首页 > 最新文献

Annals of Neurology最新文献

英文 中文
Myelitis-Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late-Onset Neuromyelitis Optica Spectrum Disorders. 脊髓炎-显性侵略性表型:揭示迟发性视神经脊髓炎谱系障碍的独特模式。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-09 DOI: 10.1002/ana.78146
Ya-Lan Pu, Jin-Zhou Feng, Hua-Xing Meng, Hai-Bing Xiao, Xiao-Ling Li, Jin Zhen, Wen-Ying Lu, Xu-Ming Xi, Ti Wu, Bao-Shi Yuan, Mo-Li Fan, Chao Zhang, De-Cai Tian, Xia Meng, Fu-Dong Shi, Tian Song

Objective: The objective of this study was to compare clinical features and prognosis of late-onset neuromyelitis optica spectrum disorder (LO-NMOSD, onset age ≥60 years) with adult-onset NMOSD (AO-NMOSD, onset age 18-59 years), and to provide insights for individualized management in elderly patients.

Methods: Data from 748 patients with NMOSD (diagnosed according to the 2015 International Panel for NMO Diagnosis criteria) in the China National Registry of Neuro-Inflammatory Diseases (CNRID) were analyzed. Patients were stratified into AO-NMOSD (18-59 years, n = 617) and LO-NMOSD (≥ 60 years, n = 131). Demographics, clinical manifestations, imaging, treatments, and outcomes were compared using appropriate statistical methods including Kaplan-Meier survival curves and Cox proportional hazards regression.

Results: LO-NMOSD showed distinct traits: a lower female predominance (76.34% vs 86.55%), higher transverse myelitis (TM) incidence at onset (57.36% vs 40.17%), elevated annualized relapse rate (ARR; 0.52 ± 0.03 vs 0.38 ± 0.01), and accelerated disability (median Expanded Disability Status Scale [EDSS] 4.75 vs 3.0). TM-predominant relapses (39 of 45, 86.67% in LO vs 96 of 148, 64.86% in AO) contributed significantly to disability. Kaplan-Meier analysis showed LO-NMOSD had a higher risk of relapse (hazard ratio [HR] = 1.932, 95% confidence interval [CI] = 1.427-2.615), disability (HR = 3.192, 95% CI = 1.932-5.274) and reaching visual acuity (VA) ≤20 of 30 (HR = 3.523, 95% CI = 1.585-7.828). Cox regression confirmed that onset age ≥60 years was an independent risk factor for relapse (HR = 2.05, 95% CI = 1.60-2.59), disability (HR = 3.16, 95% CI = 2.14-4.62), and reaching VA ≤20 of 30 (HR 3.26, 95% CI = 1.83-5.48).

Interpretation: LO-NMOSD is characterized by myelitis-predominance with recurrent spinal cord involvement, high risk of relapses, and severe disability. It thus underscores the need for heightened clinical attention, with rigorous monitoring that balance safety and efficacy for elderly patients with NMOSD. ANN NEUROL 2026.

