INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)最新文献

{"title":"Diagnostic effectiveness of intraoperative express histological examination as a tool to take decisions on the extent of surgery for papillary thyroid cancer","authors":"O. Tovkai, D. Kvitka, V. Palamarchuk, N. Belemets, S. Zemskov","doi":"10.22141/2224-0721.19.4.2023.1281","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1281","url":null,"abstract":"Background. In case of the screening use of high-resolution ultrasound, the level of detecting thyroid neoplasms is about 25 % in the population. Ultrasound criteria are not enough to detect carcinoma. The following methods are used for the differential diagnosis of malignant thyroid neoplasms: ultrasound scans, computed tomography, fine-needle aspiration (FNA) biopsy, intraoperative express histological and histopathological examination. Some authors consider FNA to be the standard method for primary morphological diagnosis of thyroid nodes. It is not always possible to conduct FNA safely. Also, FNA cannot be a method of 100% morphological identification of a primary tumor. In such cases, the extent of the surgery will depend on the data obtained from the intraoperative express histological examination. Analysis of the diagnostic effectiveness of the express histological examination will help to take a decision on the need for it when choosing the extent of a surgery on the thyroid gland. Aim of the study: to evaluate the diagnostic efficiency of the intraoperative express histological method in the detection of papillary thyroid cancer on solitary nodes (Bethesda IV, V) and metastases of papillary thyroid cancer during surgery. Materials and methods. The results of intraoperative express histological and pathohistological examinations performed at the Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues from 2018 to 2021 were analyzed. The sample included materials of surgeries on the thyroid gland in case of papillary cancer T1ab-2N0–1 and solitary nodes (Bethesda IV and Bethesda V) according to data obtained using FNA. The sample size in the study of regional metastasis included 220 examinations, 845 examinations in the “gray zone” (Bethesda IV — 465, Bethesda V — 380). Cases of discrepancy between the results of intraoperative express histological and final histopathological examinations were considered. The data was processed using the EZR v. 3.4.1 statistical analysis program. Results. The sensitivity of the express histological examination in case of detecting metastases of thyroid cancer is 72.2 % with the method specificity of 99.9 %. The diagnostic efficiency in detecting metastases of thyroid cancer is 89.1 %. When the express histological examination is used for Bethesda IV nodes, the sensitivity of the method is 8 % with a specificity of almost 100 %. The diagnostic efficiency of the express histological examination is even higher in case of Bethesda V: sensitivity of 47 % with the method specificity of almost 100 %. The values obtained correlate with international data. This testifies to the need for further improvement of the of intraoperative diagnosis method. Conclusions. The diagnostic efficiency of the intraoperative express histological examination for detecting metastases of papillary thyroid cancer in the selected group is 89.1 % with sensitivity of 72.2 % and spec","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87400740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cholecalciferol deficiency in the development of latent autoimmune diabetes in adults","authors":"I. Tsaryk, N. Pashkovska","doi":"10.22141/2224-0721.19.4.2023.1282","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1282","url":null,"abstract":"Background. Recently, a lot of information has appeared on the role of cholecalciferol deficiency in the development of the mechanisms of classical types of diabetes mellitus (DM) and its complications. However, there are currently almost no data regarding latent autoimmune diabetes in adults (LADA). The purpose of this study was to determine the effect of vitamin D deficiency on the compensation of carbohydrate metabolism in LADA. Materials and methods. The study included 56 patients with DM: 34 with LADA and 22 with classical type 1 DM (DM1), as well as 20 practically healthy individuals of the control group. According to the main phenotypes, patients with LADA were divided into 2 groups: LADA1 and LADA2. Cholecalciferol status was determined by the immunochemiluminescence method. Results. The fasting blood glucose level in LADA and DM1 group was significantly higher than in the controls, by 63.9 and 91.1 % (p < 0.001), respectively, and was also 16.6 % higher when comparing DM1/LADA groups (p < 0.05). The level of HbA1c in 