F. Bergesio, A. Ciciani, M. Lombardi, Gabriele Cerini, Alessandra Petrioli, Giuseppe Curciarello, M. Pierattelli, Neri Pucci, Alfredo Zuppiroli, Leonardo Mari, P. Dattolo
{"title":"Non perdiamo tempo prezioso","authors":"F. Bergesio, A. Ciciani, M. Lombardi, Gabriele Cerini, Alessandra Petrioli, Giuseppe Curciarello, M. Pierattelli, Neri Pucci, Alfredo Zuppiroli, Leonardo Mari, P. Dattolo","doi":"10.33393/gcnd.2023.2578","DOIUrl":"https://doi.org/10.33393/gcnd.2023.2578","url":null,"abstract":"","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81121553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Quintaliani, Maria Rinaldi Miliani, Claudia Savignani
We explore the utility of social media platforms as educational tools, providing a summary of how these sites are used by the public and demonstrating ways these findings may be applied for educational purposes. Over half of the world’s population utilizes social media platforms. More recently, these platforms have increasingly been used for educational purposes. In the field of health, a large portion of the educational content is coming from users with no formal medical or dermatologic training. In nephrology field there are not TikTok accounts. It would be useful to have an institutional account to provide serious, correct and appropriate information before others spread incorrect information.
{"title":"TikTok e l’informazione sanitaria","authors":"G. Quintaliani, Maria Rinaldi Miliani, Claudia Savignani","doi":"10.33393/gcnd.2023.2563","DOIUrl":"https://doi.org/10.33393/gcnd.2023.2563","url":null,"abstract":"We explore the utility of social media platforms as educational tools, providing a summary of how these sites are used by the public and demonstrating ways these findings may be applied for educational purposes.\u0000Over half of the world’s population utilizes social media platforms. More recently, these platforms have increasingly been used for educational purposes. In the field of health, a large portion of the educational content is coming from users with no formal medical or dermatologic training.\u0000In nephrology field there are not TikTok accounts. It would be useful to have an institutional account to provide serious, correct and appropriate information before others spread incorrect information.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80306260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefano Cabula, Elisabetta Frongia, Francesco Burrai, Francesca Mura, Maurizio Marcias
The nephrology and dialysis sector is characterized by a high technological content, considerable technological and digital complexity, continuous innovation within the care processes and a strong economic impact on the national and regional health system. The purpose of this article is to illustrate the application of the Health Technology Assessment (HTA) methodology in the evaluation of technological innovations in the nephrology and dialysis field. In particular, the evaluation steps of the multidimensional and multidisciplinary process applied to the nephrodialysis field will be described, specifically a device to be used in patients with chronic kidney disease, also considering important comorbidities such as cardiomyopathies and arrhythmias, which often require implantation of electronic cardiac implantable devices in renal patients. The HTA uses a rigorous scientific methodology, and today represents an essential tool for a governance of the modern health system, in which every innovative technological element that significantly modifies the organization must be evaluated. For this strategic reason, HTA becomes an important intervention for the dialysis sector, where technological innovations are a fundamental sector. For a precise understanding of the function of HTA in dialysis, a complete example of the application of HTA for the evaluation of a resorbable antibacterial device for the prevention of infections from cardiac implantable electronic devices on patients with high infectious risk has been shown, such as patients with chronic kidney disease.
