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Immunopharmacology
Pub Date : 2000-09-01 DOI: 10.1016/S0162-3109(00)00273-3
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引用次数: 0
Effects of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 production of murine B cells and B cell lines 中药柴胡根果胶多糖对小鼠B细胞和B细胞系白细胞介素6产生的影响
Immunopharmacology
Pub Date : 2000-09-01 DOI: 10.1016/S0162-3109(00)00245-9
Yingjie Guo , Tsukasa Matsumoto , Yuji Kikuchi , Takashi Ikejima , Benxiang Wang , Haruki Yamada

The effect of T-cell-independent B cell mitogen, a pectic polysaccharide, bupleuran 2IIc, from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 (IL-6) production of murine B cells and B cell lines was investigated in order to clarify the mechanism of enhanced immunoglobulin (Ig) secretion from B cells. Bupleuran 2IIc enhanced IgM secretion from highly purified murine normal B cells. When normal B cells from murine spleen were cultured with bupleuran 2IIc in the presence of anti-IL-6 neutralizing antibody, the enhanced IgM secretion by bupleuran 2IIc was reduced. When B cells were stimulated with bupleuran 2IIc, their IL-6 secretion and the transcription of IL-6 mRNA were enhanced. The enhanced IL-6 secretion by bupleuran 2IIc was also observed in B cell line, Y16 cell. When bupleuran 2IIc was digested with endo-α-(1→4)-d-polygalacturonase, the resulting enzyme resistant carbohydrate portion, “ramified” region (PG-1) composed of rhamnogalacturonan core containing neutral sugar side chains showed potent IL-6 secretion-enhancing activity. These results suggest that the “ramified” region of bupleuran 2IIc stimulates the secretion of IL-6 as the active site, and the resulting IL-6 may partially contribute the enhancement of IgM secretion as an autocrine and/or paracrine mechanism.

本文研究了中药柴胡根果胶多糖柴胡聚糖2IIc对小鼠B细胞及B细胞系白细胞介素6 (IL-6)分泌的影响，以阐明其增强免疫球蛋白(Ig)分泌的机制。柴胡脲2IIc增强了高纯度小鼠正常B细胞的IgM分泌。在抗il -6中和抗体存在的情况下，用柴胡酰2IIc培养小鼠脾脏正常B细胞，可降低柴胡酰2IIc增强的IgM分泌。柴胡脲2IIc刺激B细胞后，细胞IL-6分泌增强，IL-6 mRNA转录增强。在B细胞系Y16细胞中也观察到柴胡素2IIc对IL-6分泌的增强作用。当用内切酶-α-(1→4)-d-聚半乳糖醛酸酶消化柴胡聚糖2IIc时，得到的抗酶碳水化合物部分，由含有中性糖侧链的鼠李糖半乳糖醛酸核组成的“分枝化”区(PG-1)显示出强大的IL-6分泌增强活性。这些结果表明，柴胡脲2IIc的“分支”区域刺激IL-6作为活性位点的分泌，由此产生的IL-6可能作为自分泌和/或旁分泌机制部分促进了IgM分泌的增强。
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引用次数: 47
Molecular basis of complete C4 deficiency in a SLE patient with four mutant genes: A 2- BP insertion at exon 29 in C4A and A 1-BP deletion at exon 13 in C4B 4个突变基因:C4A外显子29处2- BP插入和C4B外显子13处1-BP缺失，SLE患者C4完全缺乏的分子基础
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80091-0
Kristi L. Rupert , Joann M. Moulds , Yan Yang , Robert Warren , John Reveille , Frank C. Arnett , C. Yung Yu
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引用次数: 4
Expression of soluble and membrane-bound complement regulatory proteins by human hepatocytes 人肝细胞可溶性和膜结合补体调节蛋白的表达
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80175-7
H. Vogel, J. Halme, M. Kirschfink
{"title":"Expression of soluble and membrane-bound complement regulatory proteins by human hepatocytes","authors":"H. Vogel, J. Halme, M. Kirschfink","doi":"10.1016/S0162-3109(00)80175-7","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80175-7","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"26 1","pages":"63"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74557035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex 单个活性C1r对两个C1s亚基的切割揭示了C1复合物中C1s-C1r-C1r-C1s四聚体的实质性灵活性
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80261-1
P. Závodszky, Z. Lorincz, S. Cseh, J. Dobó, K. Szilágyi, G. Ambrus, P. Gál
{"title":"The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex","authors":"P. Závodszky, Z. Lorincz, S. Cseh, J. Dobó, K. Szilágyi, G. Ambrus, P. Gál","doi":"10.1016/S0162-3109(00)80261-1","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80261-1","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"94 1","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77272764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Cobra Venom Factor (CVF) reduces hypoxicischemic (HI) cerebral edema in neonatal rats 眼镜蛇毒因子(CVF)减少新生大鼠缺氧缺血性脑水肿
