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Classification and regulation of functional food proposed by the Functional Food Center 功能食品中心提出的功能食品分类与监管
Pub Date : 2022-02-07 DOI: 10.31989/ffs.v2i2.890
D. Martirosyan, Trevor Lampert, Morgan Ekblad
There has yet to be a consensus on the definition of functional foods (FF), and accordingly many institutions lack a comprehensive process for its classification. The Functional Food Center (FFC) has previously proposed a multi-step process for the development of functional food products and ways by which to bring them to market without means to classify established items. This article is advancing the previously proposed methodology with the addition of new steps. The newest steps focus on themes of transparency by the publishing of peer-reviewed articles for the functional food product as mandatory for accreditation. In doing so, this will provide greater access to information for the functional food market, as well as, acceptance and trustworthiness of functional claims. Additionally, the Functional Food Center has created a new system for categorizing functional foods. The new categorization system uses improved research on epidemiological and after market studies, and evaluates the quality of evidence for the functional food product (FFP) as A, B, or C. A classification of A denotes the completion of aftermarket research, epidemiological studies, and certification of functional food status. Classification B denotes completion of epidemiological studies and certification of functional food status. Lastly, C indicates that the product has only been certified as functional. The Functional Food Center’s definition of functional foods, steps on how to create functional foods, and proposed categorization will help to describe our proposed regulation of FFP.  KEYWORDS: Functional Food Classification, Functional Food Regulation, Functional Food Products, Categorization Grades of Functional Food, How to Create Functional Food, Bioactive Compounds, Functional Food Definition 
功能食品(FF)的定义尚未达成共识,因此许多机构缺乏一个全面的分类过程。功能食品中心(FFC)此前提出了一个多步骤的开发功能食品的过程,以及将其推向市场的方法,而无需对已建立的项目进行分类。本文通过增加新的步骤来推进先前提出的方法。最新的步骤集中在透明度的主题上,通过发布同行评审的功能性食品文章作为强制性认证。这样做,将为功能食品市场提供更多的信息渠道,以及功能声明的接受度和可信度。此外,功能食品中心还建立了一套新的功能食品分类系统。新的分类系统采用了对流行病学和市场后研究的改进研究,并将功能食品(FFP)的证据质量评估为A、B或c。A的分类表示完成了市场后研究、流行病学研究和功能食品状态认证。B级表示已完成流行病学研究和功能性食品状态认证。最后,C表示该产品仅被认证为功能性。功能食品中心对功能食品的定义,如何创建功能食品的步骤,以及拟议的分类将有助于描述我们对FFP的拟议监管。关键词:功能食品分类,功能食品法规,功能食品产品,功能食品分类等级,如何创建功能食品,生物活性化合物,功能食品定义
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引用次数: 41
Food (in)security and (un)healthy diet on the (difficult) road to zero hunger: Celebrating the World Food Day 在实现零饥饿的(艰难)道路上的(不)安全和(不)健康饮食:庆祝世界粮食日
Pub Date : 2022-01-21 DOI: 10.31989/ffs.v2i1.876
M. Iriti, S. Vitalini, E. Varoni
The worldwide prevalence of undernourishment and food insecurity has been steadily increasing in recent years, despite the United Nations’ Zero Hunger target by 2030. At the same time, unhealthy diets represent a major cause of diet-related non-communicable diseases. This contributes to the global increase in overweight and obesity, the Janus of malnutrition. Major drivers of food insecurity are economic slowdowns and downturns (further exacerbated by the COVID-19 pandemic), conflict and food crisis, poverty and inequality, and climate-related natural disasters. In this scenario, transformation of food systems will be pivotal to address these drivers of food insecurity, malnutrition, and unaffordability of healthy diets. Keywords: prevalence of undernourishment, malnutrition, Sustainable Development Goals, food systems, overweight, obesity, non-communicable diseases
