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Catastrophic Health Expenditure in Mental Health as Coercion in Post-Suicide Attempt Care: A Population-Based Study in Latin America. 自杀未遂后心理健康的灾难性健康支出作为胁迫:拉丁美洲一项基于人口的研究。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-25 DOI: 10.1177/00207640261426477
Felipe Agudelo-Hernández, Laura Fernanda Murillo-Alzate

Background: Despite an increase in mental health problems, there is low implementation of mental health services, high catastrophic health spending, and a high incidence of coercive mental health practices. This could hinder recovery after a suicide attempt.

Aims: To analyze catastrophic spending and coercive practices, and their relationship with variables associated with recovery (depression and well-being) and with the functioning of health services (continuity of care), in people who attempted suicide during 2024 and 2025 in Caldas, Colombia.

Method: A cross-sectional and population-based was conducted with stratified random sampling in Colombia. Validated instruments were applied to determine subjective well-being, depressive symptoms and continuity of care in health services. To determine the perception of coercive practices in the care of suicidal behaviors in health services, an instrument was used that divided coercive practices into formal (physical abuse, isolation, forced hospitalization) and informal (involuntary medication, lack of participation in treatment planning).

Results: A multiple linear regression was calculated for formal and informal coercion. The model for formal coercion explained 21% of the variance, and the model for informal coercion explained 63.2%, both with high coefficients for catastrophic health expenditures. Compared to those who did not report coercion, those who did reported it presented with more depressive symptoms, worse continuity of care, catastrophic health expenditures, and a lower socioeconomic status.

Conclusions: There is a relationship between the coercive practices perceived and catastrophic spending on mental health services for psychosocial recovery. Those subjected to any coercive practice may have worse outcomes in terms of catastrophic mental health spending and depressive symptoms. Catastrophic spending is proposed as a form of structural coercion that could hinder psychosocial recovery.

背景:尽管精神卫生问题有所增加,但精神卫生服务的落实程度较低,灾难性卫生支出高,强制性精神卫生做法发生率高。这可能会阻碍自杀未遂后的恢复。目的:分析哥伦比亚卡尔达斯2024年至2025年期间企图自杀的人的灾难性支出和强制性做法,以及它们与康复(抑郁和福祉)和卫生服务功能(护理的连续性)相关变量的关系。方法:采用分层随机抽样的方法,在哥伦比亚进行横断面调查。使用经过验证的工具来确定主观幸福感、抑郁症状和保健服务的连续性。为了确定在保健服务中对治疗自杀行为的强制做法的看法,使用了一种工具,将强制做法分为正式(身体虐待、隔离、强迫住院)和非正式(非自愿用药、不参与治疗计划)。结果:对正式强迫和非正式强迫进行多元线性回归。正式强迫模型解释了21%的方差,非正式强迫模型解释了63.2%,两者都具有高灾难性卫生支出系数。与那些没有报告胁迫的人相比,那些报告了胁迫的人表现出更多的抑郁症状,更差的护理连续性,灾难性的医疗支出,以及更低的社会经济地位。结论:感知到的强制行为与用于心理社会康复的心理健康服务的灾难性支出之间存在关系。在灾难性的心理健康支出和抑郁症状方面,那些遭受任何强制性做法的人可能会有更糟糕的结果。灾难性支出被认为是一种可能阻碍心理康复的结构性强迫。
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引用次数: 0
ICD-11 PTSD and Complex PTSD Among Internally Displaced Civilian Outpatients in Ukraine During Wartime. 战时乌克兰国内流离失所平民门诊病人的创伤后应激障碍和复杂创伤后应激障碍。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-22 DOI: 10.1177/00207640261427415
Alberto Barbieri, Luca Bastiani, Francesca Badalassi, Federica Visco-Comandini, Andrii Tomko, Hanna Chmielewska

Background: Since the 2022 full-scale invasion of Ukraine, civilians have experienced substantial war-related trauma, yet little is known about the prevalence and risk factors of ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD) among internally displaced persons (IDPs) actively seeking medical or psychological care.

