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Exploring the Relationship Between Caring and Missed Nursing Care: A Scoping Review. 探究关怀与护理缺失之间的关系:一项范围回顾。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-31 DOI: 10.3390/healthcare14030365
Gregor Romih, Majda Pajnkihar, Dominika Vrbnjak

Background/Objectives: Missed nursing care is a recognized indicator of nursing quality and safety, while caring is a foundational concept in nursing practice. Few studies have empirically examined their relationship. This scoping review aimed to map and synthesize existing evidence on the conceptualisation, measurement approaches, and empirical relationships between caring and missed nursing care. Methods: The review was conducted using JBI methodology, reported according to PRISMA-ScR guidelines, and was registered in the Open Science Framework. Literature was searched in PubMed, CINAHL Ultimate (EBSCOhost), MEDLINE (EBSCOhost), and Web of Science, with additional grey literature searches in ProQuest Dissertations & Theses and Google Scholar. The review included studies examining caring in relation to missed nursing care across any healthcare setting. All study designs were considered. Data were extracted using an extraction tool, developed based on JBI guidelines, and piloted. Data were analyzed descriptively, tabulated, and summarized narratively. Results: Five quantitative cross-sectional studies met the inclusion criteria, conducted between 2012 and 2024 in the Philippines and Slovenia. Caring was assessed using the Caring Behaviors Inventory, Caring Ability Inventory, or CARE-Q, while missed nursing care was measured using the MISSCARE Survey or the Missed Nursing Care Scale. Most studies used Watson's Theory of Human Caring, Duffy's Quality Caring Model, or the Missed Nursing Care Model as theoretical frameworks. Across studies, caring behaviours and caring ability were negatively associated with missed nursing care. Conclusions: Caring can function as a moral and relational ideal and as a measurable and actionable factor related to patient outcomes. However, the evidence base remains limited, with inconsistent theoretical foundations and a lack of experimental studies. Future research should adopt theory-based, experimental approaches with diverse samples to explore causal mechanisms and evaluate strategies that strengthen caring competence and caring organizational cultures.

背景/目的:漏护是衡量护理质量和安全的公认指标,而护理是护理实践中的一个基本概念。很少有研究对它们之间的关系进行实证检验。这个范围审查的目的是绘制和综合现有的证据概念化,测量方法,和护理和错过护理之间的经验关系。方法:采用JBI方法进行综述,根据PRISMA-ScR指南进行报告,并在开放科学框架中注册。在PubMed、CINAHL Ultimate (EBSCOhost)、MEDLINE (EBSCOhost)和Web of Science中检索文献,在ProQuest Dissertations & Theses和谷歌Scholar中检索灰色文献。该综述包括了在任何医疗机构中与错过护理有关的护理研究。所有的研究设计都被考虑在内。使用基于JBI指南开发的提取工具提取数据,并进行试验。对数据进行描述性分析、制表和叙述性总结。结果:2012年至2024年间在菲律宾和斯洛文尼亚进行的5项定量横断面研究符合纳入标准。护理使用护理行为量表、护理能力量表或care - q进行评估,而错过的护理使用MISSCARE调查或错过的护理量表进行测量。大多数研究使用沃森的人类关怀理论、达菲的质量关怀模型或错过护理模型作为理论框架。在研究中,照顾行为和照顾能力与错过护理呈负相关。结论:关怀可以作为一种道德和关系理想,并作为与患者预后相关的可测量和可操作的因素。然而,证据基础仍然有限,理论基础不一致,缺乏实验研究。未来的研究应以理论为基础,采用不同样本的实验方法,探索关怀能力和关怀组织文化强化的因果机制和评价策略。
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引用次数: 0
Association Between Physical Activity Level, Quality of Life Determinants, Internet Use, and Orthorexia Among Sport Science Students Living in Naples: An Observational Study. 居住在那不勒斯的体育科学专业学生的身体活动水平、生活质量决定因素、互联网使用和正常饮食之间的关系:一项观察性研究。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-31 DOI: 10.3390/healthcare14030369
Daniela Vitucci, Sara Dei, Rosa Ghirelli, Agnese Turi, Domenico Martone, Andreina Alfieri, Stefania Orrù, Annamaria Mancini, Pasqualina Buono

Background: In recent years, growing attention has been paid to the lifestyle factors that influence young adults' well-being. University students represent young adults at risk of Sedentary Behavior (SB) and mental distress. Sport Science students represent a health-conscious population, less prone to mental distress. This study aims to investigate the associations between physical activity (PA) levels, different determinants of quality of life (QoL), orthorexia nervosa (ON) symptoms, and internet use among Sport Science students living in Naples.

Methods: An online survey comprising General Data (GD) and eight validated questionnaires was used to assess PA levels, mood, sleep quality, eating habits, and digital behavior in a population of university students enrolled in Sport Science courses at Parthenope University, Naples. The statistical analyses included descriptive statistics, Student's t-test, a Mann-Whitney U Test, frequencies, chi-square tests, and a Spearman's rank correlation. All the analyses were performed using JASP and Jamovi software.

