首页 > 最新文献

International Journal of Women's Health and Reproduction Sciences最新文献

英文 中文
Do the COVID-19 Vaccines Cause Menstrual Irregularities? COVID-19疫苗会导致月经不规律吗?
IF 0.7 Q3 Medicine Pub Date : 2021-06-04 DOI: 10.15296/ijwhr.2021.29
Z. Kurdoğlu
This new corona virus causes various health problems like pneumonia, acute respiratory distress syndrome (ARDS), kidney injury, myocardial dysfunction, and gastrointestinal diseases (1). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the immune system and causes an increase in interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α) and other cytokines. In addition to COVID-19 itself, impaired immune system may cause alteration on hypothalamic– pituitary–gonadal axis (2). Some studies showed a change in menstrual cycle, worsening of premenstrual symptoms and menorrhagia in women with COVID-19 compared to before the pandemic (3, 4). On the other hand, World Health Organization (WHO) suggests safe and effective vaccines to end COVID-19, besides wearing masks, cleaning hands, ensuring good ventilation indoors, physically distancing and avoiding crowds (5). After vaccination, some women complained of menstrual irregularities such as heavy menstrual bleeding (menorrhagia), frequent bleeding (metrorrhagia/ polymenorrhea), or postmenopausal bleeding. One of the underlying causes may be a vaccine-induced thrombocytopenia (6). The female human menstrual cycles could be affected by many situations such as stress, weight gain, hormones etc. During pandemic, studies show that women have significantly higher stress, anxiety, and depression compared to men (7, 8). Hypothalamic– pituitary–gonadal axis is sensitive to inadequate sleep, physical and psychological stress. Pulsatile mechanism of hormones is essential for regular menstrual cycle. Therefore, disruption of regularity in hormone release may cause to menstrual disorders (9). In addition, the vaccines activate the immune system and activated immune system might attack immune cells and inflammatory molecules in the uterus. This event may be associated with changes in menstrual cycles. To clarify these hypotheses, controlled studies are needed. Until now; pain, redness, swelling, tiredness, headache, muscle pain, chills, fever, Do the COVID-19 Vaccines Cause Menstrual Irregularities?
这种新型冠状病毒会引起各种健康问题,如肺炎、急性呼吸窘迫综合征(ARDS)、肾损伤、心肌功能障碍和胃肠道疾病(1)。严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)会影响免疫系统,导致白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α (TNF-α)和其他细胞因子的增加。除了COVID-19本身,免疫系统受损可能导致下丘脑-垂体-性腺轴的改变(2)。一些研究表明,与大流行前相比,COVID-19女性的月经周期发生变化,经前症状恶化,月经过多(3,4)。另一方面,世界卫生组织(WHO)建议安全有效的疫苗,除了戴口罩,洗手,确保室内良好通风,身体上保持距离并避开人群(5)。接种疫苗后,一些妇女抱怨月经不规律,如月经大量出血(月经过多)、频繁出血(月经过多)或绝经后出血。其中一个潜在的原因可能是疫苗引起的血小板减少症(6)。女性的月经周期可能受到许多情况的影响,如压力、体重增加、激素等。研究表明,在大流行期间,女性的压力、焦虑和抑郁程度明显高于男性(7,8)。下丘脑-垂体-性腺轴对睡眠不足、身体和心理压力敏感。激素的脉动机制对月经周期的规律至关重要。因此,打乱激素释放的规律可能会导致月经紊乱(9)。此外,疫苗激活免疫系统,激活的免疫系统可能会攻击子宫内的免疫细胞和炎症分子。这种情况可能与月经周期的变化有关。为了澄清这些假设,需要进行对照研究。直到现在;疼痛、红肿、疲劳、头痛、肌肉痛、发冷、发烧、COVID-19疫苗会导致月经不规律吗?
{"title":"Do the COVID-19 Vaccines Cause Menstrual Irregularities?","authors":"Z. Kurdoğlu","doi":"10.15296/ijwhr.2021.29","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.29","url":null,"abstract":"This new corona virus causes various health problems like pneumonia, acute respiratory distress syndrome (ARDS), kidney injury, myocardial dysfunction, and gastrointestinal diseases (1). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the immune system and causes an increase in interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α) and other cytokines. In addition to COVID-19 itself, impaired immune system may cause alteration on hypothalamic– pituitary–gonadal axis (2). Some studies showed a change in menstrual cycle, worsening of premenstrual symptoms and menorrhagia in women with COVID-19 compared to before the pandemic (3, 4). On the other hand, World Health Organization (WHO) suggests safe and effective vaccines to end COVID-19, besides wearing masks, cleaning hands, ensuring good ventilation indoors, physically distancing and avoiding crowds (5). After vaccination, some women complained of menstrual irregularities such as heavy menstrual bleeding (menorrhagia), frequent bleeding (metrorrhagia/ polymenorrhea), or postmenopausal bleeding. One of the underlying causes may be a vaccine-induced thrombocytopenia (6). The female human menstrual cycles could be affected by many situations such as stress, weight gain, hormones etc. During pandemic, studies show that women have significantly higher stress, anxiety, and depression compared to men (7, 8). Hypothalamic– pituitary–gonadal axis is sensitive to inadequate sleep, physical and psychological stress. Pulsatile mechanism of hormones is essential for regular menstrual cycle. Therefore, disruption of regularity in hormone release may cause to menstrual disorders (9). In addition, the vaccines activate the immune system and activated immune system might attack immune cells and inflammatory molecules in the uterus. This event may be associated with changes in menstrual cycles. To clarify these hypotheses, controlled studies are needed. Until now; pain, redness, swelling, tiredness, headache, muscle pain, chills, fever, Do the COVID-19 Vaccines Cause Menstrual Irregularities?","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79666064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Update on the Global Prevalence of Severe Fear of Childbirth in Low-Risk Pregnant Women: A Systematic Review and Meta-Analysis 全球低风险孕妇严重分娩恐惧流行情况的最新进展:一项系统回顾和荟萃分析
