International journal of pharma and bio sciences最新文献

{"title":"Review On Isolation Methods of Bio-Active Compounds from Traditional Medicinal Plants","authors":"G. T, Dr. N.Astalakshmi, Gowri Sankar K B, N. M, Hari Hara Sudhan M R, G. S., Dr.S.T. Latha, Dr.M. Surendra Kumar","doi":"10.22376/ijpbs.2022.13.4.p17-31","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.4.p17-31","url":null,"abstract":"","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87055119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE CYTOTOXICITY ACTIVITY IN THE LEAVES OF NILGIRIANTHUS CILIATUS (LINN) IN DALTON’S LYMPHOMA ASCITES CELLS","authors":"Neethumol Varghese, J. Jacob","doi":"10.22376/ijpbs.2018.9.3.p208-212","DOIUrl":"https://doi.org/10.22376/ijpbs.2018.9.3.p208-212","url":null,"abstract":"","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89191594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"b Initio and DFT Investigation of Effect of Substituent at the C7 Position of 4-Amino-DANA Sialidase Inhibitor","authors":"Chandrasekaran Krishnan","doi":"10.22376/ijpbs/lpr.2022.12.3.p29-35","DOIUrl":"https://doi.org/10.22376/ijpbs/lpr.2022.12.3.p29-35","url":null,"abstract":"Sialic acid is the active site of neuraminidase protein, eventually it cleaves form its substrate via sialsyl cation intermediate and proliferates the viral infection to other cells. On account of weak binding affinity between substrate and receptor, the viral infection communicates to other cells and leads to mortality of humans. DANA is the first sialidase inhibitor formed by the dehydration of the C2 hydroxyl group of sialic acid. The replacement of hydroxyl group at C4 position of DANA by an amino group drastically increases the binding affinity and results 4-amino-DANA inhibitor, which is potent than parent DANA. Crystal structure of DANA shows that several binding sites remain free and it should be explored for more powerful sialidase inhibitors. The current study systematically investigates the effect of substituent on the C7 position of 4-amino-DANA in gas phase and solvent phase as well. X-Ray crystallographic study reveals that the C7 of glycerol side chain remains free. Hence, substituent effect at C7 analysis is carried in search of potent sialidase inhibitors. The abinitio and DFT investigation reveals that guanidinoand methyl group at C7 position drastically increases the binding affinity between substrate and receptor. Hence further investigation of methyl and guanidine derivatives of the 4-amino-DANA could act as a promising candidate for the design and development of sialidase inhibitors. Vaccination for the H1N1 is not effective due to the new viral mutagenic strains and hence, it cannot contain the viral infection.Therefore antiviral drugs will address the limitation of vaccination. The current finding of sialidase antiviral inhibitors will effectively contain the viral infection and prevent the morbidity.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74966015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of in Vitro Anti-Inflammatory and Anticoagulant Efficacy of Tulasi Oil – A Siddha Polyherbal Formulation","authors":"S. Yavanarani, Raman Selvakumar, M. Sathiyabama","doi":"10.22376/ijpbs.2022.13.3.p55-63","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.p55-63","url":null,"abstract":"Inflammation is a normal defensive response to tissue damage caused by physical injury and harmful chemicals and currently, management of this condition is by the non-steroidal anti-inflammatory drugs (NSAIDs), which have various adverse effects. Over activity of the coagulation cascade (hypercoagulation) increases the risk of thrombosis formation leading to thromboembolism which in turn leads to ischemia by blocking blood flow and damaging the organs. Siddha formulations afford an incredible improvement in medical practice against various metabolic and lifestyle disorders. Hence, the present study was to evaluate the preliminary phytochemicals and in vitro anti-inflammatory potential of Tulasi oil (TO) against the HRBC membrane stabilization assay, egg albumin denaturation assay and the in vitro anticoagulant analysis. Tulasi oil appears to contain chemical constituents such as alkaloids, flavonoids, steroids, triterpenoids, tannins, phenols, proteins, anthocyanins and saponins. The concentration of 250 μg/ml of Tulasi oil has exhibited a maximum percentage of haemolysis (86.42 ± 0.25%) and albumin (protein) denaturation (81.15±0.82%) while the same concentration (250 μg/ml) of standard drug of hydrocortisone represented the haemolysis of 88.48 ± 0.33% and Diclofenac sodium showed 87.84±0.67 % of protein denaturation. For anticoagulant activity, the concentration of 20 mg/ml of tulasi oil showed maximum anti-coagulant activity of (1227 sec) and a minimum of 686 sec in 5 mg/ml. The standard drug EDTA and Sodium citrate showed better anti-coagulant activities of more than 30 minutes i,e., 2253 and 2156 minutes, respectively. The result of the work indicates that the polyherbal formulation of Tulasi oil has possessed remarkable in vitro anti-inflammatory and anticoagulant potential and can be applied as an alternative in the treatment of various inflammatory and cardiovascular complications.