Pub Date : 2024-05-07DOI: 10.1038/s41443-024-00898-3
Muharrem Baturu, Mehmet Solakhan, Tanyeli Guneyligil Kazaz, Omer Bayrak
The present study assessed the accuracy of artificiaI intelligence-generated responses to frequently asked questions on erectile dysfunction. A cross-sectional analysis involved 56 erectile dysfunction-related questions searched on Google, categorized into nine sections: causes, diagnosis, treatment options, treatment complications, protective measures, relationship with other illnesses, treatment costs, treatment with herbal agents, and appointments. Responses from ChatGPT 3.5, ChatGPT 4, and BARD were evaluated by two experienced urology experts using the F1 and global quality scores (GQS) for accuracy, relevance, and comprehensibility. ChatGPT 3.5 and ChatGPT 4 achieved higher GQS than BARD in categories such as causes (4.5 ± 0.54, 4.5 ± 0.51, 3.15 ± 1.01, respectively, p < 0.001), treatment options (4.35 ± 0.6, 4.5 ± 0.43, 2.71 ± 1.38, respectively, p < 0.001), protective measures (5.0 ± 0, 5.0 ± 0, 4 ± 0.5, respectively, p = 0.013), relationships with other illnesses (4.58 ± 0.58, 4.83 ± 0.25, 3.58 ± 0.8, respectively, p = 0.006), and treatment with herbal agents (3 ± 0.61, 3.33 ± 0.83, 1.8 ± 1.09, respectively, p = 0.043). F1 scores in categories: causes (1), diagnosis (0.857), treatment options (0.726), and protective measures (1), indicated their alignment with the guidelines. There was no significant difference between ChatGPT 3.5 and ChatGPT 4 regarding answer quality, but both outperformed BARD in the GQS. These results emphasize the need to continually enhance and validate AI-generated medical information, underscoring the importance of artificiaI intelligence systems in delivering reliable information on erectile dysfunction.
{"title":"Frequently asked questions on erectile dysfunction: evaluating artificial intelligence answers with expert mentorship.","authors":"Muharrem Baturu, Mehmet Solakhan, Tanyeli Guneyligil Kazaz, Omer Bayrak","doi":"10.1038/s41443-024-00898-3","DOIUrl":"10.1038/s41443-024-00898-3","url":null,"abstract":"<p><p>The present study assessed the accuracy of artificiaI intelligence-generated responses to frequently asked questions on erectile dysfunction. A cross-sectional analysis involved 56 erectile dysfunction-related questions searched on Google, categorized into nine sections: causes, diagnosis, treatment options, treatment complications, protective measures, relationship with other illnesses, treatment costs, treatment with herbal agents, and appointments. Responses from ChatGPT 3.5, ChatGPT 4, and BARD were evaluated by two experienced urology experts using the F1 and global quality scores (GQS) for accuracy, relevance, and comprehensibility. ChatGPT 3.5 and ChatGPT 4 achieved higher GQS than BARD in categories such as causes (4.5 ± 0.54, 4.5 ± 0.51, 3.15 ± 1.01, respectively, p < 0.001), treatment options (4.35 ± 0.6, 4.5 ± 0.43, 2.71 ± 1.38, respectively, p < 0.001), protective measures (5.0 ± 0, 5.0 ± 0, 4 ± 0.5, respectively, p = 0.013), relationships with other illnesses (4.58 ± 0.58, 4.83 ± 0.25, 3.58 ± 0.8, respectively, p = 0.006), and treatment with herbal agents (3 ± 0.61, 3.33 ± 0.83, 1.8 ± 1.09, respectively, p = 0.043). F1 scores in categories: causes (1), diagnosis (0.857), treatment options (0.726), and protective measures (1), indicated their alignment with the guidelines. There was no significant difference between ChatGPT 3.5 and ChatGPT 4 regarding answer quality, but both outperformed BARD in the GQS. These results emphasize the need to continually enhance and validate AI-generated medical information, underscoring the importance of artificiaI intelligence systems in delivering reliable information on erectile dysfunction.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.1038/s41443-024-00893-8
Britney L Atwater, Duygu Kirkik, Steven K Wilson, Orhan Koca, Rajveer S Purohit, Carlos Muñoz Vera, Nigel Dunglison, Martin S Gross