目的:比较迟发性视神经脊髓炎谱系障碍(LO-NMOSD,起病年龄≥60岁)与成年性NMOSD (AO-NMOSD,起病年龄18-59岁)的临床特征及预后,为老年患者的个体化治疗提供参考。方法:分析中国国家神经炎症疾病登记处(CNRID) 748例NMOSD(根据2015年国际NMO诊断标准诊断)患者的数据。患者分为AO-NMOSD(18-59岁,n = 617)和LO-NMOSD(≥60岁,n = 131)。采用Kaplan-Meier生存曲线和Cox比例风险回归等统计方法对两组患者的人口统计学、临床表现、影像学、治疗和结局进行比较。结果:lonmosd表现出明显的特点:女性患病率较低(76.34% vs 86.55%),发病时横脊髓炎(TM)发病率较高(57.36% vs 40.17%),年化复发率升高(ARR; 0.52±0.03 vs 0.38±0.01),残疾加速(扩展残疾状态量表[EDSS]中位数为4.75 vs 3.0)。以tm为主的复发(45例中有39例,LO为86.67%,148例中有96例,AO为64.86%)对残疾有显著影响。Kaplan-Meier分析显示,LO-NMOSD患者有较高的复发率(风险比[HR] = 1.932, 95%可信区间[CI] = 1.427 ~ 2.615)、致残率(HR = 3.192, 95% CI = 1.932 ~ 5.274)和视力(VA)≤20 / 30 (HR = 3.523, 95% CI = 1.585 ~ 7.828)。Cox回归证实,发病年龄≥60岁是复发(HR = 2.05, 95% CI = 1.60-2.59)、残疾(HR = 3.16, 95% CI = 2.14-4.62)、VA≤20 / 30 (HR 3.26, 95% CI = 1.83-5.48)的独立危险因素。解释:LO-NMOSD的特点是脊髓炎为主,复发性脊髓受累,复发风险高,严重残疾。因此,它强调需要加强临床关注,严格监测以平衡老年NMOSD患者的安全性和有效性。Ann neurol 2026。
{"title":"Myelitis-Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late-Onset Neuromyelitis Optica Spectrum Disorders.","authors":"Ya-Lan Pu, Jin-Zhou Feng, Hua-Xing Meng, Hai-Bing Xiao, Xiao-Ling Li, Jin Zhen, Wen-Ying Lu, Xu-Ming Xi, Ti Wu, Bao-Shi Yuan, Mo-Li Fan, Chao Zhang, De-Cai Tian, Xia Meng, Fu-Dong Shi, Tian Song","doi":"10.1002/ana.78146","DOIUrl":"https://doi.org/10.1002/ana.78146","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to compare clinical features and prognosis of late-onset neuromyelitis optica spectrum disorder (LO-NMOSD, onset age ≥60 years) with adult-onset NMOSD (AO-NMOSD, onset age 18-59 years), and to provide insights for individualized management in elderly patients.</p><p><strong>Methods: </strong>Data from 748 patients with NMOSD (diagnosed according to the 2015 International Panel for NMO Diagnosis criteria) in the China National Registry of Neuro-Inflammatory Diseases (CNRID) were analyzed. Patients were stratified into AO-NMOSD (18-59 years, n = 617) and LO-NMOSD (≥ 60 years, n = 131). Demographics, clinical manifestations, imaging, treatments, and outcomes were compared using appropriate statistical methods including Kaplan-Meier survival curves and Cox proportional hazards regression.</p><p><strong>Results: </strong>LO-NMOSD showed distinct traits: a lower female predominance (76.34% vs 86.55%), higher transverse myelitis (TM) incidence at onset (57.36% vs 40.17%), elevated annualized relapse rate (ARR; 0.52 ± 0.03 vs 0.38 ± 0.01), and accelerated disability (median Expanded Disability Status Scale [EDSS] 4.75 vs 3.0). TM-predominant relapses (39 of 45, 86.67% in LO vs 96 of 148, 64.86% in AO) contributed significantly to disability. Kaplan-Meier analysis showed LO-NMOSD had a higher risk of relapse (hazard ratio [HR] = 1.932, 95% confidence interval [CI] = 1.427-2.615), disability (HR = 3.192, 95% CI = 1.932-5.274) and reaching visual acuity (VA) ≤20 of 30 (HR = 3.523, 95% CI = 1.585-7.828). Cox regression confirmed that onset age ≥60 years was an independent risk factor for relapse (HR = 2.05, 95% CI = 1.60-2.59), disability (HR = 3.16, 95% CI = 2.14-4.62), and reaching VA ≤20 of 30 (HR 3.26, 95% CI = 1.83-5.48).</p><p><strong>Interpretation: </strong>LO-NMOSD is characterized by myelitis-predominance with recurrent spinal cord involvement, high risk of relapses, and severe disability. It thus underscores the need for heightened clinical attention, with rigorous monitoring that balance safety and efficacy for elderly patients with NMOSD. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: "Bridging Electrophysiology and Digital Health: Microneurography Findings in Long COVID Herald a New Era of AI-Powered Peripheral Nerve Monitoring". 回复:“桥接电生理学和数字健康:长期COVID的微神经造影发现预示着人工智能驱动的周围神经监测的新时代”。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-08 DOI: 10.1002/ana.78141
Ana Ribeiro, Shahrzad Hadavi, Nick Gall, Robert D M Hadden, Jordi Serra
{"title":"Reply to: \"Bridging Electrophysiology and Digital Health: Microneurography Findings in Long COVID Herald a New Era of AI-Powered Peripheral Nerve Monitoring\".","authors":"Ana Ribeiro, Shahrzad Hadavi, Nick Gall, Robert D M Hadden, Jordi Serra","doi":"10.1002/ana.78141","DOIUrl":"https://doi.org/10.1002/ana.78141","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial. 调节电刺激治疗中重度腕管综合征:双盲随机对照试验。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-08 DOI: 10.1002/ana.78155
Yusuke Osaki, Jaret L Olson, Michael J Morhart, Matthew W Curran, Douglas W Zochodne, K Ming Chan