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81103589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pomegranate Juice, Antidiabetic Therapy on Glycemic Control and Lipid Subfraction Status","authors":"Basavaraj S. Aski, N. Biradar, S. Walvekar, G. Naregal, Nikil. N. Biradar","doi":"10.22376/ijpbs.2022.13.3.b25-31","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.b25-31","url":null,"abstract":"Over the last decade, studies have linked the beneficial effect of pomegranate juice on glycemic control. They have a significant secretory influence on beta-cell, carbohydrate, and lipid metabolism turnover in preventing and treating type ii diabetes. However, hypoglycaemic drugs have side effects such as lactic acidosis and abdominal discomfort. Hence, we aimed for a new treatment regime that included oral antidiabetic drugs and pomegranate juice, which works as an anti-oxidant and a potential antidiabetic agent. The study included randomly chosen145 type 2 diabetes mellitus male subjects and 36 healthy male participants. The study was carried out in two stages. Initially, all subjects were allowed to be on their respective antidiabetic drugs/insulin and to have a regular check-up of blood glucose twice a week for four weeks, after which they were redistributed into three groups, one of which was given pomegranate juice along with their respective antidiabetic drugs. After a 4-week run-in period, patients improved their ability to self-monitor blood glucose values and a wash-out period of 3 weeks, during which oral hypoglycaemic drugs and insulin were discontinued. The subjects were randomly assigned to follow the treatment protocol. Subjects received either an antidiabetic medicine or insulin, while the others received 200 ml of pomegranate fruit juice every day, along with antidiabetic therapy assigned to two-month treatment intervals. Glycemic rate and lipid profile changes were observed at the end of the period. The subjects with Pomegranate Juice with drug treatment showed a significant reduction in the levels of HbAlc (6.2 ± 0.2% vs. 8.2 ± 0.3%.)), LDL cholesterol concentration (120.61 ± 12.81, vs 136.23 ± 16.58 mg/dl P < 0.05), and Phospotidyl choline (27.20 ± 1.98 vs 22.80 ± 2.20 mg/cc. P < 0.05 as compared to other groups. This study has observed that pomegranate juice combined with an antidiabetic therapy regime has outstanding potential advantages in glucose control and a significant reduction in dyslipidemia and increased phospholipids levels compared to insulin or drug alone. These changes are linked to disease progression in numerous tissues. Pomegranate juice therapy may lower the need for diabetic medication or insulin, and natural diet fruits may impact pancreatic cell activation.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90259989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoonotic Diseases as A Historical Public Health Problem in District Poonch and Its Adjoining Area, Union Territory of Jammu and Kashmir, India.","authors":"R. Lal","doi":"10.22376/ijpbs.2022.13.3.b1-11","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.b1-11","url":null,"abstract":"The main aim of this study in far flung border area of Poonch on the actual line control of pak- occupied Kashmir is to know the frequent out breaks of diseases, more incidences of Zoonotic diseases, emerging and re-emerging of zoonotic infections in district Poonch and its adjoining areas within objective to understand the magnitude of gravity of major emerging and remerging zoonotic public health problem not only in India but also in different parts of world. This study also deals with various aspects of prevalence of zoonotic diseases in District Poonch and its adjoining areas to provide a necessary background to the readers which shall help in better understanding of diseases like Rabies, Japanese encephalitis, Leishmoniasis, Leptospirosis, Tuberculosis, Dengue fever, Salmonella and E. coli infection etc. which has major public health concern. The result of this study would invite the attention of health, Animal husbandry and allied departments to come up with precautionary measures and to make a platform for researcher’s/budding scientists for detailed studies. The Ebola Zika virus, Lyssavirus, SARS, Nipah and Corona virus etc. have alarmed the whole world. Over the last two decades. There has been considerable change in importance of certain Zoonotic diseases in many parts of the world and in this area also which may be resulting from ecological changes such as urbanization. The Corona virus disease in various parts of the world has served a reminder of existence of infectious disease. Hence early diagnosis, treatment and its prevention is of paramount importance. In order to accomplish the study at grass root level more than two hundred informants were interviewed apart from the Medical Veterinary officers, working in rural and urban areas. A study conducted by author on flying