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Headache: The Journal of Head and Face Pain最新文献

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Treatment of chronic migraine with medication overuse: A perspective 过度用药治疗慢性偏头痛:一个视角
Pub Date : 2022-05-01 DOI: 10.1111/head.14314
T. Schwedt, Teri Robert, D. Dodick
investigations into potential impacts of the frequency with which the overused medication is taken and patient anxiety on treatment outcomes.
调查过度用药频率和患者焦虑对治疗结果的潜在影响。
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引用次数: 0
Novel ways of approaching the pharmacologic treatment of trigeminal neuralgia 三叉神经痛药物治疗的新途径
Pub Date : 2022-05-01 DOI: 10.1111/head.14316
Moises Dominguez, G. Di Stefano
their randomized, controlled trial on the treatment of TN with intravenous lidocaine. They found that intravenous lidocaine led to significant pain reduction compared to placebo and the effect was maintained for the first 24 h following treatment. 23 In patients with concomitant continuous pain, the effi - cacy of first-line drugs may drop, and both calcium channel blockers (gabapentin and pregabalin) and antidepressants should be tried as an add-on to first-line drugs. Treatment of TN can pose a great challenge for the clinician and can be frustrating for patients. Despite there being effective phar - macologic treatment there are still patients who do not respond and still experience this debilitating facial pain disorder. Novel pharma - cologic treatments are fortunately on the rise and results appear favorable, although more rigorous studies are needed to provide patients with tolerable and effective pharmacologic treatment, ob - viating the need for surgical treatment, which poses risks in and of itself
静脉注射利多卡因治疗TN的随机对照试验。他们发现,与安慰剂相比,静脉注射利多卡因显著减轻了疼痛,并且这种效果在治疗后的24小时内保持不变。对于伴有持续疼痛的患者,一线药物的疗效可能会下降,钙通道阻滞剂(加巴喷丁和普瑞巴林)和抗抑郁药都应该作为一线药物的补充。TN的治疗对临床医生来说是一个巨大的挑战,对患者来说也是令人沮丧的。尽管有有效的药物治疗,但仍然有患者没有反应,仍然经历这种使人衰弱的面部疼痛障碍。幸运的是,新的药物治疗方法正在增加,结果似乎是有利的,尽管需要更严格的研究来为患者提供可耐受和有效的药物治疗,避免手术治疗的需要,手术治疗本身就有风险
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引用次数: 0
Migraine and balance impairment: Influence of subdiagnosis, otoneurological function, falls, and psychosocial factors 偏头痛和平衡障碍:亚诊断、耳神经功能、跌倒和社会心理因素的影响
Pub Date : 2022-05-01 DOI: 10.1111/head.14309
G. Carvalho, K. Luedtke, C. F. Pinheiro, R. Moraes, Tenysson W. Lemos, C. G. Carneiro, M. Bigal, F. Dach, D. Bevilaqua-Grossi
To assess the balance sensory organization among patients with migraine, considering the influence of migraine subdiagnosis, otoneurological function, falls, and psychosocial factors.
考虑偏头痛亚诊断、耳神经功能、跌倒和社会心理因素的影响,评估偏头痛患者的平衡感觉组织。
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引用次数: 7
Different characteristics of cortical spreading depression in the sleep and wake states 睡眠和清醒状态下皮层扩张性抑制的不同特征
Pub Date : 2022-04-25 DOI: 10.1111/head.14300
Dmitri N. Yousef Yengej, Sinifunanya E Nwaobi, Isabella Ferando, Gayane Kechechyan, A. Charles, G. Faas
The objective of this study is to characterize the effects of the sleep‐wake cycle on neurovascular and behavioral characteristics of cortical spreading depression (CSD).
本研究的目的是表征睡眠-觉醒周期对皮层扩张性抑郁(CSD)的神经血管和行为特征的影响。
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引用次数: 5
Most bothersome symptoms in patients with migraine: A hospital‐based study in Taiwan 偏头痛患者最恼人的症状:台湾一项基于医院的研究
Pub Date : 2022-04-25 DOI: 10.1111/head.14308
Yi-Hsien Tu, Yen-Feng Wang, Hsiangkuo Yuan, Shih-Pin Chen, Yi-Shiang Tzeng, Wei-Ta Chen, K. Lai, Yu-Hsiang Ling, Shuu-Jiun Wang
To investigate the distribution, clinical associations, and treatment responses for the most bothersome symptoms of migraine in a large sample of patients with migraine in Taiwan.
目的探讨台湾大样本偏头痛患者最恼人症状的分布、临床关联及治疗反应。
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引用次数: 2
Impact of the 2018 Japan Floods on prescriptions for migraine: A longitudinal analysis using the National Database of Health Insurance Claims 2018年日本洪水对偏头痛处方的影响:使用国家健康保险索赔数据库的纵向分析
Pub Date : 2022-04-25 DOI: 10.1111/head.14301
Yuji Okazaki, Shuhei Yoshida, S. Kashima, S. Koike, M. Matsumoto
To determine the impact of the 2018 Japan Floods, one of the largest water disasters in Japan, on the number of prescriptions for triptans and ergotamine (acute treatment).
为了确定日本最大的水灾之一——2018年日本洪水对曲坦类药物和麦角胺(急性治疗)处方数量的影响。
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引用次数: 3
Network meta-analysis of therapies for cluster headache: Effects of acute therapies for episodic and chronic cluster. 丛集性头痛治疗的网络荟萃分析:急性治疗对发作性和慢性丛集性头痛的影响。
Pub Date : 2022-04-01 Epub Date: 2022-03-28 DOI: 10.1111/head.14283
Ioana Medrea, Suzanne Christie, Stewart J Tepper, Kednapa Thavorn, Brian Hutton

