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Global smoking-related deaths averted due to MPOWER policies implemented at the highest level between 2007 and 2020. 2007 年至 2020 年间在最高级别实施 MPOWER 政策而避免的全球吸烟相关死亡人数。
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-07 DOI: 10.1186/s12992-023-01012-w
Greg Lyle, Delia Hendrie

Background: In response to the harm caused by tobacco use worldwide, the World Health Organization (WHO) World Health Assembly actioned the WHO Framework Convention on Tobacco Control (FCTC) in 2005. To help countries meet their FCTC obligations, the WHO introduced in 2008 the MPOWER policy package and by 2020 the FCTC had been ratified by 182 parties. The package consists of six evidence-based demand reduction smoking cessation policies to assist countries to achieve best practice. We used published evaluation results and replicated the published model to estimate current policy achievement and demonstrate the impact and equity of the MPOWER policy package in reducing the global number of smokers and smoking-attributable deaths (SADs) between 2007 and 2020.

Methods: We replicated an evaluation model (the Abridged SimSmoke model) used previously for country impact assessments and validated our replicated reduction in SADs for policies between 2014 and 2016 against the published results. The replicated model was then applied to report on the country level SADs averted from achieving the highest level of implementation, that is best practice in MPOWER policies, between 2016 and 2020. The latest results were then combined with past published results to estimate the reduction in SADs since the commencement of the MPOWER policy package. Country level income status was used to investigate the equity in the uptake of MPOWER policies worldwide.

Results: Identical estimates for SADs in 41 out of 56 MPOWER policies implemented in 43 countries suggested good agreement in the model replication. The replicated model overestimated the reduction in SADs by 159,800 (1.5%) out of a total of 10.5 million SADs with three countries contributing to the majority of this replication discrepancy. Updated analysis estimated a reduction of 8.57 million smokers and 3.37 million SADs between 2016 and 2020. Between 2007 and 2020, 136 countries had adopted and maintained at least one MPOWER policy at the highest level which was associated with a reduction in 81.0 million smokers and 28.3 million SADs. Seventy five percent of this reduction was in middle income countries, 20% in high income and less than 5% in low income countries.

Conclusions: Considerable progress has been made by MPOWER policies to reduce the prevalence of smokers globally. However, there is inequality in the implementation and maintenance, reach and influence, and the number of SADs averted. Future research to modify the model could provide a more comprehensive evaluation of past and future progress in tobacco control policies, worldwide.

背景:为应对烟草使用在全球造成的危害,世界卫生组织(WHO)世界卫生大会于 2005 年通过了《世界卫生组织烟草控制框架公约》(FCTC)。为帮助各国履行《公约》义务,世卫组织于 2008 年推出了 MPOWER 一揽子政策,到 2020 年,已有 182 个缔约方批准了《公约》。该一揽子政策包括六项循证减少需求戒烟政策,以帮助各国实现最佳实践。我们利用已公布的评估结果并复制已公布的模型来估算当前的政策成就,并证明 MPOWER 一揽子政策在 2007 年至 2020 年间减少全球吸烟人数和吸烟导致死亡人数 (SAD) 方面的影响和公平性:方法: 我们复制了以前用于国家影响评估的评估模型(简略模拟吸烟模型),并根据已公布的结果验证了我们复制的 2014 年至 2016 年政策在减少 SADs 方面的效果。然后,复制的模型被用于报告在 2016 年至 2020 年期间,通过实现最高实施水平(即 MPOWER 政策的最佳实践)而避免的国家级 SAD。然后将最新结果与过去公布的结果相结合,估算自 MPOWER 一揽子政策开始实施以来所减少的 SAD。国家收入水平被用来调查 MPOWER 政策在全球范围内的公平性:在 43 个国家实施的 56 项 MPOWER 政策中,有 41 项对 SAD 的估计值相同,这表明模型复制的一致性很好。在总共 1050 万个 SAD 中,复制模型高估了 159,800 个 SAD 的减少量(1.5%),而这一复制差异主要是由三个国家造成的。最新分析估计,2016 年至 2020 年间,吸烟人数将减少 857 万,SAD 将减少 337 万。2007 年至 2020 年间,136 个国家采用并维持了至少一项最高级别的 MPOWER 政策,从而减少了 8100 万吸烟者和 2830 万 SAD。中等收入国家减少了 75%,高收入国家减少了 20%,低收入国家减少了不到 5%:MPOWER 政策在降低全球吸烟率方面取得了显著进展。结论:MPOWER 政策在降低全球吸烟率方面取得了显著进展,但在实施和维护、覆盖面和影响力以及避免的可持续发展教育数量方面存在不平等。未来对模型进行修改的研究可以对全球烟草控制政策过去和未来的进展进行更全面的评估。
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引用次数: 0
Redefining Debt-to-Health, a triple-win health financing instrument in global health. 重新定义 "债转健康"--全球健康领域的三赢健康融资工具。
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-06 DOI: 10.1186/s12992-024-01043-x
Yunxuan Hu, Zhebin Wang, Shuduo Zhou, Jian Yang, Ying Chen, Yumeng Wang, Ming Xu

Background: As a recognized win-win-win approach to international debt relief, Debt-to-Health(D2H)has successfully translated debt repayments into investments in health-related projects. Although D2H has experienced modifications and periodic suspension, it has been playing an increasingly important role in resource mobilization in public health, particularly for low-and middle-income countries deep in debt.