foxes roosting in camps on top of some old eucalyptus trees in Poonch City and adjoining areas reveals the relationship among the flying foxes, domestic animals and humans with respect to the transmission of Pathogens. Here nine villages were chosen in and around conservation area and administered a standard closed questionnaire. More than 1500 people mostly men were interviewed residing there in for rabies and other zoonotic diseases. The data so collected was analysed by score system to know the people knowledge and attitude The correlation between respondents, knowledge and residences were analysed by gamma correlation test clearly reveals the area is virulent in in zoonotic diseases. Besides while reviewing/ evaluating the data in one of the study conducted by Directorate of Health Services Jammu Division and its analyses by Z score in respect of communicable diseases indicates the incidences are maximum and composite score and incidences are on higher side in Poonch and its adjoining area. Special thrust was given to the migratory population irrespective of any gender Para-vets/medicos and local Hakims engaged in traditional treatment of ailments of humans and ","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80318504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Treatment of Alzheimer's Disease in Traditional Medicine Vs. Modern Science","authors":"Rashda Khatoon Shaikh, Vanita G.Kanase","doi":"10.22376/ijpbs.2022.13.3.p64-75","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.p64-75","url":null,"abstract":"Alzheimer's is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Medicinal plants have a major role to play in Alzheimer’s and memory loss control. Ayurveda, homeopathy, Siddha and Unani medicine systems are main conventional therapeutic approaches. Herbal remedies, like that of the Egyptians, Chinese and Indians have their roots in ancient times. Use of medicinal herbs in of AD treatment includes improving overall health and well-being. Interest in medicinal herbs has grown fast during the recent years leading to increased interest of researchers in therapeutic utilization plants for treatment and enhancement of disease and wellbeing, often without severe side effects. The modern age of drug discovery in Alzheimer's disease began with the proposal of the cholinergic memory impairment hypothesis and the 1984 research criteria for AD. There are modest symptom-reducing effects of FDA authorized medications, but they really does not affect the eventual course of the AD. In the campaign against Alzheimer's disease, the hunt for newer drugs which are safe and effective are already required the cooperation of large number of researchers with many willing subjects. But that's a long way off! 146 medications have been rejected since 1998. Popular herbal plants for treating Alzheimer's disease are discussed in this review. The report also centered on FDA-approved medications for treating Alzheimer's disease. This review discusses all aspects of AD treatment including the comparison between the traditional and the Allopathic medicines that was missed by some articles. Most review studies focus on either traditional treatment or the management in Modern science of the disease but rarely on a comparison of both. The study also addresses the possibilities for the management of AD in future.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87305646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Push-Out Bond Strength & Adaptation of A Fiber Post Cemented with Biodentine, MTA & Resin Cement: An in Vitro Study.","authors":"Harakh Chand Baranwal, N. Kumar, Prachi Rani, J. Yadav","doi":"10.22376/ijpbs.2022.13.3.p39-47","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.p39-47","url":null,"abstract":"Aim of our study is to evaluate & compare the push-out bond strength and adaptation of a fiber post cemented with Biodentine, MTA, and dual-cure Resin cement. A total of thirty mandibular premolars with a single oval root canal were prepared and obturation was done by AH plus sealer and gutta-percha. The teeth were stored at 37 0C with 100% humidity for one day. The gutta-percha was removed by peeso reamer, leaving at least 4 mm of filling material, and post spaces were prepared by corresponding fiber post drill. The specimens were randomly distributed into (n=10) among each 3 groups. Glass fiber Posts were lutted with three different materials and coronally sealed with glass ionomer cement followed by stored in water for 24 h at 37 0 C. Each tooth was sectioned into 3 parts of 2-mm-thick slices in coronal, middle and apical zone. Push-out bond strength was measured with help of a universal testing machine and evaluated the adaptation by scanning electron microscope after 7 and 28 days. Statistical analysis was done by one-way anova and post hoc test. The push-out bond strength of dual-cure resin and Biodentine was non-significant but higher in comparison to Pro Root MTA. Dual cure resin cement and Biodentine also showed better surface adaptation to post in comparison to MTA. This present study showed that Biodentine can also be used for luting the fiber post as an alternative to dual-cure resin cement.