Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/ajmap-v7i3.25162
H. Adekola, Adekunle I.A, Adesola Oluwaseun Adeleye, M. Alabi-Abass, W. O. Ogunbanjo, I. Ajewole
The current Coronavirus Disease-19 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has reportedly posed a significant threat to the global public health institution systems. The treatment has been supportive and not effective. Coupled with the lack of vaccine interventions, the search for effective therapeutic alternatives is still on. Herbal supplements have been used in the treatment of viral diseases for years and could serve as an alternative for COVID-19 therapy if the combinations are known and tested. Recent studies have proved that certain herbal supplements have exhibited antiviral activity against similar coronaviruses. Besides, molecular docking studies further proved the efficacy of the antiviral activity of the herbal supplements against SARS-CoV-2. However, there is still a need for in-vitro and in-vivo studies of the antiviral activity of these herbal supplements against SARS-CoV-2. Nevertheless, these herbal supplements have a high therapeutic potential for COVID-19 therapy. This study reveals the chemical composition of herbal supplements to come up with findings that can redefine research and development, risk analysis, and containment of the novel coronavirus disease.
{"title":"PHYTOTHERAPEUTIC POTENTIAL OF HERBAL SUPPLEMENTS FOR COVID-19","authors":"H. Adekola, Adekunle I.A, Adesola Oluwaseun Adeleye, M. Alabi-Abass, W. O. Ogunbanjo, I. Ajewole","doi":"10.48347/IMIST.PRSM/ajmap-v7i3.25162","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/ajmap-v7i3.25162","url":null,"abstract":"The current Coronavirus Disease-19 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has reportedly posed a significant threat to the global public health institution systems. The treatment has been supportive and not effective. Coupled with the lack of vaccine interventions, the search for effective therapeutic alternatives is still on. Herbal supplements have been used in the treatment of viral diseases for years and could serve as an alternative for COVID-19 therapy if the combinations are known and tested. Recent studies have proved that certain herbal supplements have exhibited antiviral activity against similar coronaviruses. Besides, molecular docking studies further proved the efficacy of the antiviral activity of the herbal supplements against SARS-CoV-2. However, there is still a need for in-vitro and in-vivo studies of the antiviral activity of these herbal supplements against SARS-CoV-2. Nevertheless, these herbal supplements have a high therapeutic potential for COVID-19 therapy. This study reveals the chemical composition of herbal supplements to come up with findings that can redefine research and development, risk analysis, and containment of the novel coronavirus disease.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"132 1","pages":"304-320"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83745303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.28448
S. Bentoura, N. Dahmani, F. Hamaidi, F. Saidi, D. Bendjoudi, M. Hamaidi
This work is part of the valuation of essential oil of Mentha Rotundifolia harvested in the mountains of El Hamdania, in the Atlas Blideen (northern Algeria). The essential oil of Mentha rotundifolia extracted by hydro distillation have been analysed by means of Gas Chromatography GC-FID and GC-FID coupled to a Mass Spectrometer GC-MS in combination with retention indices. 34 constituents were identified accounting for 92 % of the essential oil. The main components were piperitenone oxide (30.37%) and piperitone oxide (23.78%). The antimicrobial activity evaluated on seven microbial strains revealed sensitivity for the majority of the bacteria except pseudomonas aeruginosa . The antioxidant activity was determined according to the ability of the tested samples to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH*). The essential oil were slightly active 21.8% comparing with Quercetin (98.2%) of these oils can be attributed to the absence of some phenolic components, which may play an important role. The inhibitory effect of this essential oil on the development of bacteria and more particularly its effect on staphylococcus aureus sees glimpses of applications in the pharmaceutical industry as a natural antibiotic, and for other applications in the food and cosmetic industries.
