Human reproduction最新文献

{"title":"Ethical considerations on surrogacy†.","authors":"Francoise Shenfield, Basil Tarlatzis, Guiliana Baccino, Theofano Bounartzi, Lucy Frith, Guido Pennings, Veerle Provoost, Nathalie Vermeulen, Heidi Mertes","doi":"10.1093/humrep/deaf006","DOIUrl":"10.1093/humrep/deaf006","url":null,"abstract":"<p><p>Surrogacy is the assisted reproductive technology (ART) practice in which a person becomes pregnant, carries, and delivers a child on behalf of another couple/person, who are the intended parent(s). Surrogacy is an especially complex practice as the interests of the intended parents, the gestational carrier, and the future child may differ. This paper considers ethical questions related to different forms of surrogacy. It concludes that non-commercial surrogacy is an acceptable method of assisted reproduction for specific indications. When using surrogacy to form a family, it is essential that there are measures to protect all parties, to guarantee well-considered decision-making, and to minimize risks. The current paper formulates recommendations to promote these measures. This paper is an update to the ESHRE Task Force Ethics and Law Paper 10: Surrogacy and replaces this paper.</p>","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"420-425"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human ovarian tissue xenotransplantation: advancements, challenges, and future perspectives.","authors":"Paweena Thuwanut, Ellen C R Leonel, Thalles Fernando Rocha Ruiz, Porntip Sirayapiwat, Stine Gry Kristensen, Christiani A Amorim","doi":"10.1093/humrep/deae291","DOIUrl":"10.1093/humrep/deae291","url":null,"abstract":"<p><p>Ovarian tissue cryopreservation and transplantation has emerged as a promising fertility preservation technique for individuals facing premature ovarian insufficiency due to various medical conditions or treatments. Xenotransplantation, involving the transplantation of ovarian tissue into animal hosts, has played a pivotal role in refining ovarian tissue cryopreservation and transplantation techniques and addressing key challenges. This review provides a comprehensive overview of the current landscape of ovarian tissue xenotransplantation research, focusing on its applications in investigating ovarian biology, optimizing ovarian tissue cryopreservation and transplantation protocols, and assessing safety concerns. It also explores the utilization of xenografting of human ovarian tissue in mouse models in the last 10 years. Key findings from preclinical studies investigating grafting site optimization, cryopreservation protocol refinement, the development of strategies to mitigate chemotherapy-induced damage, follicle development, tissue revascularization, and the risk of malignant cell reintroduction are summarized. Moreover, the review examines the ethical considerations surrounding the use of animals in ovarian tissue xenotransplantation research and suggests emerging alternative models that aim to minimize animal use while maximizing clinical relevance.</p>","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"410-419"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling early predictors of adverse birth outcomes: the potential and limits of embryonic growth metrics.","authors":"Binglin Li, Yueqi Feng, Ruijuan Chen","doi":"10.1093/humrep/deae295","DOIUrl":"10.1093/humrep/deae295","url":null,"abstract":"","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"561-562"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent implantation failure: science or fiction?","authors":"Juan J Fraire-Zamora, George Liperis, Munevver Serdarogullari, Omar F Ammar, Paul Pirtea, Paola Viganò, Laurentiu Craciunas, Micah J Hill, Kashish Sharma","doi":"10.1093/humrep/deaf007","DOIUrl":"10.1093/humrep/deaf007","url":null,"abstract":"","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"565-569"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between endometriosis and working life among Danish women.","authors":"Eeva-Liisa Røssell, Oleguer Plana-Ripoll, Marie Josiasen, Karina Ejgaard Hansen, Bodil Hammer Bech, Dorte Rytter","doi":"10.1093/humrep/deae298","DOIUrl":"10.1093/humrep/deae298","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Study question: &lt;/strong&gt;What is the association between endometriosis and working life (lost), workforce participation, and productivity?