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Reply to “Comprehensive Analysis of Sex Differences in Amyotrophic Lateral Sclerosis Prognosis and Disease Progression” 对 "肌萎缩侧索硬化症预后和疾病进展的性别差异综合分析 "的答复
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-09 DOI: 10.1002/ana.27095
Maurizio Grassano MD, Cristina Moglia MD, PhD, Francesca Palumbo MD, Emanuele Koumantakis MD, Paolo Cugnasco, Stefano Callegaro MSc, Antonio Canosa MD, PhD, Umberto Manera MD, Rosario Vasta MD, PhD, Filippo De Mattei MD, Enrico Matteoni MD, Giuseppe Fuda MSc, Paolina Salamone PhD, Giulia Marchese BSc, Federico Casale PhD, Fabiola De Marchi MD, PhD, Letizia Mazzini MD, Gabriele Mora MD, Andrea Calvo MD, PhD, Adriano Chiò MD, FAAN
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引用次数: 0
Relapse-Associated and Relapse-Independent Contribution to Overall Expanded Disability Status Scale Progression in Multiple Sclerosis Patients Diagnosed in Different Eras. 不同时期确诊的多发性硬化症患者的复发相关性和复发依赖性对总体残疾状况扩展量表进展的影响
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-09 DOI: 10.1002/ana.27093
Noemi Montobbio, Cinzia Cordioli, Alessio Signori, Francesca Bovis, Ruggero Capra, Maria Pia Sormani

Objective: The introduction of disease-modifying therapies for multiple sclerosis (MS) has led to a deceleration of disease course over the years. Although decreased relapse rate constitutes a factor, the role of relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA) in MS course deceleration is still unclear.

Methods: We retrospectively examined long-term Expanded Disability Status Scale (EDSS) progression in patients referred to the MS Center of Montichiari (Italy) and diagnosed with relapsing-remitting MS from 1980 to 2022. To isolate PIRA, we deducted all EDSS changes associated with relapses from overall EDSS change. We compared the relative contribution of PIRA and RAW to EDSS progression in patients diagnosed in different periods using mixed-effects models.

Results: A total of 1,405 patients were included in the study, of whom 231 were diagnosed in 1980-1996 (pre-treatment era), 577 in 1997-2008 (injectable disease-modifying therapy era), and 597 after 2008 (oral drugs, monoclonal antibodies, and anti-CD20 era). Across ages, both PIRA and RAW were reduced in patients diagnosed in more recent periods as compared with earlier periods. The average contribution of PIRA to overall EDSS progression was already predominant in patients diagnosed in 1980-1996 (78%) and in 1997-2008 (76%), but it was significantly increased (p = 0.0009) in patients diagnosed in later years (87%).

Interpretation: The deceleration of MS course observed throughout the years is determined not only by fewer RAW events, but also by a reduction in PIRA. However, the shift toward a mostly relapse-independent progression highlights the importance of evaluating new therapies based on their effect on PIRA. ANN NEUROL 2024.