{"title":"Antiradical, Antimicrobial effect and Chemical composition of essential oil of mentha rotundifolia. L from mountains el Hamdania, north of Algeria","authors":"S. Bentoura, N. Dahmani, F. Hamaidi, F. Saidi, D. Bendjoudi, M. Hamaidi","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.28448","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.28448","url":null,"abstract":"This work is part of the valuation of essential oil of Mentha Rotundifolia harvested in the mountains of El Hamdania, in the Atlas Blideen (northern Algeria). The essential oil of Mentha rotundifolia extracted by hydro distillation have been analysed by means of Gas Chromatography GC-FID and GC-FID coupled to a Mass Spectrometer GC-MS in combination with retention indices. 34 constituents were identified accounting for 92 % of the essential oil. The main components were piperitenone oxide (30.37%) and piperitone oxide (23.78%). The antimicrobial activity evaluated on seven microbial strains revealed sensitivity for the majority of the bacteria except pseudomonas aeruginosa . The antioxidant activity was determined according to the ability of the tested samples to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH*). The essential oil were slightly active 21.8% comparing with Quercetin (98.2%) of these oils can be attributed to the absence of some phenolic components, which may play an important role. The inhibitory effect of this essential oil on the development of bacteria and more particularly its effect on staphylococcus aureus sees glimpses of applications in the pharmaceutical industry as a natural antibiotic, and for other applications in the food and cosmetic industries.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"55 1","pages":"407-421"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84835518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.28443
A. Sharma, Manisha Chahal, Inderjeet Kaur
Eucalyptus globulus member of Myrtacaea family, is one of the important medicinal widely used plant.In this study methanolic leaf extract of Eucalyptus globulus was studied for the estimation of phytochemical constituents , in-vitro antioxidant and anti-inflammatory activity . Fresh leaves were ground with methanol used for estimations. Phytochemical constituents were estimated by total phenolic content and total Flavonoid content determination. Spectroscopic analysis by UV-VIS, FT-IR and fluorescents analysis was also conducted. In vitro anti- inflammatory and antimicrobial activities were also monitored.Phytochemical screening revealed the presence of flavonoids , phenols , carbohydates and saponins. Considerable amount of phenolics (50 mg equivalent par g of dry weight) and flavonoids (23 mg equivalent par g of dry weight) were detected in extract. Extract exhibited considerable DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis-3-ethylbenzothiazoline-6-sulphonate) scavenging activities, Hydroxyl radical scavenging activity, Nitric oxide radical scavenging activity , Iron reducing power and Superoxide radical scavenging activity. Fluorescent spectroscopy revealed the presence of fluorophores in extracts. A strong anti-inflammatory activity of extract was observed using fluorescent spectroscopy. An appreciable in vitro antibacterial activity against gram-negative bacteria like gram-negative bacteria Escherichia coli, MTCC 40 was detected. This study confirmed that methanolic extract Eucalyptusglobulus possesses potent antioxidant anti-inflammatory and antibacterial activities possibly important quantity of flavonoid and phenolic content present in it .
{"title":"Antioxidant and bio-activities of leaf extracts from Eucalyptus globulus","authors":"A. Sharma, Manisha Chahal, Inderjeet Kaur","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.28443","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.28443","url":null,"abstract":"Eucalyptus globulus member of Myrtacaea family, is one of the important medicinal widely used plant.In this study methanolic leaf extract of Eucalyptus globulus was studied for the estimation of phytochemical constituents , in-vitro antioxidant and anti-inflammatory activity . Fresh leaves were ground with methanol used for estimations. Phytochemical constituents were estimated by total phenolic content and total Flavonoid content determination. Spectroscopic analysis by UV-VIS, FT-IR and fluorescents analysis was also conducted. In vitro anti- inflammatory and antimicrobial activities were also monitored.Phytochemical screening revealed the presence of flavonoids , phenols , carbohydates and saponins. Considerable amount of phenolics (50 mg equivalent par g of dry weight) and flavonoids (23 mg equivalent par g of dry weight) were detected in extract. Extract exhibited considerable DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis-3-ethylbenzothiazoline-6-sulphonate) scavenging activities, Hydroxyl radical scavenging activity, Nitric oxide radical scavenging activity , Iron reducing power and Superoxide radical scavenging activity. Fluorescent spectroscopy revealed the presence of fluorophores in extracts. A strong anti-inflammatory activity of extract was observed using fluorescent spectroscopy. An appreciable in vitro antibacterial activity against gram-negative bacteria like gram-negative bacteria Escherichia coli, MTCC 40 was detected. This study confirmed that methanolic extract Eucalyptusglobulus possesses potent antioxidant anti-inflammatory and antibacterial activities possibly important quantity of flavonoid and phenolic content present in it .","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"40 1","pages":"385-406"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84122539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.25697