Main text: D2H, as a practical health financing instrument, is not fully evidenced and gauged by academic literature though. We employed a five-step scoping review methodology. After posing questions, we conducted comprehensive literature searches across three databases and one official website to identify relevant studies.We also supplemented our research with expert interviews. Through this review and interviews, we were able to define the concept and structure of D2H, identify stakeholders, and assess its current shortcomings. Finally, we proposed relevant countermeasures and suggestions.

Conclusion: This paper examines the D2H project's implementation structure and influencing variables, as well as the current research plan's limitations, with a focus on the role health funding institutions have played during the project's whole life. Simultaneously, it examines the interdependencies between debtor nations, creditor nations, and health financing establishments, establishing the groundwork for augmenting and revamping D2H within the ever-changing worldwide context of health development assistance.

背景:作为一种公认的三赢国际债务减免方法,债务转健康(D2H)成功地将债务偿还转化为对健康相关项目的投资。虽然 D2H 曾经历过修改和阶段性暂停,但它在公共卫生资源调动方面发挥着越来越重要的作用,尤其是对深陷债务泥潭的中低收入国家而言:作为一种实用的卫生筹资工具,D2H 并未得到学术文献的充分证实和评估。我们采用了五步范围审查法。提出问题后,我们在三个数据库和一个官方网站上进行了全面的文献检索,以确定相关研究。通过回顾和访谈,我们界定了 D2H 的概念和结构,确定了利益相关者,并评估了其当前的不足之处。最后,我们提出了相关的对策和建议:本文研究了 D2H 项目的实施结构和影响变量,以及当前研究计划的局限性,重点关注了卫生资助机构在项目整个生命周期中所扮演的角色。同时,本文还探讨了债务国、债权国和卫生筹资机构之间的相互依存关系,为在不断变化的全球卫生发展援助背景下加强和改进 D2H 项目奠定了基础。
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引用次数: 0
From isolation to revival: trade recovery amid global health crises. 从孤立到复兴:全球健康危机中的贸易复苏。
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-06 DOI: 10.1186/s12992-024-01048-6
Lijuan Yang

Background: The COVID-19 pandemic has highlighted the importance of designing effective trade recovery measures in response to global health events (GHEs). This study combines international trade risk management theory and multi-case comparative analysis of past GHEs to present a theoretical framework for designing national trade recovery measures for future events.

Results: The research finds that during GHEs, trade risks shift to fundamental uncertainty, requiring spatial-temporal-subject dimension recovery measures. The study suggests changing the focus of trade recovery policy design from emergency-oriented and single-dimension measures to reserve-oriented and enduring-effect measures of comprehensive dimensions at micro- and macroeconomic levels.

Conclusion: The study contributes to the debate on managing trade risks in times of crisis, where there is a need to develop effective trade recovery measures that account for the complexities of global trade and the unique challenges of GHEs. The findings provide practical guidance for trade officials and policymakers to design measures in response to GHEs to improve a country's overall trade recovery.

