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Preliminary phytochemical screening of bark (powder) extracts of Ficus religiosa (peepal) plant 榕(皮)皮(粉)提取物的初步化学筛选
Pub Date : 2020-06-15 DOI: 10.47128/IJRDPL.2278-0238.2020.9(1).1-9
P. Tiwari, R. Gupta
The traditional medicine involves the use of various different plant extracts  or  the  bioactive  constituents.  The  study  such  as  ethno  medicine  keenly   r presents the best avenues in searching new economic plants for medicine. This type  of study gives the health application at affordable cost. The present study carried out to find out the phytochemical constituents in the Ficus religiosa bark. The Ficus religiosa was collected from the Rama University Campus. The shadow dried bark materials were grained and extracted with petroleum ether, chloroform, methanol and ethanol: water (50: 50). Photochemical analysis was carried out according to standard procedures. The bark powder was successively extracted ith Phytochemical screening shows the presence of carbohydrate, glycoside, alk loid, protein, amino acid, phytosterol, tannin & flavonoids. The result of the study could be useful for description and phytochemical analysis of the plant.
传统医学包括使用各种不同的植物提取物或生物活性成分。民族医学等研究为寻找新的药用经济植物提供了最好的途径。这种类型的研究以可承受的成本提供健康应用。本研究对榕皮中的植物化学成分进行了研究。榕树是从拉玛大学校园采集的。用石油醚、氯仿、甲醇和乙醇:水(50:50)对阴影干燥树皮材料进行颗粒化提取。光化学分析按标准程序进行。经植物化学筛选,提取的树皮粉中含有碳水化合物、糖苷、类脂、蛋白质、氨基酸、植物甾醇、单宁和黄酮类化合物。研究结果可为该植物的描述和植物化学分析提供参考。
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引用次数: 2
A prospective observational study on the effect of Erythropoiesis stimulating agents in chronic kidney disease Anemia patients 促红细胞生成素对慢性肾病贫血患者影响的前瞻性观察研究
M. Jose, S. Singh, Vinson Achankunju, Punitha Sundaraswamy, S. Sherief, Sivakumar Thangaval
Background and Objectives: Anemia is a frequent complication, and significant morbidity and mortality in patient with chronic kidney disease (CKD). Erythropoiesis Stimulating Agents (ESAs) have become the standard care for  anemia   t erapy and reduces need for blood transfusions. The bjective of the study was to evaluate the safety  and  effect  of  ESAs  and  to  create  the  awareness  among patients    regarding     the     Erythropoiesis     stimulating    agents     through    patient i formation leaflets. Methods: The prospective observational study of  6-month duration was conducted in a tertiary care hospital. A total of 162 patients on ESAs  were enrolled in the study. Patients were followed for continuously and the mean difference is assessed by monitoring the primary and secondary hematological parameters before and after ESAs administration. Patient information leaflet was given t the patients for education and awareness about ESAs. Results: Out of 162 patients, after the administration of ESAs mean value increase in hemoglobin level was found from base line 6.9g/dL to 11.6g/dL. Significant improvement was noted in CKD anemia patient indicating impact of patient counseli g. Conclusion: It can be  concluded that Erythropoiesis Stimulating Agents in treatment of anemia along with effective counseling from clinical pharmacist benefits CKD patients and improves the health outcomes.
