Pub Date : 2018-11-14DOI: 10.32474/papn.2018.02.000126
Naveen Ganapan, Charul Mehta
Aim- To study the disease control via pulmonary function test with usage of bronchodilators in bronchial asthma patients. Setting and design: Prospective cohort study done at Asthma clinic, Dept of pediatrics, BJ medical college, Ahmedabad. Materials and Methods- Patients enrolled in this study were from asthma clinic BJ medical college and Civil hospital. Pulmonary function test was done on total of 91 known asthma patients. Here three parameter of lung function is taken in to account. Percentage OD FEV1 of predicted, FEV1:FVC Ratio and PEFR , its effect on bronchodilators on PEFR. Results- Out of 91 patients, 72 (79.25%) patients had almost normal pulmonary function. Only 1 patient had severe restriction of pulmonary function and 18 patients had moderate restriction of lung function. All patients shows improvement in PEFR more than 20% after bronchodilators therapy which is suggestive of reversible air flow limitation.
{"title":"Study of Outcome of Children with Bronchial Asthma with Special Reference to Pulmonary Function Test","authors":"Naveen Ganapan, Charul Mehta","doi":"10.32474/papn.2018.02.000126","DOIUrl":"https://doi.org/10.32474/papn.2018.02.000126","url":null,"abstract":"Aim- To study the disease control via pulmonary function test with usage of bronchodilators in bronchial asthma patients. Setting and design: Prospective cohort study done at Asthma clinic, Dept of pediatrics, BJ medical college, Ahmedabad. Materials and Methods- Patients enrolled in this study were from asthma clinic BJ medical college and Civil hospital. Pulmonary function test was done on total of 91 known asthma patients. Here three parameter of lung function is taken in to account. Percentage OD FEV1 of predicted, FEV1:FVC Ratio and PEFR , its effect on bronchodilators on PEFR. Results- Out of 91 patients, 72 (79.25%) patients had almost normal pulmonary function. Only 1 patient had severe restriction of pulmonary function and 18 patients had moderate restriction of lung function. All patients shows improvement in PEFR more than 20% after bronchodilators therapy which is suggestive of reversible air flow limitation.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116354885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-26DOI: 10.32474/PAPN.2018.01.000124
Yaelle Chaudy, T. Connolly, B. Magowan
Clinical Decision Support (CDS) is a growing field and the technology is increasingly used by both clinicians and patients. In maternity care, numerous guidelines exist on risk assessment and proposed care plans during pregnancy and labour. However, as new evidence arise, these guidelines are subject to change. It is time consuming for clinicians to a. Compile all this information and b. Keep it up to date. This paper presents our approach to overcoming these two issues: the SAFER (Safe Assessment Form to Evaluate Risk) maternity system. This CDS system contains rules extracted from current guidelines on maternity care and generates care plans at various stages of gestation based on patient data. The system includes a mobile application and a web interface. The mobile application can be used to visualise care plans and edit patient data. The web interface includes an authoring tool allowing clinicians to edit the logic used to generate the care plans, thus keeping the rules up to date. The tool has been developed for and is currently used by NHS Scotland.
{"title":"A Clinical Decision Support System for Maternity Risk Assessment Developed for NHS Scotland","authors":"Yaelle Chaudy, T. Connolly, B. Magowan","doi":"10.32474/PAPN.2018.01.000124","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000124","url":null,"abstract":"Clinical Decision Support (CDS) is a growing field and the technology is increasingly used by both clinicians and patients. In maternity care, numerous guidelines exist on risk assessment and proposed care plans during pregnancy and labour. However, as new evidence arise, these guidelines are subject to change. It is time consuming for clinicians to a. Compile all this information and b. Keep it up to date. This paper presents our approach to overcoming these two issues: the SAFER (Safe Assessment Form to Evaluate Risk) maternity system. This CDS system contains rules extracted from current guidelines on maternity care and generates care plans at various stages of gestation based on patient data. The system includes a mobile application and a web interface. The mobile application can be used to visualise care plans and edit patient data. The web interface includes an authoring tool allowing clinicians to edit the logic used to generate the care plans, thus keeping the rules up to date. The tool has been developed for and is currently used by NHS Scotland.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125391510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-08DOI: 10.32474/PAPN.2018.01.000122
Sabriye Korkut, A. Mishra, H. Halis, A. Ozdemir, O. Baştuğ, L. Korkmaz, T. Gunes
Total anomalous pulmonary venous connection (TAPVC) may cause clinical signs and symptoms of resistant to treatment respiratory distress syndrome (RDS) in the full-term newborn. Despite echocardiography being the basic diagnostic examination method, three-dimensional reconstructive computed tomography allows making a more precise operation plan by defining the anatomy in an excellent manner. Cardiologic evaluation should be done immediately in the case of RDS with treatment-resistant full-term newborn because a delay in the diagnosis increases operative mortality.
