Pub Date : 2024-07-09DOI: 10.15674/0030-598720242101-102
Domestic medicine suffered a heavy loss: a talented scientist, head of the department of pathophysiology, anesthesiology and functional diagnostics, candidate of medical sciences Ihor Volodymyrovych Kotulskyi passed away.
{"title":"Ihor Volodymyrovych Kotulskyi","authors":"","doi":"10.15674/0030-598720242101-102","DOIUrl":"https://doi.org/10.15674/0030-598720242101-102","url":null,"abstract":"Domestic medicine suffered a heavy loss: a talented scientist, head of the department of pathophysiology, anesthesiology and functional diagnostics, candidate of medical sciences Ihor Volodymyrovych Kotulskyi passed away.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"122 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024242-47
Yulia Avramenko, S. Maslennikov, Stanislav Bondarenko, M. Golovakha
Objective. The use of infrapatellar fat pad (IPFP) as the source of mesenchymal stem cells (MSCs), show an age-independent proliferation and differentiation potential. In addition, the pronounced chondrogenic potential of IPFP-ASCs makes them promising candidates for research for use in other methodsof regenerative therapy. Methods. A direct immunohistochemical study was carried out in serial paraffin sections of the biopsy material of Hoffa`s fat pad and subcutaneus fat tissue, using monoclonal antibodies. The minimum criteria established by the International Society for Cell Therapy to ensure the identity of MSCs use CD73 and CD105 as positive markers and CD34, CD31, CD45 as a negative. Results. According to the results of histological, immunohistochemical, morphometric and statistical studies, it was found that in the biopsy of both tissues the relative number of cells with an immunoprofile CD105+, CD73+, CD34–, CD31–, CD45– in the standard field of view (×200) was: 7.25 (5.42; 8.89 ) %, and 11.11 (8.46; 13.45) %, no statistically significant difference was found between comparison groups (р > 0,05). Conclusion. The therapeutic effect of mesenchymal stem cells of subcutaneous adipose tissue has been proven, thus the identification of similar cells in the biopsy material and relatively similar density in the Hoffa body makesit an important source of adipose-derived stem cells that can be used for regenerative engineering tissue.
{"title":"Comparison of the infrapatellar and subcutaneous adipose tissue biopsy material as a source of mesenchymal stromal cells for regenerative medicine in traumatology","authors":"Yulia Avramenko, S. Maslennikov, Stanislav Bondarenko, M. Golovakha","doi":"10.15674/0030-59872024242-47","DOIUrl":"https://doi.org/10.15674/0030-59872024242-47","url":null,"abstract":"Objective. The use of infrapatellar fat pad (IPFP) as the source of mesenchymal stem cells (MSCs), show an age-independent proliferation and differentiation potential. In addition, the pronounced chondrogenic potential of IPFP-ASCs makes them promising candidates for research for use in other methodsof regenerative therapy. Methods. A direct immunohistochemical study was carried out in serial paraffin sections of the biopsy material of Hoffa`s fat pad and subcutaneus fat tissue, using monoclonal antibodies. The minimum criteria established by the International Society for Cell Therapy to ensure the identity of MSCs use CD73 and CD105 as positive markers and CD34, CD31, CD45 as a negative. Results. According to the results of histological, immunohistochemical, morphometric and statistical studies, it was found that in the biopsy of both tissues the relative number of cells with an immunoprofile CD105+, CD73+, CD34–, CD31–, CD45– in the standard field of view (×200) was: 7.25 (5.42; 8.89 ) %, and 11.11 (8.46; 13.45) %, no statistically significant difference was found between comparison groups (р > 0,05). Conclusion. The therapeutic effect of mesenchymal stem cells of subcutaneous adipose tissue has been proven, thus the identification of similar cells in the biopsy material and relatively similar density in the Hoffa body makesit an important source of adipose-derived stem cells that can be used for regenerative engineering tissue.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"52 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024254-60
M. Hrytsai, Valerii Hryhorovskyi, V. Tsokalo, V. Sabadosh, Taisiia Kuzub
