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Preliminary study to antituberculosis chemotherapy in a region of sub-Saharian Africa: annual risk of tuberculosis infection calculation and tuberculin survey. 撒哈拉以南非洲地区抗结核化疗的初步研究:年度结核感染风险计算和结核菌素调查。
Giornale italiano di chemioterapia
Pub Date : 1992-01-01
G B Migliori, A Borchesi, E Comaschi, C V Landoni, M Grandi, A Satta, A Spanevello, G Vocaturo, M Neri

A tuberculin survey was performed in Arua District (577,799 inhabitants, recent return of refugees from Zaire and Sudan) in 1987 prior to the implementation of antituberculosis Chemotherapy and Control Programme. 50 clusters (schools) of 30 pupils each were selected in the 7 Counties by Sistematic Random Sampling. 1110 students 10 year old without BCG vaccination scar were injected with 5 IU of PPD; 1016 of them (more than 6% of the estimated district population of 10 year of age) came back after 72 hours for reading. 125 of them were positives (more than 10 mm of induration). The Infection Rate detected was 1.23% +/- 0.19. Considering the infection rates found by the Ugandan National Surveys done in 1950 (2.6%) and in 1970 (2.3%), and the slight slope of the curve calculated on those values we have underestimated the real Infection Rate in the district. To avoid this bias we suggest to include schools in sampling (it is simple and cost-effective) only if the Student's population is likely to be representative of the general population.

1987年，在实施抗结核化疗和控制规划之前，在阿鲁阿区(577,799名居民，最近从扎伊尔和苏丹返回的难民)进行了结核菌素调查，采用系统随机抽样法，在7个县选择50组(学校)，每组30名学生，对1110名无卡介苗接种瘢痕的10岁学生注射5 IU PPD;其中1016人(超过该区10岁人口的6%)在72小时后返回阅读。其中125例阳性(大于10mm的硬结)。检出率为1.23%±0.19。考虑到1950年乌干达全国调查(2.6%)和1970年(2.3%)的感染率，以及根据这些值计算的曲线的轻微斜率，我们低估了该地区的实际感染率。为了避免这种偏差，我们建议只有在学生群体可能代表一般人群的情况下，才将学校纳入抽样(这是简单且具有成本效益的)。
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引用次数: 0
[Pharmacologic interactions between quinolones and oral hypoglycemic agents. An experimental study on rabbits]. 喹诺酮类药物与口服降糖药的药理相互作用。对兔子的实验研究]。
Giornale italiano di chemioterapia
Pub Date : 1992-01-01
C Losasso, A Loffreda, M Angrisani, I Marabese, C Vacca, F Rossi

The association between antibiotics and oral hypoglycemic agents can determine various pharmacological interactions. The aim of our work has been to verify experimentally the eventual pharmacological interactions that may occur when some quinolones (nalidixic acid, ofloxacin, pefloxacin and sparfloxacin) are administered in association with oral hypoglycemic drugs (phenphormine and glibenclamide). Our results showed that ofloxacin, pefloxacin and sparfloxacin only at high dosages (not used in the human clinic) can increase the phenphormine and glibenclamide hypoglycemic effect. The nalidixic acid, just at therapeutic doses, is able to increase the hypoglycemic effect of the drugs studied.

抗生素和口服降糖药之间的关联可以确定各种药理学相互作用。我们工作的目的是通过实验验证一些喹诺酮类药物(钠利地酸、氧氟沙星、培氟沙星和斯帕沙星)与口服降糖药(phenphormine和格列本脲)联合使用时可能发生的最终药理学相互作用。我们的研究结果表明，氧氟沙星、培氟沙星和斯帕沙星仅在高剂量(未用于人体临床)时可增强苯啡明和格列本脲的降糖作用。在治疗剂量下，萘啶酸能够增加所研究药物的降糖效果。
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引用次数: 0
Activity of two benzofuran-imidazoles, IM/B/4-62 and IM/B/4-66, against experimental infections with Candida albicans and Trichophyton mentagrophytes. 两种苯并呋喃咪唑IM/B/4-62和IM/B/4-66抗白色念珠菌和毛癣菌实验感染的活性
Giornale italiano di chemioterapia
Pub Date : 1992-01-01
F Dubini, M G Bellotti, L Riviera

The therapeutic activity of two new benzofuran-imidazoles, IM/B/4-62 and IM/B/4-66, formulated as 1% cream, has been evaluated against Candida albicans and Trichophyton mentagrophytes by inducing experimental vaginal candidosis in female rats and dermatophytosis in female guinea pigs. Results of the treatment were compared with those obtained by the same therapeutic regimen carried out with bifonazole. IM/B/4-66 proved to possess superior antimycotic activity to that of IM/B/4-62 and similar to that of bifonazole in both infections. Nmaley vaginal candidosis was cured in all the treated in animals at 6 days post-inoculation and skin lesions were healed in 9 of 10 animals at 15 days after infection, with negative cultures from all the infected sites.