Results: We surveyed 775 students (472 M; 303 F; 22.85 ± 3.85 y; BMI 23.74 ± 3.63 kg/m2). Regarding the MET-min/week, 65% of participants reported being highly active, 28% moderately active, and 7% inactive. Poor sleep quality was reported by 20% of those surveyed. Additionally, 84% of participants declared average internet use, which positively correlated with their emotional profile and sleep quality. High PA levels were directly associated with the presence of ON symptoms in 27% of the participants, most of whom exercised in gyms.

Conclusions: To our knowledge, this is the first study conducted on a study population of Sport Science University students addressing the complex and interconnected relationships between PA levels, QoL, ON symptoms, and internet use.

背景:近年来,影响年轻人幸福感的生活方式因素受到越来越多的关注。大学生代表了有久坐行为和精神困扰风险的年轻人。体育科学专业的学生代表了一个注重健康的群体,不太容易受到精神困扰。本研究旨在探讨生活在那不勒斯的体育科学专业学生的身体活动(PA)水平、生活质量(QoL)的不同决定因素、神经性厌食症(ON)症状和互联网使用之间的关系。方法:一项在线调查包括一般数据(GD)和8份有效问卷,用于评估那不勒斯帕特诺普大学体育科学课程的大学生群体的PA水平、情绪、睡眠质量、饮食习惯和数字行为。统计分析包括描述性统计、学生t检验、Mann-Whitney U检验、频率、卡方检验和Spearman秩相关。采用JASP和Jamovi软件进行分析。结果:共调查775名学生(472 M; 303 F; 22.85±3.85 y; 23.74±3.63 kg/m2)。关于MET-min/周,65%的参与者报告高度活跃,28%中度活跃,7%不活跃。20%的受访者表示睡眠质量差。此外,84%的参与者表示平均使用互联网,这与他们的情绪状况和睡眠质量呈正相关。在27%的参与者中,高PA水平与ON症状的存在直接相关,其中大多数人在健身房锻炼。结论:据我们所知,这是第一次对体育科学大学的学生进行研究,研究PA水平、生活质量、on症状和互联网使用之间复杂而相互关联的关系。
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引用次数: 0
The Psychometric Properties of the Moberg Pick-Up Test (MPUT) to Assess Fine Motor Skills in Adults with Haemophilia. Moberg Pick-Up测试(MPUT)评估成人血友病精细运动技能的心理测量特性。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-31 DOI: 10.3390/healthcare14030368
Arnika Lorenz, Fabian Tomschi, Alexander Schmidt, Holger Stephan, Joschua Wiese, Thomas Hilberg

Background/Objectives: Haemophilia-related bleedings primarily affect the musculoskeletal system, and functional tests are used in clinical management. Yet, fine motor skills of the upper extremities have not been evaluated in adult persons with haemophilia (PwH). The Moberg Pick-Up Test (MPUT) assesses fine motor skills but has only been psychometrically evaluated in other cohorts. This study aims to examine its psychometric properties in PwH. Methods: A total of 40 moderate or severe PwH A or B were included. The MPUT, consisting of three trials, was conducted twice by rater A and once by rater B. The best performance per hand of each MPUT was used. Subjective hand function (Duruöz Hand Index (DHI) and numeric rating scale (NRS)), elbow joint status (Haemophilia Joint Health Score (HJHS)), pain (NRS), and wrist range of motion (ROM) were utilised for convergent validity evaluation. Inter-rater and test-retest reliability were determined through intraclass correlation coefficients (ICCs) for raw and log10-transformed data. Results: Inter-rater and test-retest reliability demonstrated moderate-to-excellent ICCs for both data types (ICC range: 0.624-0.918). The DHI correlated moderately with the average MPUT score of both hands (r = 0.410; p = 0.016). Left-hand MPUT scores did not correlate with left elbow HJHS scores, whereas right-hand MPUT scores correlated with right elbow HJHS scores (r = 0.396, p = 0.018). Subjective left-hand function (NRS) correlated with the results of the MPUT (r = 0.433; p = 0.009). Conclusions: The MPUT is a reliable and partially valid tool and can be useful to assess fine motor skills in PwH.

背景/目的:血友病相关出血主要影响肌肉骨骼系统,功能检查用于临床管理。然而,成人血友病(PwH)患者的上肢精细运动技能尚未得到评估。Moberg拾取测试(MPUT)评估精细运动技能,但仅在其他队列中进行了心理测量学评估。本研究旨在探讨其在PwH中的心理测量特性。方法:选取A、B型中重度PwH患者40例。MPUT由3个试验组成,由评价者A进行2次,由评价者b进行1次。主观手功能(Duruöz手部指数(DHI)和数字评定量表(NRS))、肘关节状态(血友病关节健康评分(HJHS))、疼痛(NRS)和手腕活动范围(ROM)被用于收敛效度评估。通过对原始数据和log10转换数据的类内相关系数(ICCs)来确定测试间和测试重测信度。结果:两种数据类型的间测和重测信度均显示中等至优异的ICC (ICC范围:0.624-0.918)。DHI与双手平均MPUT得分呈正相关(r = 0.410; p = 0.016)。左手MPUT得分与左肘HJHS得分不相关,而右手MPUT得分与右肘HJHS得分相关(r = 0.396, p = 0.018)。主观左手函数(NRS)与MPUT结果相关(r = 0.433; p = 0.009)。结论:MPUT是一种可靠且部分有效的工具,可用于评估PwH患者的精细运动技能。
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引用次数: 0
Ethical Conflicts and Knowledge of the Code of Ethics Among Occupational Therapists in Spain. 西班牙职业治疗师的伦理冲突和道德规范知识。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-31 DOI: 10.3390/healthcare14030367
Daniel Emeric-Méaulle, Pablo A Cantero-Garlito, Ana A Laborda-Soriano