Testicular prosthesis implantation is a valuable solution for the physical, cosmetic, and psychological challenges associated with testicular loss which may affect males of any age. We evaluated the safety and reliability of the new Rigicon Testi10TM testicular prosthesis in adults and adolescents by performing an IRB-approved retrospective study of data drawn from Patient Information Forms (PIFs). A total of 427 patients (382 adults and 45 adolescents) had at least one testicular prosthesis implanted. Only one adult patient required revision surgery due to rupture of the Rigicon Testi10 TM saline-filled prosthesis. A 40-year-old patient was found to have a leaking prosthesis approximately one week postoperatively, which was suspected to be due to inadvertently punctured by the surgeon during the sterile saline filling process. There were no post-implantation revisions required for adolescent patients. According to our results, Kaplan-Meier calculation of survival from removal or revision was 99.8% for all patients at 54 months (99.7% for adults and 100% for adolescents). The complication rates among patients in this study are lower than those reported in previous published studies. Our study underscores the generally safe nature of testicular prosthesis implantation, as well as the very rare incidence of revision surgery for this new device.
{"title":"Short-term revision rate of Rigicon Testi10<sup>TM</sup> testicular prosthesis in adolescents and adults: a retrospective chart review.","authors":"Britney L Atwater, Duygu Kirkik, Steven K Wilson, Orhan Koca, Rajveer S Purohit, Carlos Muñoz Vera, Nigel Dunglison, Martin S Gross","doi":"10.1038/s41443-024-00893-8","DOIUrl":"https://doi.org/10.1038/s41443-024-00893-8","url":null,"abstract":"<p><p>Testicular prosthesis implantation is a valuable solution for the physical, cosmetic, and psychological challenges associated with testicular loss which may affect males of any age. We evaluated the safety and reliability of the new Rigicon Testi10<sup>TM</sup> testicular prosthesis in adults and adolescents by performing an IRB-approved retrospective study of data drawn from Patient Information Forms (PIFs). A total of 427 patients (382 adults and 45 adolescents) had at least one testicular prosthesis implanted. Only one adult patient required revision surgery due to rupture of the Rigicon Testi10 <sup>TM</sup> saline-filled prosthesis. A 40-year-old patient was found to have a leaking prosthesis approximately one week postoperatively, which was suspected to be due to inadvertently punctured by the surgeon during the sterile saline filling process. There were no post-implantation revisions required for adolescent patients. According to our results, Kaplan-Meier calculation of survival from removal or revision was 99.8% for all patients at 54 months (99.7% for adults and 100% for adolescents). The complication rates among patients in this study are lower than those reported in previous published studies. Our study underscores the generally safe nature of testicular prosthesis implantation, as well as the very rare incidence of revision surgery for this new device.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1038/s41443-024-00894-7
Karl H. Pang, Giuseppe Fallara, Asif Muneer, Hussain M. Alnajjar
The comment by Vandermaesen K and Albersen M [1] on our recent study on the oncological outcomes of penile squamous cell carcinoma (SCC) in a ≤50 years (younger) and >50 years (older) cohort of men [2] raised important points for areas of further research.
Correctly identified, the intentionally matched cohorts based on the stage of disease and surgical technique would limit a comprehensive evaluation of histopathological characteristics between the younger and older groups of men. However, the aim of our study was not to investigate this, but to understand whether the two groups of patients with similar stage of disease and surgical treatment would have different survival outcomes. We found that there were no differences in outcomes, except for overall survival. It is likely, as pointed out by Vandermaesen K and Albersen M [1] that the lower overall survival rate observed in the older cohort is associated with higher comorbidities. However, we did not compare data on comorbidities or Charlson scores to prove this. The observation that similar cancer staging in both age groups resulted in similar cancer-specific survival, recurrence-free and metastatic-free survivals implied that penile SCC in the younger patients is at least as aggressive as in older patients and should not be underestimated.
