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Reply: Unveiling early predictors of adverse birth outcomes: the potential and limits of embryonic growth metrics. 回答:揭示不良出生结局的早期预测因素:胚胎生长指标的潜力和局限性。
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deae296
Jorine Roelants, Marijn J Vermeulen, Régine Steegers-Theunissen
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引用次数: 0
Ethical considerations on surrogacy†.
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deaf006
Francoise Shenfield, Basil Tarlatzis, Guiliana Baccino, Theofano Bounartzi, Lucy Frith, Guido Pennings, Veerle Provoost, Nathalie Vermeulen, Heidi Mertes

Surrogacy is the assisted reproductive technology (ART) practice in which a person becomes pregnant, carries, and delivers a child on behalf of another couple/person, who are the intended parent(s). Surrogacy is an especially complex practice as the interests of the intended parents, the gestational carrier, and the future child may differ. This paper considers ethical questions related to different forms of surrogacy. It concludes that non-commercial surrogacy is an acceptable method of assisted reproduction for specific indications. When using surrogacy to form a family, it is essential that there are measures to protect all parties, to guarantee well-considered decision-making, and to minimize risks. The current paper formulates recommendations to promote these measures. This paper is an update to the ESHRE Task Force Ethics and Law Paper 10: Surrogacy and replaces this paper.

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引用次数: 0
Human ovarian tissue xenotransplantation: advancements, challenges, and future perspectives. 人类卵巢组织异种移植:进展、挑战和未来展望。
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deae291
Paweena Thuwanut, Ellen C R Leonel, Thalles Fernando Rocha Ruiz, Porntip Sirayapiwat, Stine Gry Kristensen, Christiani A Amorim

Ovarian tissue cryopreservation and transplantation has emerged as a promising fertility preservation technique for individuals facing premature ovarian insufficiency due to various medical conditions or treatments. Xenotransplantation, involving the transplantation of ovarian tissue into animal hosts, has played a pivotal role in refining ovarian tissue cryopreservation and transplantation techniques and addressing key challenges. This review provides a comprehensive overview of the current landscape of ovarian tissue xenotransplantation research, focusing on its applications in investigating ovarian biology, optimizing ovarian tissue cryopreservation and transplantation protocols, and assessing safety concerns. It also explores the utilization of xenografting of human ovarian tissue in mouse models in the last 10 years. Key findings from preclinical studies investigating grafting site optimization, cryopreservation protocol refinement, the development of strategies to mitigate chemotherapy-induced damage, follicle development, tissue revascularization, and the risk of malignant cell reintroduction are summarized. Moreover, the review examines the ethical considerations surrounding the use of animals in ovarian tissue xenotransplantation research and suggests emerging alternative models that aim to minimize animal use while maximizing clinical relevance.

卵巢组织冷冻保存和移植已成为一种很有前途的生育保护技术,用于因各种医疗条件或治疗而面临卵巢功能不全的个体。异种卵巢移植是一种将卵巢组织移植到动物体内的技术,在完善卵巢组织冷冻保存和移植技术以及解决关键挑战方面发挥着关键作用。本文综述了卵巢组织异种移植研究的现状,重点介绍了其在卵巢生物学研究、优化卵巢组织冷冻保存和移植方案以及评估安全性方面的应用。它还探讨了近10年来人类卵巢组织异种移植在小鼠模型中的应用。本文总结了临床前研究的主要发现,包括移植部位优化、冷冻保存方案改进、减轻化疗诱导损伤的策略发展、卵泡发育、组织血运重建和恶性细胞再引入的风险。此外,该综述探讨了围绕在卵巢组织异种移植研究中使用动物的伦理考虑,并提出了旨在最大限度地减少动物使用同时最大化临床相关性的新兴替代模型。
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引用次数: 0
Unveiling early predictors of adverse birth outcomes: the potential and limits of embryonic growth metrics. 揭示不良出生结果的早期预测因素:胚胎生长指标的潜力和局限性。
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deae295
Binglin Li, Yueqi Feng, Ruijuan Chen
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引用次数: 0
Recurrent implantation failure: science or fiction?