IF 0.7 Q3 Medicine Pub Date : 2021-06-04 DOI: 10.15296/ijwhr.2022.02
Shahrzad Sanjari, R. Chaman, S. Salehin, Shahrbanoo Goli, A. Keramat
Objectives: Severe fear of childbirth (FOC) has adverse consequences for mother and child. This study aimed to update the global prevalence of severe FOC in low-risk pregnant women. Materials and Methods: Observational studies published in English were obtained through PubMed, Scopus, Science Direct, Wiley Online, and Google Scholar databases up to April 2020. After reviewing the title and introduction, the quality of the articles that had full text and met the inclusion criteria of the study was checked with the JBI checklist. Then, the final extracted data were entered into the STATA software. The overall prevalence of severe FOC and fear in subgroups were obtained using meta-analysis. Tests of publication bias and sensitivity analysis were also performed. Results: Overall, 27 observational studies were included (26014 participants). The global prevalence of severe FOC was 16% (95% CI: 14%–19%). The subgroup analysis showed that after 2015, the prevalence of fear was higher than before (%18 versus %14). The results also showed a higher prevalence of fear in women with a diploma and lower compared to women with a university education (%19 versus %13), in single/divorced women compared to married/cohabitation women (%21 versus %15), in nulliparous women compared to multiparous women (%17 versus %14) and in women experiencing the second trimester of pregnancy compared to women in the third trimester of pregnancy (%23 versus %14). Conclusions: The global prevalence of severe FOC was 16%. Diagnostic, preventive, therapeutic and follow-up strategies are needed to reduce fear in all countries.
目的:分娩严重恐惧(FOC)对母亲和孩子都有不良后果。本研究旨在更新全球低风险孕妇严重FOC的流行情况。材料和方法:截至2020年4月,通过PubMed、Scopus、Science Direct、Wiley Online和Google Scholar数据库获得以英文发表的观察性研究。在审查标题和引言后,使用JBI检查表检查具有全文并符合研究纳入标准的文章的质量。然后,将最终提取的数据输入STATA软件。使用荟萃分析获得亚组中严重FOC和恐惧的总体患病率。还进行了发表偏倚检验和敏感性分析。结果:总共纳入了27项观察性研究(26014名受试者)。严重FOC的全球患病率为16% (95% CI: 14%-19%)。亚组分析显示,2015年后,恐惧的患病率高于之前(% 18%对% 14%)。研究结果还显示,拥有大学文凭的女性对恐惧的患病率较高,而受过大学教育的女性对恐惧的患病率较低(% 19%对% 13%),单身/离婚女性对已婚/同居女性对恐惧的患病率较高(% 21%对% 15%),未产女性对多产女性对恐惧的患病率较高(% 17%对% 14%),处于妊娠中期的女性对恐惧的患病率较高(% 23%对% 14%)。结论:全球严重FOC患病率为16%。需要制定诊断、预防、治疗和后续战略,以减少所有国家的恐惧。
{"title":"Update on the Global Prevalence of Severe Fear of Childbirth in Low-Risk Pregnant Women: A Systematic Review and Meta-Analysis","authors":"Shahrzad Sanjari, R. Chaman, S. Salehin, Shahrbanoo Goli, A. Keramat","doi":"10.15296/ijwhr.2022.02","DOIUrl":"https://doi.org/10.15296/ijwhr.2022.02","url":null,"abstract":"Objectives: Severe fear of childbirth (FOC) has adverse consequences for mother and child. This study aimed to update the global prevalence of severe FOC in low-risk pregnant women. Materials and Methods: Observational studies published in English were obtained through PubMed, Scopus, Science Direct, Wiley Online, and Google Scholar databases up to April 2020. After reviewing the title and introduction, the quality of the articles that had full text and met the inclusion criteria of the study was checked with the JBI checklist. Then, the final extracted data were entered into the STATA software. The overall prevalence of severe FOC and fear in subgroups were obtained using meta-analysis. Tests of publication bias and sensitivity analysis were also performed. Results: Overall, 27 observational studies were included (26014 participants). The global prevalence of severe FOC was 16% (95% CI: 14%–19%). The subgroup analysis showed that after 2015, the prevalence of fear was higher than before (%18 versus %14). The results also showed a higher prevalence of fear in women with a diploma and lower compared to women with a university education (%19 versus %13), in single/divorced women compared to married/cohabitation women (%21 versus %15), in nulliparous women compared to multiparous women (%17 versus %14) and in women experiencing the second trimester of pregnancy compared to women in the third trimester of pregnancy (%23 versus %14). Conclusions: The global prevalence of severe FOC was 16%. Diagnostic, preventive, therapeutic and follow-up strategies are needed to reduce fear in all countries.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72870962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women 乳腺癌放疗患者淋巴结受累及相关危险因素:一项针对15000名女性的20年研究
IF 0.7 Q3 Medicine Pub Date : 2021-06-04 DOI: 10.15296/ijwhr.2021.39
Fariborz Rousta, M. Dadashzadeh, F. Mahdavi, A. Nasseri
Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.
