Pub Date : 2022-11-15DOI: 10.3923/ijp.2022.1593.1604
Walla’a A Osman, Gomaa Mostafa-He, A. Osman, L. Rashed, Dina A Labib
{"title":"Effect of Arabic Gum (Acacia senegal) on Paracetamol-Induced Chronic Nephrotoxicity in Albino Rats","authors":"Walla’a A Osman, Gomaa Mostafa-He, A. Osman, L. Rashed, Dina A Labib","doi":"10.3923/ijp.2022.1593.1604","DOIUrl":"https://doi.org/10.3923/ijp.2022.1593.1604","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42894014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-15DOI: 10.3923/ijp.2022.1550.1559
Zhi Li, Jian-Yu Mao, Xiaodong Zhou, Zhen-dong Xu
Background and Objective: Synovitis is characterized as the inflammation of the synovial membrane, which often occurs in osteoarthritis. The incidence of this medical condition may be related to age, immunological responses and other co-morbidities. Therefore, the objective of the study was to elucidate the anti-Synovitis potential of sinomenine. Materials and Methods: The associated targets about sinomenine and synovitis were investigated in Homo sapiens, which was then elucidated by the PPI network construction via STITCH database. Furthermore, Cytoscape and its plugin were used for gene ontology (GO) analysis. Results: The literature survey and the network revealed 25 potential target proteins to be associated with sinomenine, of which many proteins such as OPRD1, CHRM1 and DAMGO were found to be significantly related to the bioactive action of sinomenine in Homosapiens. Moreover,the GO terms which were associated with the functioning of sinomenine for its anti-Synovitis potential were found to befour, analyzed by the functional annotation gene clusters and abundance values of the target proteins. Conclusion: The results of the study demonstrate the anti-Synovitis potential of sinomenine, where its action is dependent upon the molecular mechanisms that exert its beneficial role against synovitis. The core mechanisms that may be related to its anti-synovitis action may be adenylate cyclase-activating G-protein coupled receptor signalling pathway, regulation of smooth muscle contraction, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signalling pathway and positive regulation of nitric oxide metabolic process.
{"title":"Network Pharmacological Investigation of Sinomenine Action Against Synovitis","authors":"Zhi Li, Jian-Yu Mao, Xiaodong Zhou, Zhen-dong Xu","doi":"10.3923/ijp.2022.1550.1559","DOIUrl":"https://doi.org/10.3923/ijp.2022.1550.1559","url":null,"abstract":"Background and Objective: Synovitis is characterized as the inflammation of the synovial membrane, which often occurs in osteoarthritis. The incidence of this medical condition may be related to age, immunological responses and other co-morbidities. Therefore, the objective of the study was to elucidate the anti-Synovitis potential of sinomenine. Materials and Methods: The associated targets about sinomenine and synovitis were investigated in Homo sapiens, which was then elucidated by the PPI network construction via STITCH database. Furthermore, Cytoscape and its plugin were used for gene ontology (GO) analysis. Results: The literature survey and the network revealed 25 potential target proteins to be associated with sinomenine, of which many proteins such as OPRD1, CHRM1 and DAMGO were found to be significantly related to the bioactive action of sinomenine in Homosapiens. Moreover,the GO terms which were associated with the functioning of sinomenine for its anti-Synovitis potential were found to befour, analyzed by the functional annotation gene clusters and abundance values of the target proteins. Conclusion: The results of the study demonstrate the anti-Synovitis potential of sinomenine, where its action is dependent upon the molecular mechanisms that exert its beneficial role against synovitis. The core mechanisms that may be related to its anti-synovitis action may be adenylate cyclase-activating G-protein coupled receptor signalling pathway, regulation of smooth muscle contraction, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signalling pathway and positive regulation of nitric oxide metabolic process.","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46537358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-15DOI: 10.3923/ijp.2022.1623.1635
O. Ozkul, B. Ozkul, M. Erdoğan, O. Erbaş
{"title":"Ameliorating Effect of Propofol on Cisplatin-Induced Liver and Kidney Damage in Rats","authors":"O. Ozkul, B. Ozkul, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2022.1623.1635","DOIUrl":"https://doi.org/10.3923/ijp.2022.1623.1635","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49291535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.3923/ijp.2022.1449.1455
Haleema Shahin, A. Shenoy, R. Sultana, Juveriya Farooq, Manodeep Chakrabort, A. Alamri, M. Alhomrani, W. Alsanie, S. Asdaq, Shahamah Jomah
{"title":"Anti-Diabetic Potential of Alstonia scholaris Bark Extract Against Streptozotocin-Induced Diabetes Mellitus","authors":"Haleema Shahin, A. Shenoy, R. Sultana, Juveriya Farooq, Manodeep Chakrabort, A. Alamri, M. Alhomrani, W. Alsanie, S. Asdaq, Shahamah Jomah","doi":"10.3923/ijp.2022.1449.1455","DOIUrl":"https://doi.org/10.3923/ijp.2022.1449.1455","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41617137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.3923/ijp.2022.1474.1481
Wenhao Luo, Wenli Liu, Yushan Huang, Xianqing Deng
{"title":"Anticonvulsant and Proconvulsant Effects of Trazodone in Different Seizure Models","authors":"Wenhao Luo, Wenli Liu, Yushan Huang, Xianqing Deng","doi":"10.3923/ijp.2022.1474.1481","DOIUrl":"https://doi.org/10.3923/ijp.2022.1474.1481","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45751237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.3923/ijp.2022.1401.1411
Nintie San Ga Yasmina Va, L. Belemnaba, Mathieu Nitiema, Christian Windingoudi Rimwagna O, Tata Kadiatou Traoré, Souleymane Compaoré, S. Ouedraogo, N. Ouedraogo, S. Ouédraogo
{"title":"Antihypertensive Effect of the lyophilized Aqueous Extract of Lannea microcarpa in L-NAME-Induced Hypertensive Wistar Rats","authors":"Nintie San Ga Yasmina Va, L. Belemnaba, Mathieu Nitiema, Christian Windingoudi Rimwagna O, Tata Kadiatou Traoré, Souleymane Compaoré, S. Ouedraogo, N. Ouedraogo, S. Ouédraogo","doi":"10.3923/ijp.2022.1401.1411","DOIUrl":"https://doi.org/10.3923/ijp.2022.1401.1411","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43194783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.3923/ijp.2022.1366.1373
A. Elsadig, Abdel Rahim M. Muddath, E. Elamin, Nasr Eldin MA Shrif, H. Waggiallah
{"title":"Effect of CYP2C9*2 and VKORC-1639G/A Polymorphisms on Warfarin Doses Requirements in Sudanese Patients","authors":"A. Elsadig, Abdel Rahim M. Muddath, E. Elamin, Nasr Eldin MA Shrif, H. Waggiallah","doi":"10.3923/ijp.2022.1366.1373","DOIUrl":"https://doi.org/10.3923/ijp.2022.1366.1373","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46705175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.3923/ijp.2022.1359.1365
Edip Gonullu, Gozde Dagistan, M. Erdoğan, O. Erbaş
{"title":"Protective Effect of Polyethylene Glycol (PEG) 3350 on a Cisplatin-Induced Rat Model of Neuropathy","authors":"Edip Gonullu, Gozde Dagistan, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2022.1359.1365","DOIUrl":"https://doi.org/10.3923/ijp.2022.1359.1365","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44578528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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