Objective: Carpal tunnel syndrome (CTS) can drastically impair one's ability to work and interferes with activities of daily living. We recently demonstrated that, in rodents, conditioning electrical stimulation (CES) delivered to the nerve 7 days prior to surgery imparts a conditioning lesion-like effect by accelerating the rate of regeneration along the entire length of the nerve. The goal of this study is to test the hypothesis that CES could accelerate nerve regeneration and improve function in patients with moderate or severe CTS.

Methods: Using a double-blind randomized controlled study design, patients received surgery + CES or surgery + sham stimulation. They were evaluated at regular intervals for 12 months following intervention. Primary outcome was motor unit number estimation (MUNE), supplemented with secondary outcomes including motor and sensory nerve conduction studies, Semmes Weinstein Monofilaments, and Moberg Pick-Up Test.

Results: Sixty-four participants were randomized to either the treatment or control groups. There was no significant demographic or physiological difference at baseline between the groups. No major adverse event was found with treatment. Following intervention, there was significantly greater increase in MUNE of 62 ± 71 in the treatment group compared to 25 ± 66 in the controls after 12 months. In the treatment group, there was correspondingly better physiological and functional recovery and hand dexterity compared with the controls.

Interpretation: CES is a safe, feasible, and efficacious treatment to improve nerve reinnervation and functional outcomes in patients with moderate or severe CTS. This may open future possibilities for more effective treatment for other peripheral nerve injuries. ANN NEUROL 2026.