尽管联合国制定了到2030年实现零饥饿的目标,但近年来,世界范围内普遍存在的食物不足和粮食不安全问题一直在稳步增加。与此同时,不健康的饮食是导致与饮食有关的非传染性疾病的一个主要原因。这导致了全球超重和肥胖人数的增加,这是营养不良的代名词。粮食不安全的主要驱动因素是经济放缓和衰退(因2019冠状病毒病大流行而进一步加剧)、冲突和粮食危机、贫困和不平等以及与气候有关的自然灾害。在这种情况下,粮食系统的转型对于解决粮食不安全、营养不良和负担不起健康饮食的这些驱动因素至关重要。关键词:营养不良发生率、营养不良、可持续发展目标、粮食系统、超重、肥胖、非传染性疾病
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引用次数: 4
The effect of rose hip on experimental anti-GBM glomerulonephritis in systemic lupus erythematosus murine models 玫瑰果对系统性红斑狼疮小鼠实验性抗gbm肾小球肾炎的影响
Pub Date : 2021-12-24 DOI: 10.31989/ffs.v1i12.873
D. Martirosyan, S. Min, C. Xie, M. Yan, A. Bashmakov, Samantha Williams, C. Mohan
Background: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease with ominous end organ manifestations significantly affecting the kidneys and joints. One of the most frequent manifestations is glomerulonephritis (GN), a renal disease distinguished by inflammation of the glomeruli that often leads to end stage kidney failure. Treatments often have severe side effects. Rose hip (RH) is derived from Rosa canina L. and has been used as a medicinal plant for centuries; it contains numerous beneficial constituents, and has the capacity to counter lipid peroxidation, oxidative stress, and inflammation. Methods: Nephritis was induced in 129/svJ strain mice using anti-glomerular basement membrane antibodies (anti-GBM). The experimental group was fed whole RH preparation (100mg/kg body weight per day) by oral gavage from D5 to D10; the control group was fed the diluent used to dissolve RH (10 mice per group). Mice were sacrificed on D11 and phenotyped for disease. Blood urea nitrogen (BUN) and proteinuria were measured; flow cytometry of kidneys was performed on both groups.  Results: RH treatment decreased proteinuria, blood urea nitrogen, CD4+, CD8+, CD11b+Gr-1+ (neutrophil), and CD11b+CD11c+ (myeloid cells) compared with nephritis control. The presence of vitamin C was confirmed. RH largely maintained its total antioxidant capacity and some vitamin C content for 24 hours, as well as at least 7 days after preparation. Conclusion: Our preliminary results confirmed that RH has antioxidative properties, significant anti-inflammatory effects, and may be useful in managing glomerulonephritisKeywords: Rose hip, glomerulonephritis, systemic lupus erythematosus, lupus, proteinuria, blood urea nitrogen, CD4+, CD8+, CD11b+Gr-1+(neutrophil), and CD11b+CD11c+ (myeloid cells)
背景:系统性红斑狼疮(SLE或狼疮)是一种慢性自身免疫性疾病,终末器官表现不详,严重影响肾脏和关节。最常见的表现之一是肾小球肾炎(GN),这是一种以肾小球炎症为特征的肾脏疾病,常导致终末期肾衰竭。治疗通常有严重的副作用。玫瑰果(RH)是从Rosa canina L.衍生出来的,几个世纪以来一直被用作药用植物;它含有许多有益成分,并具有对抗脂质过氧化,氧化应激和炎症的能力。方法:采用抗肾小球基底膜抗体(anti-GBM)诱导129/svJ系小鼠肾炎。试验组于第5 ~ 10天灌胃全RH制剂(100mg/kg体重/天);对照组饲喂RH溶解稀释液,每组10只。D11处死小鼠,进行疾病表型分析。测定血尿素氮(BUN)和蛋白尿;两组均行肾脏流式细胞术。结果:与肾炎对照组相比,RH治疗降低了蛋白尿、血尿素氮、CD4+、CD8+、CD11b+Gr-1+(中性粒细胞)和CD11b+CD11c+(骨髓细胞)。维生素C的存在得到了证实。RH在制备后24小时和至少7天内基本保持其总抗氧化能力和部分维生素C含量。关键词:玫瑰果、肾小球肾炎、系统性红斑狼疮、狼疮、蛋白尿、血尿素氮、CD4+、CD8+、CD11b+Gr-1+(中性粒细胞)、CD11b+CD11c+(骨髓细胞)
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引用次数: 0
Phytochemical diversity behind health-promoting effects of traditional Mediterranean foods 传统地中海食物促进健康作用背后的植物化学多样性