背景:COVID-19 大流行凸显了针对全球健康事件 (GHE) 设计有效贸易恢复措施的重要性。本研究结合国际贸易风险管理理论和对以往全球卫生事件的多案例比较分析,提出了为未来事件设计国家贸易恢复措施的理论框架:研究发现,在 GHE 期间,贸易风险转向基本不确定性,需要采取空间-时间-主体维度的恢复措施。研究建议将贸易恢复政策设计的重点从以应急为导向的单一维度措施转变为以储备为导向、在微观和宏观经济层面采取综合维度的持久效应措施:本研究有助于就危机时期的贸易风险管理展开讨论,因为危机时期需要制定有效的贸易恢复措施,以应对全球贸易的复杂性和全球温室气体的独特挑战。研究结果为贸易官员和政策制定者提供了切实可行的指导,帮助他们制定应对全球经济危机的措施,从而改善国家的整体贸易复苏状况。
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引用次数: 0
Burden of cardiovascular disease attributed to air pollution: a systematic review 空气污染造成的心血管疾病负担:系统回顾
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-03 DOI: 10.1186/s12992-024-01040-0
Amir Hossein Khoshakhlagh, Mahdiyeh Mohammadzadeh, Agnieszka Gruszecka-Kosowska, Evangelos Oikonomou
Cardiovascular diseases (CVDs) are estimated to be the leading cause of global death. Air pollution is the biggest environmental threat to public health worldwide. It is considered a potentially modifiable environmental risk factor for CVDs because it can be prevented by adopting the right national and international policies. The present study was conducted to synthesize the results of existing studies on the burden of CVDs attributed to air pollution, namely prevalence, hospitalization, disability, mortality, and cost characteristics. A systematic search was performed in the Scopus, PubMed, and Web of Science databases to identify studies, without time limitations, up to June 13, 2023. Exclusion criteria included prenatal exposure, exposure to indoor air pollution, review studies, conferences, books, letters to editors, and animal and laboratory studies. The quality of the articles was evaluated based on the Agency for Healthcare Research and Quality Assessment Form, the Newcastle–Ottawa Scale, and Drummond Criteria using a self-established scale. The articles that achieved categories A and B were included in the study. Of the 566 studies obtained, based on the inclusion/exclusion criteria, 92 studies were defined as eligible in the present systematic review. The results of these investigations supported that chronic exposure to various concentrations of air pollutants, increased the prevalence, hospitalization, disability, mortality, and costs of CVDs attributed to air pollution, even at relatively low levels. According to the results, the main pollutant investigated closely associated with hypertension was PM2.5. Furthermore, the global DALY related to stroke during 2016–2019 has increased by 1.8 times and hospitalization related to CVDs in 2023 has increased by 8.5 times compared to 2014. Ambient air pollution is an underestimated but significant and modifiable contributor to CVDs burden and public health costs. This should not only be considered an environmental problem but also as an important risk factor for a significant increase in CVD cases and mortality. The findings of the systematic review highlighted the opportunity to apply more preventive measures in the public health sector to reduce the footprint of CVDs in human society.
据估计,心血管疾病(CVD)是导致全球死亡的主要原因。空气污染是全球公共健康面临的最大环境威胁。空气污染被认为是心血管疾病潜在的可改变的环境风险因素,因为它可以通过采取正确的国家和国际政策来预防。本研究旨在综合现有关于空气污染导致心血管疾病负担的研究结果,即发病率、住院率、残疾率、死亡率和成本特征。本研究在 Scopus、PubMed 和 Web of Science 数据库中进行了系统检索,以确定截至 2023 年 6 月 13 日的无时间限制的研究。排除标准包括产前暴露、室内空气污染暴露、综述研究、会议、书籍、致编辑的信以及动物和实验室研究。文章的质量根据医疗保健研究与质量机构评估表、纽卡斯尔-渥太华量表和德拉蒙德标准进行评估,采用的是自制的量表。达到 A 类和 B 类标准的文章被纳入研究范围。在获得的 566 项研究中,根据纳入/排除标准,有 92 项研究被界定为符合本系统综述的要求。这些调查结果表明,长期暴露于各种浓度的空气污染物,会增加心血管疾病的发病率、住院率、残疾率、死亡率和成本,即使在相对较低的水平上也是如此。调查结果显示,与高血压密切相关的主要污染物是 PM2.5。此外,与 2014 年相比,2016-2019 年期间与中风有关的全球残疾调整寿命年数增加了 1.8 倍,2023 年与心血管疾病有关的住院治疗增加了 8.5 倍。环境空气污染是造成心血管疾病负担和公共卫生成本的一个被低估但可改变的重要因素。这不仅是一个环境问题,也是心血管疾病病例和死亡率大幅增加的重要风险因素。系统综述的研究结果强调了在公共卫生部门采取更多预防措施的机会,以减少心血管疾病在人类社会中的足迹。
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引用次数: 0
Brief interventions 2.0: a new agenda for alcohol policy, practice and research 简单干预 2.0:酒精政策、实践和研究的新议程
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-19 DOI: 10.1186/s12992-024-01031-1
Duncan Stewart, Mary Madden, Jim McCambridge
Alcohol problems are increasing across the world and becoming more complex. Limitations to international evidence and practice mean that the screening and brief intervention paradigm forged in the 1980s is no longer fit for the purpose of informing how conversations about alcohol should take place in healthcare and other services. A new paradigm for brief interventions has been called for. We must start with a re-appraisal of the roles of alcohol in society now and the damage it does to individual and population health. Industry marketing and older unresolved ideas about alcohol continue to impede honest and thoughtful conversations and perpetuate stigma, stereotypes, and outright fictions. This makes it harder to think about and talk about how alcohol affects health, well-being, and other aspects of life, and how we as a society should respond. To progress, brief interventions should not be restricted only to the self-regulation of one’s own drinking. Content can be orientated to the properties of the drug itself and the overlooked problems it causes, the policy issues and the politics of a powerful globalised industry. This entails challenging and reframing stigmatising notions of alcohol problems, and incorporating wider alcohol policy measures and issues that are relevant to how people think about their own and others' drinking. We draw on recent empirical work to examine the implications of this agenda for practitioners and for changing the public conversation on alcohol. Against a backdrop of continued financial pressures on health service delivery, this analysis provokes debate and invites new thinking on alcohol. We suggest that the case for advancing brief interventions version 2.0 is both compelling and urgent.