Objective: We used network meta-analysis (NMA) to characterize the relative effectiveness and harms of acute treatment options for cluster headache.

Background: There are few evidence-based acute treatments available for cluster headache. As most treatments were compared only against placebos in clinical trials, few head-to-head comparisons of treatments are available.

Methods: An a priori registered scoping review was performed to identify randomized controlled trials evaluating treatments in adult patients (>18 years old) with cluster headache per accepted diagnostic criteria. Bayesian NMAs were performed to compare treatments in terms of headache relief at 15 or 30 min, and also the occurrence of adverse events. We report odds ratios (ORs) of relative treatment effects along with corresponding 95% credible intervals (CrIs), as well as measures of treatment ranking.

Results: A total of 13 randomized controlled trials informed NMAs. We found high flow oxygen to be the most effective therapy for headache response at 15 and 30 min (OR 9.0, 95% CrI 5.3 to 15.9 vs. placebo), with injectable sumatriptan demonstrating the next highest effect (OR 6.4, 95% CrI 3.75 to 11.1 vs. placebo). High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non-invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9). Sumatriptan injectable was also effective for headache relief and was found to be better than nasal spray zolmitriptan (OR 2.67, 95% CrI 1.21 to 5.9), octreotide (OR 3.20, 95% CrI 1.17 to 8.8), and nVNS (OR 3.69, 95% CrI 1.63 to 8.4). Octreotide (OR 4.1, 95% CrI 1.71 to 10.5) and sumatriptan (OR 2.40, 95% CrI 1.39 to 4.2) were associated with greater risk of adverse events compared to placebo, while other treatments did not demonstrate increased risk. When focusing on patients with episodic cluster headache, nVNS was significantly better than placebo (OR 4.9, 95% CrI 1.89 to 14.1).

Conclusions: Our findings suggest that high flow oxygen is more efficacious when compared to low flow oxygen for headache relief. When low flow oxygen fails in patients who can tolerate oxygen, increased flow rates should be tried. Additionally, high flow oxygen is likely more effective than zolmitriptan nasal spray, nVNS, and octreotide. Sumatriptan injectable is more likely to be effective when compared to zolmitriptan nasal spray, octreotide, and nVNS.