{"title":"A Rare Cause of Respiratory Distress Syndrome in Fullterm Newborn: Obstructive Infracardiac Type Total Anomalous Pulmonary Venous Connection","authors":"Sabriye Korkut, A. Mishra, H. Halis, A. Ozdemir, O. Baştuğ, L. Korkmaz, T. Gunes","doi":"10.32474/PAPN.2018.01.000122","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000122","url":null,"abstract":"Total anomalous pulmonary venous connection (TAPVC) may cause clinical signs and symptoms of resistant to treatment respiratory distress syndrome (RDS) in the full-term newborn. Despite echocardiography being the basic diagnostic examination method, three-dimensional reconstructive computed tomography allows making a more precise operation plan by defining the anatomy in an excellent manner. Cardiologic evaluation should be done immediately in the case of RDS with treatment-resistant full-term newborn because a delay in the diagnosis increases operative mortality.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126427989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-10DOI: 10.32474/PAPN.2018.01.000123
S. Kamalakannan, N. Manikandan, Sankavi Santosh Kumar
{"title":"A Profile of Microbial Isolates and Antibiotic Susceptibility Patterns in Neonatal Sepsis at a Tertiary Care Centre in South India - A Post HOC Analysis","authors":"S. Kamalakannan, N. Manikandan, Sankavi Santosh Kumar","doi":"10.32474/PAPN.2018.01.000123","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000123","url":null,"abstract":"","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126727136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-17DOI: 10.32474/PAPN.2018.01.000121
Shubhankar Mishra, A. Mishra
Neurodegenerative disorders of childhood are complicated diseases with wide range of systematic involvement. These diseases often pose great challenge to clinicians in terms of diagnosis and management. The purpose of this article is to outline a systematic approach to a child presenting with suspected neurodevelopmental regression. Many inherited metabolic disorders present with neural regression. The clinical approach depends upon the age of presentation, site of involvement in brain. Sound clinical knowledge and better approach leads to early diagnosis, better management and above all genetic counselling. As the medical science is in the track of rapid progression several treatment modalities are in the pipeline for neurodegenerative syndromes, early diagnosis and referral to higher centres can bring a better future to the child.
{"title":"Approach to Neurodegenerative Disease in Children: A Short Review","authors":"Shubhankar Mishra, A. Mishra","doi":"10.32474/PAPN.2018.01.000121","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000121","url":null,"abstract":"Neurodegenerative disorders of childhood are complicated diseases with wide range of systematic involvement. These diseases often pose great challenge to clinicians in terms of diagnosis and management. The purpose of this article is to outline a systematic approach to a child presenting with suspected neurodevelopmental regression. Many inherited metabolic disorders present with neural regression. The clinical approach depends upon the age of presentation, site of involvement in brain. Sound clinical knowledge and better approach leads to early diagnosis, better management and above all genetic counselling. As the medical science is in the track of rapid progression several treatment modalities are in the pipeline for neurodegenerative syndromes, early diagnosis and referral to higher centres can bring a better future to the child.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117080782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-13DOI: 10.32474/PAPN.2018.01.000120
K. Lomauri
Neonatal chylothorax results from the accumulation of chyle in the pleural space and may be either congenital or an acquired condition. Congenital chylothorax is most likely due to abnormal development or obstruction of the lymphatic system and often associated with hydropsfetalis. It can be idiopathic or may be associated with various chromosomal and other genetic abnormalities. It is important to identify infants with chylothorax, as there are specific issues that need to be addressed in the management of these patients. In the neonate, chylous effusion is a common cause of pleural effusions and characterized as an exudate because of the high protein and lipid content once the infant is fed. The fluid will be clear/yellow to slightly cloudy in the unfed state and will quickly become milky following feeding, as chylomicrons appear in the fluid. Lymphocytes predominate in the differential cell count of chyle. The volume of fluid output can be high, and management can be challenging. We present a case of newborn with 21 trisomy who developed moderate RDS, chest X-ray and US reveal pleural effusion on right side, rapid intervention was made before deterioration, requiring intensive life-saving measures. We review the common manifestations of congenital chylotoraxes and emphasize the importance of early diagnosis and intervention in preventing devastating outcomes from this condition.