{"title":"Health Technology Assessment in nephrology and dialysis","authors":"Stefano Cabula, Elisabetta Frongia, Francesco Burrai, Francesca Mura, Maurizio Marcias","doi":"10.33393/gcnd.2023.2509","DOIUrl":"https://doi.org/10.33393/gcnd.2023.2509","url":null,"abstract":"The nephrology and dialysis sector is characterized by a high technological content, considerable technological and digital complexity, continuous innovation within the care processes and a strong economic impact on the national and regional health system. The purpose of this article is to illustrate the application of the Health Technology Assessment (HTA) methodology in the evaluation of technological innovations in the nephrology and dialysis field. In particular, the evaluation steps of the multidimensional and multidisciplinary process applied to the nephrodialysis field will be described, specifically a device to be used in patients with chronic kidney disease, also considering important comorbidities such as cardiomyopathies and arrhythmias, which often require implantation of electronic cardiac implantable devices in renal patients. The HTA uses a rigorous scientific methodology, and today represents an essential tool for a governance of the modern health system, in which every innovative technological element that significantly modifies the organization must be evaluated. For this strategic reason, HTA becomes an important intervention for the dialysis sector, where technological innovations are a fundamental sector. For a precise understanding of the function of HTA in dialysis, a complete example of the application of HTA for the evaluation of a resorbable antibacterial device for the prevention of infections from cardiac implantable electronic devices on patients with high infectious risk has been shown, such as patients with chronic kidney disease.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79732844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sempre positivi e ottimisti!!!","authors":"Luisa Sternfeld Pavia","doi":"10.33393/gcnd.2022.2525","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2525","url":null,"abstract":"","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80391656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autosomal Dominant Polycystic Kidney (ADPKD) is the most common genetically determined kidney disease of Mendelian inheritance. It has a variable prevalence, depending on the case series, from 1:1,000 to 1:2,500, and represents the fourth cause of renal failure in the world. It is part of the so-called ciliopathies and is mainly caused by the mutation of two genes: PKD1, located on chromosome 16p and the PKD2 gene, located on chromosome 4q and coding for Polycystin-2 (PC2); although two other disease-causing genes have recently been identified: DNAJB11 and GANAB. These two proteins consist, respectively, of a calcium channel and a transmembrane receptor, and they play a decisive role in regulating cell proliferation, division and differentiation, apoptosis and autophagy. The molecular mechanisms underlying the genesis of the cysts are multiple and for this reason not yet completely understood and although several of them have been the subject of preclinical and clinical studies aimed at evaluating the efficacy of therapies that could continue to interfere in a specific way, to date, only tolvaptan and octreotide-LAR (the latter only in Italy) have been approved for the treatment of renal disease secondaryto ADPKD. Here, we therefore recapitulate the different pathogenetic pathways in ADPKD and the possible therapeutic treatments.
{"title":"Rene policistico autosomico dominante: dalla patogenesi alla terapia","authors":"Giovanni Piscopo","doi":"10.33393/gcnd.2022.2489","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2489","url":null,"abstract":"Autosomal Dominant Polycystic Kidney (ADPKD) is the most common genetically determined kidney disease of Mendelian inheritance. It has a variable prevalence, depending on the case series, from 1:1,000 to 1:2,500, and represents the fourth cause of renal failure in the world. It is part of the so-called ciliopathies and is mainly caused by the mutation of two genes: PKD1, located on chromosome 16p and the PKD2 gene, located on chromosome 4q and coding for Polycystin-2 (PC2); although two other disease-causing genes have recently been identified: DNAJB11 and GANAB. These two proteins consist, respectively, of a calcium channel and a transmembrane receptor, and they play a decisive role in regulating cell proliferation, division and differentiation, apoptosis and autophagy. The molecular mechanisms underlying the genesis of the cysts are multiple and for this reason not yet completely understood and although several of them have been the subject of preclinical and clinical studies aimed at evaluating the efficacy of therapies that could continue to interfere in a specific way, to date, only tolvaptan and octreotide-LAR (the latter only in Italy) have been approved for the treatment of renal disease secondaryto ADPKD. Here, we therefore recapitulate the different pathogenetic pathways in ADPKD and the possible therapeutic treatments.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87186055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Musso, J. P. Córdoba, Gustavo Aroca-Marinez, S. Terrasa, Adriana P. Barriga-Moreno, Marcela Lozano-Sanchez, Rafael A. Barón-Alvarez, Henry J González-Torres, Joaquín Cantos, I. Huespe
Introduction: Gattinoni et al. have recently introduced a new parameter: the “alactic base excess” (ABE). ABE is equivalent to the number of strong acids, other than lactate, which are present in the plasma in abnormal concentrations, negative ABE being associated with higher mortality in sepsis. Hemoperfusion (HPF) is an extracorporeal procedure that involves the passage of blood through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material. Then, it was decided to explore the influence of HPF on negative ABE value in sepsis. Materials and methods: Basal values of ABE, standard base excess (SBE), and lactate (mean, standard deviation [SD]) were obtained. The difference between these parameter values before and after four sessions of HPF (HA330) (delta value) was evaluated. Student’s t-test and Wilcoxon test were applied. Results: From 32 patients (age: 57±13) suffering from respiratory insufficiency secondary to COVID-19 who were treated with HPF in the critical care unit of Clinica de la Mujer, Bogotá (Colombia), 6 patients presented with metabolic acidosis with negative ABE value (‒2.7±1) with negative SBE (‒4.7±1) and high lactate serum value (2±0.7 mmol/L). Delta ABE, SBE, and lactate were: 7.7 (p = 0.005), 6.1 (p = 0.003), and 1.6 (p = NS), respectively. Thus, negative ABE was significantly reversed by HPF, since SBE value turned positive without significant change in lactate. Conclusion: Negative alactic parameter was significantly reversed by HPF in septic patients. It is necessary to carry out evaluations in larger groups to estimate their impact on clinical outcomes.