目的:多年来,针对多发性硬化症(MS)的疾病改变疗法的引入导致了病程的减缓。虽然复发率下降是一个因素,但复发相关恶化(RAW)和独立于复发活动的进展(PIRA)在多发性硬化病程减速中的作用仍不清楚:我们回顾性研究了1980年至2022年期间转诊至意大利蒙蒂奇亚里多发性硬化症中心并被诊断为复发缓解型多发性硬化症患者的长期扩展残疾状态量表(EDSS)进展情况。为了分离出 PIRA,我们从 EDSS 整体变化中扣除了所有与复发相关的 EDSS 变化。我们使用混合效应模型比较了PIRA和RAW对不同时期确诊患者EDSS进展的相对贡献:研究共纳入了 1,405 例患者,其中 231 例确诊于 1980-1996 年(前治疗时代),577 例确诊于 1997-2008 年(可注射的疾病修饰疗法时代),597 例确诊于 2008 年之后(口服药物、单克隆抗体和抗 CD20 时代)。从各年龄段来看,近期诊断的患者的 PIRA 和 RAW 均低于早期诊断的患者。在1980-1996年(78%)和1997-2008年(76%)确诊的患者中,PIRA对总体EDSS进展的平均贡献率已占主导地位,但在晚期确诊的患者(87%)中,PIRA的贡献率显著增加(p = 0.0009):多年来观察到的多发性硬化症病程减慢不仅取决于 RAW 事件的减少,还取决于 PIRA 的减少。然而,向大部分不依赖复发进展的转变凸显了根据对 PIRA 的影响评估新疗法的重要性。ann neurol 2024.
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引用次数: 0
Letter on Multiple Acyl-Coenzyme A Dehydrogenase Deficiency is Associated with Sertraline Use 关于多种酰基辅酶 A 脱氢酶缺乏症与使用舍曲林有关的信函。
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-08 DOI: 10.1002/ana.27101
Yusen Qiu, Min Zhu, Dandan Tan, Daojun Hong
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引用次数: 0
MuSK-Myasthenia Gravis and Cancer MuSK-Myasthenia Gravis 与癌症。
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-08 DOI: 10.1002/ana.27094
Shigeaki Suzuki MD, PhD, Kimiaki Utsugisawa MD, PhD
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引用次数: 0
Reply to “MuSK-Myasthenia Gravis and Cancer” 回复 "MuSK-肌萎缩症与癌症"。
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-04 DOI: 10.1002/ana.27091
Silvia Falso MD, Raffaele Iorio MD, PhD
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引用次数: 0
Pro-Ictal EEG Scheduling Improves the Yield of Epilepsy Monitoring: Validating the Use of Multiday Seizure Cycles to Optimize Video-EEG Timing. 前直肠脑电图调度提高了癫痫监测的收益率:验证使用多日发作周期来优化视频脑电图时间。
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1002/ana.27078
Jodie Naim-Feil, Rachel E Stirling, Philippa J Karoly, Daniel Payne, Nicholas Winterling, Dominique Eden, Mark J Cook, David B Grayden, Matias Maturana, Dean R Freestone, Ewan S Nurse

Objective: A significant challenge of video-electroencephalography (vEEG) in epilepsy diagnosis is timing monitoring sessions to capture epileptiform activity. In this study, we introduce and validate "pro-ictal EEG scheduling", a method to schedule vEEG monitoring to coincide with periods of increased seizure likelihood as a low-risk approach to enhance the diagnostic yield.

Methods: A database of long-term ambulatory vEEG monitoring sessions (n = 5,038) of adults and children was examined. Data from linked electronic seizure diaries were extracted (minimum 10 self-reported events) to generate cycle-based estimates of seizure risk. In adults, vEEG monitoring sessions coinciding with periods of estimated high-risk were allocated to the high-risk group (n = 305) and compared to remaining studies (baseline: n = 3,586). Test of proportions and risk-ratios (RR) were applied to index differences in proportions and likelihood of capturing outcome measures (abnormal report, confirmed seizure, and diary event) during monitoring. The impact of clinical and demographic factors (age, sex, epilepsy-type, and medication) was also explored.

Results: During vEEG monitoring, the high-risk group was significantly more likely to have an abnormal vEEG report (190/305:62% vs 1,790/3,586:50% [%change = 12%], RR = 1.25, 95% confidence interval [CI] = [1.137-1.370], p < 0.001), present with a confirmed seizure (56/305:18% vs 424/3,586:11% [%change = 7%], RR = 1.63, 95% CI = [1.265-2.101], p < 0.001) and report an event (153/305:50% vs 1,267/3,586:35% (%change = 15%), RR = 1.420, 95% CI = [1.259:1.602], p < 0.001). Similar effects were observed across clinical and demographic features.

Interpretation: This study provides the first large-scale validation of pro-ictal EEG scheduling in improving the yield of vEEG. This innovative approach offers a pragmatic and low-risk strategy to enhance the diagnostic capabilities of vEEG monitoring, significantly impacting epilepsy management. ANN NEUROL 2024.