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary answer: &lt;/strong&gt;Women with endometriosis experienced more working years lost due to disability pension and to a smaller degree sick leave, they were less frequently working or enrolled in education, had more sick days, were less productive, and had lower work ability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;What is known already: &lt;/strong&gt;Endometriosis is associated with negative consequences on working life; however, previous studies are based on self-reported data or smaller samples of women. To the best of our knowledge, no previous studies have quantified the average reduction in working hours during the entire span of working life using population-based registers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design, size, duration: &lt;/strong&gt;This study included two Danish data sources. In the register-based cohort study (main analysis), a total of 2 650 554 women aged 18-65 years were followed for a total of 42.8 million person-years from 1992 to 2021. In the questionnaire-based cross-sectional study (Supplementary Analysis), 35 490 women aged 26-51 years were invited to participate and 7298 women completed the questionnaire.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants/materials, setting, methods: &lt;/strong&gt;For the main analysis, 42 741 (1.6%) were diagnosed with endometriosis. We estimated working years lost decomposed into disability pension, voluntary early retirement, or death for women with endometriosis and the general female population. For the supplementary analysis, 270 (4.0%) reported to have endometriosis. We analysed these recent questionnaire data on women's health to further investigate working life and productivity among women with and without endometriosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main results and the role of chance: &lt;/strong&gt;Based on the main analysis, women with endometriosis lost on average an additional 0.26 years (95% CI: 0.17-0.37) of working life compared to the general female population. This was due to sick leave and especially disability pension. For the supplementary analysis, the participation rate was 20.6%. Women with endometriosis reported to be less frequently working or enrolled in education (74.1% (95% CI 68.4%-79.2%) with endometriosis, 82.7% (95% CI 81.8%-83.7%) without) and had more sick days (4-28 sick days last 4 weeks: 16.2% (95% CI 11.6%-21.8%) with endometriosis, 7.9% (95% CI 7.2%-8.7%) without). In addition, they reported lower productivity and work ability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations, reasons for caution: &lt;/strong&gt;Endometriosis is underdiagnosed in the register data as only hospital diagnoses are registered and diagnoses from private practicing gynaecologists and general practitioners are missing. In addition, sick leave might be underestimated as shorter periods of sick leave are not included in the registers. Questionnaire data were self-reported including endometriosis and participants might be a selected","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"461-468"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraovarian platelet-rich plasma injection for ovarian rejuvenation.","authors":"Gorka Barrenetxea","doi":"10.1093/humrep/deaf030","DOIUrl":"https://doi.org/10.1093/humrep/deaf030","url":null,"abstract":"","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Follicular activation, not ovarian rejuvenation: terminology matters, but outcomes remain unchanged after platelet-rich plasma administration.","authors":"Andres Reig, Nola Herlihy, Yigit Cakiroglu, Christine Whitehead, Bulent Tiras, Richard T Scott, Emre Seli","doi":"10.1093/humrep/deaf031","DOIUrl":"https://doi.org/10.1093/humrep/deaf031","url":null,"abstract":"","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.","authors":"Jack Tighe, Sophie Broughton, Rachel Roberts, Lorraine S Kasaven, Rachel Cutting, Elliot Bridges, Abigail Ng, Amanda Evans, Efstathios Theodorou, Jara Ben Nagi, Benjamin P Jones","doi":"10.1093/humrep/deaf028","DOIUrl":"https://doi.org/10.1093/humrep/deaf028","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Study question: &lt;/strong&gt;How does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary answer: &lt;/strong&gt;Two-consecutive SET may provide greater or comparable live birth rate (LBR); with lower multiple birth, preterm birth, and pregnancy loss or neonatal death rates compared to DET.