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deaf007
Juan J Fraire-Zamora, George Liperis, Munevver Serdarogullari, Omar F Ammar, Paul Pirtea, Paola Viganò, Laurentiu Craciunas, Micah J Hill, Kashish Sharma
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引用次数: 0
Association between endometriosis and working life among Danish women. 丹麦妇女子宫内膜异位症与工作寿命的关系
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-03-01 DOI: 10.1093/humrep/deae298
Eeva-Liisa Røssell, Oleguer Plana-Ripoll, Marie Josiasen, Karina Ejgaard Hansen, Bodil Hammer Bech, Dorte Rytter
<p><strong>Study question: </strong>What is the association between endometriosis and working life (lost), workforce participation, and productivity?</p><p><strong>Summary answer: </strong>Women with endometriosis experienced more working years lost due to disability pension and to a smaller degree sick leave, they were less frequently working or enrolled in education, had more sick days, were less productive, and had lower work ability.</p><p><strong>What is known already: </strong>Endometriosis is associated with negative consequences on working life; however, previous studies are based on self-reported data or smaller samples of women. To the best of our knowledge, no previous studies have quantified the average reduction in working hours during the entire span of working life using population-based registers.</p><p><strong>Study design, size, duration: </strong>This study included two Danish data sources. In the register-based cohort study (main analysis), a total of 2 650 554 women aged 18-65 years were followed for a total of 42.8 million person-years from 1992 to 2021. In the questionnaire-based cross-sectional study (Supplementary Analysis), 35 490 women aged 26-51 years were invited to participate and 7298 women completed the questionnaire.</p><p><strong>Participants/materials, setting, methods: </strong>For the main analysis, 42 741 (1.6%) were diagnosed with endometriosis. We estimated working years lost decomposed into disability pension, voluntary early retirement, or death for women with endometriosis and the general female population. For the supplementary analysis, 270 (4.0%) reported to have endometriosis. We analysed these recent questionnaire data on women's health to further investigate working life and productivity among women with and without endometriosis.</p><p><strong>Main results and the role of chance: </strong>Based on the main analysis, women with endometriosis lost on average an additional 0.26 years (95% CI: 0.17-0.37) of working life compared to the general female population. This was due to sick leave and especially disability pension. For the supplementary analysis, the participation rate was 20.6%. Women with endometriosis reported to be less frequently working or enrolled in education (74.1% (95% CI 68.4%-79.2%) with endometriosis, 82.7% (95% CI 81.8%-83.7%) without) and had more sick days (4-28 sick days last 4 weeks: 16.2% (95% CI 11.6%-21.8%) with endometriosis, 7.9% (95% CI 7.2%-8.7%) without). In addition, they reported lower productivity and work ability.</p><p><strong>Limitations, reasons for caution: </strong>Endometriosis is underdiagnosed in the register data as only hospital diagnoses are registered and diagnoses from private practicing gynaecologists and general practitioners are missing. In addition, sick leave might be underestimated as shorter periods of sick leave are not included in the registers. Questionnaire data were self-reported including endometriosis and participants might be a selected