酒精问题在全球范围内日益严重,并变得越来越复杂。国际证据和实践的局限性意味着,20 世纪 80 年代形成的筛查和简短干预模式已不再适合为医疗保健和其他服务中有关酒精问题的对话提供参考。简短干预的新模式呼之欲出。我们必须首先重新评估酒精在当今社会中的作用,以及它对个人和群体健康造成的损害。酒类行业的营销和旧有的未解决的观念继续阻碍着人们进行真诚和深思熟虑的对话,并使污名化、刻板印象和赤裸裸的虚构永久化。这使得我们更难思考和讨论酒精如何影响健康、福祉和生活的其他方面,以及我们作为一个社会应如何应对。为了取得进步,简短干预不应仅限于对自身饮酒的自我调节。干预内容可以针对毒品本身的特性、它所导致的被忽视的问题、政策问题以及强大的全球化产业的政治。这就需要挑战和重塑关于酒精问题的污名化概念,并纳入更广泛的酒精政策措施以及与人们如何看待自己和他人饮酒相关的问题。我们借鉴近期的实证工作,研究这一议程对从业人员和改变公众对酒精的看法的影响。在医疗卫生服务持续面临财政压力的背景下,这一分析引发了辩论,并引出了关于酒精的新思维。我们认为,推进简短干预 2.0 版的理由既充分又紧迫。
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引用次数: 0
Making Big Business Everybody’s Business: Aboriginal leaders’ perspectives on commercial activities influencing aboriginal health in Victoria, Australia 让大企业成为大家的企业:原住民领袖对影响澳大利亚维多利亚州原住民健康的商业活动的看法
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-18 DOI: 10.1186/s12992-024-01038-8
Alessandro Connor Crocetti, Troy Walker, Fiona Mitchell, Simone Sherriff, Karen Hill, Yin Paradies, Kathryn Backholer, Jennifer Browne
The commercial determinants of health is a rapidly expanding field of research; however Indigenous perspectives remain notably underrepresented. For Indigenous peoples the intersection of globalisation, colonialism and capitalism may amplify commercially-driven health inequities. This study aimed to explore the perspectives of Aboriginal leaders regarding the influence of commercial activities on Aboriginal health and wellbeing in Victoria, Australia. Semi-structured interviews with 23 Aboriginal leaders from across five sectors (n = 15 urban, n = 8 rural/regional) were analysed through reflexive thematic analysis. Three overarching themes were identified encompassing (i) harmful commercial practices and processes, (ii) improving corporate engagement and (iii) opportunities for self-determination through business. Participants expressed concern over aggressive marketing by the gambling industry, commercial exploitation of Aboriginal culture, the privatisation of public services, and lack of oversignt of corporate social responsibility strategies. Simultaneously, Aboriginal-led businesses were viewed as opportunities for cultural connection, and financial empowerment and self-determination. Numerous commercial entities and activities are perceived to influence Aboriginal health and wellbeing. This study highlights the need for stronger policy and regulation to mitigate harmful industry practices while incentivising the potential positive impacts of the commercial activities on Aboriginal health and wellbeing.
