{"title":"Beyond the Armchair: Defying the Myth of 1950s Fatherhood From Outside of the Household","authors":"H. Pacheco","doi":"10.5070/m414157332","DOIUrl":"https://doi.org/10.5070/m414157332","url":null,"abstract":"","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133759047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"My Parents’ Immigration Stories as a Microcosm of American Colonialism","authors":"Janelle A. Perez","doi":"10.5070/m414157337","DOIUrl":"https://doi.org/10.5070/m414157337","url":null,"abstract":"","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129681455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randy Posada, Mary S. Silva, Marisa W. Torres, Jonathan R. Allen, Jeff Drocco, Sarah Sandholtz, A. Zemla, Ucsf Spoke Investigative teams
For over a decade, drug-induced liver injury (DILI) has posed significant drawbacks in the synthesis and development of drugs and remains a consequential concern. With finite success within the existing preclinical models, DILI is one of the main causes of drug withdrawal or termination from the market. Particularly, this withdrawal occurs during the late stages of drug development (Kullak-Ublick, 2017). Since DILI is difficult to diagnose and treat, it has become an obstacle in the drug production market that in turn affects clinicians, pharmaceutical companies, and consumers. We propose a method for learning features of DILI-positive drugs based on the graphical relationships and patterns they possess within a network of biological databases. We also train various statistical and machine learning models on these learned features in order to classify the drugs as DILI-positive or negative. Our methods include Random Forest, Neural networks, and logistic regression classification. We utilize labeled DILI-positive and DILI-negative datasets, which were developed by the FDA and the National center for toxicological research, as well as additional literature datasets (Thakkar, 2020) in order to validate our results and assess our featurization and model accuracy.
{"title":"Graph-based featurization methods for classifying small molecule compounds","authors":"Randy Posada, Mary S. Silva, Marisa W. Torres, Jonathan R. Allen, Jeff Drocco, Sarah Sandholtz, A. Zemla, Ucsf Spoke Investigative teams","doi":"10.5070/m414157338","DOIUrl":"https://doi.org/10.5070/m414157338","url":null,"abstract":"For over a decade, drug-induced liver injury (DILI) has posed significant drawbacks in the synthesis and development of drugs and remains a consequential concern. With finite success within the existing preclinical models, DILI is one of the main causes of drug withdrawal or termination from the market. Particularly, this withdrawal occurs during the late stages of drug development (Kullak-Ublick, 2017). Since DILI is difficult to diagnose and treat, it has become an obstacle in the drug production market that in turn affects clinicians, pharmaceutical companies, and consumers. We propose a method for learning features of DILI-positive drugs based on the graphical relationships and patterns they possess within a network of biological databases. We also train various statistical and machine learning models on these learned features in order to classify the drugs as DILI-positive or negative. Our methods include Random Forest, Neural networks, and logistic regression classification. We utilize labeled DILI-positive and DILI-negative datasets, which were developed by the FDA and the National center for toxicological research, as well as additional literature datasets (Thakkar, 2020) in order to validate our results and assess our featurization and model accuracy.","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114317916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The evolutionary principles of Mendelian inheritance and Darwinist natural selection are not exclusive to morphological expression. On a baseline level, evolution can be most observable and understood through physical features. With recent studies, evolution has been applied to psychiatric disorders and natural behaviors. Through the peer review of different academic literature, evolution has expanded beyond the physical sciences and into the frontier of the social sciences. The biological characteristics of inheritance and natural selection still apply to inherited mental illnesses and behaviors because individuals are more likely to inherit mental illnesses or behaviors from their parents. The transgenerational inheritance of adaptations to environmental stimuli is a result of epigenetics. This adds a nuanced layer to the nature versus nurture debate. The novelties presented in the field of behavioral epigenetics broaden the perspective of evolution and create potential diagnostics, preventions, and treatments for psychiatric and behavioral disorders.
