystectomy for acute cholecystitis between 2003 and 2021. According to their respective ASA-score, patients were divided into group 1: ASA1-2 and group 2: ASA3-4. Results: We collected 578 patients. Even though the gangrenous forms were more frequent and the operative time was longer in group 2, laparoscopic cholecystectomy seems safe and effective. We didn't observe any differences in terms of intraoperative incidents, open conversion rate, or postoperative complications compared with other patients. Conclusion: ASA3-4 patients with acute cholecystitis don't face elevated risks of complications or mortality during laparoscopic cholecystectomy.
{"title":"Early laparoscopic cholecystectomy in severely comorbid patients with acute cholecystitis: results of a monocentric study.","authors":"Mohamed S Jarrar, Malek Barka, Mehdi Chahed, Radhouane Toumi, Ameni Beizig, Mohamed H Mraidha, Fehmi Hamila, Sabri Youssef","doi":"10.2144/fsoa-2023-0185","DOIUrl":"10.2144/fsoa-2023-0185","url":null,"abstract":"<p><p><b>Aim:</b> The aim is to evaluate laparoscopic cholecystectomy safety based on American Society of Anesthesiologists score for acute cholecystitis in patients with comorbidities. <b>Patients & methods:</b> This is retrospective study of patients who underwent laparoscopic cholecystectomy for acute cholecystitis between 2003 and 2021. According to their respective ASA-score, patients were divided into group 1: ASA1-2 and group 2: ASA3-4. <b>Results:</b> We collected 578 patients. Even though the gangrenous forms were more frequent and the operative time was longer in group 2, laparoscopic cholecystectomy seems safe and effective. We didn't observe any differences in terms of intraoperative incidents, open conversion rate, or postoperative complications compared with other patients. <b>Conclusion:</b> ASA3-4 patients with acute cholecystitis don't face elevated risks of complications or mortality during laparoscopic cholecystectomy.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO951"},"PeriodicalIF":2.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Histology is the most widely used test to detect H. pylori. PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of H. pylori infection compared with PCR. Results: Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti-H. pylori therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of H. pylori detection. Conclusion: Thus, histology can be considered as an efficient test compared with PCR in H. pylori detection.
{"title":"Assessment of histology's performance compared with PCR in the diagnosis of <i>Helicobacter pylori</i> infection.","authors":"Manel Moalla, Lassaad Chtourou, Basma Mnif, Slim Charfi, Hend Smaoui, Mon Boudabous, Leila Mnif, Ali Amouri, Hela Gdoura, Adnene Hammami, Tahya Boudawara, Nabil Tahri","doi":"10.2144/fsoa-2023-0217","DOIUrl":"10.2144/fsoa-2023-0217","url":null,"abstract":"<p><p><b>Aim:</b> Histology is the most widely used test to detect <i>H. pylori</i>. PCR is less used but allows the detection of both infection and antibiotics' resistance. <b>Methods:</b> We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of <i>H. pylori</i> infection compared with PCR. <b>Results:</b> Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti-<i>H. pylori</i> therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of <i>H. pylori</i> detection. <b>Conclusion:</b> Thus, histology can be considered as an efficient test compared with PCR in <i>H. pylori</i> detection.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO976"},"PeriodicalIF":2.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen
Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light therapy found to be useful in the treatment of a wide range of neurological diseases. Objective: The aim is to review the mechanism and clinical applications of photobiomodulation therapy (PBMT) in managing Alzheimer's disease. Methods: To ensure that the consensus statement accurately reflects both the experts' viewpoint and the most recent developments in the field, the expert opinions were recorded and thoroughly reviewed. Results: PBMT elicits reduction of beta-amyloid plaque, restoration of mitochondrial function, anti-inflammatory and antioxidant properties with a stimulation in ATP synthesis. Conclusion: The PBMT could be helpful in patients non-responsive to traditional pharmacological therapy providing significant aid in the management of Alzheimer's disease when introduced into the medical field.
