Ashwagandha is also known Indian ginseng, or winter cherry. It is one of the important herbs in the Ayurvedic and indigenous medical systems of medicine since long time. The roots of the plant are categorized as Rasayanas and described to promote health and longevity by augmenting defenses against disease, arresting the ageing process, revitalizing the body in debilitated conditions, and thus creating a sense of wellbeing. Ashwagandha contains mainly alkaloids (withanine, withasomnin, steroidal lactones (Withanoloids), and glycosides (Sitoindosides). It possesses analgesic, mildly sedative, anti-inflammatory and anabolic activities, and it is useful in stress, strain, fatigue, pain, skin diseases, diabetes, gastrointestinal disease, rheumatoid arthritis, and epilepsy, chronic fatigue syndrome and even during pregnancy without any side effects. The present review describes the general pharmacognostic features, phytochemistry, biopotential, methods of analysis, market potential and regulatory status of Ashwagandha.
{"title":"ASHWAGANDHA - A POTENT REGENERATIVE TONIC: SCIENTIFIC REVIEW AND UPDATE","authors":"H. Pawar, A. Pawar, ip Ashok Pawar, P. Pawar","doi":"10.21276/IJCPA","DOIUrl":"https://doi.org/10.21276/IJCPA","url":null,"abstract":"Ashwagandha is also known Indian ginseng, or winter cherry. It is one of the important herbs in the Ayurvedic and indigenous medical systems of medicine since long time. The roots of the plant are categorized as Rasayanas and described to promote health and longevity by augmenting defenses against disease, arresting the ageing process, revitalizing the body in debilitated conditions, and thus creating a sense of wellbeing. Ashwagandha contains mainly alkaloids (withanine, withasomnin, steroidal lactones (Withanoloids), and glycosides (Sitoindosides). It possesses analgesic, mildly sedative, anti-inflammatory and anabolic activities, and it is useful in stress, strain, fatigue, pain, skin diseases, diabetes, gastrointestinal disease, rheumatoid arthritis, and epilepsy, chronic fatigue syndrome and even during pregnancy without any side effects. The present review describes the general pharmacognostic features, phytochemistry, biopotential, methods of analysis, market potential and regulatory status of Ashwagandha.","PeriodicalId":13780,"journal":{"name":"International Journal of Chemical and Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73686720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.20902/ijctr.2018.110502
Mangarao Nakka
A new, simple and accurate quantitative proton nuclear magnetic resonance(qNMR) spectroscopic method was developed to determine the sumatriptan succinate in pharmaceutical tablet formulation. In this developed quantitative nuclear magnetic resonance spectroscopy method,Maleic acid was used as internal standard(IS) due to there was no overlapping of the peak to analyte peaks and deuterium oxide(D2O) was used as diluent. For the quantification of the sumatriptan succinate 4.43 ppm and 6.20 ppm peaks were used as quantitative monitoring purpose to correspong to analyte sumatriptane succinate and Maleic acid internal standard(IS) respectively. The final optimized method was validated as per International Conference on Hormonisation (ICH) guidelines in terms of Specificity, Limit of detection (LOD), Limit of Quantitation (LOQ), Pecision, Linearity, Accuracy ,Solution stability and Robustness. This method could be used to determination of sumatriptane succinate in bulk and pharmaceutical tablet dosage forms.