Vandermaesen K和Albersen M[1]对我们最近关于≤50岁(年轻)和50岁(年长)男性阴茎鳞状细胞癌(SCC)肿瘤学预后的研究发表了评论[2],提出了需要进一步研究的重要观点。然而,我们研究的目的并不是要调查这一点,而是要了解疾病分期和手术治疗方法相似的两组患者是否会有不同的生存结果。我们发现,除总生存期外,两组患者的生存结果并无差异。正如 Vandermaesen K 和 Albersen M 所指出的那样[1],老年组患者的总生存率较低可能与较高的合并症有关。不过,我们没有比较合并症数据或 Charlson 评分来证明这一点。观察发现,两个年龄组的癌症分期相似,因此癌症特异性生存率、无复发和无转移生存率也相似,这意味着年轻患者的阴茎癌至少与老年患者一样具有侵袭性,不应低估。
{"title":"Response to comment on: Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old","authors":"Karl H. Pang, Giuseppe Fallara, Asif Muneer, Hussain M. Alnajjar","doi":"10.1038/s41443-024-00894-7","DOIUrl":"https://doi.org/10.1038/s41443-024-00894-7","url":null,"abstract":"<p>The comment by Vandermaesen K and Albersen M [1] on our recent study on the oncological outcomes of penile squamous cell carcinoma (SCC) in a ≤50 years (younger) and >50 years (older) cohort of men [2] raised important points for areas of further research.</p><p>Correctly identified, the intentionally matched cohorts based on the stage of disease and surgical technique would limit a comprehensive evaluation of histopathological characteristics between the younger and older groups of men. However, the aim of our study was not to investigate this, but to understand whether the two groups of patients with similar stage of disease and surgical treatment would have different survival outcomes. We found that there were no differences in outcomes, except for overall survival. It is likely, as pointed out by Vandermaesen K and Albersen M [1] that the lower overall survival rate observed in the older cohort is associated with higher comorbidities. However, we did not compare data on comorbidities or Charlson scores to prove this. The observation that similar cancer staging in both age groups resulted in similar cancer-specific survival, recurrence-free and metastatic-free survivals implied that penile SCC in the younger patients is at least as aggressive as in older patients and should not be underestimated.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1038/s41443-024-00897-4
Alexander William Cloberry Lockie, Peter Grice, Raj Mathur, Ian Pearce, Vaibhav Modgil
Male hypogonadism is a clinical syndrome that results in low testosterone levels and frequently leads to infertility. The syndrome occurs due to disruption at one or more levels of the hypothalamic-pituitary-gonadal axis. Testosterone replacement therapy (TRT) is the most common treatment utilised for male hypogonadism. However, long-acting forms of TRT leads to infertility and so is inappropriate for patients wishing to conceive. For patients who wish to remain fertile, nasal TRT, clomiphene citrate, exogenous gonadotropins, gonadotropin releasing hormone and aromatase inhibitors have been used as alternative treatment options with different degrees of success. A review of the literature was performed to identify the safety and efficacy of alternative treatment options. Gonadotropin releasing hormone can successfully induce spermatogenesis but is impractical to administer. Likewise, aromatase inhibitors have limited use due to inducing osteopenia. Nasal TRT may be a good treatment option for these patients, but its efficacy has so far only been demonstrated in small sample sizes. However, clomiphene citrate and exogenous gonadotropins are safe, offer good symptom control and can successfully induce fertility in hypogonadism patients.