目的:腕管综合征(Carpal tunnel syndrome, CTS)可严重损害人的工作能力并干扰日常生活活动。我们最近证明,在啮齿类动物中,手术前7天向神经施加条件电刺激(CES),通过加速沿整个神经长度的再生速度,赋予条件损伤样效果。本研究的目的是验证CES可以加速中重度CTS患者的神经再生和改善功能的假设。方法:采用双盲随机对照研究设计,患者分别接受手术+ CES或手术+假刺激。他们在干预后的12个月内定期接受评估。主要结果是运动单位数估计(MUNE),辅助结果包括运动和感觉神经传导研究、Semmes Weinstein单丝和Moberg拾回测试。结果:64名参与者被随机分为治疗组和对照组。两组在基线时没有显著的人口统计学或生理差异。治疗过程中未发现重大不良事件。干预后12个月,治疗组的MUNE为62±71,显著高于对照组的25±66。与对照组相比,治疗组的生理和功能恢复以及手部灵巧度相应更好。结论:CES是一种安全、可行、有效的治疗方法,可改善中重度CTS患者的神经再生和功能结局。这可能为更有效地治疗其他周围神经损伤开辟了未来的可能性。Ann neurol 2026。
{"title":"Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial.","authors":"Yusuke Osaki, Jaret L Olson, Michael J Morhart, Matthew W Curran, Douglas W Zochodne, K Ming Chan","doi":"10.1002/ana.78155","DOIUrl":"https://doi.org/10.1002/ana.78155","url":null,"abstract":"<p><strong>Objective: </strong>Carpal tunnel syndrome (CTS) can drastically impair one's ability to work and interferes with activities of daily living. We recently demonstrated that, in rodents, conditioning electrical stimulation (CES) delivered to the nerve 7 days prior to surgery imparts a conditioning lesion-like effect by accelerating the rate of regeneration along the entire length of the nerve. The goal of this study is to test the hypothesis that CES could accelerate nerve regeneration and improve function in patients with moderate or severe CTS.</p><p><strong>Methods: </strong>Using a double-blind randomized controlled study design, patients received surgery + CES or surgery + sham stimulation. They were evaluated at regular intervals for 12 months following intervention. Primary outcome was motor unit number estimation (MUNE), supplemented with secondary outcomes including motor and sensory nerve conduction studies, Semmes Weinstein Monofilaments, and Moberg Pick-Up Test.</p><p><strong>Results: </strong>Sixty-four participants were randomized to either the treatment or control groups. There was no significant demographic or physiological difference at baseline between the groups. No major adverse event was found with treatment. Following intervention, there was significantly greater increase in MUNE of 62 ± 71 in the treatment group compared to 25 ± 66 in the controls after 12 months. In the treatment group, there was correspondingly better physiological and functional recovery and hand dexterity compared with the controls.</p><p><strong>Interpretation: </strong>CES is a safe, feasible, and efficacious treatment to improve nerve reinnervation and functional outcomes in patients with moderate or severe CTS. This may open future possibilities for more effective treatment for other peripheral nerve injuries. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging Electrophysiology and Digital Health: Microneurography Findings in Long COVID Herald a New Era of AI-Powered Peripheral Nerve Monitoring. 桥接电生理学和数字健康:长期COVID的微神经造影发现预示着人工智能驱动的周围神经监测的新时代。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-08 DOI: 10.1002/ana.78127
Shaher Yar, Reza Rafieossadat, Parvat Kuwar Chhetri
{"title":"Bridging Electrophysiology and Digital Health: Microneurography Findings in Long COVID Herald a New Era of AI-Powered Peripheral Nerve Monitoring.","authors":"Shaher Yar, Reza Rafieossadat, Parvat Kuwar Chhetri","doi":"10.1002/ana.78127","DOIUrl":"https://doi.org/10.1002/ana.78127","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Intradural Extension of Extracranial Cervical Artery Dissection on Outcomes: A Secondary Analysis From the STOP-CAD Study. 颅外颈动脉夹层硬膜内延伸对预后的影响:来自STOP-CAD研究的二次分析。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-08 DOI: 10.1002/ana.78151
Issa Metanis, Liqi Shu, Favour Akpokiere, Hamza Jubran, Daniel M Mandel, Christian H Nolte, James E Siegler, Stefan T Engelter, Brian Mac Grory, Jennifer Frontera, Muhib Khan, Aaron Rothstein, Yoel Schwartzmann, João Pedro Marto, Marialuisa Zedde, Alexandre Y Poppe, Tamer Jubeh, Zafer Keser, Mohammad AlMajali, Fatma Shalabi, Nils Henninger, Kateryna Antonenko, Mirjam R Heldner, Sara Rosa, Ossama Khazaal, Josefine E Kaufman, Christopher Traenka, Ekaterina Bakradze, Adeel Zubair, Tamra Ranasinghe, João André Sousa, Gabriel Paulo Mantovani, Alexis N Simpkins, Setareh Salehi Omran, Joao Sargento-Freitas, Marwa Elnazeir, Diana Aguiar de Sousa, Shadi Yaghi, Ronen R Leker

Objective: Cervical artery dissection (CeAD) may be limited to the extracranial extradural space or extend to the intradural space. Intradural extension can potentially increase the risk of stroke and subarachnoid hemorrhage. However, the factors associated with intradural extension and its impact on clinical outcome remain unclear.

Methods: This was a secondary analysis of the STOP-CAD observational, multi-center study. Patients with CeAD and intradural extension (CeADid) were compared with those with pure CeAD extradural dissections (CeADed) using multiple regression analyses.

Results: Of 4,023 patients with CeAD, 534 (13.3%) had CeADid. In comparison to patients with CeADed, those with CeADid more often had clinical overt stroke or transient ischemic attack (TIA) at presentation, acute infarcts on imaging, a vertebral artery affected, and severe stenosis of the involved vessel (p < 0.001 for all). In contrast, carotid involvement and complete occlusions were more frequent in patients with CeADed (p < 0.001 for both). CeADid was associated with a shift in the distribution of scores on the modified Rankin Scale (mRS) toward worse functional outcome (odds ratio [OR] = 0.76, 95% confidence interval [CI] = 0.62-0.92) but the odds for favorable outcomes (mRS = 0-2) did not differ between the groups after appropriate adjustments on multivariate analysis. CeADid was independently associated with higher mortality at 180 days on multivariate analysis (adjusted OR = 2.84, 95% CI = 1.50-5.38).

Interpretation: CeADid is associated with more severe clinical presentation, a shift toward less favorable outcomes, and higher mortality rates. These findings suggest that CeADid may represent a high-risk type of CeAD. ANN NEUROL 2026.