目的:肿瘤大小和腋窝淋巴结(LN)累及作为预后指标和选择辅助治疗的指导。本研究旨在评估乳腺癌(BC)放疗患者LN受累及相关危险因素。材料和方法:采用普查抽样方法,2000-2020年在大不里士医科大学进行的回顾性描述性研究纳入了15,000名转诊接受放疗的BC女性。记录LN累及相关危险因素,采用t检验和方差分析,P<0.05为显著性水平。结果:本研究中LN累及的患病率为25%。雌激素受体状态和淋巴结受累与转移有关。雌激素受体阴性患者发生转移的优势比约为雌激素受体阳性患者的两倍。最后,有LN累及的患者发生转移的风险是没有LN累及的患者的8倍。结论:一般来说,雌激素受体状态和淋巴结受累与BC患者的转移有关。因此,这些因素可以被视为在高危患者中早期开始必要干预的指南。
{"title":"Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women","authors":"Fariborz Rousta, M. Dadashzadeh, F. Mahdavi, A. Nasseri","doi":"10.15296/ijwhr.2021.39","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.39","url":null,"abstract":"Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80395263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Hydroalcoholic Extract of Orange Peel on PCNA and FSH-R Gene Expression in Histological Damage and Oxidative Stress Due to Ovarian Torsion in Adult Rats 桔皮水醇提取物对卵巢扭转大鼠组织损伤和氧化应激中PCNA和FSH-R基因表达的保护作用
IF 0.7 Q3 Medicine Pub Date : 2021-06-04 DOI: 10.15296/ijwhr.2021.38
Seyedeh-Roza Tafrishi Nejad, A. Khaki, Shamci Abbasalizadeh, M. Shokoohi, Nava Ainehchi
Objectives: The aim of this study was to evaluate the protective effect of the hydroalcoholic extract of orange peel on proliferating cell nuclear antigen (PCNA) and follicle-stimulating hormone receptor (FSH-R) gene expression in histological injuries and acid stress caused by ovarian torsion in adult rats. Materials and Methods: In this experimental study, 32 adult female rats were randomly divided into 4 groups. In group 1 (Sham), the abdominal wall was cut without applying torsion and in group 2, ovarian torsion was performed for 2 hours, followed by detorsion for 2 weeks. The hydro-alcoholic extract of orange peel was added to their diet for two weeks in group 3, followed by ovarian torsion for 2 hours and detorsion for 2 hours. Group 4 received the orange peel extract for two weeks and after then ovarian resection for the evaluation of histological damage and blood sampling to examine the serum level of antioxidant enzymes, as well as the expression of PCNA and FSH-R genes in the ovarian tissue. Results: Histological changes in the ovary tissue of rats showed that torsion and detorsion have destructive effects on the ovarian tissue, and torsion/detorsion led to a reduction in the expression of PCNA and FSH-R (P < 0.05). Based on biochemical and hormonal results, the ovarian torsion resulted in an imbalance in the oxidative stress markers and hormone profile of rats. Finally, the administration of the hydroalcoholic extract of orange peel due to its high antioxidant properties improves these effects. Conclusions: In general, administering an appropriate dose of the hydroalcoholic extract of orange peel for two consecutive weeks in the diet had a protective effect on the ovarian tissue at the risk of torsion/detorsion.
目的:探讨柑桔皮水酒精提取物对卵巢扭转致大鼠组织学损伤和酸应激时增殖细胞核抗原(PCNA)和促卵泡激素受体(FSH-R)基因表达的保护作用。材料与方法:选用32只成年雌性大鼠,随机分为4组。1组(Sham)切开腹壁,不施加扭转;2组卵巢扭转2小时,扭转2周。第三组在日粮中添加桔皮水酒精提取物2周,随后进行卵巢扭转2小时和卵巢扭转2小时。第4组大鼠连续2周服用橘皮提取物,切除卵巢后进行组织损伤评估,并采血检测血清抗氧化酶水平、卵巢组织中PCNA和FSH-R基因的表达。结果:大鼠卵巢组织组织学变化表明,扭转和扭转对卵巢组织有破坏作用,扭转和扭转导致PCNA和FSH-R表达降低(P < 0.05)。根据生物化学和激素结果,卵巢扭转导致大鼠氧化应激标志物和激素谱失衡。最后,由于橙皮的高抗氧化性能,使用水醇提取物可以改善这些效果。结论:一般来说,在饮食中连续两周给予适当剂量的橘皮水酒精提取物对卵巢组织有扭转/扭曲的保护作用。
{"title":"Protective Effect of Hydroalcoholic Extract of Orange Peel on PCNA and FSH-R Gene Expression in Histological Damage and Oxidative Stress Due to Ovarian Torsion in Adult Rats","authors":"Seyedeh-Roza Tafrishi Nejad, A. Khaki, Shamci Abbasalizadeh, M. Shokoohi, Nava Ainehchi","doi":"10.15296/ijwhr.2021.38","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.38","url":null,"abstract":"Objectives: The aim of this study was to evaluate the protective effect of the hydroalcoholic extract of orange peel on proliferating cell nuclear antigen (PCNA) and follicle-stimulating hormone receptor (FSH-R) gene expression in histological injuries and acid stress caused by ovarian torsion in adult rats. Materials and Methods: In this experimental study, 32 adult female rats were randomly divided into 4 groups. In group 1 (Sham), the abdominal wall was cut without applying torsion and in group 2, ovarian torsion was performed for 2 hours, followed by detorsion for 2 weeks. The hydro-alcoholic extract of orange peel was added to their diet for two weeks in group 3, followed by ovarian torsion for 2 hours and detorsion for 2 hours. Group 4 received the orange peel extract for two weeks and after then ovarian resection for the evaluation of histological damage and blood sampling to examine the serum level of antioxidant enzymes, as well as the expression of PCNA and FSH-R genes in the ovarian tissue. Results: Histological changes in the ovary tissue of rats showed that torsion and detorsion have destructive effects on the ovarian tissue, and torsion/detorsion led to a reduction in the expression of PCNA and FSH-R (P < 0.05). Based on biochemical and hormonal results, the ovarian torsion resulted in an imbalance in the oxidative stress markers and hormone profile of rats. Finally, the administration of the hydroalcoholic extract of orange peel due to its high antioxidant properties improves these effects. Conclusions: In general, administering an appropriate dose of the hydroalcoholic extract of orange peel for two consecutive weeks in the diet had a protective effect on the ovarian tissue at the risk of torsion/detorsion.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80783448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Cross-sectional Study of Psychosocial Problems Following Therapeutic Abortion With the Mother’s Spiritual Experiences 治疗性流产后心理社会问题与母亲精神体验的横断面研究