背景与目的:贫血是慢性肾脏疾病(CKD)患者常见的并发症,且具有显著的发病率和死亡率。促红细胞生成剂(ESAs)已成为贫血治疗的标准治疗方法,减少了输血需求。该研究的目的是评估ESAs的安全性和效果,并通过患者信息页提高患者对促红细胞生成药物的认识。方法:在某三级医院进行为期6个月的前瞻性观察研究。共有162名接受esa治疗的患者参加了这项研究。对患者进行连续随访,通过监测ESAs给药前后的主要和次要血液学参数来评估平均差异。向患者发放患者信息单张,提高患者对ESAs的认识和教育。结果:162例患者中,给予esa后血红蛋白水平平均值从基线6.9g/dL增加到11.6g/dL。结论:在临床药师的有效指导下,使用促红细胞生成剂治疗贫血对CKD患者有益,改善了CKD患者的健康结局。
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引用次数: 0
Catheter associated urinary tract infections in intensive care units patients in a tertiary care hospital 某三级医院重症监护病房患者尿路感染的研究
Pub Date : 2020-02-15 DOI: 10.4712821276/IJRDPL.2278-
M. Goel, D. Chhina, Veenu Gupta
Introduction: Catheter associated urinary tract infections (CAUTI) is the most common health care associated infection (HAI), accounting for 40% of all HAIs in particularly in patients admitted to intensive care units (ICU) due to their more frequent necessity of urinary catheterization and longer duration of catheter use. Knowledge about Microbiological profile and antimicrobial sensitivity pattern of CAUTI is essential to implement the infection control system in a proper manner. Aims and objectives: To study the rate and microbiological profile of catheter associated urinary tract infections and in patients admitted in Intensive Care Units. Materials and methods: A one-year prospective study was conducted in which urine samples were collected from patients admitted in Medical ICUs on indwelling urinary catheter for >48 hours and processed in Microbiology Department according to standard procedures. CA-UTI rate was calculated and their microbiological profile and various resistance patterns were studied as per CLSI guidelines. Results: Out of 1406 enrolled patients, 64 patients developed CAUTI. Overall CAUTI rate was 4.06/1000 catheter days. Most common isolate in CAUTI cases was Klebsiella spp. (32.3%), followed by Escherichia coli (24.6%). Gram negative isolates showed higher sensitivity to aminoglycosides, imipenam and nitrofurantoin as compared to cephalosporins The Enterococcus spp. were 100% sensitive to linezolid and 71.4% sensitive to both vancomycin and teicoplanin. Conclusion: CAUTI rate in our ICUs was high compared to the benchmarks. Antibiotic sensitivity pattern of the pathogens involved was also low. This study provides the data of predisposing risk factors and its causative microbial flora for CAUTI in our tertiary care.
导读:导尿管相关性尿路感染(CAUTI)是最常见的卫生保健相关感染(HAI),占所有HAI的40%,特别是在重症监护病房(ICU)的患者,因为他们更频繁地需要导尿和使用导尿管的时间更长。了解CAUTI的微生物学特征和抗菌药物敏感性模式对正确实施感染控制系统至关重要。目的和目的:研究重症监护病房患者导管相关性尿路感染的发生率和微生物学特征。材料与方法:本研究为一项为期一年的前瞻性研究,收集医学icu留置导尿>48小时患者的尿液样本,并在微生物科按标准程序处理。计算CA-UTI率,并根据CLSI指南研究其微生物谱和各种耐药模式。结果:1406例入组患者中,64例发生CAUTI。总的CAUTI率为4.06/1000个导管天。CAUTI病例中最常见的分离物是克雷伯氏菌(32.3%),其次是大肠杆菌(24.6%)。革兰氏阴性分离株对氨基糖苷类、亚胺培南和呋喃妥因的敏感性高于头孢菌素。肠球菌对利奈唑胺的敏感性为100%,对万古霉素和替柯planin的敏感性为71.4%。结论:icu的CAUTI发生率高于基准。病原菌对抗生素的敏感性也较低。本研究提供了三级护理中CAUTI的易感危险因素及其致病微生物菌群的数据。
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引用次数: 0
Medicinal plants used for Diabetes mellitus: An Overview 治疗糖尿病的药用植物综述
Pub Date : 2018-08-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(4).3022-3029
Nitin Chaudhary, N. Tyagi
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引用次数: 4
Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride 盐酸羟嗪乳状液的制备及评价
Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2962-2968
P. Lakshmi, K. Mounika, K. Kalyani
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2962-2968 ABSTRACT: Hydroxyzine hydrochloride is effective in the treatment of urticaria and other allergic skin disorders. Hydroxyzine hydrochloride emulgel potentially enhances drug penetration into the stratum corneum and localizes the drug within the dermoepidermal layers. Emulgel was formulated by first preparing the emulsion using fixed oils and non-ionic surfactants, and then incorporated into a gel base. Emulsions were primarily optimized using non-ionic surfactants, Span 60 and Tween 20 and gel was optimized using Carbopol 940, HPMC K100M and xanthan gum. These optimized formulations were studied for in vitro drug release studies followed by ex vivo, skin irritation and stability studies. The optimized o/w emulgel was compared with the w/o emulgel which showed the in vitro release of 76.7% and ex vivo studies showed 42.3% release at the end of 8th hr. The ex vivo release of optimized HESX (o/w emulgel) formulation was compared with the HESX1 (w/o emulgel) formulation which showed the release of 53% and 42.3% release respectively. The emulgel formulation HESX showed irritation potential of ‘0’, thus proving to be non-irritant. Hence, it can be concluded that o/w emulgel formulation of hydroxyzine hydrochloride showed better release than the w/o emulgel.