Aims: To examine the prevalence of PTSD and CPTSD in a clinical sample of Ukrainian IDPs, compare diagnostic rates between psychological and medical treatment-seekers, and identify sociodemographic and war-related predictors of diagnostic outcomes.

Methods: A total of 224 adult IDPs attending an outpatient clinic in Chernivtsi oblast completed the International Trauma Questionnaire. Descriptive statistics, bivariate analyses, and multinomial logistic regression models were used to assess prevalence and identify predictors of PTSD and CPTSD.

Results: In the full sample, 24.5% met criteria for ICD-11 PTSD and 7.6% for CPTSD. Among psychological treatment-seekers, prevalence was higher (PTSD: 28.3%; CPTSD: 9.0%) compared to those seeking exclusively medical care (PTSD: 13.8%; CPTSD: 3.4%). Losing someone close due to the war significantly predicted both PTSD and CPTSD in the final multivariable model, while male gender independently predicted CPTSD.

Conclusions: PTSD rates in this sample were broadly comparable to global estimates for conflict-affected populations, whereas CPTSD prevalence appeared lower than that reported in other Ukrainian samples. Relocation to safer areas within one's own country-without the additional stressors associated with forced international migration-together with the relatively older age of the sample, may have contributed to a reduced CPTSD risk. Sociocultural expectations surrounding masculine roles during wartime might also play a role in male vulnerability to CPTSD, though further evidence is needed. Individuals bereaved by the war may represent a subgroup at heightened risk, highlighting the potential value of targeted psychosocial support. Longitudinal, multi-site studies with diverse samples are needed to clarify symptom trajectories and contextual risk factors in displaced civilians.

背景:自2022年乌克兰全面入侵以来,平民经历了大量与战争有关的创伤,但在积极寻求医疗或心理治疗的国内流离失所者(IDPs)中,对ICD-11创伤后应激障碍(PTSD)和复杂创伤后应激障碍(CPTSD)的患病率和风险因素知之甚少。目的:研究乌克兰境内流离失所者临床样本中PTSD和CPTSD的患病率,比较心理和医学治疗寻求者的诊断率,并确定诊断结果的社会人口学和战争相关预测因素。方法:在切尔诺夫茨州门诊就诊的224名成年境内流离失所者完成了国际创伤问卷。使用描述性统计、双变量分析和多项逻辑回归模型来评估PTSD和CPTSD的患病率和确定预测因素。结果:在整个样本中,24.5%符合ICD-11 PTSD标准,7.6%符合CPTSD标准。在寻求心理治疗的人群中,患病率(PTSD: 28.3%; CPTSD: 9.0%)高于那些只寻求医疗护理的人群(PTSD: 13.8%; CPTSD: 3.4%)。在最终的多变量模型中,因战争失去亲近的人对PTSD和CPTSD都有显著的预测作用,而男性性别对CPTSD有独立的预测作用。结论:该样本中创伤后应激障碍的发病率与受冲突影响人群的全球估计大致相当,而CPTSD患病率似乎低于乌克兰其他样本的报告。搬迁到自己国家内更安全的地区,没有与被迫国际移民相关的额外压力因素,加上样本的年龄相对较大,可能有助于降低CPTSD风险。社会文化对战时男性角色的期望也可能在男性易患创伤后应激障碍方面发挥作用,尽管还需要进一步的证据。因战争而失去亲人的人可能是风险较高的一个亚群体,这突出了有针对性的社会心理支持的潜在价值。需要对不同样本进行纵向、多地点研究,以阐明流离失所平民的症状轨迹和环境风险因素。
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引用次数: 0
Analyzing the Impact of Depression on All-Cause Mortality in Different Sex and Age Groups: A 11-Year Follow-Up Study of Spanish Population. 分析抑郁症对不同性别和年龄组全因死亡率的影响:西班牙人群11年随访研究
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-22 DOI: 10.1177/00207640261430311
Cristina Rodríguez-Prada, María Cabello, Francisco Félix Caballero, Blanca Dolz-Del-Castellar, Lea Francia, Marta Miret, Josep María Haro, Joan Domènech-Abella, Beatriz Olaya, José Luis Ayuso-Mateos