健康的商业决定因素是一个正在迅速扩展的研究领域;然而,土著观点的代表性仍然明显不足。对于原住民来说,全球化、殖民主义和资本主义的交织可能会扩大商业驱动的健康不平等。本研究旨在探讨澳大利亚维多利亚州原住民领袖对商业活动影响原住民健康和福祉的看法。通过反思性主题分析,对来自五个部门(城市 15 人,农村/地区 8 人)的 23 位原住民领袖进行了半结构式访谈。确定了三个首要主题,包括:(i) 有害的商业行为和流程;(ii) 提高企业参与度;(iii) 通过商业实现自决的机会。与会者对博彩业的激进营销、对土著文化的商业开发、公共服务私有化以及企业社会责任战略缺乏监督等问题表示担忧。同时,原住民主导的企业也被视为文化联系、财务授权和自决的机会。许多商业实体和活动被认为会影响原住民的健康和福祉。本研究强调了加强政策和监管的必要性,以减少有害的行业做法,同时激励商业活动对原住民健康和福祉的潜在积极影响。
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引用次数: 0
Privatisation of government services in Australia: what is known about health and equity impacts 澳大利亚政府服务私有化:对健康和公平影响的认识
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-16 DOI: 10.1186/s12992-024-01036-w
Julia Anaf, Toby Freeman, Fran Baum
Historically in Australia, all levels of government created collective wealth by owning and operating infrastructure, and managing natural assets, key public goods and essential services while being answerable to the public. This strong state tradition was challenged in the 1980s when privatisation became a widespread government approach globally. Privatisation involves displacing the public sector through modes of financing, ownership, management and product or service delivery. The Australian literature shows that negative effects from privatisation are not spread equitably, and the health and equity impacts appear to be under-researched. This narrative overview aims to address a gap in the literature by answering research questions on what evidence exists for positive and negative outcomes of privatisation; how well societal impacts are evaluated, and the implications for health and equity. Database and grey literature were searched by keywords, with inclusion criteria of items limited to Australia, published between 1990 and 2022, relating to any industry or government sector, including an evaluative aspect, or identifying positive or negative aspects from privatisation, contracting out, or outsourcing. Thematic analysis was aided by NVivo qualitative data software and guided by an a-priori coding frame. No items explicitly reflected on the relationship between privatisation and health. Main themes identified were the public cost of privatisation, loss of government control and expertise, lack of accountability and transparency, constraints to accessing social determinants of health, and benefits accruing to the private sector. Our results supported the view that privatisation is more than asset-stripping the public sector. It is a comprehensive strategy for restructuring public services in the interests of capital, with privatisation therefore both a political and commercial determinant of health. There is growing discussion on the need for re-nationalisation of certain public assets, including by the Victorian government. Privatisation of public services is likely to have had an adverse impact on population health and contributed to the increase in inequities. This review suggests that there is little evidence for the benefits of privatisation, with a need for greater attention to political and commercial determinants of health in policy formation and in research.
历史上,澳大利亚各级政府通过拥有和运营基础设施、管理自然资产、关键公共产品和基本服务来创造集体财富,同时对公众负责。20 世纪 80 年代,当私有化成为全球普遍的政府管理方式时,这种强大的国家传统受到了挑战。私有化涉及通过融资、所有权、管理和产品或服务提供模式取代公共部门。澳大利亚的文献表明,私有化的负面影响并没有得到公平的传播,而且对健康和公平的影响似乎研究不足。本综述旨在通过回答以下研究问题来填补文献空白:私有化的积极和消极影响有哪些证据;社会影响的评估情况如何;以及对健康和公平的影响。通过关键词对数据库和灰色文献进行了检索,纳入标准为:仅限于澳大利亚,发表于 1990 年至 2022 年之间,与任何行业或政府部门有关,包括评估方面,或确定私有化、外包或外包的积极或消极方面。专题分析由 NVivo 定性数据软件辅助,并以先验编码框架为指导。没有任何项目明确反映了私有化与健康之间的关系。确定的主要主题是私有化的公共成本、政府控制和专业知识的丧失、缺乏问责制和透明度、获取健康的社会决定因素的限制以及私营部门获得的利益。我们的研究结果支持这样一种观点,即私有化不仅仅是公共部门的资产剥离。它是一项为资本利益而重组公共服务的综合战略,因此,私有化既是健康的政治决定因素,也是健康的商业决定因素。关于某些公共资产是否需要重新国有化的讨论越来越多,包括维多利亚州政府。公共服务私有化很可能会对人口健康产生不利影响,并导致不公平现象加剧。本研究表明,几乎没有证据表明私有化会带来好处,因此在政策制定和研究中需要更加关注健康的政治和商业决定因素。
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引用次数: 0
Characteristics and outcomes of the drug patent linkage system in China 中国药品专利链接制度的特点和成果
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-15 DOI: 10.1186/s12992-024-01035-x
Xue-Fang Yao
On July 4, 2021, China officially introduced the drug patent linkage system, which has made more localized adjustments than have similar systems in the US and South Korea. This study describes the characteristics and outcomes of China’s patent linkage system. For this study, we used the database of China’s patent information registration platform for marketed drugs to capture all listed patents and patent certifications from June 25, 2021, to June 30, 2023. We used descriptive statistics for the above data to assess the impact of patent linkage on branded drug manufacturers, generic drug manufacturers, and the public’s access to medicines. During the study period, the patents of 632 branded drugs were listed, and 5058 ANDAs submitted patent certifications to the Registration Platform. Of these 632 branded drugs, 462 (73.1%) drugs were approved before the year of patent registration, and the average number of listed patents per drug was 1.8, with a standard deviation of 1.4. However, of these 5058 ANDAs, P1 certifications accounted for 85.1%, and P3 and P4 certifications accounted for 16% combined. In addition, according to the detailed statistics of P2 certifications, we found that the proportion of patent invalidation cases was 46.4%. The remaining validity of the patents corresponding to P3 certifications was longer, with a median value of 17 months, and the IQR was 10-30.75, ranging from − 2 to 204 months. China’s patent linkage aims to promote the balance of multiple interests —innovation, imitation and public health—and has its own system characteristics. Patent listing and patent certification are the key indicators reflecting the implementation effect of the system. From the perspective of system outcomes, ANDAs have been connected to the patent linkage system in an orderly manner, but the growth of patent challenges is not obvious. Moreover, manufacturers of foreign branded drugs that have not yet entered the Chinese market need to pay more attention to the role of patent listing.