Objective: This study characterized Spanish occupational therapists' knowledge of the national Code of Ethics and perceptions of professional ethics and examined associations with sociodemographic and educational variables. It quantified knowledge of key Code elements (approving body and professional values), described ethics education and participation in formal ethical support structures, and identified resources used to manage ethical conflicts in routine practice. Methods: A descriptive cross-sectional online survey was administered between March and September 2022. The analytical sample included 596 occupational therapists practicing in Spain. The questionnaire assessed participant characteristics, ethics education, knowledge and perceived importance of the Code, participation in ethics committees or similar structures, experience of ethical conflicts, and conflict-management strategies. Descriptive and bivariate analyses were conducted (p < 0.05). Results: Respondents were mostly women (86.6%) and aged 20-40 years. Although 65.3% reported university ethics education and 73.2% rated the Code as important/very important, 11.4% were unaware of its existence. Only 28.2% identified the approving body, and 16.3% correctly identified the professional values included in the Code. Ethical conflicts were reported by 43.1%. When conflicts occurred, respondents most often consulted the interdisciplinary team (25.5%) or occupational therapy colleagues (24.3%), whereas few consulted the Code (4.5%) or an ethics committee (2.7%). Ethics education and greater professional experience were associated with higher Code knowledge. Conclusions: Occupational therapists in Spain endorse professional ethics, yet actionable knowledge and use of the Code and engagement with formal support structures remain limited. Strengthening practice-oriented ethics education and accessible deliberation mechanisms may improve ethical decision-making.

目的:本研究描述了西班牙职业治疗师对国家职业道德规范的了解和职业道德的认知,并研究了与社会人口统计学和教育变量的关联。它量化了关键准则要素(批准机构和专业价值观)的知识,描述了道德教育和参与正式的道德支持结构,并确定了在日常实践中用于管理道德冲突的资源。方法:于2022年3月至9月进行描述性横断面在线调查。分析样本包括596名在西班牙执业的职业治疗师。问卷评估了参与者的特征、道德教育、对《守则》的了解和认识的重要性、参与道德委员会或类似机构、道德冲突的经历以及冲突管理策略。进行描述性和双变量分析(p < 0.05)。结果:受访者以女性居多(86.6%),年龄在20 ~ 40岁之间。虽然65.3%的人认为大学有道德教育,73.2%的人认为守则重要/非常重要,但11.4%的人不知道守则的存在。只有28.2%的人认识到批准机构,16.3%的人正确认识到守则所包含的专业价值。伦理冲突报告占43.1%。当发生冲突时,受访者最常咨询跨学科团队(25.5%)或职业治疗同事(24.3%),而很少咨询守则(4.5%)或道德委员会(2.7%)。道德教育和更丰富的专业经验与更高的守则知识相关。结论:西班牙的职业治疗师认可职业道德,但可操作的知识和守则的使用以及与正式支持结构的接触仍然有限。加强以实践为导向的伦理教育和无障碍的审议机制,可以改善伦理决策。
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引用次数: 0
Healthcare Costs and Mortality Trends of Elderly ICU Patients: Evidence from an Eight-Year Cohort Study in China. 老年ICU患者的医疗费用和死亡率趋势:来自中国8年队列研究的证据
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-31 DOI: 10.3390/healthcare14030364
Xiaohui Zhu, Meiping Wang, Yawei Guo, Li Jiang

Background/Objectives: Elderly patients represent a growing proportion of ICU admissions, raising concerns about outcomes and healthcare costs. Evidence from China remains limited, yet understanding cost and mortality patterns is critical for optimizing care in aging populations. Methods: We retrospectively analyzed 31,535 ICU patients admitted from 2014 to 2021. After 1:1:1 matching on severity, comorbidities, sex, and admission type, three groups were formed: elderly (≥80 years), older (65-79 years), and younger (16-64 years), with 3398 patients each. Costs were inflation-adjusted, and outcomes compared across groups with appropriate statistical models. Results: Elderly patients accounted for 11.5% of admissions, had the longest ICU stay (4.5 vs. 3.8 vs. 3.1 days, p < 0.001), and the highest ICU (11.5%) and hospital (13.5%) mortality. Among non-surgical patients, elderly incurred the lowest costs; however, surgery reversed this pattern, producing a 124% increase. Expenditures were mainly driven by drugs and consumables. From 2014 to 2021, consumables rose from 32.0% to 42.0% of total costs, whereas drug costs declined. Inflation-adjusted hospital costs remained stable over time, while mortality among elderly patients decreased significantly (19.5% in 2014 vs. 8.8% in 2021; OR 0.86 per year, p < 0.001). Conclusions: Elderly ICU patients demonstrate unique cost and outcome profiles. While non-surgical elderly patients are less costly, surgery substantially increases expenses. Mortality declined over time without a rise in real costs, suggesting improved efficiency of critical care. These findings support tailored resource allocation and policy planning for aging ICU populations.