男性性腺功能减退症是一种临床综合征,会导致睾酮水平低下,并经常导致不育。该综合征的发生是由于下丘脑-垂体-性腺轴的一个或多个水平发生了紊乱。睾酮替代疗法(TRT)是治疗男性性腺功能减退症最常用的方法。然而,长效睾丸激素替代疗法会导致不育,因此不适合希望怀孕的患者。对于希望保持生育能力的患者,鼻腔TRT、枸橼酸克罗米芬、外源性促性腺激素、促性腺激素释放激素和芳香化酶抑制剂已被用作替代治疗方案,并取得了不同程度的成功。我们对文献进行了回顾,以确定替代治疗方案的安全性和有效性。促性腺激素释放激素可成功诱导精子发生,但在使用上并不实用。同样,芳香化酶抑制剂也会诱发骨质疏松,因此使用范围有限。对这些患者来说,鼻腔 TRT 可能是一个不错的治疗选择,但其疗效迄今仅在小样本量中得到证实。不过,枸橼酸克罗米芬和外源性促性腺激素是安全的,能很好地控制症状,并能成功诱导性腺功能减退症患者生育。
{"title":"Diagnosis and treatment of hypogonadism in men seeking to preserve fertility – what are the options?","authors":"Alexander William Cloberry Lockie, Peter Grice, Raj Mathur, Ian Pearce, Vaibhav Modgil","doi":"10.1038/s41443-024-00897-4","DOIUrl":"https://doi.org/10.1038/s41443-024-00897-4","url":null,"abstract":"<p>Male hypogonadism is a clinical syndrome that results in low testosterone levels and frequently leads to infertility. The syndrome occurs due to disruption at one or more levels of the hypothalamic-pituitary-gonadal axis. Testosterone replacement therapy (TRT) is the most common treatment utilised for male hypogonadism. However, long-acting forms of TRT leads to infertility and so is inappropriate for patients wishing to conceive. For patients who wish to remain fertile, nasal TRT, clomiphene citrate, exogenous gonadotropins, gonadotropin releasing hormone and aromatase inhibitors have been used as alternative treatment options with different degrees of success. A review of the literature was performed to identify the safety and efficacy of alternative treatment options. Gonadotropin releasing hormone can successfully induce spermatogenesis but is impractical to administer. Likewise, aromatase inhibitors have limited use due to inducing osteopenia. Nasal TRT may be a good treatment option for these patients, but its efficacy has so far only been demonstrated in small sample sizes. However, clomiphene citrate and exogenous gonadotropins are safe, offer good symptom control and can successfully induce fertility in hypogonadism patients.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This work aimed to evaluate the effects of the aqueous extract of Vepris afzelii roots on a rat model of hypogonadism. Phytochemical screening and acute toxicity of the extract were performed using different procedures. Hypogonadism was induced orally in adult Wistar rats using cyproterone acetate (30 mg/kg) for ten days. Besides six normal rats (10 ml/kg of distilled water, normal control), 30 hypogonadal rats were subdivided into five groups of six animals each, receiving for 14 days: distilled water (10 ml/kg, hypogonadal control), testosterone (4 mg/kg/3days) and the extract of V. afzelii (100, 200 and 400 mg/kg). Sexual behavior, sperm parameters, testes function and structure were assessed. Compared to the normal controls, significant (p = 0.0000) increases in mount (24 ± 0.94 seconds vs. 1200 ± 00 seconds) and intromission (49.16 ± 10.85 seconds vs. 1200 ± 00 seconds) latencies, and post-ejaculatory interval (381.72 ± 37.55 seconds vs. 1200 ± 00 seconds) were observed in all groups receiving cyproterone acetate on day 0. Total inhibitions of mounts (63.50 ± 8.91 vs. 00 ± 00), intromissions (36.66 ± 3.51 vs. 00 ± 00) (p = 0.0000), ejaculations (2.83 ± 00 vs. 00 ± 00, p = 0.0002) frequencies and mean copulatory interval (627.30 ± 81.80 vs. 00 ± 00, p = 0.0000) were also observed in these groups. Moreover, decreases in daily sperm production (2.65 ± 0.19 vs. 1.17 ± 0.08, p = 0.0498), percentage of sperm mobility (78.64 ± 8.41 vs. 10.12 ± 2.32), serum testosterone level (8.39 ± 0.63 ng/dl vs. 1.68 ± 0.19 ng/dl), diameter of seminiferous tubules (111.97 ± 0.51 µm vs. 94.51 ± 0.57 µm) and height of germinal epithelium (46.58 ± 0.34 µm vs. 33.74 ± 0.66 µm) (p = 0.0000) associated with increases in sperm transit (3.13 ± 0.45 vs. 11.07 ± 1.45, p = 0.0000) were also observed in these groups. Interestingly, compared to hypogonadal control and day 0, the administration of V. afzelii extract induced significant (p = 0.0000) improvements in all these altered parameters with 400 mg/kg being the most active dose. These results, attributed to saponins, flavonoids, polyphenols and triterpenes detected in this plant’s extract confirm its traditional usage and could be useful for the management of patients suffering from hypogonadism.