Background: Previous studies have shown that depression has a significant impact on all-cause mortality, particularly in men. However, the link between depression and mortality across different age and gender groups is inconsistent. This study aims to explore the relationship between depression and all-cause mortality in various age and gender categories within a Spanish national cohort, while also accounting for other influencing factors over an 11-year follow-up period.

Methods: A nationally representative sample of the Spanish adult population (n = 4,582) was followed up for 11 years. Kaplan-Meier estimates, unadjusted and adjusted Cox proportional hazard regression models were conducted to test whether baseline depression and sociodemographic characteristics (educational level, low income, marital status, feelings of loneliness, alcohol and tobacco use, and having chronic conditions) were associated with all-cause mortality for different gender and age-specific groups, separately.

Results: Unadjusted analysis by age and gender indicated that depression had a significant relationship with all-cause mortality in young-and-middle-aged women (HR = 1.75; p < .01) and men (18-64 years old; HR = 2.96; p < .001) and old men (+65; HR = 1.92; p < .001). Adjusted analysis by age and gender revealed that depression was only a significant factor for all-cause mortality in men aged 65+ (HR = 1.60; p = .025).

Limitations: Cause-specific mortality was not examined. Young adults and middle-aged participants were not analyzed separately.

Conclusions: The depression and all-cause mortality relationship was found only in +65 men. These differences may be driven by gender-specific factors such as delayed help-seeking, higher levels of social isolation, and the accumulation of chronic comorbidities. Therefore, preventive interventions must prioritize age- and gender-specific strategies to address these risk patterns.

背景:先前的研究表明,抑郁症对全因死亡率有显著影响,尤其是男性。然而,在不同的年龄和性别群体中,抑郁症和死亡率之间的联系并不一致。本研究旨在探索西班牙国家队列中不同年龄和性别类别的抑郁症与全因死亡率之间的关系,同时也考虑了11年随访期间的其他影响因素。方法:对西班牙成年人进行为期11年的全国代表性随访(n = 4582)。Kaplan-Meier估计、未调整和调整的Cox比例风险回归模型分别用于检验基线抑郁和社会人口学特征(教育水平、低收入、婚姻状况、孤独感、酒精和烟草使用以及患有慢性病)是否与不同性别和年龄特定群体的全因死亡率相关。结果:未经年龄和性别调整的分析显示,抑郁症与中青年妇女的全因死亡率有显著关系(HR = 1.75; p p p p = 0.025)。局限性:未检查病因特异性死亡率。年轻人和中年参与者没有被分开分析。结论:抑郁症与全因死亡率的关系仅在65名男性中发现。这些差异可能是由特定性别因素造成的,如求助延迟、社会孤立程度较高以及慢性合并症的积累。因此,预防性干预措施必须优先考虑针对年龄和性别的战略,以解决这些风险模式。
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引用次数: 0
Involving International Experts in DSM-6: A Geopsychiatric Approach. 让国际专家参与DSM-6:一种地球精神病学方法。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-22 DOI: 10.1177/00207640261433289
Neil Krishan Aggarwal, Antonio Ventriglio, Dinesh Bhugra, Albert Persaud
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引用次数: 0
Loneliness and Social Connectedness in Mental Health. 心理健康中的孤独和社会联系。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-13 DOI: 10.1177/00207640261427224
Antonello Bellomo, Antonio Ventriglio
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引用次数: 0
Global Mental Health Workforce Composition and National Depression Prevalence: Cross-National Evidence From the WHO Mental Health Atlas 2020 and the Global Burden of Disease Study 2019. 全球精神卫生人力构成和国家抑郁症患病率:来自世卫组织2020年精神卫生地图集和2019年全球疾病负担研究的跨国证据
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-12 DOI: 10.1177/00207640261424406
Christopher Lomas

Objective: This study examined whether the national availability and composition of mental health professionals, primarily non-psychiatrist providers, are associated with the population prevalence of depression, controlling for economic and demographic factors.