背景/目的:老年患者在ICU住院患者中所占的比例越来越大,这引起了人们对预后和医疗费用的关注。来自中国的证据仍然有限,但了解成本和死亡率模式对于优化老龄化人口的护理至关重要。方法:回顾性分析2014年至2021年收治的31535例ICU患者。按严重程度、合并症、性别、入院类型按1:1:1匹配,形成老年(≥80岁)、老年(65 ~ 79岁)、青年(16 ~ 64岁)3组,每组3398例。成本经过通货膨胀调整,结果通过适当的统计模型在各组间进行比较。结果:老年患者占入院人数的11.5%,ICU住院时间最长(4.5天比3.8天比3.1天,p < 0.001), ICU死亡率(11.5%)和住院死亡率(13.5%)最高。在非手术患者中,老年人的费用最低;然而,手术逆转了这一模式,产生了124%的增长。支出主要由药品和消耗品驱动。2014 - 2021年,耗材成本占总成本的比例从32.0%上升到42.0%,药品成本下降。随着时间的推移,通货膨胀调整后的医院费用保持稳定,而老年患者的死亡率显著下降(2014年为19.5%,2021年为8.8%;OR为0.86 /年,p < 0.001)。结论:老年ICU患者具有独特的成本和结果概况。虽然非手术老年患者的费用较低,但手术大大增加了费用。死亡率随着时间的推移而下降,而实际成本却没有上升,这表明重症监护的效率得到了提高。这些发现支持针对老年ICU人群的量身定制资源分配和政策规划。
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引用次数: 0
Care as a Central Concept: Dimensions, Inequalities and Challenges in Chronic Care in Contemporary Societies: A Narrative Review. 护理作为一个中心概念:维度,不平等和挑战在当代社会慢性护理:叙事回顾。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-30 DOI: 10.3390/healthcare14030359
Dolores Torres-Enamorado, Rosa Casado-Mejía

Background/Objective: Feminist theories and feminist economics have contributed to making visible the structural relevance of care work in sustaining capitalist societies and social reproduction, arguing that care must be addressed as a political phenomenon rather than a merely domestic issue. This perspective is particularly pertinent in contemporary healthcare, where chronic care represents one of the major public health challenges in a context of population ageing and increasing prevalence of chronic diseases. The aim is to contribute to a critical understanding that can support the development of public policies recognizing care as a fundamental pillar of socio-healthcare provision and as a matter of collective responsibility. Methods: A narrative literature review with a critical feminist approach was conducted using PubMed/MEDLINE, Scopus, and Web of Science. Results: A total of 299 records were identified, of which 30 studies were included following screening and eligibility assessment. Care is an essential element for sustaining life, although it has historically been rendered invisible, feminized, and relegated to the private sphere. Chronicity requires simultaneous consideration of the material dimension of care (as work), the subjective dimension (including emotional bonds and moral responsibility), and the political dimension (shaped by power relations). Global care chains reveal persistent inequalities related to gender, class, and race. Conclusions: Care is a structural, political, and transnational category that sustains life and healthcare systems. In the field of chronic care, the recognition, redistribution, and socialization of care are essential for achieving social justice and for safeguarding the dignity of both caregivers-predominantly women-and care recipients.

背景/目的:女性主义理论和女性主义经济学有助于揭示护理工作在维持资本主义社会和社会再生产中的结构相关性,认为护理必须作为一种政治现象而不仅仅是一个家庭问题来解决。这一观点与当代医疗保健特别相关,在人口老龄化和慢性病流行率不断上升的背景下,慢性护理是主要的公共卫生挑战之一。其目的是促进批判性理解,以支持制定公共政策,承认护理是社会保健提供的基本支柱,也是集体责任问题。方法:使用PubMed/MEDLINE、Scopus和Web of Science进行批判性女权主义方法的叙事性文献综述。结果:共确定299条记录,其中30项研究在筛选和资格评估后纳入。护理是维持生命的基本要素,尽管它在历史上被视为不可见的、女性化的,并且被降级到私人领域。慢性需要同时考虑照顾的物质维度(如工作)、主观维度(包括情感纽带和道德责任)和政治维度(由权力关系形成)。全球护理链揭示了与性别、阶级和种族相关的持续不平等。结论:护理是一个结构性的、政治性的、跨国的范畴,维持着生命和医疗保健系统。在慢性护理领域,对护理的认可、再分配和社会化对于实现社会公正和维护护理者(主要是妇女)和护理接受者的尊严至关重要。
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引用次数: 0
High-Intensity Functional Training for Older Adults with Mobility Disabilities: A Feasibility Pilot Study. 老年行动障碍患者的高强度功能训练:一项可行性试点研究。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-30 DOI: 10.3390/healthcare14030349
Lyndsie M Koon, Joseph E Donnelly, Jacob J Sosnoff, Abbas Tabatabaei, Joseph R Sherman, Anna M Rice, Morgan Means, Reed Handlery, Kaci Handlery