目的:视频脑电图(vEEG)在癫痫诊断中面临的一个重大挑战是如何把握监测时间以捕捉癫痫样活动。在本研究中,我们介绍并验证了 "发作前脑电图调度",这是一种在癫痫发作可能性增加时调度视频脑电图监测的方法,是一种提高诊断率的低风险方法:方法: 研究了一个成人和儿童长期非卧床 vEEG 监测会话数据库(n = 5,038 次)。从关联的电子癫痫发作日记中提取数据(至少 10 次自我报告事件),生成基于周期的癫痫发作风险估计值。在成人中,将与估计高风险期重合的 vEEG 监测时段分配到高风险组(n = 305),并与其余研究(基线:n = 3,586)进行比较。采用比例检验和风险比 (RR) 来衡量监测期间捕获结果指标(异常报告、确诊癫痫发作和日记事件)的比例和可能性的差异。此外,还探讨了临床和人口统计学因素(年龄、性别、癫痫类型和药物治疗)的影响:结果:在 vEEG 监测过程中,高风险组出现异常 vEEG 报告的几率明显更高(190/305:62% vs 1,790/3,586:50% [%change = 12%],RR = 1.25,95% 置信区间 [CI] = [1.137-1.370],p 解释:该研究首次大规模验证了 vEEG 监测对癫痫发作的影响:本研究首次大规模验证了发作前脑电图调度在提高 vEEG 收率方面的作用。这种创新方法提供了一种务实、低风险的策略来提高 vEEG 监测的诊断能力,从而对癫痫管理产生重大影响。ann neurol 2024。
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引用次数: 0
Prevalence and Distribution of Intracranial Vessel Occlusion on Angiography and Its Association with Functional Outcome in Patients with Atrial Fibrillation Presenting with Ischemic Stroke. 血管造影显示颅内血管闭塞的发生率和分布及其与心房颤动缺血性卒中患者功能预后的关系
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-30 DOI: 10.1002/ana.27084
Alexander P Benz, Thomas R Meinel, Alexander Salerno, Morin Beyeler, Davide Strambo, Johannes Kaesmacher, Alexandros A Polymeris, Timo Kahles, Mira Katan, Stefan T Engelter, Emmanuel Carrera, Elisabeth Dirren, Nils Peters, Carlo W Cereda, Georg Kägi, Susanne Renaud, Susanne Wegener, Manuel Bolognese, Leo H Bonati, Urs Fischer, Marcel Arnold, Patrik Michel, Ashkan Shoamanesh, Stuart J Connolly, David J Seiffge

Objectives: To determine the prevalence and distribution of intracranial vessel occlusion identified on computed tomography (CT) or magnet resonance (MR) angiography and to explore its association with functional outcome in patients with atrial fibrillation (AF) and ischemic stroke.

Methods: Multicenter cohort study enrolling consecutive patients with AF with imaging-confirmed ischemic stroke who underwent CT- or MR-angiography on admission (2014-2022). Multivariable regression was used to explore the association between intracranial vessel occlusion and poor functional outcome (modified Rankin Scale score 3-6) at 90 days.

Results: The analysis included 10,164 patients (median age 81.5 years, 47.8% female, median National Institutes of Health Stroke Scale score on admission 6; 14.7% on a vitamin K antagonist [VKA], 27.5% on a direct oral anticoagulant [DOAC], 57.8% not receiving oral anticoagulation). Angiography showed intracranial vessel occlusion in 5,190 patients (51.1%), affecting the anterior cerebral circulation in 87.4%. Overall, 29.2% and 29.4% of patients received thrombolysis and mechanical thrombectomy, respectively. The proportion of patients with poor functional outcome at 90 days was 60.6% and 42.7% in those with and without vessel occlusion, respectively. In multivariable analyses, vessel occlusion was associated with poor functional outcome (adjusted odds ratio [aOR]: 1.95, 95% confidence interval [CI]: 1.71-2.22) with consistent results in subgroups according to oral anticoagulation use (VKA, aOR: 1.98, 95% CI: 1.40-2.80; DOAC, aOR: 2.35, 95% CI: 1.83-3.03; none, aOR: 1.76, 95% CI: 1.49-2.09).

Interpretation: Intracranial vessel occlusion is common in patients with AF with ischemic stroke, mainly affects the anterior circulation and is associated with poor functional outcome. ANN NEUROL 2024.