Pub Date : 2021-11-29 DOI: 10.31989/ffs.v1i11.849
M. Iriti, E. Varoni, S. Vitalini
A healthy diet can reduce the risk of non-communicable diseases, including cardiovascular disease and some types of cancer. In general, a diet rich in fruits, vegetables, whole grain cereals, legumes, and nuts, in which products of animal origin are limited, according to the model of the Mediterranean diet, can help prevent the onset of chronic degenerative diseases, together with other lifestyles. This narrative review presents the most representative classes of bioactive phytochemicals and the main Mediterranean foods in which they are present, providing evidence in humans of their health-promoting effects. Keywords: functional foods, nutraceuticals, plant foods, Mediterranean diet, nutritional therapy, non-communicable diseases, disease prevention
健康的饮食可以减少患非传染性疾病的风险,包括心血管疾病和某些类型的癌症。一般来说,根据地中海饮食模式,富含水果、蔬菜、全谷物、豆类和坚果的饮食可以帮助预防慢性退行性疾病以及其他生活方式的发生,其中动物性产品是有限的。这篇叙述性综述介绍了最具代表性的生物活性植物化学物质类别和它们存在的主要地中海食物,为人类提供了它们促进健康作用的证据。关键词:功能食品,营养保健品,植物性食品,地中海饮食,营养疗法,非传染性疾病,疾病预防
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引用次数: 3
Aging in HIV: Can natural compounds beneficially affect its higher progression? 艾滋病毒的衰老:天然化合物能有益地影响其更高的进展吗?
Pub Date : 2021-11-29 DOI: 10.31989/ffs.v1i11.868
R. Rastmanesh, Makiko Osato, S. Pathak, A. Banerjee, S. Rasulova, F. Marotta
Aging in HIV patients is accompanied with many physical and psychological health threatening challenges. A full citation of all natural compounds and their beneficial effects in aging process in HIV-positive patients is beyond the scope of a short editorial like this and we do not intend to delve in depth of genetic pathways. However, we shortly present some useful notes below worth of ongoing research.
艾滋病毒感染者的衰老伴随着许多威胁身心健康的挑战。完整引用所有天然化合物及其在hiv阳性患者衰老过程中的有益作用超出了像这样的简短社论的范围,我们不打算深入研究遗传途径。然而,我们将在下面简要介绍一些有用的笔记,这些笔记值得正在进行的研究。
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引用次数: 0
Vitamin D fortification: A perspective to improve immunity for COVID-19 infection 强化维生素D:提高COVID-19感染免疫力的视角
Pub Date : 2021-10-27 DOI: 10.31989/ffs.v1i10.843
S. Handu, Shumaila Jan, K. Chauhan, D. C. Saxena
The need for food fortification arises because of close relation between human, health and food. The problem of prevalence of micronutrient malnutrition paved a way for food fortification to emerge and run in this technological era. This review focusses on the importance of Vitamin D in the present pandemic situation and the techniques used for fortification. The stability and bio-accessibility are the biggest question mark in the food fortification process as, a large proportion of Vitamin D is lost during food processing and storage due to environmental stress conditions such as temperature, pH, salt, oxygen and light. Vitamin D is an important micronutrient, is essentially required for the prevention of respiratory disorders, neurodegenerative diseases, cardiovascular diseases, cancer etc. which make it essential in enhancing immunity against COVID-19. Food fortification is the most efficient and safest method recognized by the WHO. The present review is an update on Vitamin D, in light of its role and importance and also fortification techniques adopted. Among all the techniques, nanoencapsulation is found to be an efficient one with the increasing demand.
