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Global crisis and mental health and well-being of older adults. 全球危机与老年人的心理健康和福祉。
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-16 DOI: 10.1017/S1041610223000960
Helen Lavretsky, Anne Margriet Pot
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引用次数: 0
Social Media Use is an Understated Social Determinant of Mental Health. 社交媒体的使用是心理健康的一个被低估的社会决定因素。
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-14 DOI: 10.1017/S1041610224000371
Dylan J Jester, Kexin Yu
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引用次数: 0
Disentangling factors that influence the spousal relationship of people with young-onset dementia: starting points for person-centered care and support? 厘清影响年轻痴呆症患者配偶关系的因素:以人为本的护理和支持的出发点?
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-14 DOI: 10.1017/S1041610224000395
Hanna E Bodde, Janne M Papma, Jackie M Poos
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引用次数: 0
Can psychotic symptom identification help to improve Young-onset dementia care? 精神病症状识别有助于改善青年期痴呆症护理吗?
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-08 DOI: 10.1017/S1041610224000358
Clarissa Giebel
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引用次数: 0
Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis. 经颅磁刺激对轻度认知障碍、阿尔茨海默病、阿尔茨海默病相关痴呆症和其他认知障碍的疗效和安全性:系统综述和荟萃分析。
IF 4.6 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-08 DOI: 10.1017/S1041610224000085
Sandeep R Pagali, Rakesh Kumar, Allison M LeMahieu, Michael R Basso, Bradley F Boeve, Paul E Croarkin, Jennifer R Geske, Leslie C Hassett, John Huston, Simon Kung, Brian N Lundstrom, Ronald C Petersen, Erik K St Louis, Kirk M Welker, Gregory A Worrell, Alvaro Pascual-Leone, Maria I Lapid

Objective: We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment.

Design: Systematic review, Meta-Analysis.

Setting: We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023.

Participants and interventions: RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included.

Measurement: Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423).

Results: The systematic review included 143 studies (n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer's Disease Assessment Scale-Cognitive Subscale (SMD = -0.96 [-1.32, -0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity.

Conclusion: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.