{"title":"Newborn With 21 Trysomy and Chilous pleural Effusion","authors":"K. Lomauri","doi":"10.32474/PAPN.2018.01.000120","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000120","url":null,"abstract":"Neonatal chylothorax results from the accumulation of chyle in the pleural space and may be either congenital or an acquired condition. Congenital chylothorax is most likely due to abnormal development or obstruction of the lymphatic system and often associated with hydropsfetalis. It can be idiopathic or may be associated with various chromosomal and other genetic abnormalities. It is important to identify infants with chylothorax, as there are specific issues that need to be addressed in the management of these patients. In the neonate, chylous effusion is a common cause of pleural effusions and characterized as an exudate because of the high protein and lipid content once the infant is fed. The fluid will be clear/yellow to slightly cloudy in the unfed state and will quickly become milky following feeding, as chylomicrons appear in the fluid. Lymphocytes predominate in the differential cell count of chyle. The volume of fluid output can be high, and management can be challenging. We present a case of newborn with 21 trisomy who developed moderate RDS, chest X-ray and US reveal pleural effusion on right side, rapid intervention was made before deterioration, requiring intensive life-saving measures. We review the common manifestations of congenital chylotoraxes and emphasize the importance of early diagnosis and intervention in preventing devastating outcomes from this condition.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122554688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-11DOI: 10.32474/PAPN.2018.01.000119
W. B. Kridis, Ines Werda, R. Kallel, N. Toumi, T. Boudawara, A. Khanfir, M. Frikha
Neuroblastoma is a relatively common pediatric pathology of the sympathetic nervous system. The particularity of neuroblastoma lies in its development from cells whose embryological maturation into adult sympathetic nerve cells or chromaffin cells is incomplete. In the literature, many cases of spontaneous regression of neuroblastoma have been reported, but the mechanisms for which they are responsible remain ambiguous. The specificity of our case is the benign evolution of an osteomedullary stage 4 neuroblastoma and its maturation into a ganglioneuroma 6 years after the end of chemotherapy. This transformation depends on various factors related to the tumor (such as the over expression or not of N-myc, the presence or absence of Treks and their receptors), the host (the intervention of the immune system) and to other external factors. Being able to induce this differentiation by not leaving it to chance would be a therapeutic challage and could categorically change the prognosis of neuroblastomas. This merits a lot of research and studies of various potential future treatments (such as treks inhibitors and retinoid).