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2962-2968摘要:盐酸羟嗪是治疗荨麻疹等过敏性皮肤病的有效药物。盐酸羟嗪乳凝胶有可能增强药物对角质层的渗透,并将药物定位在真皮表皮层内。首先用固定油和非离子表面活性剂制备乳液,然后将其掺入凝胶基中配制成乳液。乳液主要采用非离子表面活性剂Span 60和Tween 20进行优化,凝胶主要采用Carbopol 940、HPMC K100M和黄原胶进行优化。这些优化的配方进行了体外药物释放研究,随后进行了离体、皮肤刺激和稳定性研究。将优化后的0 /w乳凝胶与w/o乳凝胶进行比较,其体外释放量为76.7%,体外释放量为42.3%。将优化后的HESX (w/ w凝胶)制剂与HESX1 (w/o凝胶)制剂的体外释放度进行比较,两者的体外释放度分别为53%和42.3%。凝胶制剂HESX的刺激电位为“0”,证明其无刺激性。由此可见,盐酸羟嗪的0 /w乳剂比w/o乳剂具有更好的释放效果。
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引用次数: 3
Clinical and Laboratory evaluation of patients presenting with fever with Thrombocytopenia in a tertiary care hospital of North India 北印度三级医院出现发热伴血小板减少症患者的临床和实验室评价
Pub Date : 2018-03-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(2).2959-2961
D. Soin, P. Grover, H. Khutan, R. Malhotra
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2959-2961 ABSTRACT: Introduction: Fever with thrombocytopenia is a common condition that is associated with an increased risk of morbidity and mortality. Aims & Objectives: The study was designed to assess the etiology, clinical features and laboratory profile of fever with thrombocytopenic patients which is of great value in determining the outcome and prognosis in these patients. Material & Methods: A total number of 50 patients who were admitted with the history of fever with thrombocytopenia were studied. Detailed examination of various systems was done. Routine investigations were done, Specific and Special investigations (Blood & Urine culture, Widal, Antigen test for malaria, IgM ELISA Dengue, Bone marrow examination etc.,) were done as and when indicated. Results: From this study it was observed that infections (98%) were the most common cause and among infections malaria (36%)was the commonest cause followed by viral illness (34%). Definitive increase in platelet counts was noted after treating the underlying cause. Conclusion: Thrombocytopenia was the commonest laboratory finding in many fever cases. It is better to do platelet count in all fever cases whether they have bleeding manifestations or not.