目的:颈动脉夹层(CeAD)可局限于颅外硬膜外间隙或延伸至硬膜内间隙。硬膜内延伸可能会增加中风和蛛网膜下腔出血的风险。然而,与硬膜内延伸相关的因素及其对临床结果的影响尚不清楚。方法:这是对STOP-CAD观察性多中心研究的二次分析。采用多元回归分析,比较单纯硬膜外剥离(CeAD)患者与合并硬膜内延伸(CeADid)的患者。结果:4023例CeAD患者中,534例(13.3%)有CeADid。与ceed患者相比,CeADid患者在临床表现时更容易出现明显的中风或短暂性脑缺血发作(TIA),影像学表现为急性梗死,椎动脉受累,受累血管严重狭窄(p)。解释:CeADid与更严重的临床表现、向不太有利的结果转变以及更高的死亡率相关。这些发现表明,CeADid可能是一种高危类型的CeAD。Ann neurol 2026。
{"title":"Effects of Intradural Extension of Extracranial Cervical Artery Dissection on Outcomes: A Secondary Analysis From the STOP-CAD Study.","authors":"Issa Metanis, Liqi Shu, Favour Akpokiere, Hamza Jubran, Daniel M Mandel, Christian H Nolte, James E Siegler, Stefan T Engelter, Brian Mac Grory, Jennifer Frontera, Muhib Khan, Aaron Rothstein, Yoel Schwartzmann, João Pedro Marto, Marialuisa Zedde, Alexandre Y Poppe, Tamer Jubeh, Zafer Keser, Mohammad AlMajali, Fatma Shalabi, Nils Henninger, Kateryna Antonenko, Mirjam R Heldner, Sara Rosa, Ossama Khazaal, Josefine E Kaufman, Christopher Traenka, Ekaterina Bakradze, Adeel Zubair, Tamra Ranasinghe, João André Sousa, Gabriel Paulo Mantovani, Alexis N Simpkins, Setareh Salehi Omran, Joao Sargento-Freitas, Marwa Elnazeir, Diana Aguiar de Sousa, Shadi Yaghi, Ronen R Leker","doi":"10.1002/ana.78151","DOIUrl":"10.1002/ana.78151","url":null,"abstract":"<p><strong>Objective: </strong>Cervical artery dissection (CeAD) may be limited to the extracranial extradural space or extend to the intradural space. Intradural extension can potentially increase the risk of stroke and subarachnoid hemorrhage. However, the factors associated with intradural extension and its impact on clinical outcome remain unclear.</p><p><strong>Methods: </strong>This was a secondary analysis of the STOP-CAD observational, multi-center study. Patients with CeAD and intradural extension (CeADid) were compared with those with pure CeAD extradural dissections (CeADed) using multiple regression analyses.</p><p><strong>Results: </strong>Of 4,023 patients with CeAD, 534 (13.3%) had CeADid. In comparison to patients with CeADed, those with CeADid more often had clinical overt stroke or transient ischemic attack (TIA) at presentation, acute infarcts on imaging, a vertebral artery affected, and severe stenosis of the involved vessel (p < 0.001 for all). In contrast, carotid involvement and complete occlusions were more frequent in patients with CeADed (p < 0.001 for both). CeADid was associated with a shift in the distribution of scores on the modified Rankin Scale (mRS) toward worse functional outcome (odds ratio [OR] = 0.76, 95% confidence interval [CI] = 0.62-0.92) but the odds for favorable outcomes (mRS = 0-2) did not differ between the groups after appropriate adjustments on multivariate analysis. CeADid was independently associated with higher mortality at 180 days on multivariate analysis (adjusted OR = 2.84, 95% CI = 1.50-5.38).</p><p><strong>Interpretation: </strong>CeADid is associated with more severe clinical presentation, a shift toward less favorable outcomes, and higher mortality rates. These findings suggest that CeADid may represent a high-risk type of CeAD. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Giant Perivascular Spaces in Hypomelanosis of Ito. 伊藤低黑素症的多个巨大血管周围间隙。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-06 DOI: 10.1002/ana.78147
Daniel El Chammas, Matthieu Labriffe, Philippe Codron
{"title":"Multiple Giant Perivascular Spaces in Hypomelanosis of Ito.","authors":"Daniel El Chammas, Matthieu Labriffe, Philippe Codron","doi":"10.1002/ana.78147","DOIUrl":"https://doi.org/10.1002/ana.78147","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to the Mediterranean and Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective E3N Cohort. 坚持地中海和地中海饮食方法停止高血压干预神经退行性延迟(MIND)饮食和女性帕金森病发病率:来自前瞻性E3N队列的结果
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-06 DOI: 10.1002/ana.78115
Mariem Hajji-Louati, Emmanuelle Correia, Pei-Chen Lee, Fanny Artaud, Emmanuel Roze, Francesca Romana Mancini, Alexis Elbaz