Methods: A cross-sectional ecological analysis used data from 131 countries, sourcing workforce statistics from the WHO Mental Health Atlas 2020 and depression prevalence from GBD 2019. Ordinary Least Squares (OLS) regression models, adjusted for log Gross Domestic Product (GDP) per capita and urbanisation, assessed total workforce density, disaggregated provider densities (psychiatrists vs. psychologists) and the psychiatrist share of the workforce. Heteroskedasticity-consistent standard errors were applied.

Results: Adjusted analysis showed a significant inverse association between overall workforce density and prevalence (β = -.031, p < .001) suggesting that higher workforce density correlates with lower depression prevalence. Psychologist density showed a stronger inverse association (β = -.038, p = .001) than psychiatrist density (β = -.024, p = .048) suggesting that greater availability of psychologists is more strongly correlated with lower depression prevalence. Critically, a higher proportion of psychiatrists was independently associated with increased depression prevalence (β = 1.89 percentage points, p = .032). Analysis of regional variation indicated that the inverse association between psychologist availability and depression prevalence was globally observed, with the steepest marginal effects noted in lower-income settings.

Conclusion: Mental health workforce expansion is correlated with reduced depression, notably when systems include non-psychiatrist providers. These findings indicate that broadening service delivery capacity beyond psychiatric care could potentially improve the effectiveness of national mental health systems, pending further investigation.

目的:本研究考察了在控制经济和人口因素的情况下,全国精神卫生专业人员(主要是非精神科医生)的可得性和组成是否与抑郁症的人口患病率有关。方法:使用来自131个国家的数据进行横断面生态分析,从世界卫生组织2020年精神卫生地图集中获取劳动力统计数据,从GBD 2019中获取抑郁患病率。普通最小二乘(OLS)回归模型,根据人均国内生产总值(GDP)和城市化的对数进行调整,评估了总劳动力密度、分类提供者密度(精神科医生与心理学家)和精神科医生在劳动力中的份额。采用异方差一致的标准误差。结果:调整后的分析显示,总体劳动力密度与患病率呈显著负相关(β = - 0.031, p p =。001)精神科医生密度高于精神科医生密度(β = - 0.024, p =。[48]这表明更多的心理学家与更低的抑郁症患病率有更强的相关性。重要的是,精神病医生比例较高与抑郁症患病率增加独立相关(β = 1.89个百分点,p = 0.032)。区域差异分析表明,在全球范围内观察到心理医生的可用性与抑郁症患病率之间的负相关,在低收入环境中注意到最明显的边际效应。结论:精神卫生人力资源的扩张与抑郁症的减少相关,特别是当系统包括非精神科医生提供者时。这些发现表明,扩大精神科护理以外的服务提供能力可能会提高国家精神卫生系统的有效性,有待进一步的调查。
{"title":"Global Mental Health Workforce Composition and National Depression Prevalence: Cross-National Evidence From the WHO Mental Health Atlas 2020 and the Global Burden of Disease Study 2019.","authors":"Christopher Lomas","doi":"10.1177/00207640261424406","DOIUrl":"10.1177/00207640261424406","url":null,"abstract":"<p><strong>Objective: </strong>This study examined whether the national availability and composition of mental health professionals, primarily non-psychiatrist providers, are associated with the population prevalence of depression, controlling for economic and demographic factors.</p><p><strong>Methods: </strong>A cross-sectional ecological analysis used data from 131 countries, sourcing workforce statistics from the WHO Mental Health Atlas 2020 and depression prevalence from GBD 2019. Ordinary Least Squares (OLS) regression models, adjusted for log Gross Domestic Product (GDP) per capita and urbanisation, assessed total workforce density, disaggregated provider densities (psychiatrists vs. psychologists) and the psychiatrist share of the workforce. Heteroskedasticity-consistent standard errors were applied.</p><p><strong>Results: </strong>Adjusted analysis showed a significant inverse association between overall workforce density and prevalence (β = -.031, <i>p</i> < .001) suggesting that higher workforce density correlates with lower depression prevalence. Psychologist density showed a stronger inverse association (β = -.038, <i>p</i> = .001) than psychiatrist density (β = -.024, <i>p</i> = .048) suggesting that greater availability of psychologists is more strongly correlated with lower depression prevalence. Critically, a higher proportion of psychiatrists was independently associated with increased depression prevalence (β = 1.89 percentage points, <i>p</i> = .032). Analysis of regional variation indicated that the inverse association between psychologist availability and depression prevalence was globally observed, with the steepest marginal effects noted in lower-income settings.</p><p><strong>Conclusion: </strong>Mental health workforce expansion is correlated with reduced depression, notably when systems include non-psychiatrist providers. These findings indicate that broadening service delivery capacity beyond psychiatric care could potentially improve the effectiveness of national mental health systems, pending further investigation.</p>","PeriodicalId":14304,"journal":{"name":"International Journal of Social Psychiatry","volume":" ","pages":"207640261424406"},"PeriodicalIF":2.7,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internalized Stigma in Adolescents With Major Depressive Disorder and Their Parents: Associations With Functioning, Help-Seeking, Beliefs, and Social Support. 重度抑郁症青少年及其父母的内化污名:与功能、求助、信仰和社会支持的关系
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-12 DOI: 10.1177/00207640261424410
Hilal Nur Çalık Şentürk, Tezan Bildik