Background/objectives: There is limited empirical evidence on the feasibility of inclusive, community-based exercise programs for older adults with long-term mobility disabilities. This pilot study investigated the feasibility and preliminary effectiveness of a community-based high-intensity functional training (HIFT) intervention.

Methods: This single-group pre-post feasibility trial was delivered across four community-based HIFT facilities. Thirteen participants enrolled, and 10 (mean age 69.8 ± 6.7 years; 60% female) completed baseline assessments, two onboarding sessions, and thrice-weekly group-based workouts across 16 weeks. Physical function was assessed using the Canadian Occupational Performance Measure (COPM), Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function, Modified Falls Efficacy Scale (MFES), and standardized tests of mobility, balance, and strength. Exploratory outcomes included body mass index (BMI), waist circumference, work capacity, and quality of life (QOL).

Results: Recruitment, retention, and attendance rates were 38%, 77%, and 58% (80% including make-up sessions), respectively. The intervention was safe and well-tolerated, with one fall-related adverse event. Self-reported functional outcomes demonstrated small to large effects, with large improvements in participant-identified functional activities (d = 1.03-1.54) and fall efficacy (d = 0.97), and a small effect for standardized physical function (d = 0.36) Endurance improved substantially (d = 1.01), while mobility, balance, and strength outcomes reflected maintenance or small to moderate gains (d = 0.08-0.55). BMI remained stable (d = 0.05), work capacity increased with moderate to large effects (d = 0.61-1.43), and QOL improved modestly (d = 0.20). Exit interviews reinforced high acceptability, highlighting individualized adaptations, supportive trainers, and the group-based context as motivating contextual factors.

Conclusions: A community-based HIFT program is feasible and acceptable for older adults with mobility disabilities.

背景/目的:对于长期行动障碍的老年人,包容性的、基于社区的锻炼计划的可行性,经验证据有限。本初步研究调查了基于社区的高强度功能训练(HIFT)干预的可行性和初步有效性。方法:在四个社区的HIFT设施中进行单组术后可行性试验。13名参与者入组,其中10名(平均年龄69.8±6.7岁;60%为女性)完成了基线评估、两次入组训练和每周三次的小组训练,共16周。身体功能的评估采用加拿大职业表现量表(COPM)、患者报告结果测量信息系统(PROMIS)身体功能、改良跌倒疗效量表(MFES)以及活动能力、平衡和力量的标准化测试。探索性结果包括身体质量指数(BMI)、腰围、工作能力和生活质量(QOL)。结果:招聘率、留任率和出勤率分别为38%、77%和58%(80%包括补课)。干预是安全且耐受性良好的,只有一个与跌倒相关的不良事件。自我报告的功能结果显示了从小到大的影响,参与者识别的功能活动(d = 1.03-1.54)和跌倒疗效(d = 0.97)有很大的改善,标准化的身体功能(d = 0.36)有小的影响。耐力显著改善(d = 1.01),而活动能力、平衡和力量结果反映了维持或小到中度的改善(d = 0.08-0.55)。体重指数保持稳定(d = 0.05),工作能力有所提高(d = 0.61-1.43),生活质量略有改善(d = 0.20)。离职面谈强化了高可接受性,强调了个性化适应、支持性培训师和基于群体的情境作为激励因素。结论:以社区为基础的HIFT项目对于行动障碍的老年人是可行和可接受的。
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引用次数: 0
Machine Learning Prediction of ICU Mortality and Length of Stay in Atrial Fibrillation: A MIMIC-IV/MIMIC-III Study. 机器学习预测房颤ICU死亡率和住院时间:一项MIMIC-IV/MIMIC-III研究
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-30 DOI: 10.3390/healthcare14030356
Victoria Nguyen, Rahul Mittal