In numerous articles, monographs, and textbooks, the aspects of local application of glucocorticoid injections at the current stage of development of rheumatology are considered from the point of view of expediency, effectiveness, and safety. Factors affecting the effectiveness of this method are analyzed. Periarticular and/or intra-articular injections of corticosteroids are included in various recommendations and protocols for the treatment of arthrosis and rheumatic joint lesions available today. Objective. Determination of pathomorphological, clinical and laboratory manifestations of the infectious process after local administration of glucocorticoid drugs. Methods. Clinical, anamnestic, laboratory, bacteriological and pathomorphologicaldata of 34 patients with infectious complications were analyzed. Results. The administration of long-acting drugs was most often used: DIPROSPAN — 13 (38.2 %) cases; KENALOG — 5 (14.7 %); DEPOS — 3 (8.8 %); FLOSTERON — 2 (5.9 %); a short-acting drug (methylprednisolone acetate (METYPRED), hydrocortisone acetate) was used in 11 (32.4 %) cases. At the time of hospitalization in the clinic, the infectious process was in 8 (23.5 %) patients in the acute stage, 10 (29.4 %) in the subacute stage, and in another 16 (47.1 %) in the chronic stage, 13 (38.2 %) of which are in the active fistula phase. Conclusions. Pathomorphological manifestations and signs of a purulent-necrotic and purulent-inflammatory infectious process (infectious complications) after local administration of glucocorticoid drugs accompany and are closely statistically significantly interrelated with typical clinical and laboratory manifestations (leukocytosis with a «shift of the leukocyte formula to the left», an increase in ESR and level CRP) and etiology («bacteriology») of the infectious process.
{"title":"SEPTIC COMPLICATIONS AFTER THE USE OF GLUCOCORTICOIDS (RESULTS OF CLINICAL LABORATORY AND PATHOMORPHOLOGICAL STUDIES)","authors":"M. Hrytsai, Valerii Hryhorovskyi, V. Tsokalo, V. Sabadosh, Taisiia Kuzub","doi":"10.15674/0030-59872024254-60","DOIUrl":"https://doi.org/10.15674/0030-59872024254-60","url":null,"abstract":"In numerous articles, monographs, and textbooks, the aspects of local application of glucocorticoid injections at the current stage of development of rheumatology are considered from the point of view of expediency, effectiveness, and safety. Factors affecting the effectiveness of this method are analyzed. Periarticular and/or intra-articular injections of corticosteroids are included in various recommendations and protocols for the treatment of arthrosis and rheumatic joint lesions available today. Objective. Determination of pathomorphological, clinical and laboratory manifestations of the infectious process after local administration of glucocorticoid drugs. Methods. Clinical, anamnestic, laboratory, bacteriological and pathomorphologicaldata of 34 patients with infectious complications were analyzed. Results. The administration of long-acting drugs was most often used: DIPROSPAN — 13 (38.2 %) cases; KENALOG — 5 (14.7 %); DEPOS — 3 (8.8 %); FLOSTERON — 2 (5.9 %); a short-acting drug (methylprednisolone acetate (METYPRED), hydrocortisone acetate) was used in 11 (32.4 %) cases. At the time of hospitalization in the clinic, the infectious process was in 8 (23.5 %) patients in the acute stage, 10 (29.4 %) in the subacute stage, and in another 16 (47.1 %) in the chronic stage, 13 (38.2 %) of which are in the active fistula phase. Conclusions. Pathomorphological manifestations and signs of a purulent-necrotic and purulent-inflammatory infectious process (infectious complications) after local administration of glucocorticoid drugs accompany and are closely statistically significantly interrelated with typical clinical and laboratory manifestations (leukocytosis with a «shift of the leukocyte formula to the left», an increase in ESR and level CRP) and etiology («bacteriology») of the infectious process.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"94 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024261-68
Yevhenii Yakushkin, S. Khmyzov, Ruslan Zlatnik