66.1 % of patients of the experimental groups was more than 7 %, which indicates insufficient compensation of the disease. The content of vitamin D was significantly lower in the experimental groups compared to the controls; when comparing LADA/DM1 — by 43.7 % lower in case of classical DM1 (p < 0.05). Compensation of carbohydrate metabolism is worse in patients with LADA1 than in LADA2, and the lowest level of vitamin D was recorded in LADA1. According to the linear regression analysis of correlations in patients with LADA, negative correlations of medium strength were recorded between the level of cholecalciferol and fasting blood glucose (r = 0.487; p < 0.05), HbA1c (r = –0.593; p < 0.05); positive — between cholecalciferol and C-peptide (r = 0.412; p < 0.05). Conclusions. In patients with autoimmune diabetes, there is an insufficient supply of cholecalciferol. Low cholecalciferol content is observed in both groups of patients with LADA regardless of the disease phenotype and is associated with worse compensation of DM.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91177907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catestatin in diagnosing cardiovascular and metabolic disorders in patients with comorbid hypertension","authors":"I. Dunaieva, O. Bilovol","doi":"10.22141/2224-0721.19.4.2023.1293","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1293","url":null,"abstract":"Background. Hypertension is the major pandemic in human history, which determines the structure of cardiovascular morbidity and mortality. There is an obvious relationship between hypertension and various diseases that largely determine its development and increase the risk of cardiovascular complications. Neuropeptides appear to have a major impact on the progression of these complications. Catestatin (CST) is one of them, which deserves special scientific and practical concern, as it has a wide range of biological effects in the body. The aim of the study: to determine the place of CST in the early diagnosis of cardiovascular and metabolic complications in patients with comorbid hypertension among the Ukrainian population. Materials and methods. One hundred and eleven patients with hypertension, type 2 diabetes mellitus, obesity (men/women — 50/61) and 20 controls were examined. All patients with hypertension, type 2 diabetes mellitus, and obesity were aged 54.37 ± 1.18 years. Following a thorough examination and supervision, they were divi­ded into 2 groups depending on the median CST level of 2.45 ng/ml. The first group included 55 (49.5 %) patients who had a CST level below 2.45 ng/ml, the second one consisted of 56 patients (50.5 %) who had a CST level above 2.45 ng/ml. In all patients, we measured body weight, height, calculated body mass index, evaluated glycated hemoglobin levels, lipid metabolism (serum concentrations of total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein cholesterol); systolic and diastolic blood pressure. The content of CST, cardiotrophin 1, leptin, cystatin C, neutrophil gelatinase-associated lipocalin, N-terminal prohormone of brain natriuretic peptide, 25(OH)D, β2-microglobulin, and insulin levels in the blood serum were determined by enzyme-linked immunosorbent assay. Results. A reliable difference between the groups was found by β2-microglobulin (p = 0.008). Univariate and multivariate linear regression analysis revealed a negative correlation between CST and cardiotrophin 1, N-terminal prohormone of brain natriuretic peptide, neutrophil gelatinase-associated lipocalin, and 25(OH)D. A positive correlation was found between CST and the level of glycated hemoglobin, body mass index, and triglycerides. A statistically significant correlation was found between CST and creatinine (R = –0.21, p = 0.029), high-density lipoprotein cholesterol (R = 0.207, p = 0.029), and β2-microglobulin (R = 0.279, p = 0.0029) in the patients with hypertension. Conclusions. It has been proven that a decrease in serum catestatin concentration can be a risk factor for the development of more severe comorbidities in patients with hypertension. The detected relationships of catestatin with creatinine, urea, and β2-microglobulin suggest that CST is a predictor of chronic kidney disease in patients with comorbidities. The revealed correlation of CST with high-density lipoprotein","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74012585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between cardiovascular pathology and impaired glucose metabolism with vitamin D deficiency (literature review and own data)","authors":"O. A. Goncharova, N. Imanova","doi":"10.22141/2224-0721.19.4.2023.1288","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1288","url":null,"abstract":"Background. Vitamin