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;What is known already: &lt;/strong&gt;Elective SET in IVF/ICSI is widely encouraged over DET to minimize the risk of multiple births and associated morbidities. Despite this, multiple birth rates following IVF remain higher than the 10% target across Europe and the USA. Currently, the majority of evidence regarding SET and DET is based on various studies assessing outcomes such as LBR per treatment cycle, as opposed to per oocyte retrieval. As such, the representation of SET is mostly unfavourable. Analysis of cumulative LBR following the transfer of two embryos over consecutive cycles, rather than in one transfer event (DET) is more effective at distinguishing the two methods and will therefore provide more valuable information relevant to clinical practice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design, size, duration: &lt;/strong&gt;This retrospective cohort study was conducted using Human Fertilisation and Embryology Authority (HFEA) register data, which encompasses national data from all IVF clinics in the UK. All women who underwent their first oocyte retrieval and IVF or ICSI treatment cycle with subsequent SET, DET, or 2xSET between 2010 and 2019 using blastocyst embryos were included (N = 71 807).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants/materials, setting, methods: &lt;/strong&gt;The rate of live birth, liveborn baby rate, multiple birth, preterm birth, and pregnancy loss or neonatal death was compared between SET, DET, and 2xSET IVF/ICSI pregnancies using blastocyst-stage embryos, where data were stratified by maternal age. Data analysis was conducted in RStudio v4.2, alpha equals 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main results and the role of chance: &lt;/strong&gt;Blastocyst-stage 2xSET achieved a greater median LBR of 0.47 (interquartile range [IQR] 0.13) than SET, 0.41 (IQR 0.13), and DET, 0.38 (IQR 0.13) (P &lt; 0.05). Using SET as the reference standard, 2xSET was associated with a significantly lower odds of multiple births compared to DET ((odds ratio [OR] 6.87, 95% CI 6.14-7.68) vs 28.20, 95% CI 25.20-31.57). The odds of preterm birth were also lower following 2xSET (OR 1.11, 95% CI 1.06-1.15) compared to DET (OR 2.80, 95% CI 2.67-2.94). Similarly, the odds of pregnancy loss or neonatal death were lower following 2xSET (OR 1.14, 95% CI 1.08-1.21) compared to DET (OR 2.11, 95% CI 1.98-2.24). LBR was consistently higher following 2xSET than DET and SET in women aged 39 years and under (P &lt; 0.05). However, results were comparable in women over 39 years (P &gt; 0.05). Across all age groups, DET pregnancies had the highest multiple birth rate (P &lt; 0.05). In women aged 39 years and under, DET was associate","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time monitoring reveals the effects of low concentrations of volatile organic compounds in the embryology laboratory","authors":"Jiali Cai, Liying Zhou, Lanlan Liu, Zhenfang Liu, Jinghua Chen, Kaijie Chen, Xiaolian Yang, Xiaoming Jiang, Jianzhi Ren","doi":"10.1093/humrep/deaf008","DOIUrl":"https://doi.org/10.1093/humrep/deaf008","url":null,"abstract":"STUDY QUESTION Could real-time monitoring of volatile organic compounds (VOCs) in the embryology laboratory provide meaningful early warning for potential harm from the environment? SUMMARY ANSWER Even in a laboratory environment with a total VOC concentration lower than the recommendation of the Cairo Consensus, the real-time monitored VOC concentrations are associated with changes in embryo morphological parameters. WHAT IS KNOWN ALREADY VOCs have been considered a key environmental detriment in embryology laboratories. However, the current VOC thresholds established by the Cairo consensus were based on the practical experience of air pollution cases, and a scientifically derived threshold is lacking. STUDY DESIGN, SIZE, DURATION The study included 7076 oocyte collection (OPU) cycles carried out between June 2020 and December 2022 in the Center for Reproductive Medicine of the affiliated Chenggong Hospital of Xiamen University, 6306 of which resulted in at least one embryo transfer (ET) attempt during the study. VOC monitoring data were recorded every 10 min. The average and peak concentrations of total VOCs and formaldehyde during culture were associated with embryo parameters and implantation following the first ET attempt of the cycle in generalized estimating equations and generalized additive models. MAIN RESULTS AND THE ROLE OF CHANCE Real-time monitoring of VOCs showed a dynamic of VOC concentration in the laboratory. The concentration reached peaks during the working hours of the days and working days of the week and fell quickly at night and on weekends. The average concentrations of VOCs during the culture period were linearly associated with decreased early cleavage (OR 0.92, 95% CI: 0.85, 0.99), decreased Day 3 compaction (OR 0.51, 95% CI: 0.32, 0.83), increased asymmetry (OR 1.13, 95% CI: 1.01, 1.25), and increased grade C trophectoderm (TE) (OR 1.99, 