According to literature sources, radiography can indirectly visualize congenital insufficiency of the cruciate ligaments both in isolated form and in combination with other congenital malformations of the lower extremities. Objective. To study the parameters of the intercondylar fossa of the femur in children of different age groups with stable/unstable knee jo ints due to congenital malformations of the lower limbs using instrumental imaging methods. Methods. A prospective diagnostic study was conducted of 359 knee joints of 217 children who were treated at the pediatric orthopedics clinic from 2019to 2022 and with a retrospective control group (2010–2021). limbs, as well as with congenital malformations of the lower limbs. X-ray examinations were performed on the OPERA T90cex X-ray and fluoroscopic system. Results. 217 patients took part in the study, including 105 patients without knee jointpathology and 112 with congenital malformations of the lower limbs. Comparison of the accuracy of radiological diagnostic indicators was performed using the Studentʼs t-test with the results of computer and magnetic resonance imaging studies, which showed the absence of a statistically significant differencein the results research. A diagnostic study was also conducted to find the regularity of the development of the knee joints and to identify the parameters of the radiological norm of the development of the intercondylar fossa of the femur in children of different age categories. Conclusions. Using the resultsof instrumental studies, the parameters of the intercondylar fossa of the femur in children of different age categories with stable and unstable knee joints due to congenital malformations of the lower limbs were investigated. The results of the study should be taken into account for the diagnosis of congenital defects of the knee joint.
根据文献资料，放射摄影可间接观察到单独存在的先天性十字韧带功能不全，以及与其他先天性下肢畸形合并存在的先天性十字韧带功能不全。研究目的使用仪器成像方法研究因下肢先天性畸形导致膝关节稳定/不稳定的不同年龄组儿童的股骨髁间窝参数。方法。对2019年至2022年期间在儿科骨科诊所接受治疗的217名儿童的359个膝关节进行了前瞻性诊断研究，并与回顾性对照组（2010年至2021年）进行了对比。X 射线检查在 OPERA T90cex X 射线和透视系统上进行。研究结果217 名患者参加了研究，其中 105 名患者无膝关节病变，112 名患者患有先天性下肢畸形。采用学生 t 检验法对放射诊断指标的准确性与计算机和磁共振成像研究结果进行了比较，结果表明研究结果不存在显著的统计学差异。此外，还进行了一项诊断研究，以发现膝关节发育的规律性，并确定不同年龄段儿童股骨髁间窝发育的放射学标准参数。研究结论利用仪器研究的结果，对因下肢先天性畸形导致膝关节稳定和不稳定的不同年龄段儿童的股骨髁间窝参数进行了研究。在诊断膝关节先天性缺损时应考虑到研究结果。
{"title":"PARAMETERS OF THE INTERCONDYLAR FOSSA OF THE FEMUR IN CHILDRENIN NORMAL CONDITIONS AND WITH CONGENITAL MALFORMATIONS OF THE LOWER LIMBS","authors":"Yevhenii Yakushkin, S. Khmyzov, Ruslan Zlatnik","doi":"10.15674/0030-59872024261-68","DOIUrl":"https://doi.org/10.15674/0030-59872024261-68","url":null,"abstract":"According to literature sources, radiography can indirectly visualize congenital insufficiency of the cruciate ligaments both in isolated form and in combination with other congenital malformations of the lower extremities. Objective. To study the parameters of the intercondylar fossa of the femur in children of different age groups with stable/unstable knee jo ints due to congenital malformations of the lower limbs using instrumental imaging methods. Methods. A prospective diagnostic study was conducted of 359 knee joints of 217 children who were treated at the pediatric orthopedics clinic from 2019to 2022 and with a retrospective control group (2010–2021). limbs, as well as with congenital malformations of the lower limbs. X-ray examinations were performed on the OPERA T90cex X-ray and fluoroscopic system. Results. 217 patients took part in the study, including 105 patients without knee jointpathology and 112 with congenital malformations of the lower limbs. Comparison of the accuracy of radiological diagnostic indicators was performed using the Studentʼs t-test with the results of computer and magnetic resonance imaging studies, which showed the absence of a statistically significant differencein the results research. A diagnostic study was also conducted to find the regularity of the development of the knee joints and to identify the parameters of the radiological norm of the development of the intercondylar fossa of the femur in children of different age categories. Conclusions. Using the resultsof instrumental studies, the parameters of the intercondylar fossa of the femur in children of different age categories with stable and unstable knee joints due to congenital malformations of the lower limbs were investigated. The results of the study should be taken into account for the diagnosis of congenital defects of the knee joint.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"122 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024248-53
V.V. Shtroblia, Ruslan Lutsenko