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80065-X
H Lassiter, P Feldhoff, N Dabhia, J Parker, R Feldhoff
{"title":"Cobra Venom Factor (CVF) reduces hypoxicischemic (HI) cerebral edema in neonatal rats","authors":"H Lassiter,&nbsp;P Feldhoff,&nbsp;N Dabhia,&nbsp;J Parker,&nbsp;R Feldhoff","doi":"10.1016/S0162-3109(00)80065-X","DOIUrl":"10.1016/S0162-3109(00)80065-X","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"49 1","pages":"Page 22"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0162-3109(00)80065-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75085685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue distribution of mouse CD59 analyzed using a novel rat anti-mouse CD59 monoclonal antibody 利用一种新型大鼠抗小鼠CD59单克隆抗体分析小鼠CD59的组织分布
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80274-X
S. Hanna, C. Harris, B. Morgan
{"title":"Tissue distribution of mouse CD59 analyzed using a novel rat anti-mouse CD59 monoclonal antibody","authors":"S. Hanna, C. Harris, B. Morgan","doi":"10.1016/S0162-3109(00)80274-X","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80274-X","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"9 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81728840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Soluble complement receptor (sCR1) 1 rescues rats from lethal shock induced by priming of sublethal dose of lipopolysaccharide (LPS) and anti-Crry antibodies 可溶性补体受体(sCR1) 1可拯救亚致死剂量脂多糖(LPS)和抗crry抗体引发的致死性休克大鼠
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80177-0
M. Mizuno, K. Nishikawa, N. Okada, H. Okada, S. Matsuo
{"title":"Soluble complement receptor (sCR1) 1 rescues rats from lethal shock induced by priming of sublethal dose of lipopolysaccharide (LPS) and anti-Crry antibodies","authors":"M. Mizuno, K. Nishikawa, N. Okada, H. Okada, S. Matsuo","doi":"10.1016/S0162-3109(00)80177-0","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80177-0","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"16 1","pages":"63"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85091134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of STAT3 by sublytic C5b-9 in human aortic endothelial cells induces cell cycle 人主动脉内皮细胞中亚溶C5b-9激活STAT3诱导细胞周期
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80277-5
F. Niculescu, L. Soane, T. Badea, M. Shin, H. Rus
{"title":"Activation of STAT3 by sublytic C5b-9 in human aortic endothelial cells induces cell cycle","authors":"F. Niculescu, L. Soane, T. Badea, M. Shin, H. Rus","doi":"10.1016/S0162-3109(00)80277-5","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80277-5","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"11 1","pages":"93"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77013836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Reconstitution of the complement (C) function in C1Q deficient (CIQA-/-) mice with wild type bone marrow cells 野生型骨髓细胞C1Q缺陷(CIQA-/-)小鼠补体(C)功能的重建
Immunopharmacology
Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80230-1
F. Petry, M. Botto, M. Walport, M. Loos
{"title":"Reconstitution of the complement (C) function in C1Q deficient (CIQA-/-) mice with wild type bone marrow cells","authors":"F. Petry, M. Botto, M. Walport, M. Loos","doi":"10.1016/S0162-3109(00)80230-1","DOIUrl":"https://doi.org/10.1016/S0162-3109(00)80230-1","url":null,"abstract":"","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"40 1","pages":"79"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80430003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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