Abel Boris Kouakou, Rose-Monde Megnanou
Les coques et les tourteaux de noix de karite (Vitellaria paradoxa) sont generalement envisages comme des dechets ou seulement partiellement exploites comme engrais ou comme combustible. Cependant, la presente etude presente in vitro, l'activite antifongique de ces sous-produits macerats, contre les souches de Candida albicans, Tricophyton rubrum et Microsporum canis. Par consequent, des methodes de diffusion d'agar ont ete realisees en immergeant des disques microbiologiques steriles dans des coques de karite / tourteaux de presse rmacerats (50 mg / mL) et en les couchant sur de la Sabouraud Agar pre-impregnee de suspensions microbiennes (10-3 UFC). Le halo d'inhibition autour des disques a ete mesure quelques jours apres l'incubation. La concentration minimale inhibitrice (CMI) a egalement ete determinee. Les resultats ont revele un pouvoir d'inhibition significatif (p <0,01) des deux macerats sur toutes les souches testees; le latent a montre une variable de sensibilite. En effet, le halo d'inhibition de Tricophyton rubrum, Microsporum canis, Candida albicans 18887 et Candida albicans 18702, mesurait 13,5 ± 1 et 14 ± 1,5; 13 ± 0,6 et 15 ± 0,9; 13 ± 1,3 et 15 ± 1,2; 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats. 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats. 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats.
{"title":"Potential treatment of mycosic dermatoses by shea (Vitellaria paradoxa) nuts hulls and press cakes : in vitro efficacy of their methanolic extracts","authors":"Abel Boris Kouakou, Rose-Monde Megnanou","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.25697","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.25697","url":null,"abstract":"Les coques et les tourteaux de noix de karite (Vitellaria paradoxa) sont generalement envisages comme des dechets ou seulement partiellement exploites comme engrais ou comme combustible. Cependant, la presente etude presente in vitro, l'activite antifongique de ces sous-produits macerats, contre les souches de Candida albicans, Tricophyton rubrum et Microsporum canis. Par consequent, des methodes de diffusion d'agar ont ete realisees en immergeant des disques microbiologiques steriles dans des coques de karite / tourteaux de presse rmacerats (50 mg / mL) et en les couchant sur de la Sabouraud Agar pre-impregnee de suspensions microbiennes (10-3 UFC). Le halo d'inhibition autour des disques a ete mesure quelques jours apres l'incubation. La concentration minimale inhibitrice (CMI) a egalement ete determinee. Les resultats ont revele un pouvoir d'inhibition significatif (p <0,01) des deux macerats sur toutes les souches testees; le latent a montre une variable de sensibilite. En effet, le halo d'inhibition de Tricophyton rubrum, Microsporum canis, Candida albicans 18887 et Candida albicans 18702, mesurait 13,5 ± 1 et 14 ± 1,5; 13 ± 0,6 et 15 ± 0,9; 13 ± 1,3 et 15 ± 1,2; 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats. 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats. 17 ± 3,1 et 11 ± 1,4 mm, respectivement pour les coques de karite et les macerats de tourteaux. La CMI variait egalement de maniere significative (3,125 a 12,5 mg / mL). La meilleure efficacite antimicrobienne a ete enregistree par des coques contre Candida albicans 18702 et par des tourteaux contre Microsporum canis. Concernant Tricophyton rubrum et Candida albicans 18887, la valeur de la CMI etait de 6,25 mg / mL avec les deux macerats. Ce pouvoir antimicrobien serait lie aux flavonoides, tanins, saponosides, steroides et triterpenes, detectes dans les deux macerats.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"61 1","pages":"342-351"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88898426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.26465
Zhor Oukadir, A. Abdelfattah, Lyoussi Badiaa, Senhaji Rhazi Najib
Extracts from aromatic and medicinal plants contain a variety of phenolic compounds as well as essential oils (EO's) which are believed to have antioxidant and microorganism inhibiting activities. Essential oils of leaves and fruits of Juniperus Phoenicea collected in the region of Midelt (Morocco) were obtained by the technique of hydrodistillation and analyzed by Gas Chromatography coupled to Mass Spectrometer (GC-MS). The yield of essential oil is variable depending on the part of the plant studied; it is 0.5% for leaves and 0.14% for fruits. The main compounds of the essential oil of the leaves are α- pinene, Caryophyllene and β- phellandrene while the EO of the fruits is largely dominated by α- pinene. These EOs have a marked antioxidant activity but remains lower than that of the decocted leaves and fruits of the same plant studied, this activity measured by the DPPH method. An antibacterial activity of these EOs was also demonstrated by the aromatogram method, with a strong inhibitory activity for the fruit EO compared to that of the leaves.