{"title":"Good Evolution of Stage IV Neuroblastoma in the Absence of Stem Cell Autograft","authors":"W. B. Kridis, Ines Werda, R. Kallel, N. Toumi, T. Boudawara, A. Khanfir, M. Frikha","doi":"10.32474/PAPN.2018.01.000119","DOIUrl":"https://doi.org/10.32474/PAPN.2018.01.000119","url":null,"abstract":"Neuroblastoma is a relatively common pediatric pathology of the sympathetic nervous system. The particularity of neuroblastoma lies in its development from cells whose embryological maturation into adult sympathetic nerve cells or chromaffin cells is incomplete. In the literature, many cases of spontaneous regression of neuroblastoma have been reported, but the mechanisms for which they are responsible remain ambiguous. The specificity of our case is the benign evolution of an osteomedullary stage 4 neuroblastoma and its maturation into a ganglioneuroma 6 years after the end of chemotherapy. This transformation depends on various factors related to the tumor (such as the over expression or not of N-myc, the presence or absence of Treks and their receptors), the host (the intervention of the immune system) and to other external factors. Being able to induce this differentiation by not leaving it to chance would be a therapeutic challage and could categorically change the prognosis of neuroblastomas. This merits a lot of research and studies of various potential future treatments (such as treks inhibitors and retinoid).","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129005775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32474/papn.2019.02.000138
RF Sartori
Objective: The aim of this study was to describe the tests used to assess working memory, inhibition, and cognitive flexibility, and analyzed the main research results related to executive functions in children with Developmental Coordination Disorder or with poor motor skills. Methods: This review used as data sources studies in MEDLINE, Web of Science, APA PsycNET, EMBASE, and Google Scholar with children with poor motor skills, DCD, and typical development. Quality of the studies was conducted using the Newcastle Ottawa Scale. Results: 1475 papers found, 31 matched the review criteria; 31 different executive function tests used to assess children with poor motor skills and DCD. Across the 31 studies, included in this systematic review, eleven studies examined only the working memory; ten studies measured only inhibition, a single study measured only cognitive flexibility, three studies examined the working memory and inhibition, one study examined inhibition and cognitive flexibility, one study examined working memory and cognitive flexibility and four studies examined the three executive functions. In conclusion, many tests were used to assess children with poor motor skill and DCD requiring verbal, nonverbal, or complex visuospatial processing, with or without motor demand involved. In some tests the different demands or different types of stimulus involved cause secondary loss in execution. The executive functions deficits in children with poor motor skills and DCD are in a wide ranging and extend across basic all functions assessed (working memory, inhibition, and cognitive flexibility). The pervasive and persistent nature of the executive function deficits suggests a need for a more aligned methodological approach to investigate this phenomenon.
目的:本研究的目的是描述工作记忆、抑制和认知灵活性的测试，并分析与发展性协调障碍或运动技能差儿童执行功能相关的主要研究结果。方法:本综述采用MEDLINE、Web of Science、APA PsycNET、EMBASE和Google Scholar等数据库对运动技能差、DCD和典型发育的儿童进行研究。研究质量采用纽卡斯尔渥太华量表进行。结果:共发现文献1475篇，符合审稿标准31篇;31种不同的执行功能测试用于评估运动技能和DCD较差的儿童。在这篇系统综述中收录的31项研究中，有11项研究只考察了工作记忆;十项研究只测量了抑制，一项研究只测量了认知灵活性，三项研究检查了工作记忆和抑制，一项研究检查了抑制和认知灵活性，一项研究检查了工作记忆和认知灵活性四项研究检查了三种执行功能。总之，许多测试被用于评估运动技能差的儿童和需要语言、非语言或复杂视觉空间处理的DCD，无论是否涉及运动需求。在一些测试中，不同的要求或不同类型的刺激会导致执行中的二次损失。运动技能差和DCD儿童的执行功能缺陷范围广泛，并扩展到基本所有功能(工作记忆，抑制和认知灵活性)。执行功能缺陷的普遍性和持久性表明，需要一种更一致的方法来研究这一现象。
{"title":"Systematic Review on Executive Functions in Children with Poor Motor Skills and With Development Coordination Disorder","authors":"RF Sartori","doi":"10.32474/papn.2019.02.000138","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000138","url":null,"abstract":"Objective: The aim of this study was to describe the tests used to assess working memory, inhibition, and cognitive flexibility, and analyzed the main research results related to executive functions in children with Developmental Coordination Disorder or with poor motor skills. Methods: This review used as data sources studies in MEDLINE, Web of Science, APA PsycNET, EMBASE, and Google Scholar with children with poor motor skills, DCD, and typical development. Quality of the studies was conducted using the Newcastle Ottawa Scale. Results: 1475 papers found, 31 matched the review criteria; 31 different executive function tests used to assess children with poor motor skills and DCD. Across the 31 studies, included in this systematic review, eleven studies examined only the working memory; ten studies measured only inhibition, a single study measured only cognitive flexibility, three studies examined the working memory and inhibition, one study examined inhibition and cognitive flexibility, one study examined working memory and cognitive flexibility and four studies examined the three executive functions. In conclusion, many tests were used to assess children with poor motor skill and DCD requiring verbal, nonverbal, or complex visuospatial processing, with or without motor demand involved. In some tests the different demands or different types of stimulus involved cause secondary loss in execution. The executive functions deficits in children with poor motor skills and DCD are in a wide ranging and extend across basic all functions assessed (working memory, inhibition, and cognitive flexibility). The pervasive and persistent nature of the executive function deficits suggests a need for a more aligned methodological approach to investigate this phenomenon.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114775027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32474/papn.2019.02.000137
Li-wen Chang
Pulmonary hemorrhage (PH) is a life threatening condition in newborns, especially preterm infants. Surfactant replacement might be helpful to improve lung function and reduce the ventilation support in infants with PH. We report two premature infants (one with early onset PH and one with late onset PH) who have been successfully rescued by administering surfactant (Calsurf) after an acute episode of bleeding. Both of the 2 infants survived, and surfactant administration showed improvement in mean airway pressure and oxygenation indices. In the current study Calsurf was found effective in the treatment of both early PH and late PH in premature infants. There were no potential side effects were found in our study.