Objective: The evidence regarding adherence to dietary patterns and Parkinson's disease (PD) risk is inconsistent. Because of the long prodromal PD phase, reverse causation represents a major threat to investigations of diet in relation to PD. We examined whether adherence to the Mediterranean (MED) and Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diets is associated with PD incidence, while considering reverse causation, in a large cohort of women with a 25-year follow-up.

Methods: Participants from the E3N (Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale) study were prospectively followed-up from 1993 to 2018. PD diagnoses were validated using medical records and drug claim databases. Baseline MED and MIND scores were computed using a validated food questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression models. Exposures were lagged by 5 years in main analyses and longer lags in sensitivity analyses. We performed age-stratified analyses and adjusted for prodromal symptoms.

Results: Analyses (5-year-lag) are based on 71,542 women (845 PD patients). Higher adherence to MED and MIND diets was not associated with PD overall, but was associated with lower PD incidence in women <71 years old (MED, HRhigh vs. low+medium = 0.76 [0.58-1.00], p-Age × MED interaction = 0.038; MIND, HRhigh vs. low+medium = 0.75 [0.58-0.97], p-Age × MIND interaction = 0.035). Legumes and high unsaturated to saturated fat ratio had the strongest contribution for the MED diet, while beans and olive oil had the strongest contribution for the MIND diet. Results were consistent after adjustment for constipation/depression and in analyses with lags up to 20 years.

Interpretation: Adherence to the MED and MIND diets was associated with lower PD incidence <71 years in women. These findings are important for planning preventative interventions. ANN NEUROL 2026.