{"title":"Phytochemical, antioxidant and antibacterial study of essential oils of the leaves and fruits of Juniperus Phoenicea","authors":"Zhor Oukadir, A. Abdelfattah, Lyoussi Badiaa, Senhaji Rhazi Najib","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.26465","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.26465","url":null,"abstract":"Extracts from aromatic and medicinal plants contain a variety of phenolic compounds as well as essential oils (EO's) which are believed to have antioxidant and microorganism inhibiting activities. Essential oils of leaves and fruits of Juniperus Phoenicea collected in the region of Midelt (Morocco) were obtained by the technique of hydrodistillation and analyzed by Gas Chromatography coupled to Mass Spectrometer (GC-MS). The yield of essential oil is variable depending on the part of the plant studied; it is 0.5% for leaves and 0.14% for fruits. The main compounds of the essential oil of the leaves are α- pinene, Caryophyllene and β- phellandrene while the EO of the fruits is largely dominated by α- pinene. These EOs have a marked antioxidant activity but remains lower than that of the decocted leaves and fruits of the same plant studied, this activity measured by the DPPH method. An antibacterial activity of these EOs was also demonstrated by the aromatogram method, with a strong inhibitory activity for the fruit EO compared to that of the leaves.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"15 1","pages":"321-341"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89480575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.28408
Bnouham Mohamed, Mamri Samira, Marghich Mohamed, Bouziane Omar, Bouhrim Mohamed, Saalaoui Ennouamane, C. Mohammed, M. Hassane, Legssyer Abdelkhaleq, Ziyyat Abderrahim
In traditional therapy, Argania spinosa L. seeds oil used as a nephroprotective and hepatoprotective agent. The present work aims to investigate the acute toxicity of unroasted Argan oil, and studied the nephroprotective and the hepatoprotective activity of both oils Roasted (Roil) and unroasted Argan oil (UnRoil) on CCl 4 -induced liver and kidney damages in Wistar rats. Animals were divided into five equal groups; Control and CCl 4 groups are received only distilled water (10 mL/Kg/day). Control positive group received 50 mg/Kg/day of Silymarin. Roil and UnRoil groups treated with 2 mL/Kg/day of Roil and UnRoil. One week after each pretreatment, the rats are injected intraperitoneally with 1 mL/kg/week of CCl 4 . The treatment has lasted for 15 days. The body weight, urinary volume, water, and food intake were measured at the end of the treatment. Then, the animals are sacrificed; the blood and the liver samples were collected for determining the liver weight ratio and biochemical parameters. UnRoil did not show any sign of toxicity up to 5 mL/Kg. In Roil and UnRoil groups the water intake, ALT, AST, total and direct bilirubin, triglycerides, LDL, plasmatic creatinine, urea, uric acid, and MDA levels are reduced significantly as compared with the CCl 4 group. However, body weight,liver weight ratio, food intake, urine urea, urinary creatinine, hepatic glycogen, and GSH levels showed a significant increase compared to the CCl 4 group. Roil and UnRoil showed important nephroprotective and hepatoprotective effects against CCl 4 . Although, the roasting process does not influence the ability of Argan seed oils towards these activities. Keywords:
{"title":"Evaluation of toxicity, nephroprotective and hepatoprotective activities of Argan oil on CCl4-induced nephrotoxicity and hepatotoxicity in Wistar rats","authors":"Bnouham Mohamed, Mamri Samira, Marghich Mohamed, Bouziane Omar, Bouhrim Mohamed, Saalaoui Ennouamane, C. Mohammed, M. Hassane, Legssyer Abdelkhaleq, Ziyyat Abderrahim","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.28408","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.28408","url":null,"abstract":"In traditional therapy, Argania spinosa L. seeds oil used as a nephroprotective and hepatoprotective agent. The present work aims to investigate the acute toxicity of unroasted Argan oil, and studied the nephroprotective and the hepatoprotective activity of both oils Roasted (Roil) and unroasted Argan oil (UnRoil) on CCl 4 -induced liver and kidney damages in Wistar rats. Animals were divided into five equal groups; Control and CCl 4 groups are received only distilled water (10 mL/Kg/day). Control positive group received 50 mg/Kg/day of Silymarin. Roil and UnRoil groups treated with 2 mL/Kg/day of Roil and UnRoil. One week after each pretreatment, the rats are injected intraperitoneally with 1 mL/kg/week of CCl 4 . The treatment has lasted for 15 days. The body weight, urinary volume, water, and food intake were measured at the end of the treatment. Then, the animals are sacrificed; the blood and the liver samples were