Osteoarthritis is considered one of the leading causes of chronic disability and is a significant problem on human health and the economy. Chronic pain is the dominant symptom that prompts patients to seek medical attention. Pain mechanisms in osteoarthritis remained unknown for a long time. However, it is known that chronic inflammation of the joint can be a key factor in the occurrence and exacerbation of pain or changes in the perception of pain. Pharmacological therapy is often based on the use of steroidal and non-steroidal anti-inflammatory drugs, but their long-term use or large doses can cause side effects. That is why the development of new methods of treatment of inflammatory processes is the object of active research, as they can affect various mechanisms. In this context, carboxytherapy is an interesting alternative or addition to existing treatment regimens aimed at reducing pain in patients with osteoarthritis. This method involves the administration of medical carbon dioxide (CO2) to improve blood supply to tissues, which can contribute to humoral, biochemical and tissue mechanisms. Studying the effects of carboxytherapy in animal models of inflammation is important for understanding its potential benefits and mechanisms of action. Objective. Study of anti-inflammatory properties of carboxytherapy both in monotherapy and in its combined use. Methods. Carboxytherapy is the injection of carbon dioxide in monotherapy and when used in combination on the formalin model of inflammation in animals. Results. The obtained research results prove the anti-inflammatory properties of carbon dioxide on the model of formalin inflammationin animals. Conclusions. The combined use of carboxytherapy enhanced the effect of conventional drugs on the formalin model of inflammation in animals. The establishment of an anti-inflammatory effect of carboxytherapy indicates the therapeutic value of CO2, while emphasizing the need for further in-depth studies to explore its mechanisms and confirm the efficacy for clinical use.
{"title":"EXPERIMENTAL RESEARCH OF THE PHARMACOLOGICAL EFFECT OF CARBON DIOXIDE IN THE CORRECTION OF INFLAMMATION","authors":"V.V. Shtroblia, Ruslan Lutsenko","doi":"10.15674/0030-59872024248-53","DOIUrl":"https://doi.org/10.15674/0030-59872024248-53","url":null,"abstract":"Osteoarthritis is considered one of the leading causes of chronic disability and is a significant problem on human health and the economy. Chronic pain is the dominant symptom that prompts patients to seek medical attention. Pain mechanisms in osteoarthritis remained unknown for a long time. However, it is known that chronic inflammation of the joint can be a key factor in the occurrence and exacerbation of pain or changes in the perception of pain. Pharmacological therapy is often based on the use of steroidal and non-steroidal anti-inflammatory drugs, but their long-term use or large doses can cause side effects. That is why the development of new methods of treatment of inflammatory processes is the object of active research, as they can affect various mechanisms. In this context, carboxytherapy is an interesting alternative or addition to existing treatment regimens aimed at reducing pain in patients with osteoarthritis. This method involves the administration of medical carbon dioxide (CO2) to improve blood supply to tissues, which can contribute to humoral, biochemical and tissue mechanisms. Studying the effects of carboxytherapy in animal models of inflammation is important for understanding its potential benefits and mechanisms of action. Objective. Study of anti-inflammatory properties of carboxytherapy both in monotherapy and in its combined use. Methods. Carboxytherapy is the injection of carbon dioxide in monotherapy and when used in combination on the formalin model of inflammation in animals. Results. The obtained research results prove the anti-inflammatory properties of carbon dioxide on the model of formalin inflammationin animals. Conclusions. The combined use of carboxytherapy enhanced the effect of conventional drugs on the formalin model of inflammation in animals. The establishment of an anti-inflammatory effect of carboxytherapy indicates the therapeutic value of CO2, while emphasizing the need for further in-depth studies to explore its mechanisms and confirm the efficacy for clinical use.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"1 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024269-75
Oleksandr Sitenko, Taras Sitenko