由于人体、健康和食品之间的密切关系,食品强化的必要性应运而生。微量营养素营养不良普遍存在的问题为食品强化在这个技术时代的出现和运行铺平了道路。本文综述了维生素D在当前大流行形势下的重要性以及用于强化维生素D的技术。稳定性和生物可及性是食品强化过程中最大的问题,因为在食品加工和储存过程中,由于温度、pH、盐、氧和光等环境胁迫条件,很大一部分维生素D会损失。维生素D是一种重要的微量营养素,对预防呼吸系统疾病、神经退行性疾病、心血管疾病、癌症等至关重要,对增强对COVID-19的免疫力至关重要。食品强化是世界卫生组织认可的最有效、最安全的方法。鉴于维生素D的作用和重要性以及所采用的强化技术,本综述是对维生素D的最新介绍。在这些技术中,随着需求的增加,纳米封装技术被认为是一种有效的技术。
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引用次数: 4
The effect of amaranth oil on proteinuria in lupus prone mice 苋菜油对狼疮易感小鼠蛋白尿的影响
Pub Date : 2021-10-26 DOI: 10.31989/ffs.v1i10.848
D. Martirosyan, J. Hutcheson, D. Sajitharan, Samantha Williams, C. Mohan
Background: Kidney disease is a leading cause of death in the United States and the world. Proteinuria signifies kidney damage and can exacerbate kidney disease. It has become an important indicator of kidney disease; reducing proteinuria results in renoprotective effects and slows renal disease. Existing treatments do not work for every patient. Aim of Study: Amaranth is a tropical plant that was regularly consumed in the ancient Central American diet. It has a plethora of health effects and is a strong functional food candidate. This study examines whether a regular oral dose of amaranth oil decreased proteinuria concentration in murine subjects.  Methods: Mice in the experimental group (n = 3) were given 4μl of amaranth oil per gram of mouse weight for 5 days a week over 84 days. Control mice (n = 2) were sham treated on the same schedule with no oil. Urine protein concentration was determined by Bradford assay, measuring absorbance at 595nm, then comparing with a BSA standard curve.  Results: The experimental group showed decreased proteinuria levels throughout the entire 84 days of study.Conclusion: Results show amaranth oil may help decrease proteinuria levels in lupus prone murine subjects. Given the small sample size, the data are preliminary. More research is needed to validate the results, and determine the optimal dose and treatment schedule. Key words: proteinuria, amaranth oil, renoprotective, kidney disease, renal disease, lupus, functional food
背景:肾脏疾病是美国和世界上导致死亡的主要原因。蛋白尿表明肾脏受损,可加重肾脏疾病。它已成为肾脏疾病的重要指标;减少蛋白尿可以起到保护肾脏的作用,减缓肾脏疾病。现有的治疗方法并不是对每个病人都有效。研究目的:苋菜是一种热带植物,在古代中美洲饮食中经常食用。它对健康有很多影响,是一种强有力的功能性食品。本研究考察了定期口服苋菜油是否能降低小鼠尿蛋白浓度。方法:实验组小鼠(n = 3)每克小鼠体重给予苋菜油4μl,每周5天,连续给予84 d。对照小鼠(n = 2)按相同的治疗方案进行假治疗,不加油。采用Bradford法测定尿蛋白浓度,在595nm处测量吸光度,然后与BSA标准曲线进行比较。结果:在整个84天的研究中,实验组的蛋白尿水平下降。结论:苋菜油可降低狼疮易感小鼠的蛋白尿水平。由于样本量小,这些数据是初步的。需要更多的研究来验证结果,并确定最佳剂量和治疗计划。关键词:蛋白尿,苋菜油,肾保护,肾病,肾病,狼疮,功能食品
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引用次数: 6
Evaluation of in vitro antioxidant and antidiabetic potential of extracts from Phaseolus vulgaris L. seeds (Black turtle beans) 黑龟豆种子提取物体外抗氧化和抗糖尿病活性评价
Pub Date : 2021-09-30 DOI: 10.31989/ffs.v1i9.821
B. Abdulrahman, M. Bala, Bello Oluwasesan