摘要:介绍:发热伴血小板减少症是一种常见的疾病,与发病率和死亡率增加相关。目的:本研究旨在评估发热伴血小板减少患者的病因学、临床特征和实验室资料,这对确定这些患者的结局和预后具有重要价值。材料与方法:对50例有发热伴血小板减少病史的住院患者进行分析。对各种系统进行了详细的检查。常规检查、特异性和特殊检查(血尿培养、维达尔、疟疾抗原检测、IgM ELISA登革、骨髓检查等)。结果:从本研究中观察到,感染(98%)是最常见的原因,在感染中,疟疾(36%)是最常见的原因,其次是病毒性疾病(34%)。在治疗了根本原因后,血小板计数明显增加。结论:血小板减少是许多发热病例中最常见的实验室检查结果。所有发热病例,不论有无出血表现,均应做血小板计数。
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引用次数: 0
Pyrazole: A potent drug candidate with various Pharmacological activities 吡唑:一种具有多种药理活性的有效候选药物
Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2941-2948
Anandi Kapri, G. Raj, Nitin Gupta
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2941-2948 ABSTRACT: Aromatic organic heterocycle containing pyrimidine scaffolds. Pyrazole possess, a five-membered hetero aromatic ring with two nitrogen atoms. Presence of this nucleus in these Pyrazole skeletons comprise various ranges of pharmacological activities viz. analgesic, antipyretic, anticancer, antiviral, anti-Inflammatory, antioxidants, antimicrobial, anti-diabetic, anticonvulsant & antiarrhythmic. Pyrazole is a multipurpose lead compound which is developed by chemical architecture for effective molecules which are mostly biologically active. Several synthetic routes are accorded for the development of pyrazole containing reactions to afford a novel molecule.
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2941-2948摘要:含嘧啶的芳香有机杂环支架。吡唑具有一个含两个氮原子的五元杂环。这些吡唑骨架中该核的存在包括各种药理学活性,即镇痛、解热、抗癌、抗病毒、抗炎、抗氧化剂、抗菌、抗糖尿病、抗惊厥和抗心律失常。吡唑是一种多用途先导化合物,是根据化学结构发展而来的具有生物活性的有效分子。为发展含吡唑反应提供了几种合成途径,以获得一种新的分子。
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引用次数: 0
Antibiotic Susceptibility in metal tolerant Pseudomonas Spp. from Tannery waste water 制革厂废水中耐金属假单胞菌的抗生素敏感性
Pub Date : 2018-03-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(2).2954-2958
Z. Hasan, Seema Singh, Ras Khuswaha, Santosh Kumar, Supriya Karpathak, Rajeev Kumar
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2954-2958 ABSTRACT: In the present study total ten heavy metal resistant Pseudomonas sp were isolated from Tannery waste water from Unnao (U.P) India, against Nickel, Chromium and Zinc. All the isolates exhibited high resistance to heavy metals with minimum inhibitory concentration (MIC) for heavy metals ranging from 100μg/ml to 1200μg/ml. All isolates showed multiple tolerances to heavy metal and were multi antibiotic resistant. Heavy Metal Tolerance Test indicated maximum microbial tolerance of Pseudomonas sp (Ps-6&9) to Nickel (400 μg/ml) and no growth was found at 200 μg/ml to Zinc. All the Pseudomonas isolates were found to have a wide range of multi-drug and multi-metal resistant property indicating the tannery waste effluents are highly enriched which supports and spread of Antibiotics and heavy Metal tolerant microbes in the environment.
摘要:本研究从印度Unnao (up)制革厂废水中分离出10种对镍、铬和锌具有抗性的假单胞菌。所有菌株均表现出较高的重金属抗性,对重金属的最小抑制浓度(MIC)在100 ~ 1200μg/ml之间。所有分离株均表现出对重金属的多重耐受性和多重耐药。重金属耐受性试验表明,假单胞菌sp (Ps-6&9)对镍(400 μg/ml)的耐受性最大,对锌(200 μg/ml)无生长。所有假单胞菌分离株均具有广泛的多药物和多金属耐药特性,表明制革废水高度富集,为抗生素和耐重金属微生物在环境中的传播提供了支持。
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引用次数: 0
Assessment of Phytochemical and Antiulcer activity of Curcuma longa leaves 姜黄叶的植物化学和抗溃疡活性评价
Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2949-2953
Sandhya Sujane, N. Shukla, N. Shukla, M. Bhowmick, J. Rathi
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引用次数: 0
Study of miRNA based gene regulation involved in Squamous Lung Carcinoma by assistance of Argonaute Protein Argonaute蛋白辅助下肺鳞癌miRNA基因调控的研究
Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2913-2917
Roma Chandra, Sumit Kumar, M. Khan
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引用次数: 0
期刊
International Journal of Research and Development in Pharmacy and Life Sciences
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