研究问题:子宫内膜异位症与工作寿命(丧失)、工作参与率和生产力之间有什么联系?概要回答:患有子宫内膜异位症的女性由于残疾抚恤金而失去了更多的工作年限,并且在较小程度上病假,她们工作或上学的频率更低,请病假的次数更多,工作效率更低,工作能力更低。已知情况:子宫内膜异位症与工作生活的负面影响有关;然而,之前的研究是基于自我报告的数据或较小的女性样本。据我们所知,以前没有研究使用基于人口的登记来量化整个工作寿命期间工作时间的平均减少。研究设计、规模、持续时间:本研究包括两个丹麦数据源。在基于登记的队列研究(主要分析)中,从1992年到2021年,共有2650554名年龄在18-65岁之间的女性被随访,共计4280万人年。在以问卷为基础的横断面研究(补充分析)中,邀请35 490名26-51岁的女性参与,7298名女性完成了问卷。参与者/材料、环境、方法:主要分析42441例(1.6%)诊断为子宫内膜异位症。我们估计了子宫内膜异位症女性和一般女性人群中分解为残疾抚恤金、自愿提前退休或死亡的丧失工作年数。在补充分析中,270例(4.0%)报告患有子宫内膜异位症。我们分析了这些最近关于女性健康的问卷数据,以进一步调查有和没有子宫内膜异位症的女性的工作生活和生产力。主要结果和偶然性的作用:根据主要分析,与普通女性人群相比,患有子宫内膜异位症的女性平均减少了0.26年的工作寿命(95% CI: 0.17-0.37)。这是由于请病假,特别是残疾养恤金。在补充分析中,参与率为20.6%。据报道,患有子宫内膜异位症的妇女工作或接受教育的频率较低(74.1% (95% CI 68.4%-79.2%)患有子宫内膜异位症,82.7% (95% CI 81.8%-83.7%)没有),并且有更多的病假(4-28天持续4周:16.2% (95% CI 11.6%-21.8%)患有子宫内膜异位症,7.9% (95% CI 7.2%-8.7%)没有)。此外,他们的工作效率和工作能力也较低。局限性,谨慎的原因:子宫内膜异位症在登记数据中诊断不足,因为只有医院诊断被登记,而私人执业妇科医生和全科医生的诊断缺失。此外,病假可能被低估,因为较短的病假没有被列入登记册。问卷数据是自我报告的,包括子宫内膜异位症,参与者可能是一组选定的妇女。研究结果的更广泛意义:这项研究与之前关于子宫内膜异位症及其对工作寿命影响的研究一致。此外,据我们所知,之前没有研究量化了在整个工作生涯中平均减少的工作年限。然而,这些发现可能只适用于丹麦或北欧国家,因为这些国家的福利制度在失业、生病或工作能力下降期间提供了经济保障。研究资金/竞争利益:本研究由“使用机器学习发现子宫内膜异位症”项目(FEMaLe/101017562)资助,该项目已获得欧盟地平线2020研究和创新计划的资助。作者没有利益冲突。试验注册号:无。
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引用次数: 0
Intraovarian platelet-rich plasma injection for ovarian rejuvenation.
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-27 DOI: 10.1093/humrep/deaf030
Gorka Barrenetxea
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引用次数: 0
Reply: Follicular activation, not ovarian rejuvenation: terminology matters, but outcomes remain unchanged after platelet-rich plasma administration.
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-27 DOI: 10.1093/humrep/deaf031
Andres Reig, Nola Herlihy, Yigit Cakiroglu, Christine Whitehead, Bulent Tiras, Richard T Scott, Emre Seli
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引用次数: 0
Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.
IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-25 DOI: 10.1093/humrep/deaf028
Jack Tighe, Sophie Broughton, Rachel Roberts, Lorraine S Kasaven, Rachel Cutting, Elliot Bridges, Abigail Ng, Amanda Evans, Efstathios Theodorou, Jara Ben Nagi, Benjamin P Jones
<p><strong>Study question: </strong>How does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)?</p><p><strong>Summary answer: </strong>Two-consecutive SET may provide greater or comparable live birth rate (LBR); with lower multiple birth, preterm birth, and pregnancy loss or neonatal death rates compared to DET.</p><p><strong>What is known already: </strong>Elective SET in IVF/ICSI is widely encouraged over DET to minimize the risk of multiple births and associated morbidities. Despite this, multiple birth rates following IVF remain higher than the 10% target across Europe and the USA. Currently, the majority of evidence regarding SET and DET is based on various studies assessing outcomes such as LBR per treatment cycle, as opposed to per oocyte retrieval. As such, the representation of SET is mostly unfavourable. Analysis of cumulative LBR following the transfer of two embryos over consecutive cycles, rather than in one transfer event (DET) is more effective at distinguishing the two methods and will therefore provide more valuable information relevant to clinical practice.</p><p><strong>Study design, size, duration: </strong>This retrospective cohort study was conducted using Human Fertilisation and Embryology Authority (HFEA) register data, which encompasses national data from all IVF clinics in the UK. All women who underwent their first oocyte retrieval and IVF or ICSI treatment cycle with subsequent SET, DET, or 2xSET between 2010 and 2019 using blastocyst embryos were included (N = 71 807).</p><p><strong>Participants/materials, setting, methods: </strong>The rate of live birth, liveborn baby rate, multiple birth, preterm birth, and pregnancy loss or neonatal death was compared between SET, DET, and 2xSET IVF/ICSI pregnancies using blastocyst-stage embryos, where data were stratified by maternal age. Data analysis was conducted in RStudio v4.2, alpha equals 0.05.