目的:关于坚持饮食模式和帕金森病(PD)风险的证据是不一致的。由于PD前驱期较长,反向因果关系是PD相关饮食调查的主要威胁。我们研究了是否坚持地中海(MED)和地中海饮食方法停止高血压干预神经退行性延迟(MIND)饮食与PD发病率有关,同时考虑反向因果关系,在一个25年随访的大型女性队列中。方法:从1993年到2018年,对E3N (Etude epidacmiologique auprires des femmes de la Mutuelle gsamnacriale de l’education national)研究的参与者进行前瞻性随访。PD诊断使用医疗记录和药物声明数据库进行验证。基线MED和MIND评分使用有效的食物问卷计算。使用多变量Cox回归模型估计风险比(HR)和95%置信区间(CI)。在主要分析中,暴露滞后5年,在敏感性分析中滞后时间更长。我们进行了年龄分层分析并调整了前驱症状。结果:分析(5年滞后)基于71,542名女性(845名PD患者)。总体而言,较高的MED和MIND饮食依从性与PD无关,但与女性PD发病率较低相关。高vs低+中= 0.76 [0.58-1.00],p-Age × MED相互作用= 0.038;MIND, HRhigh vs. low+medium = 0.75 [0.58-0.97], p-Age × MIND交互作用= 0.035)。豆类和高不饱和脂肪比对MED饮食的贡献最大,而豆类和橄榄油对MIND饮食的贡献最大。在对便秘/抑郁进行调整后,在滞后长达20年的分析中,结果是一致的。解释:坚持MED和MIND饮食与较低的PD发病率相关
{"title":"Adherence to the Mediterranean and Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective E3N Cohort.","authors":"Mariem Hajji-Louati, Emmanuelle Correia, Pei-Chen Lee, Fanny Artaud, Emmanuel Roze, Francesca Romana Mancini, Alexis Elbaz","doi":"10.1002/ana.78115","DOIUrl":"https://doi.org/10.1002/ana.78115","url":null,"abstract":"<p><strong>Objective: </strong>The evidence regarding adherence to dietary patterns and Parkinson's disease (PD) risk is inconsistent. Because of the long prodromal PD phase, reverse causation represents a major threat to investigations of diet in relation to PD. We examined whether adherence to the Mediterranean (MED) and Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diets is associated with PD incidence, while considering reverse causation, in a large cohort of women with a 25-year follow-up.</p><p><strong>Methods: </strong>Participants from the E3N (Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale) study were prospectively followed-up from 1993 to 2018. PD diagnoses were validated using medical records and drug claim databases. Baseline MED and MIND scores were computed using a validated food questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression models. Exposures were lagged by 5 years in main analyses and longer lags in sensitivity analyses. We performed age-stratified analyses and adjusted for prodromal symptoms.</p><p><strong>Results: </strong>Analyses (5-year-lag) are based on 71,542 women (845 PD patients). Higher adherence to MED and MIND diets was not associated with PD overall, but was associated with lower PD incidence in women <71 years old (MED, HR<sub>high vs. low+medium</sub> = 0.76 [0.58-1.00], p-Age × MED interaction = 0.038; MIND, HR<sub>high vs. low+medium</sub> = 0.75 [0.58-0.97], p-Age × MIND interaction = 0.035). Legumes and high unsaturated to saturated fat ratio had the strongest contribution for the MED diet, while beans and olive oil had the strongest contribution for the MIND diet. Results were consistent after adjustment for constipation/depression and in analyses with lags up to 20 years.</p><p><strong>Interpretation: </strong>Adherence to the MED and MIND diets was associated with lower PD incidence <71 years in women. These findings are important for planning preventative interventions. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Internal Carotid Artery Agenesis. 双侧颈内动脉不全。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-06 DOI: 10.1002/ana.78150
Shane Musick, Stephen Schaffner
{"title":"Bilateral Internal Carotid Artery Agenesis.","authors":"Shane Musick, Stephen Schaffner","doi":"10.1002/ana.78150","DOIUrl":"https://doi.org/10.1002/ana.78150","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Missing Medication Acutely Change Seizure Risk? A Prospective Study. 药物缺失会改变癫痫发作风险吗?前瞻性研究。
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-05 DOI: 10.1002/ana.78134
Daniel M Goldenholz, Joshua C Cheng, Chi-Yuan Chang, Robert Moss, M Brandon Westover

Objective: The objective of this study was to determine whether missing individual doses of anti-seizure medications (ASMs) elevate short-term seizure risk in people with drug-resistant epilepsy.

Methods: In a prospective, community-based cohort, adults with drug-resistant epilepsy (≥ 3 seizures/month) or their caregivers recorded seizures and ASM intake with smartphone applications for 10 months each. Individual level analysis modeled the relationships between ASM adherence with seizure occurrence, as well as with a simplified seizure forecast via a 90-day moving average ("Napkin method"). Group-level analysis with a mixed-effects model was performed to examine the relationship between ASM adherence and simplified forecasts, while controlling for differences in individual seizure frequency via random effects.

Results: Twenty-seven participants (median age = 29 years) contributed 7,853 person-days. Individual analysis showed that only a small (n = 2) number of participants had a weak relationship between ASM adherence with seizure occurrence. Group-level analysis showed that seizure occurrence was highly linked to the Napkin method, but not ASM adherence.

Interpretation: Among individuals with frequent, drug-resistant epilepsy, occasional missed ASM doses did not measurably raise immediate seizure risk. Whereas sustained nonadherence remains a clinical concern, clinicians may reassure patients that infrequent brief lapses are unlikely to trigger seizures acutely, yet they should continue emphasizing overall adherence for long-term seizure control. ANN NEUROL 2026.