目的:我们使用网络荟萃分析(NMA)来描述丛集性头痛急性治疗方案的相对有效性和危害。背景:目前针对丛集性头痛的循证急性治疗方法很少。由于大多数治疗方法在临床试验中只与安慰剂进行比较,因此很少有治疗方法的正面比较。方法:根据公认的诊断标准,对丛集性头痛成年患者(bb0 ~ 18岁)进行随机对照试验评价治疗。采用贝叶斯nma来比较治疗在15或30分钟时头痛缓解情况以及不良事件的发生情况。我们报告了相对治疗效果的优势比(ORs)以及相应的95%可信区间(CrIs),以及治疗排名的衡量标准。结果:共有13项随机对照试验为nma提供了信息。我们发现高流量氧是15分钟和30分钟头痛反应最有效的治疗方法(OR 9.0, 95% CrI 5.3至15.9,与安慰剂相比),注射舒马曲坦显示出第二高的效果(OR 6.4, 95% CrI 3.75至11.1,与安慰剂相比)。高流量氧也比低流量氧(OR 2.55, 95% CrI 1.13至5.8)、鼻腔喷雾剂唑米曲坦(OR 3.75, 95% CrI 1.72至8.4)、奥曲肽(OR 4.5, 95% CrI 1.64至12.5)和无创迷走神经刺激(nVNS;OR为5.2,95% CrI为2.29 - 11.9)。注射舒马曲坦也能有效缓解头痛,并且优于鼻腔喷雾剂唑米曲坦(OR 2.67, 95% CrI 1.21至5.9)、奥曲肽(OR 3.20, 95% CrI 1.17至8.8)和nVNS (OR 3.69, 95% CrI 1.63至8.4)。与安慰剂相比,奥曲肽(OR 4.1, 95% CrI 1.71至10.5)和舒马曲坦(OR 2.40, 95% CrI 1.39至4.2)与更大的不良事件风险相关,而其他治疗并未显示出风险增加。当专注于发作性丛集性头痛患者时,nVNS显着优于安慰剂(OR 4.9, 95% CrI 1.89至14.1)。结论:我们的研究结果表明,与低流量氧气相比,高流量氧气在缓解头痛方面更有效。当能够耐受氧气的患者出现低流量氧气失败时,应尝试增加流量。此外,高流量氧可能比唑米曲坦鼻喷雾剂、nVNS和奥曲肽更有效。与佐米曲坦鼻喷雾剂、奥曲肽和nVNS相比,舒马曲坦注射可能更有效。
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引用次数: 0
Current practice for primary headache disorders and perspectives on peripheral nerve blocks among emergency physicians in Canada: A national survey 加拿大急诊医生对原发性头痛疾病的当前实践和周围神经阻滞的看法:一项全国性调查
Pub Date : 2022-04-01 DOI: 10.1111/head.14293
Dilan Patel, M. Taljaard, K. Yadav, Daniella James, J. Perry
This national postal survey aimed to examine Canadian emergency physicians’ practice patterns with respect to drug treatment and perspectives on peripheral nerve blocks.
这项全国邮政调查旨在检查加拿大急诊医生在药物治疗和周围神经阻滞方面的实践模式。
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引用次数: 4
Do behavioral treatments work for migraine prevention? 行为疗法对预防偏头痛有效吗?
Pub Date : 2022-03-16 DOI: 10.1111/head.14290
E. Seng, R. Lipton
migraine symptoms, attack frequency, and/or migraine- related disability. Further, migraine is a highly stigmatized disorder; people with migraine are sometimes labelled “hysterical,” and may have been dismissed as attention- seekers unable to cope with routine life stressors. Using the terminology “behavioral treatments” can com municate more effectively to patients that we do not see migraine disease as psychological in origin, but instead we are recommending targeted migraine- focused behavior change that has a biologically plausible rationale and has demonstrated efficacy to reduce mi graine symptoms and disability. and
偏头痛症状、发作频率和/或偏头痛相关残疾。此外,偏头痛是一种高度污名化的疾病;偏头痛患者有时被贴上“歇斯底里”的标签,并可能被认为是无法应对日常生活压力的注意力寻求者。使用“行为治疗”这一术语可以更有效地与患者沟通,我们并不认为偏头痛是心理上的疾病,相反,我们推荐有针对性的偏头痛行为改变,这种行为改变具有生物学上合理的理由,并已证明有效减少偏头痛症状和残疾。和
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引用次数: 2
Asking the right questions: The value of headache specialty care 提出正确的问题:头痛专科护理的价值
Pub Date : 2022-03-16 DOI: 10.1111/head.14288
Brad C Klein
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Headache: The Journal of Head and Face Pain
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