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87268809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Method for Treating Bronchial Asthma with Newly Designed Histaglobulin Therapy","authors":"S. K., D. S.","doi":"10.22376/ijpbs.2022.13.3.b42-50","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.b42-50","url":null,"abstract":"Asthma, a chronic inflammatory disease of the airways is considered as an incurable disease and extensive research is going on in developing novel treatment. The objective of the study is to establish that the antihistamine antibody has low serum histamine binding capacity (SHBC) in allergic patients as compared to normal persons and that it can be raised with our novel method of Histaglobulin treatment thereby effecting a ‘cure’ in bronchial asthma. About 67 normal and 135 allergic persons, were identified based on serum level of total immunoglobulin E (IgE) estimated by ELISA. Antihistamine antibody was separated from serum by affinity chromatography. Presence of antihistamine antibody in the elute was confirmed by SDS-PAGE test. The antihistamine antibody was IgG, confirmed by MALDI-TOF analysis. The SHBC of the antihistamine antibody was estimated based on standard curve, plotted with different concentrations of serum antihistamine antibody by histamine ELISA test. Total Immunoglobulin E and SHBC were estimated in 135 allergic patients. In normal and allergic persons, the total IgE level was <100 IU/ml and 200 IU/ml respectively. The average SHBC of normal persons was 116 µg/ml, which was 39% more as compared to allergic patients whose average SHBC before treatment was 83.6 µg/ml. 135 allergic patients were first subjected to antihistamine, mast cell-membrane stabilizers, anti-inflammatory and bronchodilator drugs followed by histaglobulin injection. The SHBC level was raised in 122 (90.4%) patients to an average of 111.6 µg/ml. Overall, 132 (97.8%) allergic patients responded well to our treatment and were free from allergic manifestation throughout the follow-up period of about 5 years. Hence, this novel treatment with histaglobulin which has scientific basis, effective and well tolerated can be adopted across the world for effecting a cure from bronchial asthma and allergic rhinitis.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82030756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Quality Audit: A Boon for Pharmaceutical Sector","authors":"Anita Patidar, Gurmeet S. Chhabra, Dinesh K. Mishra","doi":"10.22376/ijpbs.2022.13.3.p24-31","DOIUrl":"https://doi.org/10.22376/ijpbs.2022.13.3.p24-31","url":null,"abstract":"This review article covers a combination of aspects of the sole entity which defines the quality of products in the pharmaceutical sector. Quality audit is one of the essential elements of ISO 9001 quality system standards. It assures that an organization has distinctly defined a quality system to manufacture the quality products and work according to it. Concession or negotiation in quality of pharmaceutical products would directly impact the health of patients so audits are performed at specified time interval to ensure the quality as it is benefaction for the companies towards gaining loyalty from customers, maintain regulatory standards, long term revenue and profit. Regulatory bodies have their standard assessment tools termed Audits and Inspection, which reviews and evaluates various records, systems, and procedures followed in an organization. Most of the articles glorify that the quality audits mainly involve documented examinations and verification of all the processes and activities routinely performed, leading to ensure the required quality standards. The article is a result of a collection of data about the principles and objectives of quality audit and the benefits it provides to the respective firm by following the proper audit plan, procedures, corrective actions, and follow up making us aware of methods of gathering information for an audit, a brief knowledge of audit closure meetings, reports and basic criteria for selecting the auditor. Auditors play an important role to guarantee their organization’s consistency with pharmaceutical United States Food and Drug Administration and current Good Manufacturing Practices guidelines and other quality standards like ICH Q10. The article also describes the deficiencies occurring during and after the audit and a case study regarding the audit. The figures represented in the given article comprises the basic principles of audit, types of audits, steps of conducting an audit efficiently, audit management, and flow cycle of audit which gives an overall idea of the running of audit in a consistent manner to check the product meets the regulatory requirements, expected results and patient’s compliance.","PeriodicalId":14279,"journal":{"name":"International journal of pharma and bio sciences","volume":"14 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80935619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}