研究目的确定计算机断层扫描(CT)或磁共振(MR)血管造影确定的颅内血管闭塞的发生率和分布情况,并探讨其与心房颤动(AF)和缺血性卒中患者功能预后的关系:多中心队列研究:研究对象为入院时接受 CT 或 MR 血管造影检查(2014-2022 年)、影像学确诊为缺血性卒中的连续房颤患者。研究采用多变量回归法探讨颅内血管闭塞与90天后不良功能预后(改良Rankin量表评分3-6分)之间的关系:分析包括 10,164 名患者(中位年龄 81.5 岁,47.8% 为女性,入院时美国国立卫生研究院卒中量表中位评分 6 分;14.7% 正在服用维生素 K 拮抗剂 [VKA],27.5% 正在服用直接口服抗凝剂 [DOAC],57.8% 未接受口服抗凝治疗)。血管造影显示,5190 名患者(51.1%)出现颅内血管闭塞,其中 87.4% 影响到大脑前循环。总体而言,分别有 29.2% 和 29.4% 的患者接受了溶栓治疗和机械性血栓切除术。90天后功能预后不良的患者比例在血管闭塞和未闭塞的患者中分别为60.6%和42.7%。在多变量分析中,血管闭塞与功能预后不佳相关(调整后比值比[aOR]:1.95,95% 置信区间[CI]:1.71-2.22),根据口服抗凝药的使用情况(VKA,aOR:1.98,95% CI:1.40-2.80;DOAC,aOR:2.35,95% CI:1.83-3.03;无,aOR:1.76,95% CI:1.49-2.09)在亚组中结果一致:颅内血管闭塞在房颤伴缺血性卒中患者中很常见,主要影响前循环,与功能预后不良有关。ann neurol 2024.
{"title":"Prevalence and Distribution of Intracranial Vessel Occlusion on Angiography and Its Association with Functional Outcome in Patients with Atrial Fibrillation Presenting with Ischemic Stroke.","authors":"Alexander P Benz, Thomas R Meinel, Alexander Salerno, Morin Beyeler, Davide Strambo, Johannes Kaesmacher, Alexandros A Polymeris, Timo Kahles, Mira Katan, Stefan T Engelter, Emmanuel Carrera, Elisabeth Dirren, Nils Peters, Carlo W Cereda, Georg Kägi, Susanne Renaud, Susanne Wegener, Manuel Bolognese, Leo H Bonati, Urs Fischer, Marcel Arnold, Patrik Michel, Ashkan Shoamanesh, Stuart J Connolly, David J Seiffge","doi":"10.1002/ana.27084","DOIUrl":"https://doi.org/10.1002/ana.27084","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence and distribution of intracranial vessel occlusion identified on computed tomography (CT) or magnet resonance (MR) angiography and to explore its association with functional outcome in patients with atrial fibrillation (AF) and ischemic stroke.</p><p><strong>Methods: </strong>Multicenter cohort study enrolling consecutive patients with AF with imaging-confirmed ischemic stroke who underwent CT- or MR-angiography on admission (2014-2022). Multivariable regression was used to explore the association between intracranial vessel occlusion and poor functional outcome (modified Rankin Scale score 3-6) at 90 days.</p><p><strong>Results: </strong>The analysis included 10,164 patients (median age 81.5 years, 47.8% female, median National Institutes of Health Stroke Scale score on admission 6; 14.7% on a vitamin K antagonist [VKA], 27.5% on a direct oral anticoagulant [DOAC], 57.8% not receiving oral anticoagulation). Angiography showed intracranial vessel occlusion in 5,190 patients (51.1%), affecting the anterior cerebral circulation in 87.4%. Overall, 29.2% and 29.4% of patients received thrombolysis and mechanical thrombectomy, respectively. The proportion of patients with poor functional outcome at 90 days was 60.6% and 42.7% in those with and without vessel occlusion, respectively. In multivariable analyses, vessel occlusion was associated with poor functional outcome (adjusted odds ratio [aOR]: 1.95, 95% confidence interval [CI]: 1.71-2.22) with consistent results in subgroups according to oral anticoagulation use (VKA, aOR: 1.98, 95% CI: 1.40-2.80; DOAC, aOR: 2.35, 95% CI: 1.83-3.03; none, aOR: 1.76, 95% CI: 1.49-2.09).</p><p><strong>Interpretation: </strong>Intracranial vessel occlusion is common in patients with AF with ischemic stroke, mainly affects the anterior circulation and is associated with poor functional outcome. ANN NEUROL 2024.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balamuthia Mandrillaris Encephalitis Post-Raw Beef Ingestion. 生牛肉摄入后的山魈巴尔拉姆斯脑炎。
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-26 DOI: 10.1002/ana.27082
Yongqin Xiong, Xin Lou
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引用次数: 0
MEK Pathway Inhibitor-Mediated Response in BRAF V600-Mutant Melanoma with Brain Parenchymal and Leptomeningeal Metastases. MEK 通路抑制剂对伴有脑实质和脑膜转移的 BRAF V600 突变黑色素瘤的反应
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-26 DOI: 10.1002/ana.27062
Saud Alhusaini, Lewis Naya, Sunil A Reddy, Chirag B Patel
{"title":"MEK Pathway Inhibitor-Mediated Response in BRAF V600-Mutant Melanoma with Brain Parenchymal and Leptomeningeal Metastases.","authors":"Saud Alhusaini, Lewis Naya, Sunil A Reddy, Chirag B Patel","doi":"10.1002/ana.27062","DOIUrl":"https://doi.org/10.1002/ana.27062","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease. 干扰素刺激基因表达是原发性线粒体疾病的生物标志物
IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-25 DOI: 10.1002/ana.27081
Nandaki Keshavan, Lana Mhaldien, Kimberly Gilmour, Shamima Rahman

Objective: Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD).

