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Jefferson Journal of Psychiatry最新文献

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A New Voice on Personality Disorders 人格障碍的新声音
Pub Date : 1900-01-01 DOI: 10.29046/jjp.011.1.008
D. Block
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引用次数: 0
Carbamazepine-Associated Hyponatremia Carbamazepine-Associated低钠血症
Pub Date : 1900-01-01 DOI: 10.29046/JJP.011.2.005
M. Gandelman, S. Dabora, Rebecca Lynn Johnson, M. Riba
Four cases of CBZ-induced or exacerbated hyponatremia are described in middle-aged to elderly .females. Two cases are remarkable in that the pretreatment sodium levels demonstrate hyponatremia. A return to prior sodium levels was observed upon the discontinuation ofcarbamazepine therapy . No definitioe conclusions can be drawn from these case reports; however, similarities in the cases can be examined asfoiloios: (1) allfo ur women have medical problems, in particular two patients had pre-existing hyponatremia; (2) allfo ur patients were using concurren t medications; (3) all fo ur women presented psychotic. A literature review examines riskf actors, pharmacological mechanism, and the time coursefor CBZ-inducedhyponatremia. Carba mazepine-an iminodiben zyl com pound-was introduced int o clinica l medi cin e in 1962 ( I). Since th at t ime, clinica l stud ies have demonstrat ed ca rbamaz epine (CBZ) to be effec tive in th e treatment of numerou s psychiatric and neu rologic di sorders such as bip olar di sorder (2,3), unipolar depression (3) , gen era lized and psychomotor seizures (4,5) , schizophre nia (6), schizoaffec t ive d isorder (6) , pain syndromes (5,7) , and borderline personality di sorder (8). Addition ally, in 1966 Braunhofer a nd Zicka reported th e an t idiu re tic effect of (C BZ) in neurohypophysial di ab et es insipidus (9). Unfortunat ely, t he a n t id iu re tic effect of C BZ ca n signifi cantly com plica te th e effec t ivene ss of C BZ for th e treatment of psychiatric disorder s by producin g hypon atrem ia. Numerous case re po rts (10-22), studi es (2332), an d two reviews (33,34) have clearly documented th e pr obl e m; however, litt le conse nsus prevail s towards underst anding either th e mech an ism or pr edisposing ca uses for CBZ-induced hyponatremia. In this study, we pr esent four women , middle to elde rly in ag e, who dem onst ra te d hyponatremia after a short duration of C BZ th erapy. Of sig nificance is th e fact that a ll four wom en had pr eviou s medi cal com plica t ions, a nd fu rt hermore, two were hyponatremic prior to CBZ th erap y. Thus, medi cal com plica tions, espec ia lly a prior abnor mality of osmoregula t ion were obse rved to be associa ted with hypon atreWhen th is study was wr itten, Dr. Gandelman a nd Dr. J oh nson wer e resid ent s in th e Dep artment of Psychiat ry, Dr. Dab ora was a th ird yea r med ica l student , a nd Dr. Rib a was an Assist ant Profess or of Psychi atry a t t he U nive rs ity of Conne cti cut. Presently Dr. Gand elm an is an Assist ant Professor of Psych iat ry a t Yale Universi ty, whereas the other Co-authors are pu rsuing ca reers in th eir chose n medi cal specia lt ies.
本文报道4例cbz诱发或加重的中老年女性低钠血症。两例值得注意的是,预处理钠水平显示低钠血症。在停止卡马西平治疗后,观察到钠水平恢复到先前的水平。从这些病例报告中无法得出明确的结论;然而,这些病例的相似之处可以通过以下几个方面加以审查:(1)所有4名妇女都有医疗问题,特别是两名患者先前患有低钠血症;(2)所有患者均同时使用药物;(3) 4例女性均有精神病表现。文献综述探讨了cbz诱导的低钠血症的风险因素、药理机制和时间过程。Carba mazepine-an iminodiben zyl com英镑被引入int l o我们读出cin e(我)。1962年以来,t输入法,我们共同l螺栓ies朱元璋有ed ca rbamaz epine(卡马西平)是很有效的治疗numerou年代精神病学和神经膜rologic di sorders如毕普极di sorder(2、3)、单相抑郁症(3),创时代国家精神运动性癫痫(4、5),精神分裂症nia (6), schizoaffec t ive d残疾(6),疼痛综合症(5、7)和边缘型人格di sorder(8)。除了盟友,1966年Braunhofer nd Zicka报道th e t idiu重新抽搐的影响(C BZ) neurohypophysial di ab等西文崩症(9)。Unfortunat ely t他n t id iu再保险抽搐影响C BZ ca n明显不能com皱襞te的代用t登山队ss C BZ th e治疗精神障碍的年代培养什么样g海宝atrem ia。许多病例报告(10-22)、研究(2332)和两篇综述(33,34)都清楚地记录了这一问题。然而,对于cbz诱导的低钠血症的机制或处理方法,目前还没有广泛的共识。在这项研究中,我们报告了四名中老年妇女,她们在接受短时间的C - BZ治疗后出现了低钠血症。的团体nificance th e炊烟我四个女人有公关eviou s读出com皱襞t离子,和傅rt hermore,前两个是钠血症卡马西平th erap y。因此,读出com皱襞,易翔ia前增加一个abnor mality osmoregula t离子是obse房车与海宝associa ted atreWhen th是研究wr itten Gandelman博士和博士J哦nson回答e渣油ent s Psychiat ry的本科,涂博士奥拉是一个地中海th ird是的r l ica的学生,瑞伯博士是一名精神病学助理教授,曾在美国康乃尔大学担任助理教授。目前,甘德姆博士是耶鲁大学心理学助理教授,而其他合著者则在他们选择的医学专业中寻求职业发展。
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引用次数: 0
Perspectives On Psychotherapy: In Our Evolving Profession 心理治疗的观点:在我们不断发展的职业中
Pub Date : 1900-01-01 DOI: 10.29046/jjp.011.1.006
S. Hall
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引用次数: 0
Book Review: The Feel of the Road 书评:路的感觉
Pub Date : 1900-01-01 DOI: 10.29046/jjp.005.1.012
G. B. Sullivan
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引用次数: 0
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Jefferson Journal of Psychiatry
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