目的:本研究的目的是确定缺少抗癫痫药物(asm)是否会增加耐药癫痫患者的短期发作风险。方法:在一项前瞻性社区队列研究中,成人耐药癫痫患者(≥3次发作/月)或其护理人员分别用智能手机应用记录10个月的癫痫发作和ASM摄入量。个体水平分析模拟了ASM依从性与癫痫发作之间的关系,以及通过90天移动平均线(“餐巾法”)简化的癫痫发作预测。使用混合效应模型进行群体水平分析,以检验ASM依从性与简化预测之间的关系,同时通过随机效应控制个体癫痫发作频率的差异。结果:27名参与者(中位年龄= 29岁)贡献了7,853人次。个体分析显示,只有一小部分(n = 2)参与者在ASM依从性与癫痫发作之间存在弱关系。组水平分析显示癫痫发作与Napkin方法高度相关,但与ASM依从性无关。解释:在频繁的耐药癫痫患者中,偶尔错过ASM剂量并没有明显增加立即发作的风险。鉴于持续的不依从性仍然是临床关注的问题,临床医生可以向患者保证,不频繁的短暂失误不太可能引发急性癫痫发作,但他们应该继续强调长期癫痫发作控制的总体依从性。Ann neurol 2026。
{"title":"Does Missing Medication Acutely Change Seizure Risk? A Prospective Study.","authors":"Daniel M Goldenholz, Joshua C Cheng, Chi-Yuan Chang, Robert Moss, M Brandon Westover","doi":"10.1002/ana.78134","DOIUrl":"10.1002/ana.78134","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to determine whether missing individual doses of anti-seizure medications (ASMs) elevate short-term seizure risk in people with drug-resistant epilepsy.</p><p><strong>Methods: </strong>In a prospective, community-based cohort, adults with drug-resistant epilepsy (≥ 3 seizures/month) or their caregivers recorded seizures and ASM intake with smartphone applications for 10 months each. Individual level analysis modeled the relationships between ASM adherence with seizure occurrence, as well as with a simplified seizure forecast via a 90-day moving average (\"Napkin method\"). Group-level analysis with a mixed-effects model was performed to examine the relationship between ASM adherence and simplified forecasts, while controlling for differences in individual seizure frequency via random effects.</p><p><strong>Results: </strong>Twenty-seven participants (median age = 29 years) contributed 7,853 person-days. Individual analysis showed that only a small (n = 2) number of participants had a weak relationship between ASM adherence with seizure occurrence. Group-level analysis showed that seizure occurrence was highly linked to the Napkin method, but not ASM adherence.</p><p><strong>Interpretation: </strong>Among individuals with frequent, drug-resistant epilepsy, occasional missed ASM doses did not measurably raise immediate seizure risk. Whereas sustained nonadherence remains a clinical concern, clinicians may reassure patients that infrequent brief lapses are unlikely to trigger seizures acutely, yet they should continue emphasizing overall adherence for long-term seizure control. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis. 与脑萎缩相关的风险变异rs10191329扩展到多发性硬化症之外
IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-05 DOI: 10.1002/ana.78148
Cato E A Corsten, Ana M Marques, Elisabeth J Vinke, C Louk de Mol, Rinze F Neuteboom, M Kamran Ikram, Mohsen Ghanbari, Frank J Wolters, Beatrijs Wokke, Meike W Vernooij, Joost Smolders

The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age-related brain atrophy in a population-based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross-sectional and longitudinal analyses. We observed associations between the rs10191329*A allele and lower total brain volume and gray matter volume in middle-aged (< 55 years of age), but not in older participants. These data suggest that rs10191329*A contributes to earlier onset of atrophy in the general population, and that mediating mechanisms of accelerated neurodegeneration extend beyond MS. ANN NEUROL 2026.

风险等位基因rs10191329*A与多发性硬化症(MS)患者的疾病严重程度和脑萎缩有关。在一项以人群为基础的队列研究中,我们对4815名年龄≥45岁、无MS的参与者进行了10308次磁共振成像(MRI)扫描,并进行了横断面和纵向分析,研究了rs10191329与年龄相关性脑萎缩的关系。我们观察到rs10191329*A等位基因与中年人群总脑容量和灰质体积的降低有关。
{"title":"Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis.","authors":"Cato E A Corsten, Ana M Marques, Elisabeth J Vinke, C Louk de Mol, Rinze F Neuteboom, M Kamran Ikram, Mohsen Ghanbari, Frank J Wolters, Beatrijs Wokke, Meike W Vernooij, Joost Smolders","doi":"10.1002/ana.78148","DOIUrl":"https://doi.org/10.1002/ana.78148","url":null,"abstract":"<p><p>The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age-related brain atrophy in a population-based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross-sectional and longitudinal analyses. We observed associations between the rs10191329*A allele and lower total brain volume and gray matter volume in middle-aged (< 55 years of age), but not in older participants. These data suggest that rs10191329*A contributes to earlier onset of atrophy in the general population, and that mediating mechanisms of accelerated neurodegeneration extend beyond MS. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Neurology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1