collected for determining the liver weight ratio and biochemical parameters. UnRoil did not show any sign of toxicity up to 5 mL/Kg. In Roil and UnRoil groups the water intake, ALT, AST, total and direct bilirubin, triglycerides, LDL, plasmatic creatinine, urea, uric acid, and MDA levels are reduced significantly as compared with the CCl 4 group. However, body weight,liver weight ratio, food intake, urine urea, urinary creatinine, hepatic glycogen, and GSH levels showed a significant increase compared to the CCl 4 group. Roil and UnRoil showed important nephroprotective and hepatoprotective effects against CCl 4 . Although, the roasting process does not influence the ability of Argan seed oils towards these activities. Keywords:","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"58 1","pages":"438-464"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89831505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.26574
A. Rochdi, E. Houda, Mesfioui Abdelhalim, E. Aboubaker, E. Younes, Rochdi Atmane
The search for a natural alternative against the resistance of bacterial strains pathogenic to antibiotics remains a necessity to prevent human diseases. In this work the identification of the chemical composition of essential oil by GC/ MS revealed the presence of three major compounds; Carvacrol (72.97%), r-Cymene (14.5%), and g- Terpinene (6.01%). The evaluation of the antibacterial activity of the essential oil of Origanum compactum and two synthetic antibiotics (Piperacillin (PRL), Ampicillin (AMP)) was carried out by diffusion techniques on agar and micro-Dilution on agar medium for the determination of the minimum inhibitory concentration , against strains of clinical origin; Escherichia coli, salmonella sp, Klebsiella pneumoniae, Pseudomonas Aeruginosa, streptococcus sp, Staphylococcus aureus . The toxicity assessment was conducted in accordance with OECD Protocol 423 (Organization for Economic Cooperation and Development). The results showed a strong antibacterial effect of the volatile extract compared to the two antibiotics used. The essential oil is classified in category 5 GHS (harmonized classification system) with LD50 greater than 5000 mg/kg. These results suggest the use of this natural product in the treatment and prevention of infectious diseases caused by pathogenic bacteria.
{"title":"Assessment of bioactive compounds, antibacterial potential and acute toxicity of a volatile Origanum compactum extract, an endemic plant of northern Morocco","authors":"A. Rochdi, E. Houda, Mesfioui Abdelhalim, E. Aboubaker, E. Younes, Rochdi Atmane","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.26574","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.26574","url":null,"abstract":"The search for a natural alternative against the resistance of bacterial strains pathogenic to antibiotics remains a necessity to prevent human diseases. In this work the identification of the chemical composition of essential oil by GC/ MS revealed the presence of three major compounds; Carvacrol (72.97%), r-Cymene (14.5%), and g- Terpinene (6.01%). The evaluation of the antibacterial activity of the essential oil of Origanum compactum and two synthetic antibiotics (Piperacillin (PRL), Ampicillin (AMP)) was carried out by diffusion techniques on agar and micro-Dilution on agar medium for the determination of the minimum inhibitory concentration , against strains of clinical origin; Escherichia coli, salmonella sp, Klebsiella pneumoniae, Pseudomonas Aeruginosa, streptococcus sp, Staphylococcus aureus . The toxicity assessment was conducted in accordance with OECD Protocol 423 (Organization for Economic Cooperation and Development). The results showed a strong antibacterial effect of the volatile extract compared to the two antibiotics used. The essential oil is classified in category 5 GHS (harmonized classification system) with LD50 greater than 5000 mg/kg. These results suggest the use of this natural product in the treatment and prevention of infectious diseases caused by pathogenic bacteria.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"3 1","pages":"422-437"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75026811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I3.26721
A. Hossain, Jaroof Al-Touby Salem Said