目的：光生物调节涉及使用低强度光疗法或近红外线光疗法，这些疗法被认为可用于治疗多种神经系统疾病。目的旨在回顾光生物调控疗法（PBMT）治疗阿尔茨海默病的机制和临床应用。方法：为确保共识声明准确反映专家观点和该领域的最新进展，对专家意见进行了记录和全面审查。结果：PBMTPBMT 可减少β-淀粉样蛋白斑块、恢复线粒体功能、抗炎和抗氧化并促进 ATP 合成。结论：对传统药物疗法无反应的患者可以使用 PBMT，该疗法一旦被引入医疗领域，将为阿尔茨海默病的治疗提供重要帮助。
{"title":"Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment","authors":"Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen","doi":"10.2144/fsoa-2023-0155","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0155","url":null,"abstract":"Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light therapy found to be useful in the treatment of a wide range of neurological diseases. Objective: The aim is to review the mechanism and clinical applications of photobiomodulation therapy (PBMT) in managing Alzheimer's disease. Methods: To ensure that the consensus statement accurately reflects both the experts' viewpoint and the most recent developments in the field, the expert opinions were recorded and thoroughly reviewed. Results: PBMT elicits reduction of beta-amyloid plaque, restoration of mitochondrial function, anti-inflammatory and antioxidant properties with a stimulation in ATP synthesis. Conclusion: The PBMT could be helpful in patients non-responsive to traditional pharmacological therapy providing significant aid in the management of Alzheimer's disease when introduced into the medical field.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman
Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2. Missense variants were identified using ensemble-based algorithms and homology/structure-based models like SIFT, PROVEAN, Predict-SNP and MutPred-2. Results: Eight missense variants were identified in viral sequences. Four damaging variants were found, with SNPs&Go and PolyPhen-2. Promising therapeutic candidates, including gilteritinib, pictilisib, sorafenib, RO5126766 and omipalisib, were identified. Conclusion: This research offers insights into SARS-CoV-2 pathogenicity, highlighting potential treatments and harmful variants in viral proteins.
{"title":"SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning","authors":"Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman","doi":"10.2144/fsoa-2023-0112","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0112","url":null,"abstract":"Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2. Missense variants were identified using ensemble-based algorithms and homology/structure-based models like SIFT, PROVEAN, Predict-SNP and MutPred-2. Results: Eight missense variants were identified in viral sequences. Four damaging variants were found, with SNPs&Go and PolyPhen-2. Promising therapeutic candidates, including gilteritinib, pictilisib, sorafenib, RO5126766 and omipalisib, were identified. Conclusion: This research offers insights into SARS-CoV-2 pathogenicity, highlighting potential treatments and harmful variants in viral proteins.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"4 24","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam
Aim: In this study, we have selected two different Ocimum tenuiflorum plants, Ocimum tenuiflorum (Rama tulsi) (OTRT) and Ocimum tenuiflorum (Krishna tulsi) (OTKT). Materials & methods: In the present investigation, ethanol was used as a solvent to estimate the bioactive compounds present in it through gas chromatography-mass spectrometry (GC–MS). Results: Based on the GC-MS data benzenepropanoic acid, 3-methoxy-alpha,4-bis[(trimethylsilyl)oxy was found to be the potent compound in OTRT (MW:428.74 g/mol) and methyl 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropanoate in OTKT (MW:342.39 g/mol). To estimate its pharmacological application, an integrated Network Pharmacology approach is performed toward the disease target obesity. Conclusion: From the Protein–Protein interaction from the string database, SRC, BCL2, EGFR, MTOR, CDK1, ERBB2, MAPK1, FYN, AR and MAPK14 are the top-ranked targets.
{"title":"GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity","authors":"Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam","doi":"10.2144/fsoa-2023-0202","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0202","url":null,"abstract":"Aim: In this study, we have selected two different Ocimum tenuiflorum plants, Ocimum tenuiflorum (Rama tulsi) (OTRT) and Ocimum tenuiflorum (Krishna tulsi) (OTKT). Materials & methods: In the present investigation, ethanol was used as a solvent to estimate the bioactive compounds present in it through gas chromatography-mass spectrometry (GC–MS). Results: Based on the GC-MS data benzenepropanoic acid, 3-methoxy-alpha,4-bis[(trimethylsilyl)oxy was found to be the potent compound in OTRT (MW:428.74 g/mol) and methyl 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropanoate in OTKT (MW:342.39 g/mol). To estimate its pharmacological application, an integrated Network Pharmacology approach is performed toward the disease target obesity. Conclusion: From the Protein–Protein interaction from the string database, SRC, BCL2, EGFR, MTOR, CDK1, ERBB2, MAPK1, FYN, AR and MAPK14 are the top-ranked targets.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamdi Nsairat, Areej M. Jaber, Haya Faddah, Somaya Ahmad
Colorectal cancer (CRC) is considered the third most common cancer in the world. In Mediterranean region, olives and olive oil play a substantial role in diet and medical traditional behaviors. They totally believe that high consumption of olive products can treat a wide range of diseases and decrease risk of illness. Oleuropein is the main active antioxidant molecule found in pre-mature olive fruit and leaves. Recently, it has been demonstrated that oleuropein is used in cancer therapy as an anti-proliferative and apoptotic agent for some cancer cells. In this review, we would like to explore the conclusive effects of oleuropein on CRC with respect to in vitro and in vivo studies.