Background: Adolescents with major depressive disorder (MDD) often internalize stigma, undermining functioning and help-seeking. Parents may likewise internalize stigma about their child's condition, shaping family dynamics and care engagement.

Aim: To examine internalized stigma in adolescents with MDD and their parents, and its associations with adolescent depressive severity, perceived social support, beliefs about mental illness, help-seeking attitudes, and adolescents' global functioning.

Method: Cross-sectional tertiary-clinic study (July-October 2023) of 55 adolescents (12-18 years) with DSM-5 MDD and one parent each (n = 55); 81.8% of adolescents were female. Adolescents completed BDI, SSDS, ISMI-CA, BTMI, MSPSS, and ATSPPH-SF; clinicians rated GAF. Parents completed BDI, P-ISMI, BTMI, and ATSPPH-SF. Group comparisons, correlations, and multivariable linear regression were used.

Results: Parents of adolescents with a suicide attempt or non-suicidal self-injury (NSSI) reported higher P-ISMI (higher alienation and stereotype endorsement; for NSSI also higher perceived discrimination and social withdrawal). Greater adolescent depressive severity correlated with higher self-stigma across SSDS subscales, which related to poorer GAF and lower MSPSS. Higher parental depressive symptoms correlated with higher P-ISMI. Adolescents' social-inadequacy self-stigma was associated with parental social withdrawal. Help-seeking attitudes were more positive with increasing adolescent age and education. Longer psychiatric follow-up related to higher parental stereotype endorsement and social withdrawal, whereas higher parental education related to lower perceived discrimination. In multivariable models, adolescent depressive symptoms predicted poorer functioning, and parental depressive symptoms explained substantial variance in parental internalized stigma, whereas other predictors showed more limited independent effects.

Conclusion: Internalized stigma in adolescents with MDD and their parents is strongly associated with clinical burden and functioning in this clinical, predominantly female sample. Findings underscore internalized stigma as a family-embedded, interconnected process and suggest that integrating family-inclusive, stigma-informed care that strengthens social support may improve youth depression management and treatment engagement.