IF 0.7 Q3 Medicine Pub Date : 2021-06-04 DOI: 10.15296/ijwhr.2023.12
Sedighe Alipanahpour, M. Zarshenas, M. Taheri, M. Akbarzadeh
Objectives: Abortion can be stressful for the family and may lead to psychological problems. The question arises whether religious attitudes can be restructured into women who experience induced and spontaneous abortions. In this regard, the present study aimed to investigate the relationship of post-traumatic stress disorder (PTSD) after therapeutic abortion (Induced and spontaneous) with the mother’s spiritual experiences. Materials and Methods: This cross-sectional study with a sample size of 104 people was conducted in 2018-2019 in the selected hospitals of Shiraz University of Medical Sciences. The convenience sampling method was used in 2018. Research tools including the Mississippi PTSD Scale questionnaire were implemented for measuring stress and religious attitudes and completed immediately and a month after abortion. Data were analyzed by SPSS software using one-way ANOVA, least significant difference post hoc test, and paired t-test or Wilcoxon test. Results: Based on the results, 68.7%, 71.8%, and 72.7% of the abortion group with forensic medical letter, other causes, and spontaneous abortion had a high level of religious attitudes, respectively. In addition, 78.1%, 69.2%, and 72.7% of those who had an abortion with a forensic medical letter, underwent abortion for other causes, and experienced a spontaneous abortion had moderate PTSD immediately after abortion, respectively. Further, 62.5%, 64.1%, and 66.7% of women having an abortion with forensic medical letter, undergoing abortion for other causes, and experiencing spontaneous abortion had moderate PTSD one month after abortion, respectively. The findings revealed no significant relationship between PTSD differences immediately and a month after the abortion in the subjects (P=0.175). Conclusions: The research community had a high religious attitude while having no association with PTSD reductions. More than half of the pregnancies were unwanted, which may be due to stress levels.
目的:流产会给家庭带来压力,并可能导致心理问题。问题出现了,宗教态度是否可以重新调整到经历人工流产和自然流产的妇女身上。因此,本研究旨在探讨治疗性流产(诱发和自发)后创伤后应激障碍(PTSD)与母亲精神体验的关系。材料与方法:本横断面研究于2018-2019年在设拉子医科大学附属医院进行,样本量为104人。2018年采用方便抽样方法。研究工具包括密西西比创伤后应激障碍量表问卷,用于测量压力和宗教态度,并在堕胎后立即和一个月完成。数据采用SPSS软件进行单因素方差分析、最小显著差异事后检验、配对t检验或Wilcoxon检验。结果:结果显示,有法医证明的流产组、其他原因流产组和自然流产组中,宗教态度较高的分别为68.7%、71.8%和72.7%。此外,78.1%、69.2%和72.7%的有法医证明的堕胎者、因其他原因堕胎者和自然流产者在堕胎后立即患有中度创伤后应激障碍。此外,62.5%、64.1%和66.7%的有法医证明的堕胎妇女、因其他原因堕胎妇女和自然流产妇女在堕胎后一个月分别患有中度创伤后应激障碍。研究结果显示,流产后1个月与即刻PTSD差异无显著相关性(P=0.175)。结论:研究界有高度的宗教态度,但与PTSD的减少没有关联。超过一半的怀孕是意外的,这可能是由于压力过大。
{"title":"A Cross-sectional Study of Psychosocial Problems Following Therapeutic Abortion With the Mother’s Spiritual Experiences","authors":"Sedighe Alipanahpour, M. Zarshenas, M. Taheri, M. Akbarzadeh","doi":"10.15296/ijwhr.2023.12","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.12","url":null,"abstract":"Objectives: Abortion can be stressful for the family and may lead to psychological problems. The question arises whether religious attitudes can be restructured into women who experience induced and spontaneous abortions. In this regard, the present study aimed to investigate the relationship of post-traumatic stress disorder (PTSD) after therapeutic abortion (Induced and spontaneous) with the mother’s spiritual experiences. Materials and Methods: This cross-sectional study with a sample size of 104 people was conducted in 2018-2019 in the selected hospitals of Shiraz University of Medical Sciences. The convenience sampling method was used in 2018. Research tools including the Mississippi PTSD Scale questionnaire were implemented for measuring stress and religious attitudes and completed immediately and a month after abortion. Data were analyzed by SPSS software using one-way ANOVA, least significant difference post hoc test, and paired t-test or Wilcoxon test. Results: Based on the results, 68.7%, 71.8%, and 72.7% of the abortion group with forensic medical letter, other causes, and spontaneous abortion had a high level of religious attitudes, respectively. In addition, 78.1%, 69.2%, and 72.7% of those who had an abortion with a forensic medical letter, underwent abortion for other causes, and experienced a spontaneous abortion had moderate PTSD immediately after abortion, respectively. Further, 62.5%, 64.1%, and 66.7% of women having an abortion with forensic medical letter, undergoing abortion for other causes, and experiencing spontaneous abortion had moderate PTSD one month after abortion, respectively. The findings revealed no significant relationship between PTSD differences immediately and a month after the abortion in the subjects (P=0.175). Conclusions: The research community had a high religious attitude while having no association with PTSD reductions. More than half of the pregnancies were unwanted, which may be due to stress levels.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87495779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the In Vitro Fertilization Success Rate in Transfer of Top-Quality Embryo Versus Poor-Quality Embryos: A Cohort Study 优质胚胎与劣质胚胎移植的体外受精成功率评价:一项队列研究
