Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.55
R. Scofield, Christina G. Bruxvoort, B. Kurien, Valerie M Lewis
{"title":"904 Lupus Sex Bias and TLR7 Signaling","authors":"R. Scofield, Christina G. Bruxvoort, B. Kurien, Valerie M Lewis","doi":"10.1136/lupus-2022-lupus21century.55","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.55","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41423803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.56
R. Fernandez-Ruiz, Justin Shum, Ilona Nln, J. L. Paredes, T. Niewold
{"title":"905 Impact of the cGMP-dependent protein kinase I on the Rho-Kinase 2 signaling pathway and type I Interferon production","authors":"R. Fernandez-Ruiz, Justin Shum, Ilona Nln, J. L. Paredes, T. Niewold","doi":"10.1136/lupus-2022-lupus21century.56","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.56","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42231019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.54
Qiang Wang, Xiaoming Lu, M. Weirauch, P. Nigrovic
{"title":"903 Decoding genome-wide association study (GWAS) hits for lupus using massively parallel reporter assays","authors":"Qiang Wang, Xiaoming Lu, M. Weirauch, P. Nigrovic","doi":"10.1136/lupus-2022-lupus21century.54","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.54","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43450716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.57
Sarah K. Baxter, S. Gulsuner, M. Eckert, Ming K. Lee, T. Walsh, Anne Stevens, M. King
{"title":"906 De novomutations in childhood-onset systemic lupus erythematosus","authors":"Sarah K. Baxter, S. Gulsuner, M. Eckert, Ming K. Lee, T. Walsh, Anne Stevens, M. King","doi":"10.1136/lupus-2022-lupus21century.57","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.57","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43422553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.62
Ryan J Pachucki, Xinyan Zhang, L. Kohler, S. Tursi, Lauren K Nicastro, Laurie Kilpatrick, Ç. Tükel, S. Gallucci, R. Caricchio
{"title":"1002 Bacterial amyloid curli/eDNA complexes induce NETosis in lupus patients positive for anti-dsDNA","authors":"Ryan J Pachucki, Xinyan Zhang, L. Kohler, S. Tursi, Lauren K Nicastro, Laurie Kilpatrick, Ç. Tükel, S. Gallucci, R. Caricchio","doi":"10.1136/lupus-2022-lupus21century.62","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.62","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44013110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.59
Vrati M. Mehra, D. Dominguez, Nicholas Gold, A. Knight, D. Levy, FangMing Liao, E. Pullenayegum, A. Shammas, E. Sochett, Raza Vali, Declan Webber, E. Silverman, L. Hiraki
{"title":"908 The association between Systemic lupus Erythematosus (SLE) and bone mineral density (BMD) polygenic risk scores with lumbar spine BMD z-score: a retrospective cohort study","authors":"Vrati M. Mehra, D. Dominguez, Nicholas Gold, A. Knight, D. Levy, FangMing Liao, E. Pullenayegum, A. Shammas, E. Sochett, Raza Vali, Declan Webber, E. Silverman, L. Hiraki","doi":"10.1136/lupus-2022-lupus21century.59","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.59","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49575813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.58
P. Raj, C. Liang, C. Arana, N. V. Oers, Quanzhen Li, E. Wakeland, D. Karp
{"title":"907 ANA associated regulatory polymorphisms in HLA class III region downregulate complement 4 (C4) gene expression","authors":"P. Raj, C. Liang, C. Arana, N. V. Oers, Quanzhen Li, E. Wakeland, D. Karp","doi":"10.1136/lupus-2022-lupus21century.58","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.58","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43602100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.63
Haoyang Zhuang, Erin E. Hudson, Shuhong Han, Rawad Daniel Arja, Li Lu, W. Reeves
{"title":"1003 Impaired intracellular protein transport and an endothelial stress response reminiscent of COPA syndrome in SLE-associated diffuse alveolar hemorrhage","authors":"Haoyang Zhuang, Erin E. Hudson, Shuhong Han, Rawad Daniel Arja, Li Lu, W. Reeves","doi":"10.1136/lupus-2022-lupus21century.63","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.63","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47471152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.60
Mariana Saint Just Ribeiro, P. Tripathi, B. Namjou, J. Harley, I. Chepelev
{"title":"909 Haplotype-specific chromatin looping reveals genetic interactions of regulatory regions modulating gene expression at the SLE susceptibility locusFAM167A-BLK","authors":"Mariana Saint Just Ribeiro, P. Tripathi, B. Namjou, J. Harley, I. Chepelev","doi":"10.1136/lupus-2022-lupus21century.60","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.60","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45058894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1136/lupus-2022-lupus21century.61
N. Maria, Shani Martinez, Chirag Raparia, Z. Yi, H. Tao, Ke Lin, Weijia Zhang, A. Davidson
{"title":"1001 A new model of spontaneous anti-phospholipid antibody induced pregnancy loss in mice over-expressing human TLR8","authors":"N. Maria, Shani Martinez, Chirag Raparia, Z. Yi, H. Tao, Ke Lin, Weijia Zhang, A. Davidson","doi":"10.1136/lupus-2022-lupus21century.61","DOIUrl":"https://doi.org/10.1136/lupus-2022-lupus21century.61","url":null,"abstract":"","PeriodicalId":12706,"journal":{"name":"Genetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47077570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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