{"title":"QUANTITATIVE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION OF SUMATRIPTAN SUCCINATE IN PHARMACEUTICAL TABLET DOSAGE FORM","authors":"Mangarao Nakka","doi":"10.20902/ijctr.2018.110502","DOIUrl":"https://doi.org/10.20902/ijctr.2018.110502","url":null,"abstract":"A new, simple and accurate quantitative proton nuclear magnetic resonance(qNMR) spectroscopic method was developed to determine the sumatriptan succinate in pharmaceutical tablet formulation. In this developed quantitative nuclear magnetic resonance spectroscopy method,Maleic acid was used as internal standard(IS) due to there was no overlapping of the peak to analyte peaks and deuterium oxide(D2O) was used as diluent. For the quantification of the sumatriptan succinate 4.43 ppm and 6.20 ppm peaks were used as quantitative monitoring purpose to correspong to analyte sumatriptane succinate and Maleic acid internal standard(IS) respectively. The final optimized method was validated as per International Conference on Hormonisation (ICH) guidelines in terms of Specificity, Limit of detection (LOD), Limit of Quantitation (LOQ), Pecision, Linearity, Accuracy ,Solution stability and Robustness. This method could be used to determination of sumatriptane succinate in bulk and pharmaceutical tablet dosage forms.","PeriodicalId":13780,"journal":{"name":"International Journal of Chemical and Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89569725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-01DOI: 10.11648/j.sjc.20150302.12
Hayelom Dargo Beyene
ABSTRACT : Cactus is a member of the Cactaceae family, which was originated in Mexico and grows in many other parts of the world, such as Africa, Australia and the Mediterranean basin. Cactus is generally known as a plant has great economical value, which occurs in the dry zone of north Ethiopia, mostly in south tigray and east tigray. It is a popular fruit all over tigray. Heavy metals are natural components of the earth’s crust and they can enter the water and food cycles through a variety of chemical and geochemical processes. Living organisms require trace amounts of some heavy metals, including Co, Cu, Fe, Mn, Mo, Ni and Zn. Excessive levels of these metals, however, can be detrimental to living organisms. This paper was focus on level of the metals and to investigate the effect of digestion temperature and time on the concentration metals. The method was developed by adjusting reagent volume and by varying the time and temperature, then the digested sample was run into atomic absorption spectrophotometer (AAS). Sample leaf collected from Kidane Mhiret (KM), the concentration of metals with respect to time was found in the order of Cu>Mn>Ni but, with respect to temperature Ni>Mn>Cu. Therefore, in the leaf of cactus in KM, Mn abundantly existed as the micronutrients. At the MK the concentration of metals with respect to time was found in the order of Ni >Cu >Mn but, with respect to temperature Mn>Cu>Ni. Therefore, in the leaf of cactus in MK, Mn abundantly existed as the micronutrients .
{"title":"Parameter optimization for metal (Mn, Cu, Ni) digestion from Cactus opuntia leaf.","authors":"Hayelom Dargo Beyene","doi":"10.11648/j.sjc.20150302.12","DOIUrl":"https://doi.org/10.11648/j.sjc.20150302.12","url":null,"abstract":"ABSTRACT : Cactus is a member of the Cactaceae family, which was originated in Mexico and grows in many other parts of the world, such as Africa, Australia and the Mediterranean basin. Cactus is generally known as a plant has great economical value, which occurs in the dry zone of north Ethiopia, mostly in south tigray and east tigray. It is a popular fruit all over tigray. Heavy metals are natural components of the earth’s crust and they can enter the water and food cycles through a variety of chemical and geochemical processes. Living organisms require trace amounts of some heavy metals, including Co, Cu, Fe, Mn, Mo, Ni and Zn. Excessive levels of these metals, however, can be detrimental to living organisms. This paper was focus on level of the metals and to investigate the effect of digestion temperature and time on the concentration metals. The method was developed by adjusting reagent volume and by varying the time and temperature, then the digested sample was run into atomic absorption spectrophotometer (AAS). Sample leaf collected from Kidane Mhiret (KM), the concentration of metals with respect to time was found in the order of Cu>Mn>Ni but, with respect to temperature Ni>Mn>Cu. Therefore, in the leaf of cactus in KM, Mn abundantly existed as the micronutrients. At the MK the concentration of metals with respect to time was found in the order of Ni >Cu >Mn but, with respect to temperature Mn>Cu>Ni. Therefore, in the leaf of cactus in MK, Mn abundantly existed as the micronutrients .","PeriodicalId":13780,"journal":{"name":"International Journal of Chemical and Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81406118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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