The prospects of creating new opportunities in the rehabilitation of patients with limb amputations are generally associated with the method of osseointegration and endo-exo-prosthetics (EEP). The results of the practical application of the method indicate attention to the analytical consideration of all its components, all stages. Objective. To substantiate the expediency and directions of research and development of the theoretical and practical principles of EEP from the standpoint of the full cycle, including both the problems of osseointegration and functional qualities, constructive and technological principles regarding the prostheses themselves, the methodology of the process of mastering and using them. Results. Considered biomechanical and other arguments, which substantiate the objects of research and development of medicaltechnical and medical-technological means, including the constructions of endo-exo-prostheses, methods of learning to use them, evaluation of the quality of locomotion, increasing the reliability of the «implant-bone» c ontact. The d esign principle of a hip prosthesis with a removable unloading module is proposed, which is installed at the stage of mastering the prosthesis, and in necessary cases, during constant use. The possibilities of the method of recognizing biomechanical patterns of movements for teaching patients to walk on prostheses, for adjusting functional nodes and assessing the quality of prosthetics are shown. Conclusions. The problemof endo-exo-prosthetics is considered for the first time from the standpoint of the requirements for the functions and qualities of the prostheses themselves. Reasoned directions of application and significance of clinical, experimental and mathematical biomechanics methods for analysis and development of the functional structure of endo-exo prostheses, to reduce risks when using them.
{"title":"BIOMECHANICAL ASPECTS OF ENDO-EXO-PROSTHETICS OF THE LOWER LIMBS","authors":"Oleksandr Sitenko, Taras Sitenko","doi":"10.15674/0030-59872024269-75","DOIUrl":"https://doi.org/10.15674/0030-59872024269-75","url":null,"abstract":"The prospects of creating new opportunities in the rehabilitation of patients with limb amputations are generally associated with the method of osseointegration and endo-exo-prosthetics (EEP). The results of the practical application of the method indicate attention to the analytical consideration of all its components, all stages. Objective. To substantiate the expediency and directions of research and development of the theoretical and practical principles of EEP from the standpoint of the full cycle, including both the problems of osseointegration and functional qualities, constructive and technological principles regarding the prostheses themselves, the methodology of the process of mastering and using them. Results. Considered biomechanical and other arguments, which substantiate the objects of research and development of medicaltechnical and medical-technological means, including the constructions of endo-exo-prostheses, methods of learning to use them, evaluation of the quality of locomotion, increasing the reliability of the «implant-bone» c ontact. The d esign principle of a hip prosthesis with a removable unloading module is proposed, which is installed at the stage of mastering the prosthesis, and in necessary cases, during constant use. The possibilities of the method of recognizing biomechanical patterns of movements for teaching patients to walk on prostheses, for adjusting functional nodes and assessing the quality of prosthetics are shown. Conclusions. The problemof endo-exo-prosthetics is considered for the first time from the standpoint of the requirements for the functions and qualities of the prostheses themselves. Reasoned directions of application and significance of clinical, experimental and mathematical biomechanics methods for analysis and development of the functional structure of endo-exo prostheses, to reduce risks when using them.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"20 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-598720242105-106
M. Golovakha
Report on the All-Ukrainian Scientific and Practical Conference "Actual Issues of Modern Traumatology and Orthopedics", which took place on May 17, 2024 in the city of Zaporizhzhia
{"title":"Report on the All-Ukrainian Scientific and Practical Conference \"Actual Issues of Modern Traumatology and Orthopedics\", which took place on May 17, 2024 in the city of Zaporizhzhia","authors":"M. Golovakha","doi":"10.15674/0030-598720242105-106","DOIUrl":"https://doi.org/10.15674/0030-598720242105-106","url":null,"abstract":"Report on the All-Ukrainian Scientific and Practical Conference \"Actual Issues of Modern Traumatology and Orthopedics\", which took place on May 17, 2024 in the city of Zaporizhzhia","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"93 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024281-87
P. Vorontsov, Valentyna Maltseva
