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[Disseminated sclerotic hypopigmentation with dark skin coloring]. [散发性硬化性色素沉着伴深色皮肤]。
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2025-06-01 DOI: 10.1007/s00105-020-04649-5
Aleksander Markovic, Jan Christoph Simon, Henriette Kirsten, Johannes Kohlmann, Manfred Kunz
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引用次数: 0
Schnitzler syndrome. 施尼茨勒综合征
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2025-06-01 DOI: 10.1007/s00105-019-4434-4
F F Gellrich, C Günther

Schnitzler syndrome is a very rare acquired systemic disease with many similarities to hereditary autoinflammatory syndromes. The main characteristics are generalized exanthema and IgM monoclonal gammopathy. Other clinical features include fever, muscle, bone, and/or joint pain, and lymphadenopathy. About 15-20% of patients with Schnitzler syndrome develop lymphoproliferative diseases and, in rare cases, amyloid A (AA) amyloidosis can occur if the disease is not treated. Activation of the innate immune system, especially interleukin (IL)-1β, is central to the pathogenesis of disease. Consequently, complete control of disease symptoms can be achieved in 80% of patients by treatment with the IL-1 receptor antagonist anakinra.

施尼茨勒综合征是一种非常罕见的获得性系统疾病，与遗传性自身炎症综合征有许多相似之处。其主要特征是全身性红斑和 IgM 单克隆抗体阳性。其他临床特征包括发热、肌肉、骨骼和/或关节疼痛以及淋巴结病。约 15-20% 的施尼茨勒综合征患者会发展为淋巴组织增生性疾病，在极少数情况下，如果不进行治疗，可能会发生淀粉样蛋白 A（AA）淀粉样变性。先天性免疫系统的激活，尤其是白细胞介素（IL）-1β，是疾病发病机制的核心。因此，通过使用IL-1受体拮抗剂anakinra治疗，80%的患者可以完全控制疾病症状。
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引用次数: 0
Skin damage by tropospheric ozone. 对流层臭氧对皮肤的伤害
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2025-06-01 DOI: 10.1007/s00105-018-4319-y
K B Fuks, B Woodby, G Valacchi

Tropospheric (ground level) ozone (O3) is a secondary pollutant, emerging from other pollutants in the sunshine. Exposure to O3 correlates with higher pulmonary and cardiovascular mortality and affects reproductive health and the central nervous system acutely and chronically. Skin might be a potentially overlooked target organ of ambient O3. The experimental evidence suggests a positive correlation of O3 exposure with oxidative damage, impaired antioxidant defence and proinflammatory response in the skin. In time series studies it was observed that acute rises in O3 levels correlated with seeking medical help for skin conditions; however, whether these findings are specific to O3, is not yet clear. There is preliminary epidemiological evidence that long-term exposure to O3 is associated with premature skin aging. This finding was independent of co-exposure to other environmental factors affecting skin (e.g. ultraviolet radiation and air pollution). As concentrations of O3 are rising in many regions of the world, adverse cutaneous effects of O3 present a relevant public health concern.

对流层（地面）臭氧（O3）是一种二次污染物，从阳光中的其他污染物中产生。暴露于 O3 与较高的肺部和心血管死亡率相关，并对生殖健康和中枢神经系统造成急性和慢性影响。皮肤可能是环境中 O3 潜在的被忽视的靶器官。实验证据表明，暴露于 O3 与皮肤的氧化损伤、抗氧化防御受损和促炎反应呈正相关。在时间序列研究中观察到，臭氧水平的急剧上升与皮肤病的求医相关；但是，这些发现是否是针对臭氧的，尚不清楚。有初步流行病学证据表明，长期暴露于 O3 与皮肤过早老化有关。这一发现与同时暴露于影响皮肤的其他环境因素（如紫外线辐射和空气污染）无关。由于世界许多地区的臭氧浓度正在上升，臭氧对皮肤的不良影响已成为一个相关的公共健康问题。
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引用次数: 0
Lanadelumab Lanadelumab
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2023-06-01 DOI: 10.1007/s40278-023-41083-y
{"title":"Lanadelumab","authors":"","doi":"10.1007/s40278-023-41083-y","DOIUrl":"https://doi.org/10.1007/s40278-023-41083-y","url":null,"abstract":"","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"1960 1","pages":"255 - 255"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52672378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Grey discoloration of the skin in a female goldsmith]. [女金匠皮肤上的灰色斑点]。
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-06-01 Epub Date: 2021-08-24 DOI: 10.1007/s00105-021-04877-3
Bettina Santler, Dieter Metze, Peter Fritz Schmidt, Kerstin Steinbrink, Markus Böhm
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引用次数: 0
Innovative eCME courses-an approach with tangible augmented reality. 创新的eCME课程-一种使用有形增强现实的方法。
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-06-01 Epub Date: 2022-02-23 DOI: 10.1007/s00105-022-04960-3
Klaus Böhm, Wolfram Wiegers, Ralf Dörner
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引用次数: 1
[Chronic brachioradial pruritus in cervical spine meningioma]. [颈脊膜瘤伴慢性肱桡瘙痒]。
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-06-01 Epub Date: 2021-10-05 DOI: 10.1007/s00105-021-04897-z
Julia Wermelt, Sonja Ständer, Manuel P Pereira, Manoj Mannil

We report a case of a 57-year-old slightly obese woman with localized itch on the arms accompanied by stinging and burning sensations. A few excoriations were observed upon clinical examination. The MRI examination of the cervical spine revealed a meningioma at C5/C6 level. The diagnosis of brachioradial pruritus due to compression of the cervical myelon was further supported by a positive ice-pack sign. Disc herniation or prolapse, foraminal stenosis and degenerative alterations constitute other possible causes of brachioradial pruritus.

我们报告一个病例的57岁轻微肥胖的妇女局部瘙痒的手臂伴随刺痛和灼烧的感觉。临床检查发现少量擦伤。颈椎MRI检查显示C5/C6位脑膜瘤。由于压迫颈髓引起的肱桡瘙痒的诊断进一步得到了积极的冰袋征的支持。椎间盘突出或脱垂、椎间孔狭窄和退行性改变是引起肱桡瘙痒的其他可能原因。
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引用次数: 1
Virusinfektionen der Haut 皮肤感染了病毒
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-05-31 DOI: 10.1007/s00105-022-05002-8
A. Kreuter, E. von Stebut
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引用次数: 0
Masern – auch bei Exanthemen nach Fernreisen daran denken 麻疹——在国外旅行时也会想到这个问题
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-05-31 DOI: 10.1007/s00105-022-05008-2
Luisa Bopp, M. Fabri
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引用次数: 0
Virale Exantheme im Kindesalter
4区 医学 Q3 Medicine
Hautarzt
Pub Date : 2022-05-25 DOI: 10.1007/s00105-022-05000-w
Julia Fromme, I. Tantcheva-Poór, R. Fölster‐Holst
{"title":"Virale Exantheme im Kindesalter","authors":"Julia Fromme, I. Tantcheva-Poór, R. Fölster‐Holst","doi":"10.1007/s00105-022-05000-w","DOIUrl":"https://doi.org/10.1007/s00105-022-05000-w","url":null,"abstract":"","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"1997 1","pages":"452 - 460"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78104064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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