D plays a significant role in many processes in the human body, which diversifies the symptoms of its insufficiency, so it is not always possible to diagnose its deficiency in a timely manner. At the same time, according to a number of clinical studies, an inverse relationship has been proven between a reduced level of vitamin D and mortality from all causes and cardiovascular diseases, the course of diabetes mellitus (DM), hypertension, chronic kidney disease, atherosclerosis, coronary heart disease; and the mechanisms of the influence of vitamin D deficiency on various metabolic processes have been revealed. The development and progression of cardiovascular diseases and vascular complications of DM are currently the main causes of disability and mortality of patients. All this substantiates the need to control and monitor the vitamin D supply in patients with this comorbid pathology. Aim of the study is to investigate the presence and severity of vitamin D deficiency in patients with type 2 DM and the presence of concomitant cardiac pathology. Materials and methods. Main group included 31 patients (17 men and 14 women aged 51.51 ± 1.73 years, with duration of DM of 8.59 ± 1.70 years) who were treated in the endocrinology clinic from October 2022 to May 2023. The comparison group consisted of 27 patients with type 2 DM who stayed in this clinic in 2020–2021. Serum level of 25-hydroxycholecalciferol (25(OH)D) was studied using the enzyme-linked immunosorbent assay. The level of vitamin D less than 20–30 ng/ml was considered as its insufficiency, and the level below 20 ng/ml as deficiency. Statistical processing was carried out using Microsoft Excel and Statistica 6.0. Results. In the main group, cardiac pathology manifested itself by the presence of hypertension detected in all patients (stage I — 6 cases; stage II — 21 and stage IІI — 4); coronary heart disease and cardiosclerosis — in 7 patients; heart failure of the first or second degree — in all individuals. All patients in the main group were vitamin D deficient or insufficient: 15 had a deficiency (12.96 ± 1.06 ng/ml), and 16 had an insufficiency (23.68 ± 0.72 ng/ml). In contrast to the comparison group, patients from the main group had a significantly lower average level of vitamin D (18.49 ± 1.16 ng/ml vs 28.98 ± 1.02 ng/ml, p < 0.001). Taking into account a decrease in the level of vitamin D supply of patients, including those with comorbid pathology examined in 2022–2023, which is obviously associated with a long stay in shelters and a stressful situation caused by the state of war, and its impact on the course of cardiovascular diseases and diabetes, it is necessary to pay more attention to the detection and timely appropriate correction of vitamin D deficiency. Conclusions. In patients with type 2 diabetes and comorbid cardiovascular pathology, there is a decrease in the level of vitamin D supply. During the war in Ukraine, there is a probable deepening of vitamin","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73865468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspects of the development of hypothyroid cardiomyopathy associated with chronic systemic inflammation","authors":"О.Yu. Horodynska, О. Muravlova, Z. Shaienko, І. Dvornyk","doi":"10.22141/2224-0721.19.4.2023.1289","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1289","url":null,"abstract":"Background. Cardiovascular manifestations are rated first among the symptoms of hypothyroidism. Since the highest prevalence of both coronary heart disease (CHD) and hypothyroidism is observed in the age group over 50 years old, the problem of combination of these nosologies in older people is increasing. Aim of the study is to investigate the structural and functional state of the left ventricular myocardium in hypothyroidism and CHD associated with chronic systemic inflammation. Materials and methods. To reach the objectives of the study, a randomized controlled clinical trial has been conducted in parallel groups of patients with hypothyroidism, CHD and combination of both. To form the main group, a screening analysis of 556 medical histories of patients with hypothyroidism and CHD during the period of 2006–2015 has been made, which were selected for further study. Results. It has been found that myocardial hypertrophy develops in all groups of patients, a decrease in thyroid function leads to remodeling of the left ventricular myocardium with the development of eccentric hypertrophy and the progression of systolic heart failure in comorbidity. A direct correlation between reduced ejection fraction and elevated interleukin-8 level has been detected. Evaluation of the state of chronic systemic inflammation revealed a significant increase in the level of