The bone healing impairment, such as non-union fractures after injuries of long bones, lead to loss of working capacity and result in significant financial costs, which emphasizes the socioeconomic significance of the problem. However, it is not known which method of modeling the non-union bone fractures is more optimal for further research into the effectiveness of biological therapy aimed at treating bone healing impairment. For a detailed study of methods of non-union fracture treatment of, it is necessary to determine the developed animal models. The objective was to analyze the existing animal models of fracture nonunion in long bones in vivo and to consider the possibility of their further use to evaluate the effectiveness of the use of modern biotechnologies for the in the management of fracture nonunion. It was found that the majority of developed animal models of atrophic long bone non-union were created using small animals, namely rats, mice, and rabbits. A more common method of modeling bone non-union is performing an osteotomy with the formation of a defect of different widths between the bone fragments and subsequent removal of the periosteum proximal and distal to the osteotomy site; damage to the endosteum or removal of bone marrow. Also, in such animal models, researchers use a silicone spacer, a polysulfone plate, or a latex-silicone foil to physically prevent fracture union. In these animal models, studies using mesenchymal stromal cells, platelet-rich plasma or bone morphogenetic protein-2 (BMP-2) have already been conducted for the management of non-union bone fractures. At the same time, the clinical results of the application of various biological therapies are ambiguous, which determines the conduct of further experimental studies, in particular, in vivo. However, there are disagreements about which in vivo modeling methods give a reproducible result and prevent bone union, which determines the need for further analysis of existing modeling tools for conducting research in this direction.
{"title":"A REVIEW OF ANIMAL MODELS FOR BONE FRACTURE NONUNION AND THEIR ROLE IN STUDYING BIOLOGICAL THERAPY EFFICACY","authors":"P. Vorontsov, Valentyna Maltseva","doi":"10.15674/0030-59872024281-87","DOIUrl":"https://doi.org/10.15674/0030-59872024281-87","url":null,"abstract":"The bone healing impairment, such as non-union fractures after injuries of long bones, lead to loss of working capacity and result in significant financial costs, which emphasizes the socioeconomic significance of the problem. However, it is not known which method of modeling the non-union bone fractures is more optimal for further research into the effectiveness of biological therapy aimed at treating bone healing impairment. For a detailed study of methods of non-union fracture treatment of, it is necessary to determine the developed animal models. The objective was to analyze the existing animal models of fracture nonunion in long bones in vivo and to consider the possibility of their further use to evaluate the effectiveness of the use of modern biotechnologies for the in the management of fracture nonunion. It was found that the majority of developed animal models of atrophic long bone non-union were created using small animals, namely rats, mice, and rabbits. A more common method of modeling bone non-union is performing an osteotomy with the formation of a defect of different widths between the bone fragments and subsequent removal of the periosteum proximal and distal to the osteotomy site; damage to the endosteum or removal of bone marrow. Also, in such animal models, researchers use a silicone spacer, a polysulfone plate, or a latex-silicone foil to physically prevent fracture union. In these animal models, studies using mesenchymal stromal cells, platelet-rich plasma or bone morphogenetic protein-2 (BMP-2) have already been conducted for the management of non-union bone fractures. At the same time, the clinical results of the application of various biological therapies are ambiguous, which determines the conduct of further experimental studies, in particular, in vivo. However, there are disagreements about which in vivo modeling methods give a reproducible result and prevent bone union, which determines the need for further analysis of existing modeling tools for conducting research in this direction.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"67 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.15674/0030-59872024299-100
The article is dedicated to Dr of Medical Sciences Anatoly Ivanovich Zhigun.