这项研究旨在评估 Vepris afzelii 根的水提取物对大鼠性腺功能减退症模型的影响。采用不同的程序对提取物进行了植物化学筛选和急性毒性研究。用醋酸环丙孕酮(30 毫克/千克)诱导成年 Wistar 大鼠性腺功能减退症,连续十天。除了 6 只正常大鼠(10 毫升/千克蒸馏水,正常对照组)外,30 只性腺功能减退大鼠被分成 5 组,每组 6 只,分别接受蒸馏水(10 毫升/千克,性腺功能减退对照组)、睾酮(4 毫克/千克/3 天)和 V. afzelii 提取物(100、200 和 400 毫克/千克)治疗 14 天。对性行为、精子参数、睾丸功能和结构进行了评估。与正常对照组相比,在第 0 天接受醋酸环丙孕酮治疗的所有组中,都观察到勃起(24 ± 0.94 秒 vs. 1200 ± 00 秒)和射精(49.16 ± 10.85 秒 vs. 1200 ± 00 秒)潜伏期和射精后间歇(381.72 ± 37.55 秒 vs. 1200 ± 00 秒)显著增加(p = 0.0000)。在这些组别中还观察到骑乘(63.50 ± 8.91 vs. 00 ± 00)、插入(36.66 ± 3.51 vs. 00 ± 00)(p = 0.0000)、射精(2.83 ± 00 vs. 00 ± 00,p = 0.0002)频率和平均交配间隔(627.30 ± 81.80 vs. 00 ± 00,p = 0.0000)的总抑制。此外,日精子产量(2.65 ± 0.19 vs. 1.17 ± 0.08,p = 0.0498)、精子活动率(78.64 ± 8.41 vs. 10.12 ± 2.32)、血清睾酮水平(8.39 ± 0.63 ng/dl vs. 1.68 ± 0.19 ng/dl)、曲细精管直径(111.97 ± 0.51 µm vs. 94.51 ± 0.57 µm)和生精上皮的高度(46.58 ± 0.34 µm vs. 33.74 ± 0.66 µm)(p = 0.0000)(p = 0.0000),同时还观察到这些组中精子转运量的增加(3.13 ± 0.45 vs. 11.07 ± 1.45,p = 0.0000)。有趣的是,与性腺功能低下的对照组和第 0 天相比,服用 V. afzelii 提取物可显著(p = 0.0000)改善所有这些改变的参数,其中 400 毫克/千克是最有效的剂量。这些结果归功于在这种植物的提取物中检测到的皂苷、黄酮类、多酚和三萜类化合物,证实了它的传统用途,可用于治疗性腺功能减退症患者。
{"title":"Aphrodisiac and androgenic effects of the aqueous extract of the roots of Vepris afzelii on cyproterone acetate-induced hypogonadism in rat","authors":"Modeste Wankeu-Nya, Ornéla Néely Djeumeni, Zacharie Nde, Marie Claire Tchamadeu, Tomutou Inès Kengne, Towo Dominique Hyacinthe Hatho, Brice Landry Koloko, Lembè Dieudonné Massoma, Alain Bertrand Dongmo, Fewou Paul Moundipa, Pierre Watcho","doi":"10.1038/s41443-024-00892-9","DOIUrl":"https://doi.org/10.1038/s41443-024-00892-9","url":null,"abstract":"<p>This work aimed to evaluate the effects of the aqueous extract of <i>Vepris afzelii</i> roots on a rat model of hypogonadism. Phytochemical screening and acute toxicity of the extract were performed using different procedures. Hypogonadism was induced orally in adult Wistar rats using cyproterone acetate (30 mg/kg) for ten days. Besides six normal rats (10 ml/kg of distilled water, normal control), 30 hypogonadal rats were subdivided into five groups of six animals each, receiving for 14 days: distilled water (10 ml/kg, hypogonadal control), testosterone (4 mg/kg/3days) and the extract of <i>V. afzelii</i> (100, 200 and 400 mg/kg). Sexual behavior, sperm parameters, testes function and structure were assessed. Compared to the normal controls, significant (<i>p</i> = 0.0000) increases in mount (24 ± 0.94 seconds vs. 1200 ± 00 seconds) and intromission (49.16 ± 10.85 seconds vs. 1200 ± 00 seconds) latencies, and post-ejaculatory interval (381.72 ± 37.55 seconds vs. 1200 ± 00 seconds) were observed in all groups receiving cyproterone acetate on day 0. Total inhibitions of mounts (63.50 ± 8.91 vs. 00 ± 00), intromissions (36.66 ± 3.51 vs. 00 ± 00) (<i>p</i> = 0.0000), ejaculations (2.83 ± 00 vs. 00 ± 00, <i>p</i> = 0.0002) frequencies and mean copulatory interval (627.30 ± 81.80 vs. 00 ± 00, <i>p</i> = 0.0000) were also observed in these groups. Moreover, decreases in daily sperm production (2.65 ± 0.19 vs. 1.17 ± 0.08, <i>p</i> = 0.0498), percentage of sperm mobility (78.64 ± 8.41 vs. 10.12 ± 2.32), serum testosterone level (8.39 ± 0.63 