</p><p><strong>Main results and the role of chance: </strong>Blastocyst-stage 2xSET achieved a greater median LBR of 0.47 (interquartile range [IQR] 0.13) than SET, 0.41 (IQR 0.13), and DET, 0.38 (IQR 0.13) (P < 0.05). Using SET as the reference standard, 2xSET was associated with a significantly lower odds of multiple births compared to DET ((odds ratio [OR] 6.87, 95% CI 6.14-7.68) vs 28.20, 95% CI 25.20-31.57). The odds of preterm birth were also lower following 2xSET (OR 1.11, 95% CI 1.06-1.15) compared to DET (OR 2.80, 95% CI 2.67-2.94). Similarly, the odds of pregnancy loss or neonatal death were lower following 2xSET (OR 1.14, 95% CI 1.08-1.21) compared to DET (OR 2.11, 95% CI 1.98-2.24). LBR was consistently higher following 2xSET than DET and SET in women aged 39 years and under (P < 0.05). However, results were comparable in women over 39 years (P > 0.05). Across all age groups, DET pregnancies had the highest multiple birth rate (P < 0.05). In women aged 39 years and under, DET was associate
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引用次数: 0
Real-time monitoring reveals the effects of low concentrations of volatile organic compounds in the embryology laboratory
IF 6.1 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-25 DOI: 10.1093/humrep/deaf008
Jiali Cai, Liying Zhou, Lanlan Liu, Zhenfang Liu, Jinghua Chen, Kaijie Chen, Xiaolian Yang, Xiaoming Jiang, Jianzhi Ren
STUDY QUESTION Could real-time monitoring of volatile organic compounds (VOCs) in the embryology laboratory provide meaningful early warning for potential harm from the environment? SUMMARY ANSWER Even in a laboratory environment with a total VOC concentration lower than the recommendation of the Cairo Consensus, the real-time monitored VOC concentrations are associated with changes in embryo morphological parameters. WHAT IS KNOWN ALREADY VOCs have been considered a key environmental detriment in embryology laboratories. However, the current VOC thresholds established by the Cairo consensus were based on the practical experience of air pollution cases, and a scientifically derived threshold is lacking. STUDY DESIGN, SIZE, DURATION The study included 7076 oocyte collection (OPU) cycles carried out between June 2020 and December 2022 in the Center for Reproductive Medicine of the affiliated Chenggong Hospital of Xiamen University, 6306 of which resulted in at least one embryo transfer (ET) attempt during the study. VOC monitoring data were recorded every 10 min. The average and peak concentrations of total VOCs and formaldehyde during culture were associated with embryo parameters and implantation following the first ET attempt of the cycle in generalized estimating equations and generalized additive models. MAIN RESULTS AND THE ROLE OF CHANCE Real-time monitoring of VOCs showed a dynamic of VOC concentration in the laboratory. The concentration reached peaks during the working hours of the days and working days of the week and fell quickly at night and on weekends. The average concentrations of VOCs during the culture period were linearly associated with decreased early cleavage (OR 0.92, 95% CI: 0.85, 0.99), decreased Day 3 compaction (OR 0.51, 95% CI: 0.32, 0.83), increased asymmetry (OR 1.13, 95% CI: 1.01, 1.25), and increased grade C trophectoderm (TE) (OR 1.99, 95% CI: 1.32, 3.01). On the other hand, increased Day 3 arrest, delayed blastocyst formation, and decreased grade A TE showed a non-linear association with VOCs, suggesting a possible threshold of effect. In the first transfer attempt, negative associations were observed between maximal formaldehyde concentrations and pregnancy in both fresh transfer (RR 0.971, 95% CI: 0.94, 0.99) and freeze-all frozen-thawed ET (RR 0.959, 95% CI: 0.92, 0.99) cycles. LIMITATIONS, REASONS FOR CAUTION The sensitivity and specificity of the monitor are not comparable to the standard protocols, such as chromatography-mass spectroscopy. Due to the lack of ability to identify the chemical nature of the components of VOCs, the toxicity and source of the VOCs were largely unknown. The representative sampling of the laboratory air may not necessarily reflect the exposure of embryos. WIDER IMPLICATIONS OF THE FINDINGS While the environment of the embryology laboratory has been significantly improved, the data suggested that a low VOC level could still be a concern. Due to the dynamic of VOC concentration in the