这篇文章献给医学博士阿纳托利-伊万诺维奇-日君。
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Pub Date : 2024-07-09DOI: 10.15674/0030-59872024224-32
Stanislav Bondarenko, Dmytro Sereda, O. Karpinska
Muscles that can be damaged during endoprosthesis are indicated. Objective. To study the features of muscle work to ensure walking function after hip arthroplasty depending on the surgical approach. Methods. The basis of the simulation is the basic OpenSim Gate2392 model. Six models were created that predicted the condition of the muscles of the lower limb in normal conditions, during coxarthrosis and after 6 and 12 months. after surgery with lateral and anterior approaches. The results. For lateral access in 6 months. after the operation, the adductor muscles responsible for stabilizing the pelvis in the single-support phase of the step and during the transfer of the foot do not work enough, while the hip flexor muscles (in the model, the rectus femoris muscle) take over the responsibility for the step, but with overvoltage. On the contrary, with the front approach, we observe a weakening of the flexor muscles, which leads to overstrain of the gluteal muscles and hip stabilizer muscles. After 12 months, the muscle strength normalizes for most of them to 90–95 % of the norm, a 2–3 times increase in the torque of the hip flexor muscles and hip stabilizer muscles is observed. Taking a normal step causes muscle strain. During the anterior approach, the foot is transferred during the phase, that is, when most of the muscles are involved. The rectus femoris muscle, which is the strongest of the muscles discussed in the paper, does the main work of moving the foot. In the case of possible damage to the rectus muscle during anterior access, even after a year there is a violation of its work — excessive overexertion and involvement of the reserves of other muscles. Conclusions. Mathematical modeling of the work of muscles that may be damaged during hip arthroplasty surgery, conditional muscle strength for 6 months. after the operation, they are not able to develop the necessary torque to take a normal step. For muscle strength, which in the model corresponded to 12 months,the muscles are able to perform a normal function regardless of surgical access, but their overstrain is observed.
{"title":"THE STUDY OF THE WORK OF THE MUSCLES RESPONSIBLE FOR THE FUNCTIONALITY OF THE HIP JOINT AFTER TOTAL HIP ARTHROPLASTY USING DIFFERENT SURGICAL APPROACHES","authors":"Stanislav Bondarenko, Dmytro Sereda, O. Karpinska","doi":"10.15674/0030-59872024224-32","DOIUrl":"https://doi.org/10.15674/0030-59872024224-32","url":null,"abstract":"Muscles that can be damaged during endoprosthesis are indicated. Objective. To study the features of muscle work to ensure walking function after hip arthroplasty depending on the surgical approach. Methods. The basis of the simulation is the basic OpenSim Gate2392 model. Six models were created that predicted the condition of the muscles of the lower limb in normal conditions, during coxarthrosis and after 6 and 12 months. after surgery with lateral and anterior approaches. The results. For lateral access in 6 months. after the operation, the adductor muscles responsible for stabilizing the pelvis in the single-support phase of the step and during the transfer of the foot do not work enough, while the hip flexor muscles (in the model, the rectus femoris muscle) take over the responsibility for the step, but with overvoltage. On the contrary, with the front approach, we observe a weakening of the flexor muscles, which leads to overstrain of the gluteal muscles and hip stabilizer muscles. After 12 months, the muscle strength normalizes for most of them to 90–95 % of the norm, a 2–3 times increase in the torque of the hip flexor muscles and hip stabilizer muscles is observed. Taking a normal step causes muscle strain. During the anterior approach, the foot is transferred during the phase, that is, when most of the muscles are involved. The rectus femoris muscle, which is the strongest of the muscles discussed in the paper, does the main work of moving the foot. In the case of possible damage to the rectus muscle during anterior access, even after a year there is a violation of its work — excessive overexertion and involvement of the reserves of other muscles. Conclusions. Mathematical modeling of the work of muscles that may be damaged during hip arthroplasty surgery, conditional muscle strength for 6 months. after the operation, they are not able to develop the necessary torque to take a normal step. For muscle strength, which in the model corresponded to 12 months,the muscles are able to perform a normal function regardless of surgical access, but their overstrain is observed.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"90 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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