ng/dl vs. 1.68 ± 0.19 ng/dl), diameter of seminiferous tubules (111.97 ± 0.51 µm vs. 94.51 ± 0.57 µm) and height of germinal epithelium (46.58 ± 0.34 µm vs. 33.74 ± 0.66 µm) (p = 0.0000) associated with increases in sperm transit (3.13 ± 0.45 vs. 11.07 ± 1.45, <i>p</i> = 0.0000) were also observed in these groups. Interestingly, compared to hypogonadal control and day 0, the administration of <i>V. afzelii</i> extract induced significant (<i>p</i> = 0.0000) improvements in all these altered parameters with 400 mg/kg being the most active dose. These results, attributed to saponins, flavonoids, polyphenols and triterpenes detected in this plant’s extract confirm its traditional usage and could be useful for the management of patients suffering from hypogonadism.</p><figure></figure>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1038/s41443-024-00896-5
G. Hatzichristodoulou
{"title":"Response to the Commentary on \"Intermediate-term results of TachoSil grafting to correct residual curvature during inflatable penile prosthesis implantation in patients with Peyronie's disease\".","authors":"G. Hatzichristodoulou","doi":"10.1038/s41443-024-00896-5","DOIUrl":"https://doi.org/10.1038/s41443-024-00896-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140666605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1038/s41443-024-00856-z
Xi Gu, F. Zhu, Ping Gao, Ying Shen, Leiqun Lu
{"title":"Association between visceral adipose tissue and total testosterone among the United States male adults: a cross-sectional study.","authors":"Xi Gu, F. Zhu, Ping Gao, Ying Shen, Leiqun Lu","doi":"10.1038/s41443-024-00856-z","DOIUrl":"https://doi.org/10.1038/s41443-024-00856-z","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-22DOI: 10.1038/s41443-024-00883-w
M. VanDyke
{"title":"Response to the comment on: \"Current opinions on the management of prolonged ischemic priapism: does penoscrotal decompression outperform corporoglanular tunneling?\"","authors":"M. VanDyke","doi":"10.1038/s41443-024-00883-w","DOIUrl":"https://doi.org/10.1038/s41443-024-00883-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.1038/s41443-024-00889-4
K. Vandermaesen, M. Albersen
{"title":"Young men with penile cancer fare as poorly as elder patients: clinical implications.","authors":"K. Vandermaesen, M. Albersen","doi":"10.1038/s41443-024-00889-4","DOIUrl":"https://doi.org/10.1038/s41443-024-00889-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.1038/s41443-024-00891-w
Daniel Turner, Priscilla Gregório Hertz, Laura Biedermann, Steffen Barra, Wolfgang Retz
Previous research has found some peculiarities in sexual functioning of adults with attention deficit/hyperactivity disorder (ADHD). Using a set of questionnaires that had to be answered online, we assessed the prevalence of paraphilic fantasies and behaviors in a sample of 160 adults with ADHD in comparison to 75 adults without ADHD and evaluated the association between paraphilias and hypersexuality in the ADHD group. Both groups reported high rates of paraphilic fantasies and behaviors. ADHD individuals were more likely to report about very sexually arousing paraphilic