Since the ancient time, medicinal plants play a central role in the day-to-day life of humankind as crucial additive agents in foods, drinks and drugs and also as components in perfumes and cosmetics. The nutritional, pharmacological, biological and toxicological properties of the medicinal plants also have extensive applications. Globally, the majority of people nowadays rely on alternative and complementary medicines as safe sources for the treatment of various ailments obtained from natural sources. Plenty of plant and marine sources are available worldwide including the Sultanate of Oman with notable medicinal values. Hyoscyamus gallagheri ( H. gallagheri ), is one of the leafy plants grown in the desert areas of the Sultanate of Oman which belongs to the family of Solanaceae. Omanis have used the selected plant species traditionally to increase hair density, hair fall, dental pain, relieve snake bite, scorpion sting pain, motion sickness, asthma and cough. This plant is considered as a new species because still now there is no evidence on phytochemicals, pharmacological and toxicological studies available of the selected species. Previously, our group from Nizwa University has conducted two studies on the pharmacological and phytochemicals of the selected plant species and the results showed that the plant extracts contain different groups of phytochemicals, which possess notable biological activity. This present review is to summarize the updated scientific information available on the selected plant species grown in Oman. Therefore, the main objective of this current review is to compare and contrast the morphology, toxicity, pharmacological activity, phytochemicals, potential uses with other species belong to this family including the selected plant species of H. gallagheri . In conclusion, the raw plant materials, its crude extracts and isolated ingredients might be used as a novel therapeutic or herbal medicine to treat various ailments.
{"title":"A phytopharmacological review on an important indigenous medicinal plant Hyoscyamus gallagheri","authors":"A. Hossain, Jaroof Al-Touby Salem Said","doi":"10.48347/IMIST.PRSM/AJMAP-V7I3.26721","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I3.26721","url":null,"abstract":"Since the ancient time, medicinal plants play a central role in the day-to-day life of humankind as crucial additive agents in foods, drinks and drugs and also as components in perfumes and cosmetics. The nutritional, pharmacological, biological and toxicological properties of the medicinal plants also have extensive applications. Globally, the majority of people nowadays rely on alternative and complementary medicines as safe sources for the treatment of various ailments obtained from natural sources. Plenty of plant and marine sources are available worldwide including the Sultanate of Oman with notable medicinal values. Hyoscyamus gallagheri ( H. gallagheri ), is one of the leafy plants grown in the desert areas of the Sultanate of Oman which belongs to the family of Solanaceae. Omanis have used the selected plant species traditionally to increase hair density, hair fall, dental pain, relieve snake bite, scorpion sting pain, motion sickness, asthma and cough. This plant is considered as a new species because still now there is no evidence on phytochemicals, pharmacological and toxicological studies available of the selected species. Previously, our group from Nizwa University has conducted two studies on the pharmacological and phytochemicals of the selected plant species and the results showed that the plant extracts contain different groups of phytochemicals, which possess notable biological activity. This present review is to summarize the updated scientific information available on the selected plant species grown in Oman. Therefore, the main objective of this current review is to compare and contrast the morphology, toxicity, pharmacological activity, phytochemicals, potential uses with other species belong to this family including the selected plant species of H. gallagheri . In conclusion, the raw plant materials, its crude extracts and isolated ingredients might be used as a novel therapeutic or herbal medicine to treat various ailments.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"17 1","pages":"367-384"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72715706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I2.26288
G. Mustafa, A. A. Abdalla, K. Ahmed, A. Z. Almagboul, Eltayeb Fadul
In this study, three samples of oleo-gum resins of Boswellia papyrifera (Tarak tarak) grown in different regions of the Sudan were used ( Kordofan , Damazine and Nagawa ). Solvent extracts, acid fractions and essential oils of the three samples were evaluated for their cytotoxicity potential via the brine shrimp lethality assay. Results revealed a dose–dependent response in mortality, and where the degree of lethality was directly proportional to the concentration of the extracts. Among all tested materials, the best cytotoxic activity was exhibited by the methanolic extracts and acid fractions of the three samples, non acid fractions from Kordofan and Damazine olibanum as well as the petroleum extract of Damazine sample. All examined materials, excluding the volatile oils of Damazine and Nagawa samples, showed high cytotoxicity with LD 50 values less than 20 μg /ml; thus can be used to predict anti-carcinogenic activity.