{"title":"Negative alactic base excess is reversed by hemoperfusion in septic patients","authors":"C. Musso, J. P. Córdoba, Gustavo Aroca-Marinez, S. Terrasa, Adriana P. Barriga-Moreno, Marcela Lozano-Sanchez, Rafael A. Barón-Alvarez, Henry J González-Torres, Joaquín Cantos, I. Huespe","doi":"10.33393/gcnd.2022.2490","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2490","url":null,"abstract":"Introduction: Gattinoni et al. have recently introduced a new parameter: the “alactic base excess” (ABE). ABE is equivalent to the number of strong acids, other than lactate, which are present in the plasma in abnormal concentrations, negative ABE being associated with higher mortality in sepsis. Hemoperfusion (HPF) is an extracorporeal procedure that involves the passage of blood through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material. Then, it was decided to explore the influence of HPF on negative ABE value in sepsis.\u0000Materials and methods: Basal values of ABE, standard base excess (SBE), and lactate (mean, standard deviation [SD]) were obtained. The difference between these parameter values before and after four sessions of HPF (HA330) (delta value) was evaluated. Student’s t-test and Wilcoxon test were applied.\u0000Results: From 32 patients (age: 57±13) suffering from respiratory insufficiency secondary to COVID-19 who were treated with HPF in the critical care unit of Clinica de la Mujer, Bogotá (Colombia), 6 patients presented with metabolic acidosis with negative ABE value (‒2.7±1) with negative SBE (‒4.7±1) and high lactate serum value (2±0.7 mmol/L). Delta ABE, SBE, and lactate were: 7.7 (p = 0.005), 6.1 (p = 0.003), and 1.6 (p = NS), respectively. Thus, negative ABE was significantly reversed by HPF, since SBE value turned positive without significant change in lactate.\u0000Conclusion: Negative alactic parameter was significantly reversed by HPF in septic patients. It is necessary to carry out evaluations in larger groups to estimate their impact on clinical outcomes.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87467515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Risk profile of dialysis people as regards Covid 19 pandemic is unique; they stay together for some hours in an open-space, sharing transport before and after treatment as a shuttle between families and dialysis centre. As demonstrated by the waves of pandemic, isolation becomes more and more difficult, especially in centres lacking pathways and spaces devoted to contaminated patients. In our setting, dialysis centres were born as marginal areas, discarded from other uses and their design was seldom addressed to out-patients treatment. Logistic and preventive needs (spaces, distances, pathways) were often laid down to a social vision of dialysis. We describe our immediate response to adapt a network of public dialysis centres to pandemic. These measures, and the dedication of our personnel, resulted in a very low mortality rate, but we are still reporting a progressive increase of Covid patients. Organizational response becomes useless without structural changes. We therefore propose a plan oriented to transform dialysis centres into dynamic and safe places of care. Since other pandemics are expected in the future, it appears mandatory to redirect our choices towards a more conservative approach in designing a dialysis point of care, resembling the isolated pavilions of older hospital buildings. Separate entries and exits, mobile walls and large waiting rooms are needed; some personnel redundancy will be required in spite of lean management principles, strongly disproved by Covid. Dialysis rebuilding will be an extraordinary opportunity to create a sustainable way of treatment.