背景:患有重度抑郁障碍(MDD)的青少年经常内化耻辱感,破坏功能和寻求帮助。同样,父母可能会将孩子的状况内化,从而影响家庭动态和护理参与。目的:研究MDD青少年及其父母的内化污名,以及其与青少年抑郁严重程度、感知到的社会支持、对精神疾病的信念、寻求帮助的态度和青少年整体功能的关系。方法:横断面三级临床研究(2023年7月- 10月)55例(12-18岁)患有DSM-5型重度抑郁症的青少年,父母各1例(n = 55);81.8%的青少年为女性。青少年完成了BDI、SSDS、ISMI-CA、BTMI、MSPSS和ATSPPH-SF;临床医生评定GAF。家长完成了BDI、P-ISMI、BTMI和ATSPPH-SF。采用分组比较、相关性和多变量线性回归。结果:有自杀企图或非自杀自伤行为的青少年的父母报告了更高的P-ISMI(更高的疏离感和刻板印象认可;对于自伤行为,也有更高的感知歧视和社会退缩)。青少年抑郁严重程度越高,SSDS子量表的自我耻辱感越高,这与较差的GAF和较低的MSPSS相关。较高的父母抑郁症状与较高的P-ISMI相关。青少年的社交不足自我耻辱感与父母的社交退缩有关。青少年年龄和受教育程度越高,寻求帮助的态度越积极。较长的精神病学随访与较高的父母刻板印象认同和社会退缩相关,而较高的父母教育与较低的感知歧视相关。在多变量模型中,青少年抑郁症状预示着较差的功能,父母抑郁症状解释了父母内化耻辱的实质性差异,而其他预测因素显示出更有限的独立影响。结论:在这个以女性为主的临床样本中,MDD青少年及其父母的内化耻辱与临床负担和功能密切相关。研究结果强调了内化的耻辱是一个嵌入家庭的、相互关联的过程,并表明整合家庭包容性的、耻辱知情的护理,加强社会支持,可能会改善青少年抑郁症的管理和治疗参与。
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引用次数: 0
Depression and Social Capital Among High-Altitude Residents in Ladakh: A Cross-Sectional Study.
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-12 DOI: 10.1177/00207640261428862
Motonao Ishikawa

Background: Depression and social capital (SC) have been increasingly studied in diverse cultural settings, yet little is known about their relationship in high-altitude regions such as Ladakh, India.

Aims: This study examines the association between social capital and depressive tendencies among Ladakhi residents.

Method: We conducted a cross-sectional survey of 140 residents of Domkhar village, Ladakh, during community medical camps in 2018 to 2019. Depressive tendencies were assessed using the PHQ-9 (cutoff ⩾5, selected to capture mild depressive states based on Asian literature). Social capital was measured with structural and cognitive SC indices, along with the Multidimensional Scale of Perceived Social Support (MSPSS) and the Religious Commitment Inventory (RCI-10). Personality traits were assessed using the Ten-Item Personality Inventory (TIPI).

Results: Depressive tendencies were identified in 12 participants (8.6%). Univariate logistic regression revealed that age ⩾60 years and living alone were significant risk factors, while being married, good subjective well-being, good health, good economic satisfaction, and engagement in structural SC were protective. Cognitive SC showed a protective trend. Extraversion scores were significantly lower among those with depressive tendencies. MSPSS and RCI-10 demonstrated a strong positive correlation. In multivariate analysis including all predictors simultaneously, only subjective well-being remained statistically significant (OR = 0.89, 95% CI [0.80, 0.98]).

Conclusions: Our findings suggest that both social capital and personality traits, particularly extraversion, play protective roles against depressive tendencies in Ladakh. Practical implications include leveraging community and religious structures, such as monasteries and local leaders, to enhance resilience in high-altitude populations.