Introduction: Phaseolus vulgaris L also known as common beans or black turtle beans are known worldwide as the most important legume for direct human consumption. Many parts of the plant are known to have important pharmacological potential against many diseases including diabetes. Despite the importance of this legume, P. vulgaris remains an underutilized and under-researched legume in Nigeria. Its therapeutic potential is being overlooked and undermined due to insufficient data on its bioactivity. These bioactive compounds present in some plant derived foods are found as fraction, crude extract, and isolated bioactive compounds that have been screened for antioxidative and antidiabetic potential.  Several plant-derived foods and isolated bioactive compounds with potential antidiabetic properties are very limited.Objective: To investigate and estimate the antioxidative and antidiabetic effect of the different solvent extracts of P. vulgaris seed in vitro. Methods: Samples were subjected to antioxidant assays using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity, ferric reducing power and 2,2-azino-bis (3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) Anti-diabetic potential in vitro was estimated by evaluating various solvent extracts on α-amylase and α-glucosidase for any inhibitory effects at doses ranging from (100-500μg/ml). Characterization of possible bioactive constituent in the different solvent extract was done using FTIR spectroscopy.Results: Aqueous extract showed a higher number of total polyphenol (11.3 ± 0.01mg/gGAE) and anthocyanin content of 76.34 ± 1.12 mg/g when compared with the other solvent extract. This was followed closely by the ethanol extract with a value of 7.3±0.01Mg and 74.53 ± 0.24 Mg/g. Ascorbic acid had a significantly higher (P<0.05) activity in the antioxidant assays used. However, among the solvent extracts tested, ethanol extract displayed highest (P<0.05) for ferric reducing power activity, (80.78±0.6mg/ml), ethyl acetate, aqueous and ethanol extracts had similar DPPH activities (12.92±2.30 mg/ml, 12.59±2.33 mg/ml and 12.54±2.30mg/ml) respectively. Dichloromethane, hexane, ethanol and ethyl acetate had similar ABTS activities. (5.69±2.86 mg/ml; 6.92±0.14 mg/ml; 10.10±1.11 mg/ml; 10.76±2.98 mg/ml) respectively. All solvent extracts displayed similar inhibitory activities against α amylase. However, ethyl acetate, aqueous and ethanol extracts showed significantly (P<0.05) higher values for α-glucosidase (3.07±0.61mg/ml; 2.82±0.14mg/ml; 2.60±0.61mg/ml). The Fourier Transform infra-red spectrophotometer (FTIR) of the extracts disclosed that the presence of polyphenol and flavonoids were due to the OH stretching and the terpenes were due to the C-H group. Conclusion: In conclusion, different solvent extracts from the seed of Phaseolus vulgaris have demonstrated low antioxidative but very promising anti –diabetic activities in vitro. The ethanol extract however displayed higher activity than other s