2021 年 7 月 4 日,中国正式引入药品专利链接制度,与美国和韩国的类似制度相比,中国对该制度进行了更多的本土化调整。本研究介绍了中国专利链接制度的特点和成果。在本研究中,我们使用了中国上市药品专利信息登记平台数据库,以获取 2021 年 6 月 25 日至 2023 年 6 月 30 日期间的所有上市专利和专利证书。我们对上述数据进行了描述性统计,以评估专利联动对品牌药生产企业、仿制药生产企业和公众用药的影响。在研究期间,共有 632 种品牌药的专利被列入,5058 个 ANDAs 向注册平台提交了专利认证。在这 632 种品牌药品中,有 462 种(73.1%)药品在专利注册当年之前获得批准,平均每种药品的上市专利数为 1.8,标准差为 1.4。然而,在这 5058 个 ANDA 中,P1 认证占 85.1%,P3 和 P4 认证合计占 16%。此外,根据对 P2 证书的详细统计,我们发现专利无效案件的比例为 46.4%。P3认证对应的专利剩余有效期较长,中位值为17个月,IQR为10-30.75,范围在-2-204个月之间。中国的专利联动旨在促进创新、模仿和公众健康等多方利益的平衡,具有自身的制度特点。专利上市和专利认证是反映制度实施效果的关键指标。从制度成果来看,ANDA 与专利链接制度的衔接有序,但专利挑战的增长并不明显。此外,尚未进入中国市场的国外品牌药品生产企业需要更加重视专利上市的作用。
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引用次数: 0
Correction: Mapping study for health emergency and disaster risk management competencies and curricula: literature review and cross-sectional survey 更正:卫生应急和灾害风险管理能力与课程规划研究:文献综述和横向调查
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-12 DOI: 10.1186/s12992-024-01037-9
Kevin K. C. Hung, Makiko K. MacDermot, Theresa S. I. Hui, Suet Yi Chan, Sonoe Mashino, Catherine P. Y. Mok, Pak Ho Leung, Ryoma Kayano, Jonathan Abrahams, Chi Shing Wong, Emily Y. Y. Chan, Colin A. Graham
<p><b>Globalization and Health (2024) 20:15</b></p><p>https://doi.org/10.1186/s12992-023-01010-y</p><p>Following publication of the original article, it was brought to the journal's attention that the article had published with the wrong license: it had published with the Creative Commons Attribution 4.0 International License, whereas the correct license is the Creative Commons Attribution 3.0 IGO License. The license has been corrected in the published article. The publisher thanks you for reading this erratum and apologizes for any inconvenience caused.</p><h3>Authors and Affiliations</h3><ol><li><p>Accident and Emergency Medicine Academic Unit, Trauma & Emergency Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Shatin, Hong Kong</p><p>Kevin K. C. Hung, Makiko K. MacDermot, Theresa S. I. Hui, Suet Yi Chan, Catherine P. Y. Mok, Pak Ho Leung, Emily Y. Y. Chan & Colin A. Graham</p></li><li><p>Collaborating Centre for Oxford University, JC School of Public Health and Primary Care, Chinese University of Hong Kong for Disaster and Medical Humanitarian Response (CCOUC), The Chinese University of Hong Kong, Shatin, Hong Kong, China</p><p>Kevin K. C. Hung, Chi Shing Wong, Emily Y. Y. Chan & Colin A. Graham</p></li><li><p>Research Institute of Nursing Care for People and Community, University of Hyogo, 673-8588, Akashi, Japan</p><p>Sonoe Mashino</p></li><li><p>World Health Organization, Centre for Health Development, 651-0073, Kobe, Japan</p><p>Ryoma Kayano</p></li><li><p>Disaster Resilience Initiative, Monash University, Monash University, Clayton, Australia</p><p>Jonathan Abrahams</p></li></ol><span>Authors</span><ol><li><span>Kevin K. C. Hung</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Makiko K. MacDermot</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Theresa S. I. Hui</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Suet Yi Chan</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Sonoe Mashino</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Catherine P. Y. Mok</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Pak Ho Leung</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Ryoma Kayano</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Jonathan Abrahams</span>View author publications<p>You can also sear