{"title":"Oleuropein impact on colorectal cancer","authors":"Hamdi Nsairat, Areej M. Jaber, Haya Faddah, Somaya Ahmad","doi":"10.2144/fsoa-2023-0131","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0131","url":null,"abstract":"Colorectal cancer (CRC) is considered the third most common cancer in the world. In Mediterranean region, olives and olive oil play a substantial role in diet and medical traditional behaviors. They totally believe that high consumption of olive products can treat a wide range of diseases and decrease risk of illness. Oleuropein is the main active antioxidant molecule found in pre-mature olive fruit and leaves. Recently, it has been demonstrated that oleuropein is used in cancer therapy as an anti-proliferative and apoptotic agent for some cancer cells. In this review, we would like to explore the conclusive effects of oleuropein on CRC with respect to in vitro and in vivo studies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"34 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shankar Dutt, B. Karawdeniya, Yapa Mndy Bandara, Patrick Kluth
{"title":"Nanopore sensing and machine learning: future of biomarker analysis and disease detection","authors":"Shankar Dutt, B. Karawdeniya, Yapa Mndy Bandara, Patrick Kluth","doi":"10.2144/fsoa-2023-0226","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0226","url":null,"abstract":"","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"63 16","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: This study aimed to assess the quality of life (QoL) of parents of children with autism spectrum disorder (ASD) in Jordan and its associated factors. Methods: This comparative study was conducted among parents of children with ASD and non-ASD. Data collection took four setting areas that include three centers for autism in three different municipalities and the control group was collected using social media. A convenience sample of 242 parents agreed to complete a QoL questionnaire. Results: Parents of children with ASD in Jordan have poor QoL across the five domains of QoL in compare with parents with non-ASD child. Factors such as gender, level of education, living condition and employment status were found impacting QoL.
目的：本研究旨在评估约旦自闭症谱系障碍（ASD）儿童家长的生活质量（QoL）及其相关因素。研究方法这项比较研究的对象是自闭症谱系障碍儿童和非自闭症谱系障碍儿童的家长。数据收集涉及四个环境区域，包括三个不同城市的三个自闭症中心，对照组则通过社交媒体收集数据。方便抽样调查的 242 名家长同意填写 QoL 问卷。结果：与非自闭症儿童的家长相比，约旦自闭症儿童家长在五个方面的生活质量都较差。性别、教育水平、生活条件和就业状况等因素都会对其生活质量产生影响。
{"title":"Parents of children with autism spectrum disorder quality of life in Jordan: a comparative study","authors":"Abedallah Kasem, S. Abuhammad, Naemah Jamal","doi":"10.2144/fsoa-2023-0096","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0096","url":null,"abstract":"Aim: This study aimed to assess the quality of life (QoL) of parents of children with autism spectrum disorder (ASD) in Jordan and its associated factors. Methods: This comparative study was conducted among parents of children with ASD and non-ASD. Data collection took four setting areas that include three centers for autism in three different municipalities and the control group was collected using social media. A convenience sample of 242 parents agreed to complete a QoL questionnaire. Results: Parents of children with ASD in Jordan have poor QoL across the five domains of QoL in compare with parents with non-ASD child. Factors such as gender, level of education, living condition and employment status were found impacting QoL.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"53 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mona Boudabbous, Baha Barkia, W. Feki, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Zeinab Mnif, N. Tahri
Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.
{"title":"Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis","authors":"Mona Boudabbous, Baha Barkia, W. Feki, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Zeinab Mnif, N. Tahri","doi":"10.2144/fsoa-2023-0109","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0109","url":null,"abstract":"Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"6 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139007838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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