interleukin-8 in patients with coronary heart disease associated with hypothyroidism (7.66 ± 2.18 pg/ml; p < 0.05). This indicate that the persistence of pro-inflammatory state in patients with combined pathology is a negative prognostic factor for the development of cardiovascular complications. Conclusion. During echocardioscopy of patients with hypothyroidism, the impaired central hemodynamics can be determined by the indicators of the diastolic and systolic heart function. In patients with isolated hypothyroidism and in combination with coronary heart disease, thickening of the left ventricular myocardial walls is noted, which proves the specificity of changes in the heart geometry that leads to the development of eccentric hypertrophy. This can be considered as the marker of a “hypothyroid” heart whose severity can determine the severity of hypothyroidism. Activation of chronic systemic inflammation is more pronounced in conditions of comorbidity, with a negative prognostic effect on the state of the cardiovascular system.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78265966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of cortisol in the formation of metabolic syndrome in children: literature review and own observations","authors":"N. Gromnatska, I. Pasichnyuk, O. Tomashevska, D. Halytsky","doi":"10.22141/2224-0721.19.4.2023.1286","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1286","url":null,"abstract":"Background. The issue of the pathogenetic influence of cortisol on the development of metabolic syndrome (MS) in children is considered. The above-threshold values of cortisol are proposed to be taken as a marker of MS. The purpose was to study the relationship between blood cortisol and MS components in children. Materials and methods. We have examined 44 children with MS (study group; waist circumference > 90th percentile of the distribution according to age and sex) and 14 children without signs of MS (controls). The children of the study groups did not differ in age and gender. Anthropometric parameters (body weight, height, body mass index, neck, waist, and hip circumferences, waist/hip circumference index), blood cortisol and leptin, blood lipid and carbohydrate spectrum (total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides, blood glucose, and insulin, HOMA-IR and glucose/insulin indices) were evaluated. The measurement of blood pressure with the calculation of the average level was conducted three times. The diagnosis of MS was formed according to the IDF guidelines, 2007. Results. It was found that the level of blood cortisol in children with MS (362.9 (255.5–634.1) µg/l) was 37.9 % lower than in controls (р > 0.05). The frequency of the above-threshold blood cortisol values in children of both groups was 31.8 and 50.0 %, respectively (р > 0.05). The study of dependence using the Spearman’s rank correlation coefficient between blood cortisol and anthropometric parameters (rmax = 0.16; p > 0.05), lipids (rmax = 0.4; р > 0.05), carbohydrate metabolism (rmax = 0.26; р > 0.05), and blood leptin (r = 0.19; р > 0.05) did not reveal any significance. A significant correlation was found between cortisol and systolic blood pressure. Conclusions. In children with MS, there was no significant difference in the level of blood cortisol compared to those without MS criteria. The association of blood cortisol and MS criteria other than systolic blood pressure has not been found. Although cortisol is important in the formation of systolic blood pressure, it cannot serve as a marker of MS in children since it is not a criterion-forming sign of MS.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88687160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of the DAPA-CKD trial and their impact on clinical practice","authors":"O. Bilchenko","doi":"10.22141/2224-0721.19.4.2023.1290","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1290","url":null,"abstract":"Chronic kidney disease (CKD) is a growing medical and social problem in the world. Data from population base stu­dies demonstrate an increase in the prevalence of CKD and mortality. One of the causes is an increase in the number of patients with diabetes. Another reason is the limited ability to prevent the progression of the loss of kidney function. The first studies with dapagliflozin, such as DECLARE-TIMI 58 in patients with type 2 diabetes, showed a slowing of the progression of CKD to end-stage renal disease. The DAPA-CKD trial included patients with both type 2 diabetes and those without diabetes with an estimated glomerular filtration rate of 25 to 75 ml/min/1.73 m2 and albuminuria. The DAPA-CKD trial was terminated prematurely by independent monitors because of dapagliflozin overwhelming placebo. The