{"title":"I Got My Attitude From My Mom: Behavioral Inheritance","authors":"Destini Nguyen","doi":"10.5070/m413255533","DOIUrl":"https://doi.org/10.5070/m413255533","url":null,"abstract":"The evolutionary principles of Mendelian inheritance and Darwinist natural selection are not exclusive to morphological expression. On a baseline level, evolution can be most observable and understood through physical features. With recent studies, evolution has been applied to psychiatric disorders and natural behaviors. Through the peer review of different academic literature, evolution has expanded beyond the physical sciences and into the frontier of the social sciences. The biological characteristics of inheritance and natural selection still apply to inherited mental illnesses and behaviors because individuals are more likely to inherit mental illnesses or behaviors from their parents. The transgenerational inheritance of adaptations to environmental stimuli is a result of epigenetics. This adds a nuanced layer to the nature versus nurture debate. The novelties presented in the field of behavioral epigenetics broaden the perspective of evolution and create potential diagnostics, preventions, and treatments for psychiatric and behavioral disorders.","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115500954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 outbreak, originating in China and spreading across the globe, has affected the entire world by taking the lives of millions and leaving millions more in hospital beds fighting for their lives. This infectious disease was considered a pandemic by the World Health Organization (WHO) in March of 2020, and since then has created an urgent response from world leaders and health organizations to develop an effective strategy to overcome this deadly disease and put an end to the pandemic. Several techniques have been developed by health organizations and vocalized by world leaders around the world which have all been helpful in the fight against COVID-19, however this article looks to address how living a healthy lifestyle might also be one of the most important techniques that should be implemented and vocalized in order to put an end to this novel virus. Research has shown that continuous physical activity and healthy eating habits have been and continue to be one of the most effective ways in protecting individuals from severe outcomes after infection with SARS-CoV-2. These practices must be adopted by every individual in order to defeat this disease and ultimately put an end to the COVID-19 pandemic.
{"title":"An In-Depth Analysis of the Novel SARS-CoV-2","authors":"Joseph Younan","doi":"10.5070/m413255539","DOIUrl":"https://doi.org/10.5070/m413255539","url":null,"abstract":"The COVID-19 outbreak, originating in China and spreading across the globe, has affected the entire world by taking the lives of millions and leaving millions more in hospital beds fighting for their lives. This infectious disease was considered a pandemic by the World Health Organization (WHO) in March of 2020, and since then has created an urgent response from world leaders and health organizations to develop an effective strategy to overcome this deadly disease and put an end to the pandemic. Several techniques have been developed by health organizations and vocalized by world leaders around the world which have all been helpful in the fight against COVID-19, however this article looks to address how living a healthy lifestyle might also be one of the most important techniques that should be implemented and vocalized in order to put an end to this novel virus. Research has shown that continuous physical activity and healthy eating habits have been and continue to be one of the most effective ways in protecting individuals from severe outcomes after infection with SARS-CoV-2. These practices must be adopted by every individual in order to defeat this disease and ultimately put an end to the COVID-19 pandemic.","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130214308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sexual Education and the LGBT+ Community: The Impact of Information Sources on Sexual Outcomes","authors":"Raven Burton, Dr. Ross Avilla","doi":"10.5070/m413255540","DOIUrl":"https://doi.org/10.5070/m413255540","url":null,"abstract":"","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131534577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Negotiations of Power: The Persistence of Indigenous Meanings of Space in Mission-era Alta California","authors":"Kiana Hugins","doi":"10.5070/m413255537","DOIUrl":"https://doi.org/10.5070/m413255537","url":null,"abstract":"","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132980757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AI Technology Ethics in Cognitive Science: A Review of the Literature","authors":"Martos Montiel","doi":"10.5070/m413255536","DOIUrl":"https://doi.org/10.5070/m413255536","url":null,"abstract":"","PeriodicalId":131320,"journal":{"name":"UC Merced Undergraduate Research Journal","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127105651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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