全球化与健康》(2024)20:15https://doi.org/10.1186/s12992-023-01010-yFollowing,在发表原文时,本刊注意到文章使用了错误的许可协议:文章使用的是知识共享署名 4.0 国际许可协议,而正确的许可协议是知识共享署名 3.0 IGO 许可协议。已发布文章中的许可协议已更正。出版商感谢您阅读此勘误,并对造成的不便深表歉意。作者及所属单位香港中文大学威尔斯亲王医院急症中心意外及急症医学学术组、创伤及门诊部香港中文大學牛津大學、公共衛生及基層醫療學院、香港中文大學災難及人道主義醫療應變合作中心(CCOUC),香港中文大學,中國香港沙田Kevin K. C. Hung, Chi Shing Wong, Emily Y. Y. Chan & Colin A. GrahamResearch Institute of Nursing Care Services, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaKevin K. C. Hung, Chi Shing Wong, Emily Y. Y. Chan & Colin A. GrahamResearch Institute of Nursing Care Services, The Chinese University of Hong Kong, Shatin, Hong Kong.GrahamResearch Institute of Nursing Care for People and Community, University of Hyogo, 673-8588, Akashi, JapanSonoe MashinoWorld Health Organization, Centre for Health Development, 651-0073, Kobe, JapanRyoma KayanoDisaster Resilience Initiative, Monash University, Monash University, Clayton, AustraliaJonathan AbrahamsAuthorsKevin K. C. HungView author publications您也可以在PubMed Google ScholarMakiko K. MacDermot中搜索该作者。MacDermotView 作者发表作品您也可以在PubMed Google Scholar中搜索该作者Theresa S. I. HuiView 作者发表作品您也可以在PubMed Google Scholar中搜索该作者Suet Yi ChanView 作者发表作品您也可以在PubMed Google Scholar中搜索该作者Sonoe MashinoView 作者发表作品您也可以在PubMed Google Scholar中搜索该作者Catherine P. Y. Mok查看作者发表作品Y.MokView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Pak Ho LeungView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Ryoma KayanoView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Jonathan AbrahamsView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Chi Shing WongView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Emily Y. Y. ChanView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Emily Y. Y. ChanView作者发表论文您也可以在PubMed Google Scholar中搜索该作者Emily Y. Y.Y.ChanView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者Colin A. GrahamView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者Corresponding authorCorrespondence to Colin A. Graham.Graham.Publisher'sNoteSpringerNature对已出版地图中的管辖权主张和机构隶属关系保持中立。原文的在线版本可在https://doi.org/10.1186/s12992-023-01010-y.Open Access本文采用知识共享署名 4.0 国际许可协议进行许可,该协议允许以任何媒介或格式使用、共享、改编、分发和复制,只要您适当注明原作者和来源,提供知识共享许可协议的链接,并说明是否进行了修改。本文中的图片或其他第三方材料均包含在文章的知识共享许可协议中,除非在材料的署名栏中另有说明。如果材料未包含在文章的知识共享许可协议中,且您打算使用的材料不符合法律规定或超出许可使用范围,则您需要直接从版权所有者处获得许可。要查看该许可的副本,请访问 http://creativecommons.org/licenses/by/4.0/。除非在数据的信用行中另有说明,否则知识共享公共领域专用免责声明 (http://creativecommons.org/publicdomain/zero/1.0/) 适用于本文提供的数据。转载与许可引用本文Hung, K.K.C., MacDermot, M.K., Hui, T.S.I. et al. Correction:卫生应急与灾害风险管理能力和课程的绘图研究:文献综述和横断面调查。Global Health 20, 30 (2024). https://doi.org/10.1186/s12992-024-01037-9Download citationPublished: 12 April 2024DOI: https://doi.org/10.1186/s12992-024-01037-9Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
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引用次数: 0
Binge drinking associated with mean temperature: a cross-sectional study among Mexican adults living in cities 暴饮与平均气温相关:对生活在城市中的墨西哥成年人的横断面研究
IF 10.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-12 DOI: 10.1186/s12992-024-01033-z
Martha Carnalla, Nancy López-Olmedo, Yenisei Ramírez-Toscano, Luz Mery Cárdenas-Cárdenas, Francisco Canto-Osorio, Herney Rengifo-Reina, David Barrera-Núñez, Josúe Alai Quiroz-Reyes, M. Arantxa Colchero, Tonatiuh Barrientos-Gutiérrez