primary endpoint, which included a sustained decrease in estimated glomerular filtration rate ≥ 50 %, end-stage renal disease, or death from renal or cardiovascular causes, was 39 % lower in the dapagliflozin group than in the placebo group. The effect of dapagliflozin on the primary endpoint was also similar among patients with dia­betic nephropathy, glomerulonephritis, ischemic or hypertensive CKD, and CKD of other or unknown cause. Also, the effect of dapagliflozin was the same regardless of concomitant cardiovascular diseases or chronic heart failure. All-cause mortality was 31 % lower among patients who received dapagliflozin at a dose of 10 mg. Dapagliflozin also significantly reduced the frequency of sudden decline in kidney function in CKD patients by 32 %. According to the results of a post-hoc analysis of the DAPA-CKD trial, compared to placebo, dapagliflozin reduced the frequency of hospitalizations due to cardiac causes, kidney and urinary tract diseases, metabolic and nutritional disorders, and oncological problems. This effect of dapagliflozin was independent of baseline type 2 diabetes. Based on the DAPA-CKD trial, dapagliflozin was approved by the Food and Drug Administration for use in reducing the risk of worsening kidney function, kidney failure, cardiovascular death, and heart failure hospitalization in adults with CKD.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86710473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сlinical features of asthma-COPD overlap syndrome with comorbid type 2 diabetes mellitus","authors":"V.O. Halytska, H. Stupnytska","doi":"10.22141/2224-0721.19.4.2023.1283","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1283","url":null,"abstract":"Background. Comorbidity profiles are a common subject of research in patients with asthma-COPD (chronic obstructive pulmonary disease) overlap (ACO), but in case of concurrent type 2 diabetes mellitus (T2DM), there is a lack of targeted research on the quality of life, clinical course, and lung function. The aim of the study was to clarify the clinical features of asthma-COPD overlap in combination with T2DM. Materials and methods. Sixty-nine patients were examined: 24 with ACO and T2DM (group 1), 21 with asthma and T2DM (group 2), and 24 with COPD and T2DM (group 3). A diagnosis of ACO was made according to GINA and GOLD 2017 guidelines. Quality of life was assessed using the CAT, ACQ, and SGRQ, and the severity of dyspnea was assessed using the mMRC scale, disease severity and prognosis using the BODE index. Spirometry with bronchodilation test, 6-minute walk test, and bioimpedance analysis were performed. Results. Patients in the main group had a higher total SGRQ score than those in group 3 (by 33 %, p = 0.001). Higher ACQ and total SGRQ scores indicate a trend toward worse asthma control and lower quality of life in patients with ACO and T2DM compared to the asthma + T2DM group (p = 0.056 and p = 0.054, respectively). Body mass index was higher than in patients with COPD and T2DM (by 16.3 %, p = 0.001). Higher serum glucose levels were found in patients with ACO and T2DM than in those with COPD and T2DM (by 18.3 %, p = 0.028). The FEV1 in the ACO and T2DM group was lower than in the asthma + T2DM group (by 18.7 %, p = 0.027), and the SVC was lower by 33 % (p = 0.021). There was a tendency to a lower result in the 6-minute walk test in the main group compared to patients from group 3 (p = 0.0548), and a higher frequency of exacerbations per year compared to groups 2 (p = 0.08) and 3 (p = 0.06). Conclusions. Patients with asthma-COPD overlap and concurrent type 2 diabetes mellitus have worse quality of life, lower FEV1 and SVC, submaximal exercise tolerance, higher fasting glucose levels, and a tendency towards increased exacerbation frequency.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78527457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary thyroid carcinoma coexisting with benign thyroid and parathyroid pathology: clinical and pathomorphological features","authors":"A. Dinets, M. Gorobeiko, V. Hoperia, A. Lovin, S. Tarasenko","doi":"10.22141/2224-0721.19.4.2023.1285","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1285","url":null,"abstract":"Background. Papillary thyroid carcinoma (PTC) is the most frequent malignant neoplasm originating from follicular cells of thyroid gland. PTC is often coexisting with other benign thyroid pathology such as chronic lymphocytic thyroiditis, follicular thyroid adenoma, toxic thyroid adenoma, Graves’ disease, non-toxic multinodular goiter. PTC can be diagnosed in patients undergoing surgical treatment for hyperparathyroidism. However, the clinical and pathomorphological features of PTC in the presence of other benign thyroid or