95% CI: 1.32, 3.01). On the other hand, increased Day 3 arrest, delayed blastocyst formation, and decreased grade A TE showed a non-linear association with VOCs, suggesting a possible threshold of effect. In the first transfer attempt, negative associations were observed between maximal formaldehyde concentrations and pregnancy in both fresh transfer (RR 0.971, 95% CI: 0.94, 0.99) and freeze-all frozen-thawed ET (RR 0.959, 95% CI: 0.92, 0.99) cycles. LIMITATIONS, REASONS FOR CAUTION The sensitivity and specificity of the monitor are not comparable to the standard protocols, such as chromatography-mass spectroscopy. Due to the lack of ability to identify the chemical nature of the components of VOCs, the toxicity and source of the VOCs were largely unknown. The representative sampling of the laboratory air may not necessarily reflect the exposure of embryos. WIDER IMPLICATIONS OF THE FINDINGS While the environment of the embryology laboratory has been significantly improved, the data suggested that a low VOC level could still be a concern. Due to the dynamic of VOC concentration in the","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"15 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography","authors":"Cheri Margolis, Nicolás Garrido, Leah Roberts, Andres Reig, Pavan Gill, Stephanie Willson, Haley Genovese, Francesca Barrett, Caroline Zuckerman, Christine Whitehead, Paul Bergh, Emre Seli, Marie Werner","doi":"10.1093/humrep/deaf029","DOIUrl":"https://doi.org/10.1093/humrep/deaf029","url":null,"abstract":"STUDY QUESTION Does the objective and quantitative assessment of uterine tissue stiffness via ultrasound shear wave elastography (SWE) predict the outcome after single euploid frozen embryo transfer (FET)? SUMMARY ANSWER Uterine SWE data might be predictive of clinical pregnancy in good prognosis patients undergoing single euploid FET. WHAT IS KNOWN ALREADY Few prior studies have evaluated the usefulness of strain uterine elastography in assessing the likelihood of conception in an infertile patient population following IUI or FET. These studies suggest that elastography parameters may be predictive of pregnancy following ART treatments. However, these studies are limited based on their use of strain uterine elastography, which provides a relative measurement between two areas of interest. No prior study has evaluated the more robust technology of SWE, which provides quantitative and objective measurements, on likelihood of conception following infertility treatment. STUDY DESIGN, SIZE, DURATION This is a prospective pilot study of 153 patients with no known uterine pathology undergoing single euploid FET at a university-affiliated center between June 2022 and December 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS Patients scheduled for upcoming single euploid blastocyst FET during the study period were evaluated for study participation. On the day prior to embryo transfer, SWE assessment of 15 regions of interest of the sagittal uterus measuring 6 mm in diameter was performed on included participants. Regions of interest included the cervix, anterior/posterior distal myometrium, anterior/posterior lower uterine segment, fundus, endometrium, and the anterior myometrial/endometrial interface. The elastography data points generated were collected in a standardized fashion by a single investigator blinded to patient outcome. The elasticity parameters analyzed included the mean, SD, minimum, and maximum values in kilopascals and meters per second. These data were assessed for relationship to clinical pregnancy, defined as discharge from fertility care at 9 weeks’ gestation. MAIN RESULTS AND THE ROLE OF CHANCE There were 22 uterine elastography parameters that showed a significant relationship to clinical pregnancy with P &amp;lt; 0.10 using univariant analyses. Regions of interest that were predictive of clinical pregnancy with P &amp;lt; 0.10 included the cervix, the anterior myometrium, the posterior myometrium, the fundus, and the anterior myometrial/endometrial interface. Increased mean (stiffer elastography metrics) in the posterior myometrium and anterior myometrial/endometrial interface was associated with increased likelihood of clinical pregnancy in comparison to FETs that did not result in clinical pregnancy. These values were then subjected to a multivariable logistic regression model to estimate areas under the curves and predictive values with and without clinical parameters. Using elastography data only, the model for predicting clinic","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"82 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}