{"title":"Cytotoxicity Potential of Essential Oils and Extracts of Oleo-Gum Resins from Boswellia papyrifera (Tarak tarak) Grown in Different Regions of the Sudan","authors":"G. Mustafa, A. A. Abdalla, K. Ahmed, A. Z. Almagboul, Eltayeb Fadul","doi":"10.48347/IMIST.PRSM/AJMAP-V7I2.26288","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I2.26288","url":null,"abstract":"In this study, three samples of oleo-gum resins of Boswellia papyrifera (Tarak tarak) grown in different regions of the Sudan were used ( Kordofan , Damazine and Nagawa ). Solvent extracts, acid fractions and essential oils of the three samples were evaluated for their cytotoxicity potential via the brine shrimp lethality assay. Results revealed a dose–dependent response in mortality, and where the degree of lethality was directly proportional to the concentration of the extracts. Among all tested materials, the best cytotoxic activity was exhibited by the methanolic extracts and acid fractions of the three samples, non acid fractions from Kordofan and Damazine olibanum as well as the petroleum extract of Damazine sample. All examined materials, excluding the volatile oils of Damazine and Nagawa samples, showed high cytotoxicity with LD 50 values less than 20 μg /ml; thus can be used to predict anti-carcinogenic activity.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"os-51 1","pages":"215-226"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87364095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-04DOI: 10.48347/IMIST.PRSM/AJMAP-V7I2.26289
K. Vennila, A. Arunprasath
This study emphasizes screening of DPPH, secondary metabolites and antimicrobial activity of Blastonia garcinii an annual wine with a slender stem, climbing using tendrils, leaves are ovate and flowers are unisexual. The leaves were collected, shade dried and powdered. The powdered sample was extracted by using soxhlet apparatus with petroleum ether and ethanol. The antioxidant activity of the plant extracts was measured using spectrophotometry by their ability to scavenge free radicals such as DPPH (2,2-diphenyl-1-picrylhydrazyl), hydrogen peroxide and also quantification of total flavonoids, total phenol content and antimicrobial activity of plant extracts. The significant result observed in when compared Petroleum ether and Ethanol extract, the DPPH and H 2 O 2 activities and the total phenol and total flavonoid content and Antibacterial and antifungal activity were shown significant activity in ethanolic extract of B. garcinii.
{"title":"Evaluation of 2,2-diphenyl-1-picrylhydrazyl, secondary metabolite contents and antimicrobial efficacy of Blastonia garcinii(Burm.f.) Cogn.","authors":"K. Vennila, A. Arunprasath","doi":"10.48347/IMIST.PRSM/AJMAP-V7I2.26289","DOIUrl":"https://doi.org/10.48347/IMIST.PRSM/AJMAP-V7I2.26289","url":null,"abstract":"This study emphasizes screening of DPPH, secondary metabolites and antimicrobial activity of Blastonia garcinii an annual wine with a slender stem, climbing using tendrils, leaves are ovate and flowers are unisexual. The leaves were collected, shade dried and powdered. The powdered sample was extracted by using soxhlet apparatus with petroleum ether and ethanol. The antioxidant activity of the plant extracts was measured using spectrophotometry by their ability to scavenge free radicals such as DPPH (2,2-diphenyl-1-picrylhydrazyl), hydrogen peroxide and also quantification of total flavonoids, total phenol content and antimicrobial activity of plant extracts. The significant result observed in when compared Petroleum ether and Ethanol extract, the DPPH and H 2 O 2 activities and the total phenol and total flavonoid content and Antibacterial and antifungal activity were shown significant activity in ethanolic extract of B. garcinii.","PeriodicalId":14019,"journal":{"name":"International Journal of Medicinal and Aromatic Plants","volume":"22 1","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88098431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：