fantasies (ADHD: 58.2% vs. non-ADHD: 40.5%; χ2 = 6.323, p = 0.01) and behaviors (ADHD: 44.9% vs. non-ADHD: 28.4%; χ2 = 5.774, p = 0.02). Furthermore, ADHD individuals reported on average about more very sexually arousing paraphilic behaviors compared to non-ADHD individuals (ADHD: M = 1.28, SD = 0.10 vs. non-ADHD: M = 0.81, SD = 0.09; T = 2.68, p < 0.01). Furthermore, in ADHD individuals both very sexually arousing paraphilic interests in masturbation fantasies (r(158) = 0.17, p = 0.03) and in sexual behaviors (r(158) =0.19, p = 0.02) showed a significant correlation with hypersexuality. In non-ADHD individuals no such significant correlation could be found. Altogether, it can be concluded that individuals with ADHD seem to be more prone to develop and act out paraphilic sexuality than those without ADHD, however, found differences were rather small. The results of the present study add to the current trend to depathologize paraphilic sexuality in the general as well as in clinical populations.
{"title":"Paraphilic fantasies and behavior in attention deficit/hyperactivity disorder and their association with hypersexuality","authors":"Daniel Turner, Priscilla Gregório Hertz, Laura Biedermann, Steffen Barra, Wolfgang Retz","doi":"10.1038/s41443-024-00891-w","DOIUrl":"https://doi.org/10.1038/s41443-024-00891-w","url":null,"abstract":"<p>Previous research has found some peculiarities in sexual functioning of adults with attention deficit/hyperactivity disorder (ADHD). Using a set of questionnaires that had to be answered online, we assessed the prevalence of paraphilic fantasies and behaviors in a sample of 160 adults with ADHD in comparison to 75 adults without ADHD and evaluated the association between paraphilias and hypersexuality in the ADHD group. Both groups reported high rates of paraphilic fantasies and behaviors. ADHD individuals were more likely to report about very sexually arousing paraphilic fantasies (ADHD: 58.2% vs. non-ADHD: 40.5%; <i>χ</i><sup><i>2</i></sup> = 6.323, <i>p</i> = 0.01) and behaviors (ADHD: 44.9% vs. non-ADHD: 28.4%; <i>χ</i><sup><i>2</i></sup> = 5.774, <i>p</i> = 0.02). Furthermore, ADHD individuals reported on average about more very sexually arousing paraphilic behaviors compared to non-ADHD individuals (ADHD: M = 1.28, SD = 0.10 vs. non-ADHD: M = 0.81, SD = 0.09; T = 2.68, <i>p</i> < 0.01). Furthermore, in ADHD individuals both very sexually arousing paraphilic interests in masturbation fantasies (<i>r</i>(158) = 0.17, <i>p</i> = 0.03) and in sexual behaviors (<i>r</i>(158) =0.19, <i>p</i> = 0.02) showed a significant correlation with hypersexuality. In non-ADHD individuals no such significant correlation could be found. Altogether, it can be concluded that individuals with ADHD seem to be more prone to develop and act out paraphilic sexuality than those without ADHD, however, found differences were rather small. The results of the present study add to the current trend to depathologize paraphilic sexuality in the general as well as in clinical populations.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140610722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}