Methods: Expression of interferon stimulated genes (ISGs) was measured by real-time polymerase chain reaction (PCR) in whole blood samples from a cohort of patients with PMD.

Results: Upregulated ISG expression was observed in a high proportion (41/55, 75%) of patients with PMD on at least 1 occasion, most frequently IFI27 upregulation, seen in 50% of the samples. Some patients had extremely high IFI27 levels, similar to those seen in patients with primary interferonopathies. A statistically significant correlation was observed between elevated IFI27 gene expression and PMD, but not between IFI27 and secondary mitochondrial dysfunction, suggesting that ISG upregulation is a biomarker of PMD. In some patients with PMD, ISG abnormalities persisted on repeat measurement over several years, indicative of ongoing chronic inflammation. Subgroup analyses suggested common ISG signatures in patients with similar mitochondrial disease mechanisms and positive correlations with disease severity among patients with identical genetic diagnoses.

Interpretation: Dysregulated interferon signaling is frequently seen in patients with PMD suggesting that interferon dysregulation is a contributor to pathophysiology. This may indicate a role for repurposing of immunomodulatory therapies for the treatment of PMDs by targeting interferon signaling. ANN NEUROL 2024.

目的线粒体与先天性免疫反应的调节有关。我们假设干扰素信号传导异常可能会导致原发性线粒体疾病(PMD)患者的病理生理学:方法:在一组原发性线粒体病(PMD)患者的全血样本中,通过实时聚合酶链反应(PCR)测量干扰素刺激基因(ISGs)的表达:结果:在很高比例的 PMD 患者(41/55,75%)中至少有一次观察到 ISG 表达上调,最常见的是 IFI27 上调,见于 50%的样本中。一些患者的IFI27水平极高,与原发性干扰素病患者的情况类似。据统计,IFI27 基因表达升高与 PMD 之间存在明显的相关性,但 IFI27 与继发性线粒体功能障碍之间不存在相关性,这表明 ISG 上调是 PMD 的生物标志物。在一些 PMD 患者中,ISG 异常在重复测量时持续数年,表明慢性炎症仍在持续。分组分析表明,在具有相似线粒体疾病机制的患者中存在共同的ISG特征,在具有相同基因诊断的患者中,ISG特征与疾病严重程度呈正相关:在 PMD 患者中经常出现干扰素信号失调,这表明干扰素失调是病理生理学的一个因素。这可能表明,以干扰素信号为靶点的免疫调节疗法在治疗原发性骨髓增生异常综合征方面具有重新定位的作用。ann neurol 2024.
{"title":"Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease.","authors":"Nandaki Keshavan, Lana Mhaldien, Kimberly Gilmour, Shamima Rahman","doi":"10.1002/ana.27081","DOIUrl":"https://doi.org/10.1002/ana.27081","url":null,"abstract":"<p><strong>Objective: </strong>Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD).</p><p><strong>Methods: </strong>Expression of interferon stimulated genes (ISGs) was measured by real-time polymerase chain reaction (PCR) in whole blood samples from a cohort of patients with PMD.</p><p><strong>Results: </strong>Upregulated ISG expression was observed in a high proportion (41/55, 75%) of patients with PMD on at least 1 occasion, most frequently IFI27 upregulation, seen in 50% of the samples. Some patients had extremely high IFI27 levels, similar to those seen in patients with primary interferonopathies. A statistically significant correlation was observed between elevated IFI27 gene expression and PMD, but not between IFI27 and secondary mitochondrial dysfunction, suggesting that ISG upregulation is a biomarker of PMD. In some patients with PMD, ISG abnormalities persisted on repeat measurement over several years, indicative of ongoing chronic inflammation. Subgroup analyses suggested common ISG signatures in patients with similar mitochondrial disease mechanisms and positive correlations with disease severity among patients with identical genetic diagnoses.</p><p><strong>Interpretation: </strong>Dysregulated interferon signaling is frequently seen in patients with PMD suggesting that interferon dysregulation is a contributor to pathophysiology. This may indicate a role for repurposing of immunomodulatory therapies for the treatment of PMDs by targeting interferon signaling. ANN NEUROL 2024.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of Neurology
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