Background: Atrial fibrillation (AF) is common among intensive care unit (ICU) patients and is associated with increased mortality, prolonged length of stay (LOS), and greater resource utilization. Widely used AF risk scores were developed for stable outpatient populations and have limited applicability in critically ill patients. This study aimed to (1) characterize ICU patients with AF, (2) develop and temporally externally validate machine learning models to predict ICU mortality and ICU LOS, and (3) identify early clinical factors associated with these outcomes using interpretable methods. Methods: Adult ICU patients with AF from MIMIC-IV (n = 20,058) were used for model development with grouped cross-validation, and MIMIC-III (n = 11,475) served as a temporal external validation cohort. Predictors included demographics, admission characteristics, vital signs, laboratory values, vasoactive support, and AF-related medications available within the first 24 h of ICU admission. Eight classification algorithms were evaluated for ICU mortality, and six regression algorithms were evaluated for ICU LOS. Discrimination was primarily assessed using the area under the receiver operating characteristic curve (AUC) and average precision (AP), with additional threshold-dependent metrics reported to characterize operating-point behavior under low event prevalence. Probability-threshold optimization using out-of-fold predictions was applied to the primary mortality model. LOS performance was evaluated using mean absolute error (MAE), root mean squared error (RMSE), and the coefficient of determination (R2). Model interpretability was assessed using SHapley Additive exPlanations (SHAP). Results: The median age was 75 years, and ICU mortality was 8.9%. For mortality prediction, the XGBoost model demonstrated preserved discrimination on temporal external validation (MIMIC-III) (AUC = 0.743; AP = 0.226). At the default probability threshold (0.50), recall and F1 scores were low due to low event prevalence; applying a prespecified F1-optimized threshold derived from the development cohort improved sensitivity while maintaining overall discrimination. For ICU LOS, models explained little variance on temporal validation; LightGBM performed best, but the explained variance was low (MAE = 88.9 h; RMSE = 163.9 h; R2 = 0.038), indicating that the first 24-h structured data provide an insufficient signal to accurately predict ICU LOS, likely due to downstream clinical and operational factors. SHAP analysis identified clinically plausible predictors of mortality and prolonged ICU stay, including reduced urine output, renal dysfunction, metabolic derangement, hypoxemia, early vasopressor use, advanced age, and admission pathways.

背景:房颤(AF)在重症监护病房(ICU)患者中很常见,并与死亡率增加、住院时间延长(LOS)和资源利用率增加有关。广泛使用的房颤风险评分是为稳定的门诊人群开发的,对危重患者的适用性有限。本研究旨在(1)确定ICU房颤患者的特征,(2)开发并暂时外部验证机器学习模型以预测ICU死亡率和ICU LOS,以及(3)使用可解释的方法确定与这些结果相关的早期临床因素。方法:采用MIMIC-IV型成年AF ICU患者(n = 20,058)进行模型开发并进行分组交叉验证,MIMIC-III型患者(n = 11,475)作为临时外部验证队列。预测因素包括人口统计学、入院特征、生命体征、实验室值、血管活性支持和ICU入院前24小时内可用的房颤相关药物。评估ICU死亡率的8种分类算法和ICU LOS的6种回归算法。鉴别主要通过受试者工作特征曲线下的面积(AUC)和平均精度(AP)进行评估,并报告了附加的阈值相关指标,以表征低事件发生率下的操作点行为。使用折叠外预测的概率阈值优化应用于初级死亡率模型。采用平均绝对误差(MAE)、均方根误差(RMSE)和决定系数(R2)评价LOS的性能。采用SHapley加性解释(SHAP)评价模型可解释性。结果:患者中位年龄75岁,ICU病死率8.9%。对于死亡率预测,XGBoost模型在时间外部验证(MIMIC-III)上表现出保留的歧视(AUC = 0.743; AP = 0.226)。在默认概率阈值(0.50)下,由于事件发生率低,召回率和F1得分较低;应用源自发展队列的预先指定的f1优化阈值可提高灵敏度,同时保持总体判别。对于ICU LOS,模型在时间验证上解释的方差较小;LightGBM表现最好,但解释方差较低(MAE = 88.9 h; RMSE = 163.9 h; R2 = 0.038),表明前24小时结构化数据提供的信号不足,无法准确预测ICU LOS,可能是由于下游临床和操作因素。SHAP分析确定了死亡率和延长ICU住院时间的临床合理预测因素,包括尿量减少、肾功能障碍、代谢紊乱、低氧血症、早期使用血管加压剂、高龄和入院途径。
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引用次数: 0
Demographic and Clinical Correlates of Quality of Life Domains in Spinal Cord Injury. 脊髓损伤中生活质量领域的人口学和临床相关因素。
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-30 DOI: 10.3390/healthcare14030357
Monika Zackova, Paola Rucci, Golcin Maknouni, Simona Udriste, Emanuele Salvatori, Maria Cristina Pirazzoli

Background/Objectives: In patients with spinal cord injury (SCI), quality of life (QoL) is increasingly recognized as an important indicator of their ability to sustain both the rehabilitation process and post-rehabilitation community reintegration, and it plays a crucial role in prognosis. The primary purpose of this study was to identify the demographic and clinical correlates of different QoL domains as perceived by patients hospitalized after SCI. Methods: We conducted a cross-sectional study on a single day in the units of the Montecatone Rehabilitation Institute (MRI), the largest Italian center for intensive rehabilitation of individuals with SCI. We administered the World Health Organization Quality of Life-Short Version (WHOQOL-BREF), which consists of 26 items rated on a five-point Likert scale. Study participants included 88 adults with SCI; a total of 74% were male, with a mean age of 53.3 years (SD = 15.05). The lesion was traumatic in 74% of cases and complete in 59%. Physical health showed a weak negative association with age (r = -0.213, p = 0.05), whereas social QoL demonstrated a significant positive association with age (r = 0.215, p = 0.046). Psychological QoL was significantly lower in females compared with males (46.9 vs. 55.1, p < 0.05) and in patients living alone compared with those not living alone (46.1 vs. 54.6, p < 0.05). Conclusions: Clinicians should consider routine assessment of QoL to personalize post-discharge therapeutic plans and to implement targeted interventions aimed at improving outcomes in patients with SCI.