parathyroid pathology, as well as possible differences in surgical tactics, remain relevant as evidenced by previously published reports. The purpose of the study is to assess the prevalence and determine the differences in the clinical and pathomorphological parameters of PTC in the presence of benign thyroid and parathyroid pathology. Materials and methods. There were identified 91 patients with PTC, who underwent surgical treatment at the clinical bases of the Department of Surgery of the NSC “Institute of Biology and Medicine” of Taras Shevchenko National University of Kyiv. Results. In the studied PTC cohort, 31 (35 %) patients were without coexisted benign thyroid pathology and 60 (35 %) patients had it (PTC/coexisted). A statistically significantly higher number of mitoses per 10 high power fields in the PTC group were identified in 3 (10 %) patients, as compared to the absence of this pathohistological parameter in the PTC/coexisted (p = 0.037). Further analysis of these 3 cases showed that 4 mitotic figures were found in one PTC, and one mitotic figure in the other two cases per 10 high power fields (400×). Conclusions. Papillary thyroid carcinoma in patients with other benign thyroid pathology is associated with lower biological aggressiveness than PTC without comorbidity as evidenced by a lower frequency of mitotic figures per 10 high power fields. The presence of concomitant benign thyroid pathology can be considered as a favorable prognostic factor for patients with PTC.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80195917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal imbalance in patients with chronic kidney disease in the pre-dialysis and dialysis periods (part 2)","authors":"I. Katerenchuk, S. T. Rustamyan, V. Talash, T. Yarmola","doi":"10.22141/2224-0721.19.4.2023.1292","DOIUrl":"https://doi.org/10.22141/2224-0721.19.4.2023.1292","url":null,"abstract":"In the previous article, we presented the results of literature review showing the changes in hormone concentrations (parathyroid hormone, insulin, growth factor, prolactin) in patients with chronic renal failure (CRF) at the pre-dialysis and dialysis stages, described pathological relationships between renal failure and serum hormones concentrations, as well as changes in their biological effects. In this article, that continues the general topic, we provide the results of literature review that shows changes in serum concentrations of thyroid, adrenal, sex hormones and the features of the functioning of hypothalamus-pituitary-peripheral glands axis in patients with CRF. The presence of close pathogenic interactions of renal functional condition with hormonal activity of the thyroid gland was evaluated, as well as the ability of thyroid gland to influence the CRF progression both during pre-dialysis and dialysis sta­ges of CRF. Most patients with CRF have low serum triiodothyronine and thyroxine levels. It means that CRF is a pathological condition associated with thyroid hypofunction that progressively worsening as glomerular filtration rate decreases. For patients receiving dialysis treatment, hypothyroidism is associated with higher mortality. Secondary adrenal insufficiency is usually progresses in patients on renal replacement therapy. Non-diagnosed chronic adrenal failure may be life-threating that’s why the analysis of adrenal function is especially actual for patients on both pre-­dialysis and dialysis stages of CRF. Secondary adrenal insufficiency caused by long-lasting treatment with corticoids is a diagnostic problem for patients on dialysis treatment, because many nephrological diseases are treated by corticoids, and immunosuppressive therapy protocols used after the kidney transplantation are usually include prednisone. As the endocrine dysfunction progresses in patients with CRF, sexual dysfunction develops due to sex hormone imbalance. Abnormal androgen concentration is a typical fin­ding in CRF. A negative correlation was found between endogenic testosterone concentration and CRF stages I–V that indicated an abnormal profile of male sex hormones. There are gender-specific features of the development and progression of clinical symptoms of hormonal imbalance. The number of experimental studies show that continuous estradiol treatment may prevent the development of glomerulosclerosis. The results of clinical trials concluded that lower CRF progression and the lower incidence of CRF observed in young females compared to males, as well as the absence of gender protection in post-menopausal period, shows the important role of female sex hormones.","PeriodicalId":13962,"journal":{"name":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84347610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}