目的:探讨社会资本与拉达克居民抑郁倾向的关系。使用PHQ-9评估抑郁倾向(根据亚洲文献选择截断或小于5来捕捉轻度抑郁状态)。社会资本采用结构指数和认知SC指数,以及多维感知社会支持量表(MSPSS)和宗教承诺量表(RCI-10)进行测量。人格特征采用十项人格量表(TIPI)进行评估。结果:有抑郁倾向者12人(8.6%)。单变量逻辑回归显示,年龄大于或小于60岁和独居是重要的风险因素,而结婚、良好的主观幸福感、健康状况、良好的经济满意度和参与结构性SC是保护性的。认知SC表现出保护倾向。有抑郁倾向的人的外向性得分明显较低。MSPSS与RCI-10呈正相关。在同时包含所有预测因子的多变量分析中,只有主观幸福感具有统计学意义(OR = 0.89, 95% CI[0.80, 0.98])。实际影响包括利用社区和宗教结构,如修道院和地方领导人,来增强高海拔地区人口的复原力。
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引用次数: 0
Real-World Testing of an Artificial Intelligence Conversational Agent as an Early Intervention and Support Tool in the Mental Health Referral Care Pathway: A Mixed-Methods Study. 人工智能会话代理在心理健康转诊护理途径中作为早期干预和支持工具的真实世界测试:一项混合方法研究
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-05 DOI: 10.1177/00207640251415507
Edward Meinert, Madison Milne-Ives, Emma Taylor, Becky Inkster, Alina Paik, Ananya Ananthakrishnan, Martin Orr, Ceire Costelloe, Rohit Shankar

Background: The incidence of mental health concerns is growing, and demand for support is exceeding service capacity. Digital tools can provide additional support but risk causing harm if not delivered safely.

Aims: We aimed to establish real-world evidence of the impact of an artificial intelligence-based mental health conversational agent (Wysa) on depression and anxiety in patients waiting for Talking Therapies treatment.

Methods: A mixed-methods randomized controlled trial was conducted with patients referred to Talking Therapies in the Central and Northwest London NHS Foundation Trust. The primary outcome was change in depression severity over 12 weeks between groups; secondary outcomes included anxiety severity, quality of life, safety, engagement, and app usage. Comparative analyses used linear regression; thematic analysis was conducted on qualitative data.

Results: 2,161 patients were screened, 625 were invited, 99 consented, and 76 were randomized (2:1). Thirty patients were lost to follow-up. Descriptive analysis found that mean differences in depression were similar between arms, but with large standard deviations (M = 2.62, SD = 5.07 and 6.56 for Wysa; M = 2.59, SD = 4.38 and 3.82 for control). Results were similar for secondary outcomes. Wysa was potentially helpful, easy to use, and appreciated as an accessible source of support, but limitations with the conversational agent negatively affected engagement.

Conclusions: Although sample size limited the analysis, participant feedback highlighted its potential to supplement clinical services. Our study findings suggest that the change of depression score is similar in both arms thus indicating that there is no evidence that Wysa treats depression in this study. However, limited sample size could have influenced this. Key lessons to improve the quality of effectiveness studies of digital health technologies were identified.

背景:心理健康问题的发生率正在上升,对支持的需求超出了服务能力。数字工具可以提供额外的支持,但如果不安全交付,可能会造成伤害。目的:我们旨在建立基于人工智能的心理健康会话代理(Wysa)对等待谈话疗法治疗的患者的抑郁和焦虑的影响的现实证据。方法:对伦敦中部和西北部NHS基金会信托的谈话疗法患者进行了一项混合方法随机对照试验。主要结局是各组间抑郁严重程度在12周内的变化;次要结果包括焦虑严重程度、生活质量、安全性、参与度和应用程序使用情况。比较分析采用线性回归;对定性数据进行专题分析。结果:筛选2161例患者,邀请625例,同意99例,随机76例(2:1)。30例患者未随访。描述性分析发现两组间抑郁的平均差异相似,但标准差较大(Wysa组M = 2.62, SD = 5.07和6.56;对照组M = 2.59, SD = 4.38和3.82)。次要结局的结果相似。Wysa有潜在的帮助,易于使用,并作为一个可访问的支持来源而受到赞赏,但会话代理的局限性对参与度产生了负面影响。结论:虽然样本量限制了分析,但参与者的反馈强调了其补充临床服务的潜力。我们的研究结果表明,两组患者抑郁评分的变化相似,因此没有证据表明Wysa在本研究中治疗抑郁症。然而,有限的样本量可能会影响这一点。确定了提高数字卫生技术有效性研究质量的关键经验教训。
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引用次数: 0
Internalized Stigma Predicts Life Engagement in People With Schizophrenia: A Cross-Sectional Observational Study in a Real-World Setting. 内化耻辱预测精神分裂症患者的生活投入:一项现实世界背景下的横断面观察研究。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2026-03-05 DOI: 10.1177/00207640261424408
Stefano Barlati, Gabriele Nibbio, Lorenzo Bertoni, Irene Calzavara-Pinton, Donato Morena, Nicola Necchini, Stefano Paolini, Antonio Baglioni, Daniela Zardini, Laura Poddighe, Jacopo Lisoni, Giacomo Deste, Roger S McIntyre, Antonio Vita