背景/目的:在脊髓损伤(SCI)患者中,生活质量(QoL)越来越被认为是其维持康复过程和康复后重返社区能力的重要指标,并在预后中起着至关重要的作用。本研究的主要目的是确定脊髓损伤后住院患者感知的不同生活质量域的人口学和临床相关性。方法:我们在Montecatone康复研究所(MRI)进行了一天的横断面研究,该研究所是意大利最大的脊髓损伤患者强化康复中心。我们使用了世界卫生组织短生命质量版本(WHOQOL-BREF),它由26个项目组成,按5分李克特量表评分。研究参与者包括88名患有脊髓损伤的成年人;男性占74%,平均年龄53.3岁(SD = 15.05)。74%的病例为外伤性病变,59%为完全性病变。身体健康与年龄呈弱负相关(r = -0.213, p = 0.05),社会生活质量与年龄呈显著正相关(r = 0.215, p = 0.046)。女性患者的心理生活质量明显低于男性(46.9比55.1,p < 0.05),独居患者的心理生活质量明显低于非独居患者(46.1比54.6,p < 0.05)。结论:临床医生应考虑对生活质量进行常规评估,以制定个性化的出院后治疗计划,并实施有针对性的干预措施,以改善脊髓损伤患者的预后。
{"title":"Demographic and Clinical Correlates of Quality of Life Domains in Spinal Cord Injury.","authors":"Monika Zackova, Paola Rucci, Golcin Maknouni, Simona Udriste, Emanuele Salvatori, Maria Cristina Pirazzoli","doi":"10.3390/healthcare14030357","DOIUrl":"10.3390/healthcare14030357","url":null,"abstract":"<p><p><b>Background/Objectives</b>: In patients with spinal cord injury (SCI), quality of life (QoL) is increasingly recognized as an important indicator of their ability to sustain both the rehabilitation process and post-rehabilitation community reintegration, and it plays a crucial role in prognosis. The primary purpose of this study was to identify the demographic and clinical correlates of different QoL domains as perceived by patients hospitalized after SCI. <b>Methods</b>: We conducted a cross-sectional study on a single day in the units of the Montecatone Rehabilitation Institute (MRI), the largest Italian center for intensive rehabilitation of individuals with SCI. We administered the World Health Organization Quality of Life-Short Version (WHOQOL-BREF), which consists of 26 items rated on a five-point Likert scale. Study participants included 88 adults with SCI; a total of 74% were male, with a mean age of 53.3 years (SD = 15.05). The lesion was traumatic in 74% of cases and complete in 59%. Physical health showed a weak negative association with age (r = -0.213, <i>p</i> = 0.05), whereas social QoL demonstrated a significant positive association with age (r = 0.215, <i>p</i> = 0.046). Psychological QoL was significantly lower in females compared with males (46.9 vs. 55.1, <i>p</i> < 0.05) and in patients living alone compared with those not living alone (46.1 vs. 54.6, <i>p</i> < 0.05). <b>Conclusions</b>: Clinicians should consider routine assessment of QoL to personalize post-discharge therapeutic plans and to implement targeted interventions aimed at improving outcomes in patients with SCI.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"14 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of In-Hospital Mortality Among Type 2 Diabetes Mellitus-Related Admissions in a Tertiary Teaching Hospital. 某三级教学医院2型糖尿病相关住院患者住院死亡率的决定因素
IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-30 DOI: 10.3390/healthcare14030347
Norfarhana Samsudin, Roszita Ibrahim, Azimatun Noor Aizuddin, Siti Noorain Hamid

Background/Objectives: Globally, type 2 diabetes mellitus (T2DM) accounts for about 90% of diabetes cases and contributes to hospital admissions and mortality in Malaysia. Identifying the determinants of in-hospital mortality is crucial for improving clinical management and resource allocation. This study aims to determine the clinical and disease-related determinants of in-hospital mortality among T2DM-related admissions in a tertiary teaching hospital. Methods: A cross-sectional study at Hospital Canselor Tuanku Muhriz (HCTM) in Kuala Lumpur involving 2838 T2DM-related admissions from the hospital casemix database. Demographic data, complications, disease group, length of stay, and number of diagnoses were analyzed. Logistic regression assessed factors associated with in-hospital mortality among T2DM-related admissions. Results: The in-hospital mortality rate among T2DM-related admissions was 4.2%. T2DM-related admissions resulting in in-hospital death involved individuals with a higher mean age (67.72 years, SD 12.06) compared to admissions that did not result in death (65.11 years, SD 11.03). Significant determinants of mortality included infections and parasitic diseases (aOR = 8.042; 95% CI: 2.999, 21.569; p < 0.001), respiratory system (aOR = 3.004; 95% CI: 1.192, 7.571; p = 0.020), hepatobiliary/pancreatic (aOR = 3.674; 95% CI: 1.143, 11.871; p = 0.029), and central nervous system (aOR = 3.484; 95% CI: 1.236, 9.826; p =0.018) conditions, and severity level 3 (aOR = 2.994; 95% CI: 1.464, 6.221; p = 0.003). Each additional diagnosis increased the mortality risk (aOR = 1.107; 95% CI: 1.032, 1.189; p = 0.005). Conclusions: Mortality among hospitalized T2DM-related admissions is driven by severe infections, respiratory, hepatobiliary, and neurological conditions, together with overall disease burden. Early identification of high-risk clinical presentations and a timely multidisciplinary approach may reduce preventable deaths among T2DM patients.