菜豆(Phaseolus vulgaris L)也被称为普通豆或黑龟豆,是世界上最重要的人类直接食用的豆类。众所周知,这种植物的许多部分对包括糖尿病在内的许多疾病具有重要的药理潜力。尽管这种豆科植物很重要,但在尼日利亚,P. vulgaris仍然是一种未被充分利用和研究的豆科植物。由于其生物活性数据不足,其治疗潜力被忽视和破坏。这些生物活性化合物存在于一些植物性食品中,被发现为部分、粗提取物和分离的生物活性化合物,已被筛选为具有抗氧化和抗糖尿病的潜力。几种植物性食品和分离的生物活性化合物具有潜在的抗糖尿病特性非常有限。目的:研究和评价不同溶剂提取物的体外抗氧化和抗糖尿病作用。方法:采用1,1-二苯基-2-苦酰基-肼(DPPH)自由基清除能力、铁还原能力和2,2-氮基-双(3-乙基苯并噻唑啉)-6-磺酸(ABTS)进行抗氧化实验,评价不同溶剂提取物在(100-500μg/ml)剂量范围内对α-淀粉酶和α-葡萄糖苷酶的抑制作用。利用傅里叶红外光谱对不同溶剂提取物中可能的生物活性成分进行了表征。结果:水提物总多酚含量为11.3±0.01mg/gGAE,花青素含量为76.34±1.12 mg/g,高于其他溶剂提物。其次是乙醇提取物,分别为7.3±0.01Mg和74.53±0.24 Mg/g。抗坏血酸的抗氧化活性显著高于对照组(P<0.05)。而溶剂提取物中,乙醇提取物的铁还原力最强(80.78±0.6mg/ml),乙酸乙酯、水提液和乙醇提取物的DPPH活性相近(分别为12.92±2.30 mg/ml、12.59±2.33 mg/ml和12.54±2.30mg/ml)。二氯甲烷、己烷、乙醇和乙酸乙酯的ABTS活性相似。(5.69±2.86毫克/毫升;6.92±0.14毫克/毫升;10.10±1.11毫克/毫升;10.76±2.98 mg/ml)。所有溶剂提取物对α淀粉酶均表现出相似的抑制活性。乙酸乙酯、水提液和乙醇提液中α-葡萄糖苷酶含量显著(P<0.05)升高(3.07±0.61mg/ml);2.82±0.14毫克/毫升;2.60±0.61毫克/毫升)。傅里叶变换红外分光光度计(FTIR)表明,多酚和黄酮类化合物的存在是由于羟基的拉伸,萜烯是由于C-H基团的拉伸。结论:菜豆种子不同溶剂提取物均具有较低的抗氧化活性,但具有较好的抗糖尿病活性。乙醇提取物的活性高于其他溶剂提取物,红外光谱结果显示乙醇提取物中含有黄酮类、花青素和酚类物质。这项研究可能进一步表明,菜豆种子在治疗2型糖尿病方面是一种功能性食品和营养保健品。关键词:菜豆,α淀粉酶,α葡萄糖苷酶,抗氧化
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引用次数: 3
Effect of Brewing Method on Quality Parameters and Antioxidant Capacity of Black Tea 冲泡方法对红茶品质参数及抗氧化能力的影响
Pub Date : 2021-01-01 DOI: 10.31989/ffs.v1i8.807
Z. Guzel‐Seydim, A. C. Seydim, A. Greene
Introduction: The traditional method for brewing tea in Turkey involves use of a two-vessel apparatus known as a “caydanlik.” The caydanlik allows for tea to be brewed for a longer time than typical brewing methods and involves introducing boiling water to tea leaves and steeping them in a teapot as the temperature declines over 15 minutes. In comparison, the typical tea brewing method used in other parts of the world involves steeping tea leaves in a single vessel teapot for 5 minutes. This study evaluated the effects of these two methods of brewing using two brands of tea.  Results: Results of this experiment indicate that use of the caydanlik and the accompanying longer brewing time significantly changed key quality parameters and increased the antioxidant capacity of the brewed black tea beverage. Use of the caydanlik method resulted in significantly higher (P < 0.05) theaflavins, thearubigins, theabrownins, and total polyphenols in the resultant tea than in tea brewed in a traditional teapot. Additionally, analysis of color values of the brewed tea indicated the L and b-values were significantly (P < 0.05) lower in the caydanlik brewed tea while a and hue values were significantly higher (P < 0.05). However, chroma values were not significantly different (P < 0.05) between the two methods.   Conclusions: In addition to influencing color, flavor and aroma, the brewing method also influenced the functional properties of prepared black tea. Use of the traditional two-vessel caydanlik for tea preparation increased concentrations of beneficial functional components in the tea.Keywords: Black tea, Caydanlik, Brewing, Camelia sinensis, ORAC, Total Phenolic Content
简介:土耳其传统的泡茶方法包括使用一种称为“caydanlik”的双容器装置。与传统的泡茶方法相比,caydanlik可以泡茶更长的时间,它需要向茶叶中加入沸水,然后将茶叶浸泡在茶壶中,让温度下降15分钟。相比之下,世界其他地区使用的典型泡茶方法是将茶叶浸泡在单容器茶壶中5分钟。本研究评估了这两种冲泡方法使用两种品牌的茶的效果。结果:本实验结果表明,添加凯丹利克并延长冲泡时间可显著改变冲泡红茶饮料的关键品质参数,提高其抗氧化能力。与传统茶壶泡制的茶相比,使用凯丹利克方法泡制的茶中茶黄素、茶红素、茶褐素和总多酚含量显著增加(P < 0.05)。此外,对冲泡茶的颜色值分析表明,凯丹利克冲泡茶的L值和b值显著(P < 0.05)降低,而a值和色相值显著升高(P < 0.05)。两种方法的色度值差异无统计学意义(P < 0.05)。结论:冲泡方法除了影响红茶的色、香、味外,还会影响冲泡后红茶的功能特性。使用传统的双容器制茶方法可以增加茶中有益功能成分的浓度。关键词:红茶,凯丹利克,冲泡,茶树,ORAC,总酚含量