通过诱导雌性大鼠阴道念珠菌病和雌性豚鼠皮肤真菌病，研究了两种新型苯并呋喃咪唑制剂IM/B/4-62和IM/B/4-66对白色念珠菌和毛癣菌的治疗作用。将治疗结果与用联苯唑进行相同治疗方案的结果进行比较。在两种感染中，IM/B/4-66的抗真菌活性均优于IM/B/4-62，且与联苯唑相似。接种后6天，所有接受治疗的动物阴道念珠菌病均治愈，感染后15天，10只动物中有9只皮肤病变愈合，所有感染部位培养均为阴性。
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引用次数: 0
[Adhesion capacity of Enterococcus faecium (SF 68) and Enterococcus faecalis to various substrates]. [粪肠球菌和粪肠球菌对各种底物的粘附能力]。
Giornale italiano di chemioterapia
Pub Date : 1992-01-01
G Chisari, A M Lo Bue, L Drago, R Abbiati, M R Gismondo

The author's studied the adherence ability of Enterococcus faecium SF 68 compared to that of Enterococcus faecalis IM 11f, on various substrates: vascular catheters and cardiac valves of rabbit, immunodepressed rats and diabetic rats. The bacterial adherence test was calculated by the number of bacteria adhered for microscopic field enlarged to 2000. The data obtained by scanning electron microscope SEM (Cambridge Stereoscan 150 MK2) revealed a different adherence action of the two germs on the various substrates. All the adherence tests showed a higher and uniform adherence activity of E. faecalis compared to that of E. faecium.

作者研究了粪肠球菌SF 68与粪肠球菌IM 11f在兔血管导管、心脏瓣膜、免疫抑制大鼠、糖尿病大鼠等基质上的粘附能力。细菌黏附试验以显微镜场黏附细菌数扩大到2000个计算。扫描电镜(Cambridge steroscan 150 MK2)的数据显示，两种细菌在不同底物上的粘附作用不同。所有黏附试验均显示粪肠杆菌黏附活性高于粪肠杆菌。
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引用次数: 0
[Role of home therapy with ofloxacin in patients with cystic fibrosis (CF)]. 氧氟沙星家庭治疗在囊性纤维化(CF)患者中的作用。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
L Romano, L Minicucci, E Spallone, D Girosi, A Campelli, A Fabbri, C Palmero
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引用次数: 0
[Treatment of imported malaria in Italy from 1989 and 1990]. [意大利1989年和1990年输入性疟疾的治疗]。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
G Majori, G Sabatinelli, F P Gianzi, C Cavallini, S Squarcione, A Forte
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引用次数: 0
[Response to an alternated chemo-radiotherapeutic treatment as neoadjuvant therapy of non-small-cell lung carcinoma (NSCLC). Report of a clinical case]. [非小细胞肺癌(NSCLC)的新辅助治疗对化疗-放疗交替治疗的反应。]临床病例报告1例]。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
M Della Vittoria Scarpati, F De Vita, A Rippa, A Gattoni, N Pilerci, G Catalano
{"title":"[Response to an alternated chemo-radiotherapeutic treatment as neoadjuvant therapy of non-small-cell lung carcinoma (NSCLC). Report of a clinical case].","authors":"M Della Vittoria Scarpati,&nbsp;F De Vita,&nbsp;A Rippa,&nbsp;A Gattoni,&nbsp;N Pilerci,&nbsp;G Catalano","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12704,"journal":{"name":"Giornale italiano di chemioterapia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibacterial agents and neurotransmission]. [抗菌剂与神经传递]。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
G B De Sarro, G Nisticò
{"title":"[Antibacterial agents and neurotransmission].","authors":"G B De Sarro,&nbsp;G Nisticò","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12704,"journal":{"name":"Giornale italiano di chemioterapia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From cervico-vaginitis to PID: therapeutic prospects]. [从宫颈阴道炎到PID:治疗前景]。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
G Tempera, A Cianci, G Nicoletti
{"title":"[From cervico-vaginitis to PID: therapeutic prospects].","authors":"G Tempera,&nbsp;A Cianci,&nbsp;G Nicoletti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12704,"journal":{"name":"Giornale italiano di chemioterapia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chemoprophylaxis and chemotherapy of malaria in the 90s]. [90年代疟疾的化学预防和化疗]。
Giornale italiano di chemioterapia
Pub Date : 1991-01-01
R Esposito
{"title":"[Chemoprophylaxis and chemotherapy of malaria in the 90s].","authors":"R Esposito","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12704,"journal":{"name":"Giornale italiano di chemioterapia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12538637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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