The association between environmental temperature and alcohol consumption has not been widely explored despite the potential that increasing temperatures could promote the consumption of alcoholic beverages and the alcohol-related burden of disease. We aimed to explore the association between temperature and binge drinking in Mexican adults from urban cities, overall, and by alcoholic beverage type. Data on 10,552 adults ≥ 18 years was obtained from the 2016 National Survey on Drug, Alcohol, and Tobacco Consumption. The mean annual temperature at the municipality was obtained from the Mexican National Weather Service using monthly temperatures from 2015 to 2016. We analyzed binge drinking for all alcoholic beverages in the last year and by type of alcohol as beer, liquor, wine, and coolers. Associations between mean temperature over the past year and binge drinking over the past year among current drinkers were estimated using multilevel Poisson models with robust standard errors adjusted for age, sex, education level, marital status, and household socioeconomic status, with a fixed effect by region. We observed a non-significant increase in the prevalence of binge drinking for every difference of 1 °C between municipalities of the same region. By alcohol type, a 1 °C increase in mean annual temperature across municipalities of the same region increased the prevalence of beer binge drinking in the past year by 0.9% (PR = 1.009, 95%CI 1.005, 1.013) among beer consumers and the prevalence of coolers’ binge drinking by 3.0% (PR = 1.030, 95%CI 1.003, 1.057) in coolers consumers. We observed non-significant results for liquor binge drinking (PR = 1.047, 95%CI 0.994, 1.102) and wine binge drinking (PR = 1.047, 95% 0.944, 1.161). People living in municipalities with higher temperatures reported a higher beer binge drinking in Mexican cities. This could account for 196,000 cases of beer binge drinking in 2016. The context of each country needs to be considered when generalizing these findings, and they need to be further explored with longitudinal data as there might be implications for climate change. If our findings are confirmed given the forecasted rising temperatures, we could expect an increase in binge drinking and therefore, in the alcohol burden of disease.
尽管气温升高有可能促进酒精饮料的消费和与酒精相关的疾病负担,但环境温度与酒精消费之间的关系尚未得到广泛探讨。我们的目的是探究墨西哥城市成年人的总体气温与暴饮之间的关系,以及按酒精饮料类型划分的气温与暴饮之间的关系。我们从 2016 年全国毒品、酒精和烟草消费调查中获得了 10,552 名≥ 18 岁成年人的数据。该市的年平均气温来自墨西哥国家气象局,采用的是 2015 年至 2016 年的月气温。我们分析了过去一年中所有酒精饮料的暴饮情况,并按啤酒、白酒、葡萄酒和清凉饮料等酒类类型进行了分析。我们使用多层次泊松模型估算了过去一年的平均气温与当前饮酒者过去一年暴饮之间的关系,并根据年龄、性别、教育程度、婚姻状况和家庭社会经济状况调整了稳健标准误差,同时使用了地区固定效应。我们观察到,同一地区不同城市之间的暴饮流行率每相差 1 °C,暴饮流行率的上升幅度并不显著。按酒类划分,同一地区各城市的年平均气温每升高 1 °C,啤酒消费者在过去一年中暴饮啤酒的发生率增加 0.9%(PR = 1.009,95%CI 1.005,1.013),凉爽饮料消费者暴饮凉爽饮料的发生率增加 3.0%(PR = 1.030,95%CI 1.003,1.057)。我们观察到白酒暴饮(PR = 1.047,95%CI 0.994,1.102)和葡萄酒暴饮(PR = 1.047,95% 0.944,1.161)的结果不显著。在墨西哥城市中,居住在气温较高城市的人报告的啤酒酗酒率较高。这可能是 2016 年发生 19.6 万例啤酒狂欢的原因。在归纳这些发现时,需要考虑每个国家的具体情况,并且需要利用纵向数据对这些发现进行进一步探讨,因为它们可能会对气候变化产生影响。如果我们的研究结果在预测气温升高的情况下得到证实,我们可以预期暴饮现象会增加,从而增加酒精造成的疾病负担。
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Globalization and Health
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