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引用次数: 1
Pycnogenol - extract from French maritime pine bark (Pinus pinaster), as an effective antioxidant against superoxide radical 碧萝芷酚-提取自法国海松树皮(Pinus pinaster),作为一种有效的抗氧化自由基
Pub Date : 2021-01-01 DOI: 10.31989/ffs.v1i8.816
B. Čižmárová, A. Birková, B. Hubková, B. Bolerázska
Background: Interest in the positive impact of naturally occurring polyphenols is still increasing in the scientific community. Research is focused mainly on their antioxidant properties, due to their significant effects in the prevention of diseases associated with oxidative stress. Pycnogenol is an extract from French maritime pine bark (Pinus pinaster), which is composed of a mixture of phenolic compounds: monomers (catechin, epicatechin, taxifolin), flavonoids (classed as procyanidins/proanthocyanidins), phenolic or cinnamic acids and their glycosides. Due to its composition, it has a high antioxidant capacity, and is used in traditional folk medicine, cosmetics and medicine.Purpose of the study: The aim is to study the antioxidant properties of pycnogenol in order to obtain experimental information on the antioxidant effect of pycnogenol in terms of concentration dependence and pH conditions.Methods: In our study, we used a methionine-riboflavin superoxide generator, and focused on determining the antioxidant capacity of Pycnogenol against the superoxide radical in different pH values (range 6.5 – 8) using the spectroscopic method.Results: Our results showed that the antioxidant properties increased with a higher concentration of the tested compound in the tested pH range. Amongst all tested pH values, the most appropriate for pycnogenol antioxidant capacity is slightly basic pH (pH 8).Conclusion: Information on the antioxidant and prooxidant properties of naturally occurring compounds is very important for understanding their activity and their proper use in prevention, disease treatment, and detection of pathological processes. The antioxidant activity of pycnogenol depends on the structure and concentration of antioxidants; it only slightly changes at different pH values. Increasing concentration of pycnogenol enhances its antioxidant properties.Keywords: Pycnogenol, reactive oxygen species, spectrophotometry, pH dependency
背景:科学界对天然存在的多酚的积极影响的兴趣仍在增加。研究主要集中在它们的抗氧化特性上,因为它们在预防与氧化应激相关的疾病方面具有重要作用。碧萝芷酚是从法国海松树皮(Pinus pinaster)中提取的一种提取物,由酚类化合物的混合物组成:单体(儿茶素、表儿茶素、杉木素)、类黄酮(分类为原花青素/原花青素)、酚酸或肉桂酸及其苷。由于其组成,它具有很高的抗氧化能力,被用于传统民间医药、化妆品和医药。研究目的:研究碧萝芷酚的抗氧化性能,以获得碧萝芷酚在浓度依赖性和pH条件下抗氧化作用的实验信息。方法:采用蛋氨酸-核黄素超氧化物发生器,采用光谱法测定碧萝酚在不同pH值(6.5 ~ 8)下对超氧化物自由基的抗氧化能力。结果:在pH范围内,化合物的抗氧化性能随浓度的增加而增加。在所有测试的pH值中,碧萝芷酚抗氧化能力最适宜的pH值为微碱性pH值(pH值为8)。结论:了解天然化合物的抗氧化和促氧化性质对了解其活性及其在预防、疾病治疗和病理过程检测中的正确应用非常重要。碧萝芷酚的抗氧化活性取决于抗氧化剂的结构和浓度;它在不同的pH值下只有轻微的变化。增加碧萝芷酚浓度可增强其抗氧化性能。关键词:碧萝芷酚,活性氧,分光光度法,pH依赖性
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引用次数: 1
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Functional Food Science
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