{"title":"Successful Treatment with Surfactant in Preterm Infants with Pulmonary Hemorrhage","authors":"Li-wen Chang","doi":"10.32474/papn.2019.02.000137","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000137","url":null,"abstract":"Pulmonary hemorrhage (PH) is a life threatening condition in newborns, especially preterm infants. Surfactant replacement might be helpful to improve lung function and reduce the ventilation support in infants with PH. We report two premature infants (one with early onset PH and one with late onset PH) who have been successfully rescued by administering surfactant (Calsurf) after an acute episode of bleeding. Both of the 2 infants survived, and surfactant administration showed improvement in mean airway pressure and oxygenation indices. In the current study Calsurf was found effective in the treatment of both early PH and late PH in premature infants. There were no potential side effects were found in our study.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114604114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32474/papn.2019.02.000136
M. Barak
Objective: To investigate the effect of USDA in the treatment of indirect hyperbilirubinemia of neonates. Study design: This randomized clinical trial was conducted on neonates with indirect hyperbilirubinemia whom were hospitalized at Ardabil city hospital. 100 newborns were enrolled in the study and randomly divided into two groups. The treatment group (n=50) received 10 mg/kg/day divided q12h USDA in addition to phototherapy, while the control group (n=50) only received phototherapy. Total bilirubin levels were measured every 12 hours until reaching bilirubin below 10mg/dL. Also, duration of phototherapy and hospitalization in both groups were recorded. Data were analyzed in SPSS.21 using statistical methods. Results: There was no difference in the mean of total bilirubin between treatment and control groups at baseline, 12, 24, 36, and 48 hours after admission. Conclusions: Our study revealed that adding USDA to phototherapy in treating indirect hyperbilirubinemia of newborns had no preference to just phototherapy treatment.
{"title":"Effect of Ursodeoxycholic Acid (USDA) on Indirect Hyperbilirubinemia in Neonates Treated with Phototherapy","authors":"M. Barak","doi":"10.32474/papn.2019.02.000136","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000136","url":null,"abstract":"Objective: To investigate the effect of USDA in the treatment of indirect hyperbilirubinemia of neonates. Study design: This randomized clinical trial was conducted on neonates with indirect hyperbilirubinemia whom were hospitalized at Ardabil city hospital. 100 newborns were enrolled in the study and randomly divided into two groups. The treatment group (n=50) received 10 mg/kg/day divided q12h USDA in addition to phototherapy, while the control group (n=50) only received phototherapy. Total bilirubin levels were measured every 12 hours until reaching bilirubin below 10mg/dL. Also, duration of phototherapy and hospitalization in both groups were recorded. Data were analyzed in SPSS.21 using statistical methods. Results: There was no difference in the mean of total bilirubin between treatment and control groups at baseline, 12, 24, 36, and 48 hours after admission. Conclusions: Our study revealed that adding USDA to phototherapy in treating indirect hyperbilirubinemia of newborns had no preference to just phototherapy treatment.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133842560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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