Background: People living with schizophrenia often experience high levels of stigma and are consistently at risk of internalizing it. Internalized stigma has a negative impact on several clinical and recovery outcomes in people with schizophrenia, but the effect of internalized stigma on important patient reported outcomes that are gaining increasing scientific and clinical relevance, such as life engagement, has not yet been extensively investigated.

Aims: This study aims to investigate the relationship between several different socio-demographic, clinical, functional and medication-related variables and life engagement, with the hypothesis that internalized stigma, alongside other factors, could represent an individual predictor of reduced life engagement.

Methods: Ninety-four participants diagnosed with schizophrenia were included in this cross-sectional study and were investigated with validated instruments assessing life engagement, schizophrenia symptoms severity, global clinical severity, internalized stigma, psychosocial functioning, antipsychotic-related side effects, attitude toward medications, and subjective well-being. Predictors of life engagement were assessed using a stepwise multivariate linear regression analysis.

Results: Greater global clinical severity (β = .685, p < .001), fewer years of education (β = -.240, p < .001), and greater stigma endorsement (β = .180, p = .005) emerged as individual predictors of reduced patient life engagement, explaining a large proportion of the observed variance (Adjusted R2 = .649, p = .001).

Conclusions: Internalized stigma, among other well-recognized variables, appears to represent an individual predictor of worse patient life engagement in people living with schizophrenia. This finding should strengthen the notion that stigma, and internalized stigma in particular, represent important dimensions and treatment targets in the clinical management of schizophrenia, also in the perspective of improving patient-reported outcomes.

背景:精神分裂症患者经常经历高度的耻辱,并且始终存在将其内化的风险。内化耻辱感对精神分裂症患者的一些临床和康复结果有负面影响,但内化耻辱感对重要的患者报告结果的影响正在获得越来越多的科学和临床相关性,如生活参与度,尚未得到广泛的研究。目的:本研究旨在探讨几个不同的社会人口学、临床、功能和药物相关变量与生活投入之间的关系,并假设内化的耻辱感与其他因素一起可能代表生活投入降低的个体预测因子。方法:94名被诊断为精神分裂症的参与者被纳入这项横断面研究,并使用经过验证的工具进行调查,评估生活投入、精神分裂症症状严重程度、整体临床严重程度、内化耻辱、社会心理功能、抗精神病药物相关副作用、对药物的态度和主观幸福感。使用逐步多元线性回归分析评估生活投入的预测因子。结果:总体临床严重程度更高(β =。685、p p p =。005)成为患者生活参与度降低的个体预测因子,解释了观察到的大部分方差(调整后的R2 =。649, p = .001)。结论:在其他公认的变量中,内化的耻辱似乎代表了精神分裂症患者更糟糕的患者生活参与的个体预测因子。这一发现应该加强这样一种观念,即耻辱,特别是内化耻辱,在精神分裂症的临床管理中代表了重要的维度和治疗目标,也从改善患者报告结果的角度来看。
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International Journal of Social Psychiatry
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