{"title":"Real-time monitoring reveals the effects of low concentrations of volatile organic compounds in the embryology laboratory","authors":"Jiali Cai, Liying Zhou, Lanlan Liu, Zhenfang Liu, Jinghua Chen, Kaijie Chen, Xiaolian Yang, Xiaoming Jiang, Jianzhi Ren","doi":"10.1093/humrep/deaf008","DOIUrl":"https://doi.org/10.1093/humrep/deaf008","url":null,"abstract":"STUDY QUESTION Could real-time monitoring of volatile organic compounds (VOCs) in the embryology laboratory provide meaningful early warning for potential harm from the environment? SUMMARY ANSWER Even in a laboratory environment with a total VOC concentration lower than the recommendation of the Cairo Consensus, the real-time monitored VOC concentrations are associated with changes in embryo morphological parameters. WHAT IS KNOWN ALREADY VOCs have been considered a key environmental detriment in embryology laboratories. However, the current VOC thresholds established by the Cairo consensus were based on the practical experience of air pollution cases, and a scientifically derived threshold is lacking. STUDY DESIGN, SIZE, DURATION The study included 7076 oocyte collection (OPU) cycles carried out between June 2020 and December 2022 in the Center for Reproductive Medicine of the affiliated Chenggong Hospital of Xiamen University, 6306 of which resulted in at least one embryo transfer (ET) attempt during the study. VOC monitoring data were recorded every 10 min. The average and peak concentrations of total VOCs and formaldehyde during culture were associated with embryo parameters and implantation following the first ET attempt of the cycle in generalized estimating equations and generalized additive models. MAIN RESULTS AND THE ROLE OF CHANCE Real-time monitoring of VOCs showed a dynamic of VOC concentration in the laboratory. The concentration reached peaks during the working hours of the days and working days of the week and fell quickly at night and on weekends. The average concentrations of VOCs during the culture period were linearly associated with decreased early cleavage (OR 0.92, 95% CI: 0.85, 0.99), decreased Day 3 compaction (OR 0.51, 95% CI: 0.32, 0.83), increased asymmetry (OR 1.13, 95% CI: 1.01, 1.25), and increased grade C trophectoderm (TE) (OR 1.99, 95% CI: 1.32, 3.01). On the other hand, increased Day 3 arrest, delayed blastocyst formation, and decreased grade A TE showed a non-linear association with VOCs, suggesting a possible threshold of effect. In the first transfer attempt, negative associations were observed between maximal formaldehyde concentrations and pregnancy in both fresh transfer (RR 0.971, 95% CI: 0.94, 0.99) and freeze-all frozen-thawed ET (RR 0.959, 95% CI: 0.92, 0.99) cycles. LIMITATIONS, REASONS FOR CAUTION The sensitivity and specificity of the monitor are not comparable to the standard protocols, such as chromatography-mass spectroscopy. Due to the lack of ability to identify the chemical nature of the components of VOCs, the toxicity and source of the VOCs were largely unknown. The representative sampling of the laboratory air may not necessarily reflect the exposure of embryos. WIDER IMPLICATIONS OF THE FINDINGS While the environment of the embryology laboratory has been significantly improved, the data suggested that a low VOC level could still be a concern. Due to the dynamic of VOC concentration in the","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"15 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Human reproduction
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