背景/目的:在全球范围内,2型糖尿病(T2DM)约占糖尿病病例的90%,是马来西亚住院和死亡的原因之一。确定院内死亡率的决定因素对于改善临床管理和资源分配至关重要。本研究旨在确定某三级教学医院t2dm相关入院患者住院死亡率的临床和疾病相关决定因素。方法:在吉隆坡的医院(HCTM)进行横断面研究,涉及2838名来自医院病例混合数据库的t2dm相关入院患者。分析人口学资料、并发症、疾病组、住院时间和诊断次数。Logistic回归评估t2dm相关入院患者住院死亡率相关因素。结果:t2dm相关住院患者的住院死亡率为4.2%。导致院内死亡的t2dm相关入院患者的平均年龄(67.72岁,SD 12.06)高于未导致死亡的入院患者(65.11岁,SD 11.03)。死亡的重要决定因素包括感染和寄生虫病(aOR = 8.042; 95% CI: 2.999, 21.569; p < 0.001)、呼吸系统(aOR = 3.004; 95% CI: 1.192, 7.571; p = 0.020)、肝胆/胰腺(aOR = 3.674; 95% CI: 1.143, 11.871; p = 0.029)、中枢神经系统(aOR = 3.484; 95% CI: 1.236, 9.826; p =0.018)和严重程度3级(aOR = 2.994; 95% CI: 1.464, 6.221; p = 0.003)。每增加一次诊断,死亡风险均增加(aOR = 1.107; 95% CI: 1.032, 1.189; p = 0.005)。结论:t2dm相关住院患者的死亡率是由严重感染、呼吸道、肝胆和神经系统疾病以及总体疾病负担驱动的。早期识别高危临床表现和及时采用多学科方法可减少T2DM患者可预防的死亡。
{"title":"Determinants of In-Hospital Mortality Among Type 2 Diabetes Mellitus-Related Admissions in a Tertiary Teaching Hospital.","authors":"Norfarhana Samsudin, Roszita Ibrahim, Azimatun Noor Aizuddin, Siti Noorain Hamid","doi":"10.3390/healthcare14030347","DOIUrl":"10.3390/healthcare14030347","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Globally, type 2 diabetes mellitus (T2DM) accounts for about 90% of diabetes cases and contributes to hospital admissions and mortality in Malaysia. Identifying the determinants of in-hospital mortality is crucial for improving clinical management and resource allocation. This study aims to determine the clinical and disease-related determinants of in-hospital mortality among T2DM-related admissions in a tertiary teaching hospital. <b>Methods</b>: A cross-sectional study at Hospital Canselor Tuanku Muhriz (HCTM) in Kuala Lumpur involving 2838 T2DM-related admissions from the hospital casemix database. Demographic data, complications, disease group, length of stay, and number of diagnoses were analyzed. Logistic regression assessed factors associated with in-hospital mortality among T2DM-related admissions. <b>Results</b>: The in-hospital mortality rate among T2DM-related admissions was 4.2%. T2DM-related admissions resulting in in-hospital death involved individuals with a higher mean age (67.72 years, SD 12.06) compared to admissions that did not result in death (65.11 years, SD 11.03). Significant determinants of mortality included infections and parasitic diseases (aOR = 8.042; 95% CI: 2.999, 21.569; <i>p</i> < 0.001), respiratory system (aOR = 3.004; 95% CI: 1.192, 7.571; <i>p</i> = 0.020), hepatobiliary/pancreatic (aOR = 3.674; 95% CI: 1.143, 11.871; <i>p</i> = 0.029), and central nervous system (aOR = 3.484; 95% CI: 1.236, 9.826; <i>p</i> =0.018) conditions, and severity level 3 (aOR = 2.994; 95% CI: 1.464, 6.221; <i>p</i> = 0.003). Each additional diagnosis increased the mortality risk (aOR = 1.107; 95% CI: 1.032, 1.189; <i>p</i> = 0.005). <b>Conclusions</b>: Mortality among hospitalized T2DM-related admissions is driven by severe infections, respiratory, hepatobiliary, and neurological conditions, together with overall disease burden. Early identification of high-risk clinical presentations and a timely multidisciplinary approach may reduce preventable deaths among T2DM patients.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"14 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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