{"title":"La rete dialitica ai tempi della pandemia Covid: prospettive strutturali","authors":"D. Bonucchi, Grazie Portale","doi":"10.33393/gcnd.2022.2518","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2518","url":null,"abstract":"Risk profile of dialysis people as regards Covid 19 pandemic is unique; they stay together for some hours in an open-space, sharing transport before and after treatment as a shuttle between families and dialysis centre. As demonstrated by the waves of pandemic, isolation becomes more and more difficult, especially in centres lacking pathways and spaces devoted to contaminated patients. In our setting, dialysis centres were born as marginal areas, discarded from other uses and their design was seldom addressed to out-patients treatment. Logistic and preventive needs (spaces, distances, pathways) were often laid down to a social vision of dialysis. We describe our immediate response to adapt a network of public dialysis centres to pandemic. These measures, and the dedication of our personnel, resulted in a very low mortality rate, but we are still reporting a progressive increase of Covid patients. Organizational response becomes useless without structural changes. We therefore propose a plan oriented to transform dialysis centres into dynamic and safe places of care. Since other pandemics are expected in the future, it appears mandatory to redirect our choices towards a more conservative approach in designing a dialysis point of care, resembling the isolated pavilions of older hospital buildings. Separate entries and exits, mobile walls and large waiting rooms are needed; some personnel redundancy will be required in spite of lean management principles, strongly disproved by Covid. Dialysis rebuilding will be an extraordinary opportunity to create a sustainable way of treatment.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73151281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GUIDA DEL DONATORE: Saperne di più su come donare un rene da vivi","authors":"M. Lombardi","doi":"10.33393/gcnd.2022.2519","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2519","url":null,"abstract":" ","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86054979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreana De Mauri, Deborah Carrera, Elena Capello, Sergio Riso, Doriana Chiarinotti, C. D'Alessandro
National and International Societies recommend the Low Protein Diet (LPD) as nutritional therapy for chronic kidney disease not on dialysis, because it reduces the uremic symptoms and toxins generation, preserves the nutritional status, delays the progression to the dialysis and reshapes the dysbiotic microbiota. Finally, LPD is low cost and eco- and planet friendly. As some Authors already described LPD as a traditional drug, with particular indications, contraindications, special populations and so on, we for the first time re-wrote the LPD characteristics according to the “Summary of Product Characteristics” required by the Italian Health Department and Italian Medicines Agency. However, the contents of this paper could not be “literally” applied by clinicians, but must be included in a global assessment of the patient and performed by a trained physician or dietitian with expertise in the management of chronic kidney disease.
{"title":"Dieta ipoproteica: Riassunto delle Caratteristiche del Prodotto","authors":"Andreana De Mauri, Deborah Carrera, Elena Capello, Sergio Riso, Doriana Chiarinotti, C. D'Alessandro","doi":"10.33393/gcnd.2022.2493","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2493","url":null,"abstract":"National and International Societies recommend the Low Protein Diet (LPD) as nutritional therapy for chronic kidney disease not on dialysis, because it reduces the uremic symptoms and toxins generation, preserves the nutritional status, delays the progression to the dialysis and reshapes the dysbiotic microbiota. Finally, LPD is low cost and eco- and planet friendly. As some Authors already described LPD as a traditional drug, with particular indications, contraindications, special populations and so on, we for the first time re-wrote the LPD characteristics according to the “Summary of Product Characteristics” required by the Italian Health Department and Italian Medicines Agency. However, the contents of this paper could not be “literally” applied by clinicians, but must be included in a global assessment of the patient and performed by a trained physician or dietitian with expertise in the management of chronic kidney disease.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82172681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gallo, S. Aterini, Barbara Vadalà, Lorenzo Aterini, P. Beneforti, F. Balboni, N. Stomaci
Presentiamo il caso clinico di un uomo di 66 anni, senza fissa dimora, giunto alla nostra osservazione per infezione delle vie urinarie e disidratazione. Gli esami strumentali hanno consentito di evidenziare una calcolosi vescicale multipla con formazioni di dimensioni raramente osservate in letteratura. L’intervento di cistotomia ha consentito di rimuovere non solo i calcoli multipli (del peso complessivo di 550 grammi) ma anche uno stent ureterale, posizionato molti anni prima, che aveva costituito il nucleo attorno al quale si erano formate le formazioni litiasiche.
{"title":"Calcolo vescicale gigante accompagnato da una collana di calcoli delle vie urinarie in un paziente con proteinuria nefrosica concomitante con neoplasia vescicale e prostatica","authors":"M. Gallo, S. Aterini, Barbara Vadalà, Lorenzo Aterini, P. Beneforti, F. Balboni, N. Stomaci","doi":"10.33393/gcnd.2022.2484","DOIUrl":"https://doi.org/10.33393/gcnd.2022.2484","url":null,"abstract":"Presentiamo il caso clinico di un uomo di 66 anni, senza fissa dimora, giunto alla nostra osservazione per infezione delle vie urinarie e disidratazione. Gli esami strumentali hanno consentito di evidenziare una calcolosi vescicale multipla con formazioni di dimensioni raramente osservate in letteratura. L’intervento di cistotomia ha consentito di rimuovere non solo i calcoli multipli (del peso complessivo di 550 grammi) ma anche uno stent ureterale, posizionato molti anni prima, che aveva costituito il nucleo attorno al quale si erano formate le formazioni litiasiche.","PeriodicalId":12617,"journal":{"name":"Giornale di Clinica Nefrologica e Dialisi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90802777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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