IF 0.7 Q3 Medicine Pub Date : 2021-05-02 DOI: 10.15296/ijwhr.2022.27
Firoozeh Akbari Asbagh, Fatemeh Davari tanha, Z. Rezaei, M. Ebrahimi, T. Hemmati, Mojgan Talebbidokhti, Amir Ahmadi, Elham Feizabad
Objectives: To evaluate the in vitro fertilization success rate by transferring top- versus low-quality embryos. Materials and Methods: This prospective cohort study was conducted on 199 infertile women. Ninety-nine patients underwent an agonist cycle (70 fresh embryo transfer [ET] and 29 frozen ET), and 100 patients received an antagonist cycle (28 fresh ET and 72 frozen ET) in the infertility department of a tertiary university-based hospital between May 2019 and March 2020. The blastocysts classified as AA, AB, and BB, as well as AC, BC, and CC were considered as top- and poor-quality embryos (TQE and PQE). The study outcomes were biochemical and clinical and determined the rate of pregnancy. Results: The average age of the participants was 32.44±5.25 years old. Women with TQE were significantly younger than those with PQE (31.35±4.97 vs. 34.09±5.27, P<0.001). In addition, the duration of women’s infertility was significantly (P<0.001) correlated with the embryo’s top quality. A positive β-human chorionic gonadotropin was detected in 12.6% (n=25) of women while clinical pregnancy was investigated in 8% (n=16) of them. The fetal heart rate was detected in 7.5% (n=15). Eventually, the clinical (P=0.020) and determined (P=0.030) pregnancy rates significantly differed between two study groups with a higher level in the TQE group. Conclusions: It seems that TQP transfer should be the first recommendation for infertile women, but when the double-embryo transfer (DET) is needed according to the patient’s condition, she should be informed that the quality of the second embryo may have an adverse impact on pregnancy consequences.
目的:比较高质量胚胎与低质量胚胎的体外受精成功率。材料与方法:本前瞻性队列研究纳入199名不孕妇女。2019年5月至2020年3月,在一所高等大学附属医院的不孕症科,99例患者接受了激动剂周期(70例新鲜胚胎移植[ET]和29例冷冻ET), 100例患者接受了拮抗剂周期(28例新鲜ET和72例冷冻ET)。分类为AA、AB、BB以及AC、BC、CC的囊胚分别为优质胚和劣质胚(TQE和PQE)。研究结果是生化和临床,并确定了妊娠率。结果:参与者平均年龄32.44±5.25岁。TQE患者明显比PQE患者年轻(31.35±4.97∶34.09±5.27,P<0.001)。此外,女性不孕的持续时间与胚胎的高质量显著相关(P<0.001)。12.6% (n=25)的妇女检测到β-人绒毛膜促性腺激素阳性,8% (n=16)的妇女进行了临床妊娠调查。胎儿心率为7.5% (n=15)。最终,两组临床妊娠率(P=0.020)和测定妊娠率(P=0.030)差异有统计学意义,TQE组妊娠率较高。结论:对于不孕症患者,TQP移植应作为首选方案,但当根据患者情况需要进行双胚胎移植时,应告知患者第二胚胎的质量可能会对妊娠后果产生不利影响。
{"title":"Evaluation of the In Vitro Fertilization Success Rate in Transfer of Top-Quality Embryo Versus Poor-Quality Embryos: A Cohort Study","authors":"Firoozeh Akbari Asbagh, Fatemeh Davari tanha, Z. Rezaei, M. Ebrahimi, T. Hemmati, Mojgan Talebbidokhti, Amir Ahmadi, Elham Feizabad","doi":"10.15296/ijwhr.2022.27","DOIUrl":"https://doi.org/10.15296/ijwhr.2022.27","url":null,"abstract":"Objectives: To evaluate the in vitro fertilization success rate by transferring top- versus low-quality embryos. Materials and Methods: This prospective cohort study was conducted on 199 infertile women. Ninety-nine patients underwent an agonist cycle (70 fresh embryo transfer [ET] and 29 frozen ET), and 100 patients received an antagonist cycle (28 fresh ET and 72 frozen ET) in the infertility department of a tertiary university-based hospital between May 2019 and March 2020. The blastocysts classified as AA, AB, and BB, as well as AC, BC, and CC were considered as top- and poor-quality embryos (TQE and PQE). The study outcomes were biochemical and clinical and determined the rate of pregnancy. Results: The average age of the participants was 32.44±5.25 years old. Women with TQE were significantly younger than those with PQE (31.35±4.97 vs. 34.09±5.27, P<0.001). In addition, the duration of women’s infertility was significantly (P<0.001) correlated with the embryo’s top quality. A positive β-human chorionic gonadotropin was detected in 12.6% (n=25) of women while clinical pregnancy was investigated in 8% (n=16) of them. The fetal heart rate was detected in 7.5% (n=15). Eventually, the clinical (P=0.020) and determined (P=0.030) pregnancy rates significantly differed between two study groups with a higher level in the TQE group. Conclusions: It seems that TQP transfer should be the first recommendation for infertile women, but when the double-embryo transfer (DET) is needed according to the patient’s condition, she should be informed that the quality of the second embryo may have an adverse impact on pregnancy consequences.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81471129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Suitability of the Health Belief Model as an Assessment Framework for Women With Breast Ill-Health 健康信念模型作为乳腺疾病评估框架的适用性
IF 0.7 Q3 Medicine Pub Date : 2021-05-02 DOI: 10.15296/ijwhr.2021.46
Agatha Ogunkorode, Lorraine Holtslander, L. Ferguson, J. Maree, J. Anonson, V. Ramsden, D. Esan, I. Owoeye
