Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.
{"title":"Effect of Pantoprazole in the Treatment of Peptic Ulcer Complicated with PUCH (Upper Gastrointestinal Hemorrhage)","authors":"Tang-lei Shao","doi":"10.47939/mh.v2i1.104","DOIUrl":"https://doi.org/10.47939/mh.v2i1.104","url":null,"abstract":"Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.","PeriodicalId":12906,"journal":{"name":"Herald of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70463765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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