Objectives: Globally, breast cancer is the commonest cancer in women. Empirical literature indicate that it is the second cause of cancer-related mortality in high-resource regions, while it is the most common cause of cancer-related deaths among women in poor-resource regions. This study presents the suitability of the health belief model (HBM) as a framework for carrying out a comprehensive assessment of women with late-stage breast cancer in Nigeria. Materials and Methods: This qualitative study employed interpretive description as its methodological approach, while the HBM was the conceptual framework. Two institutional review boards granted approval to conduct the study. Thirty women with advanced breast cancer were recruited for the study using purposeful sampling techniques. Components of the original HBM were identified to carry out the investigation. Data analysis was inductive. Results: Findings indicated that the participants viewed breast cancer as a definite threat- both as a spiritual attack – an arrow shot by the enemy, and as a killer disease. Many of their perceptions appeared to be culturally based, while others were based on their individual experiences. They perceived some benefits to both traditional and medical treatment options. Conclusions: Interventions that address people’s cultural and individual perceptions enables a comprehensive assessment of the patients with breast cancer, which can improve the treatment outcomes and survival rates of disease.
目的:在全球范围内,乳腺癌是女性中最常见的癌症。经验文献表明,在资源丰富的地区,它是癌症相关死亡的第二大原因,而在资源贫乏的地区,它是妇女癌症相关死亡的最常见原因。本研究提出了健康信念模型(HBM)作为对尼日利亚晚期乳腺癌妇女进行全面评估的框架的适用性。材料与方法:本定性研究采用解释性描述作为研究方法,以HBM为概念框架。两个机构审查委员会批准进行这项研究。采用有目的的抽样技术,研究人员招募了30名晚期乳腺癌妇女。原始HBM的组成部分被确定以进行调查。数据分析采用归纳法。结果:研究结果表明,参与者将乳腺癌视为一种明确的威胁——既是一种精神上的攻击,是敌人射出的箭,也是一种致命的疾病。他们的许多看法似乎是基于文化,而另一些则是基于他们的个人经历。他们认为传统和医学治疗方案都有一些好处。结论:针对人们的文化和个人观念的干预措施可以对乳腺癌患者进行全面评估,从而可以改善治疗结果和疾病存活率。
{"title":"The Suitability of the Health Belief Model as an Assessment Framework for Women With Breast Ill-Health","authors":"Agatha Ogunkorode, Lorraine Holtslander, L. Ferguson, J. Maree, J. Anonson, V. Ramsden, D. Esan, I. Owoeye","doi":"10.15296/ijwhr.2021.46","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.46","url":null,"abstract":"Objectives: Globally, breast cancer is the commonest cancer in women. Empirical literature indicate that it is the second cause of cancer-related mortality in high-resource regions, while it is the most common cause of cancer-related deaths among women in poor-resource regions. This study presents the suitability of the health belief model (HBM) as a framework for carrying out a comprehensive assessment of women with late-stage breast cancer in Nigeria. Materials and Methods: This qualitative study employed interpretive description as its methodological approach, while the HBM was the conceptual framework. Two institutional review boards granted approval to conduct the study. Thirty women with advanced breast cancer were recruited for the study using purposeful sampling techniques. Components of the original HBM were identified to carry out the investigation. Data analysis was inductive. Results: Findings indicated that the participants viewed breast cancer as a definite threat- both as a spiritual attack – an arrow shot by the enemy, and as a killer disease. Many of their perceptions appeared to be culturally based, while others were based on their individual experiences. They perceived some benefits to both traditional and medical treatment options. Conclusions: Interventions that address people’s cultural and individual perceptions enables a comprehensive assessment of the patients with breast cancer, which can improve the treatment outcomes and survival rates of disease.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89095585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Does Coronavirus Disease Affect Sleep Disorders in the Third Trimester of Pregnancy in Women With Low Back Pain? 冠状病毒病是否会影响腰痛妇女妊娠晚期的睡眠障碍?
IF 0.7 Q3 Medicine Pub Date : 2021-05-02 DOI: 10.15296/ijwhr.2021.49
R. Dargahi, Behrooz Nazari, A. Dorosti, S. Charsouei
Objectives: Many factors such as stress and psychological tension affect the mental and physical health of pregnant women in the third trimester during the coronavirus pandemic. These factors can cause severe complications such as sleep disorders and low back pain. Therefore, this study focused on investigating sleep disorders in women by diagnosing low back pain in pregnant women with coronavirus and the affecting factors. Materials and Methods: This descriptive-analytical study was performed during the four months ending July 5, 2020 with the participation of 40 pregnant women (with coronavirus disease detected in the last trimester of pregnancy) with a diagnosis of low back pain in Tabriz (Iran) using a random sampling technique. Demographic data, anxiety and depression, Petersburg’s sleep quality, factors affecting sleep quality, and the severity of back pain (visual analog scale) were electronically collected and analyzed using SPSS 20 by ANOVA and multivariate regression. Results: All participants were at a weak level. The majority of participants had a score of "serious sleep problem", and nausea and vomiting (P=0.041), low back pain (P=0.003), frequent urination (P=0.011), leg cramps (P=0.031), and constipation (P=0.018) caused severe sleep disturbance in pregnant women during coronavirus pandemic. Conclusions: In general, having coronavirus disease causes severe pain in pregnant women, leading to severe back pain in pregnancy, eventually worsening sleep disorders.
目的:新冠肺炎大流行期间,压力、心理紧张等诸多因素影响孕晚期孕妇的身心健康。这些因素会导致严重的并发症,如睡眠障碍和腰痛。因此,本研究重点通过诊断新冠肺炎孕妇腰痛及其影响因素,探讨女性睡眠障碍。材料和方法:本描述性分析研究在截至2020年7月5日的四个月内进行,采用随机抽样技术,在大不里士(伊朗)有40名诊断为腰痛的孕妇(妊娠最后三个月检测到冠状病毒疾病)参与。电子收集人口学资料、焦虑抑郁、彼得堡睡眠质量、睡眠质量影响因素、背痛严重程度(视觉模拟量表),采用SPSS 20进行方差分析和多元回归分析。结果:所有受试者均处于弱水平。大多数参与者都有“严重睡眠问题”的评分,在冠状病毒大流行期间,恶心和呕吐(P=0.041)、腰痛(P=0.003)、尿频(P=0.011)、腿痉挛(P=0.031)和便秘(P=0.018)会导致孕妇严重的睡眠障碍。结论:一般来说,冠状病毒感染会导致孕妇剧烈疼痛,导致孕期严重的背部疼痛,最终加重睡眠障碍。
{"title":"Does Coronavirus Disease Affect Sleep Disorders in the Third Trimester of Pregnancy in Women With Low Back Pain?","authors":"R. Dargahi, Behrooz Nazari, A. Dorosti, S. Charsouei","doi":"10.15296/ijwhr.2021.49","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.49","url":null,"abstract":"Objectives: Many factors such as stress and psychological tension affect the mental and physical health of pregnant women in the third trimester during the coronavirus pandemic. These factors can cause severe complications such as sleep disorders and low back pain. Therefore, this study focused on investigating sleep disorders in women by diagnosing low back pain in pregnant women with coronavirus and the affecting factors. Materials and Methods: This descriptive-analytical study was performed during the four months ending July 5, 2020 with the participation of 40 pregnant women (with coronavirus disease detected in the last trimester of pregnancy) with a diagnosis of low back pain in Tabriz (Iran) using a random sampling technique. Demographic data, anxiety and depression, Petersburg’s sleep quality, factors affecting sleep quality, and the severity of back pain (visual analog scale) were electronically collected and analyzed using SPSS 20 by ANOVA and multivariate regression. Results: All participants were at a weak level. The majority of participants had a score of \"serious sleep problem\", and nausea and vomiting (P=0.041), low back pain (P=0.003), frequent urination (P=0.011), leg cramps (P=0.031), and constipation (P=0.018) caused severe sleep disturbance in pregnant women during coronavirus pandemic. Conclusions: In general, having coronavirus disease causes severe pain in pregnant women, leading to severe back pain in pregnancy, eventually worsening sleep disorders.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80305572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childbirth Satisfaction in Women With Psychological Traumatic Childbirth 心理创伤性分娩妇女的分娩满意度
IF 0.7 Q3 Medicine Pub Date : 2021-05-02 DOI: 10.15296/ijwhr.2023.03
F. Mokhtari, Shekoofehsadat Mousavi, Roghaiyeh Nourizadeh, S. Hakimi, E. Mehrabi, Neda Shamsalizadeh
Objectives: This study was conducted to determine factors related to childbirth satisfaction in women who experienced psychological traumatic childbirth. Materials and Methods: This cross-sectional study was conducted to examine 375 postpartum women who had experienced psychological traumatic childbirth according to criterion A of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5 [A]). Data-gathering tools were the demographic and obstetric characteristics questionnaire and Mackey childbirth satisfaction questionnaire. The data were analyzed using SPSS (version 24.0), and independent t test, ANOVA, Pearson correlation coefficient, as well as multivariate linear regression test were used to perform data analysis. Results: The mean (standard deviation) of the delivery satisfaction score was 120.09 (27.11) out of 170. The predictors of satisfaction with delivery in women who had experienced psychological traumatic childbirth included type of delivery (P < 0.001), accordance of the delivery with the desired delivery (P = 0.013), and analgesia (P = 0.02). Conclusions: It seems that with continuous training and counseling about the type of delivery, the mother’s participation in delivery decisions, and also providing a variety of analgesia methods during delivery can increase childbirth satisfaction and reduce psychological traumatic childbirth.
目的:本研究旨在探讨心理创伤性分娩妇女分娩满意度的相关因素。材料与方法:本横断面研究按照《精神障碍诊断与统计手册》(DSM-5 [A])第五版A标准,对375例经历过心理创伤性分娩的产后妇女进行调查。数据收集工具为人口统计学和产科特征问卷和麦基分娩满意度问卷。采用SPSS(24.0版)对数据进行分析,采用独立t检验、方差分析、Pearson相关系数及多元线性回归检验进行数据分析。结果:分娩满意度评分均值(标准差)为120.09分(27.11分)。心理创伤性分娩妇女分娩满意度的预测因子包括分娩方式(P < 0.001)、分娩是否符合预期分娩(P = 0.013)和镇痛(P = 0.02)。结论:通过对分娩方式的持续培训和辅导,让产妇参与分娩决策,并在分娩过程中提供多种镇痛方法,可提高分娩满意度,减少分娩心理创伤性。
{"title":"Childbirth Satisfaction in Women With Psychological Traumatic Childbirth","authors":"F. Mokhtari, Shekoofehsadat Mousavi, Roghaiyeh Nourizadeh, S. Hakimi, E. Mehrabi, Neda Shamsalizadeh","doi":"10.15296/ijwhr.2023.03","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.03","url":null,"abstract":"Objectives: This study was conducted to determine factors related to childbirth satisfaction in women who experienced psychological traumatic childbirth. Materials and Methods: This cross-sectional study was conducted to examine 375 postpartum women who had experienced psychological traumatic childbirth according to criterion A of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5 [A]). Data-gathering tools were the demographic and obstetric characteristics questionnaire and Mackey childbirth satisfaction questionnaire. The data were analyzed using SPSS (version 24.0), and independent t test, ANOVA, Pearson correlation coefficient, as well as multivariate linear regression test were used to perform data analysis. Results: The mean (standard deviation) of the delivery satisfaction score was 120.09 (27.11) out of 170. The predictors of satisfaction with delivery in women who had experienced psychological traumatic childbirth included type of delivery (P < 0.001), accordance of the delivery with the desired delivery (P = 0.013), and analgesia (P = 0.02). Conclusions: It seems that with continuous training and counseling about the type of delivery, the mother’s participation in delivery decisions, and also providing a variety of analgesia methods during delivery can increase childbirth satisfaction and reduce psychological traumatic childbirth.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80518658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mefenamic Acid for the Prevention of Bleeding and Spotting From Depot-medroxyprogesterone Acetate: A Randomized Controlled Trial 甲氧胺酸预防醋酸甲氧孕酮出血和点滴:一项随机对照试验
IF 0.7 Q3 Medicine Pub Date : 2021-05-02 DOI: 10.15296/ijwhr.2021.53
J. Sothornwit, Y. Werawatakul, Orathai Saenbon
Objectives: To evaluate the efficacy of mefenamic acid for the reduction of bleeding and spotting in post-partum women initiating the use of depot-medroxyprogesterone acetate (DMPA) for contraception. Materials and Methods: This double-blind, placebo-controlled study included postpartum breastfeeding women in Khon Kaen, Thailand. Mefenamic acid or placebo was administered over the first 12 weeks of DMPA use. Then, participants completed a self-report bleeding diary. Results: Forty women, initiating the use of DMPA for postpartum contraception, were randomized to mefenamic acid (n=20) or placebo (n=20) group. The study was discontinued after 27 months because of suboptimal enrollment. The mefenamic acid group was less likely to have prolonged bleeding compared to placebo although this was not statistically significant (37.5% vs. 50%, respectively, P = 0.491). DMPA discontinuation rates were high at 50% in both groups although no participants in the mefenamic acid group stopped using DMPA due to bleeding side effects. Conclusions: The high discontinuation rates in the postpartum use of DMPA are attributed to the occurrence of bleeding/spotting side effects. Although mefenamic acid prophylaxis appeared to be beneficial to some women, a larger randomized controlled trial is required to confirm the effectiveness of this approach.
目的:评价甲氧胺酸对产后开始使用醋酸甲氧孕酮(DMPA)避孕的妇女减少出血和点滴的疗效。材料和方法:这项双盲、安慰剂对照研究包括泰国孔敬的产后母乳喂养妇女。在使用DMPA的前12周内给予甲氧胺酸或安慰剂。然后,参与者完成一份自我报告出血日记。结果:40名开始使用DMPA进行产后避孕的妇女,随机分为甲芬那酸组(n=20)和安慰剂组(n=20)。该研究在27个月后因入组不理想而终止。与安慰剂组相比,甲氧胺酸组出血时间延长的可能性较小,尽管这在统计学上没有显著性差异(分别为37.5%对50%,P = 0.491)。两组的DMPA停药率均高达50%,尽管甲氧胺酸组没有参与者因出血副作用而停止使用DMPA。结论:产后DMPA停药率高与出血/点滴副作用的发生有关。虽然甲氧胺酸预防似乎对一些妇女有益,但需要更大的随机对照试验来证实这种方法的有效性。
{"title":"Mefenamic Acid for the Prevention of Bleeding and Spotting From Depot-medroxyprogesterone Acetate: A Randomized Controlled Trial","authors":"J. Sothornwit, Y. Werawatakul, Orathai Saenbon","doi":"10.15296/ijwhr.2021.53","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.53","url":null,"abstract":"Objectives: To evaluate the efficacy of mefenamic acid for the reduction of bleeding and spotting in post-partum women initiating the use of depot-medroxyprogesterone acetate (DMPA) for contraception. Materials and Methods: This double-blind, placebo-controlled study included postpartum breastfeeding women in Khon Kaen, Thailand. Mefenamic acid or placebo was administered over the first 12 weeks of DMPA use. Then, participants completed a self-report bleeding diary. Results: Forty women, initiating the use of DMPA for postpartum contraception, were randomized to mefenamic acid (n=20) or placebo (n=20) group. The study was discontinued after 27 months because of suboptimal enrollment. The mefenamic acid group was less likely to have prolonged bleeding compared to placebo although this was not statistically significant (37.5% vs. 50%, respectively, P = 0.491). DMPA discontinuation rates were high at 50% in both groups although no participants in the mefenamic acid group stopped using DMPA due to bleeding side effects. Conclusions: The high discontinuation rates in the postpartum use of DMPA are attributed to the occurrence of bleeding/spotting side effects. Although mefenamic acid prophylaxis appeared to be beneficial to some women, a larger randomized controlled trial is required to confirm the effectiveness of this approach.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84487056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Women's Health and Reproduction Sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1