目的:我们旨在分析TMS对轻度认知障碍(MCI)、阿尔茨海默病(AD)、AD相关痴呆症以及合并认知障碍的非痴呆症患者认知能力的有效性和安全性:设计:系统回顾、元分析:我们检索了 2000 年 1 月 1 日至 2023 年 2 月 9 日期间的 MEDLINE、Embase、Cochrane 数据库、APA PsycINFO、Web of Science 和 Scopus:纳入了报告 TMS 干预后认知结果的 RCT、开放标签和病例系列研究:测量:认知和安全性结果。采用 Cochrane RCT 偏倚风险和 MINORS(非随机研究方法指数)标准评估研究质量。本研究已在 PROSPERO(CRD42022326423)注册:系统综述纳入了全球 143 项研究(n = 5800 名参与者),包括 94 项研究性临床试验、43 项开放标签前瞻性研究、3 项开放标签回顾性研究和 3 项病例系列研究。荟萃分析包括 25 项针对 MCI 和 AD 的研究。总体而言,这些研究提供的证据表明,在不同的诊断组别中,TMS 可改善整体和特定的认知指标。在 143 项研究中,只有 2 项研究报告了 4 次癫痫发作的不良事件:其中 3 项被认为与 TMS 无关,另一项则在线圈重新定位后得到解决。元分析显示,对 MCI 和 AD 的整体认知(迷你精神状态检查(SMD = 0.80 [0.26, 1.33],p = 0.003)、蒙特利尔认知评估(SMD = 0.85 [0.26, 1.44],p = 0.005)、阿尔茨海默病评估量表-认知分量表(SMD = -0.96 [-1.32, -0.60],p < 0.001))有较大的效应量,但存在显著的异质性:综述研究提供了有利的证据,证明TMS可改善所有认知障碍群体的认知能力。TMS安全且耐受性良好,很少发生严重不良反应。
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引用次数: 0
Euthanasia and Ageism 安乐死与老龄歧视
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-02 DOI: 10.1017/s1041610223002260
Manuel Martín-Carrasco
It is clear that old people do not necessarily lose their autonomy as they age and nor should they lose their rights to make their own decisions, including the right to request euthanasia or assisted suicide, if the Law of the jurisdiction allows it. However, there are also vulnerable elderly and there is a concern that frail older people could be coerced into ending their lives because of their fears about being a burden on either their family or society. This presentation analyses how ageism can influence the formation of the desire to die in the elderly, especially in those of greater physical and/or mental frailty
显然,老年人并不一定会随着年龄的增长而丧失自主权,他们也不应该丧失自己做决定的权利,包括在司法管辖区法律允许的情况下要求安乐死或协助自杀的权利。然而,也有一些脆弱的老年人,人们担心体弱的老年人会因为害怕成为家庭或社会的负担而被迫结束自己的生命。本讲座将分析年龄歧视如何影响老年人,尤其是身体和/或精神较为虚弱的老年人形成死亡的愿望。
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引用次数: 0
S9: Green care farms and other innovative care environments for older people living with dementia: concept, mechanisms and impact on residents S9:为老年痴呆症患者提供绿色护理农场和其他创新护理环境:概念、机制和对居民的影响
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-02 DOI: 10.1017/s1041610223002016
Hilde Verbeek
Key goals of the dementia care environment focus on increasing autonomy, supporting independence and trying to enable the own lifestyle of older people living with dementia for as long as possible. To meet these goals, innovative, small-scale and homelike care environments have been developed across the world that have radically changed of the physical, social and organizational aspects. This symposium presents examples of these facilities in the Netherlands (Green Care Farms) and Germany (Shared Housing Arrangements) for people living with dementia. These presentations cover the whole spectrum of long-term care from day-care services, assisted living facilities and nursing home care. It focuses on the concepts and their impact on older people living with dementia. Furthermore, it presents an overview of other innovative long-term care environments across the world, aiming to provide care for older people living with dementia. The first presentation will highlight working mechanisms of green care farms as alternative to nursing homes in the Netherlands and how these mechanisms can be transferred to other regular care settings. The second presentation focuses on the potential of green care farming as a daycare service for older people living with dementia from ethnic minority backgrounds. The third presentation discusses shared housing arrangements in Germany and has investigated the impact of a complex care intervention to reduce the number of hospital admissions for people living with dementia in these facilities. The final presentation provides an overview of international concepts of innovative care environments for older people living with dementia and gives insights in their characteristics.
痴呆症护理环境的主要目标是提高痴呆症老年人的自主性,支持其独立生活,并努力使其能够尽可能长时间地保持自己的生活方式。为了实现这些目标,世界各地开发出了创新型、小规模和家庭式的护理环境,从物质、社会和组织方面进行了彻底改变。本次研讨会介绍了荷兰(绿色护理农场)和德国(共享住房安排)为痴呆症患者提供的这些设施的实例。这些介绍涵盖了从日间护理服务、辅助生活设施到养老院护理等整个长期护理领域。报告的重点是概念及其对老年痴呆症患者的影响。此外,它还概述了世界各地旨在为痴呆症老年人提供护理的其他创新型长期护理环境。第一个演讲将重点介绍荷兰作为疗养院替代品的绿色护理农场的工作机制,以及如何将这些机制移植到其他常规护理环境中。第二个演讲将重点介绍绿色护理农场作为日托服务为少数民族背景的老年痴呆症患者提供服务的潜力。第三个发言讨论了德国的合住安排,并调查了复杂护理干预措施对减少这些设施中痴呆症患者入院次数的影响。最后一个发言概述了为老年痴呆症患者提供创新护理环境的国际概念,并深入分析了这些环境的特点。
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引用次数: 0
P67: Digital Technologies to Prevent Social Isolation and Loneliness in Dementia: A Systematic Review P67:防止痴呆症患者社交孤立和孤独的数字技术:系统回顾
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-02 DOI: 10.1017/s1041610223002971
Harleen Rai, David Kernaghan, Linda Schoonmade, Kieren J Egan, Anne Margriet Pot
Background:Dementia poses significant and sustained challenges to global society. Diagnosis can lead to increased feelings of loneliness and social isolation. People with dementia living alone are particularly at risk. Considering the growing number of technologies proposed to aid people with dementia address social isolation and loneliness, we reviewed the existing literature.Objective:To collate and summarize current evidence for digital technologies to prevent social isolation and loneliness for people with dementia.Methods:Following the PRISMA guidelines, we systematically searched five databases to identify studies of digital technologies designed to support or prevent social isolation or loneliness for people with dementia. Pre-specified outcomes included social isolation, loneliness, and quality of life. We used deductive thematic analysis to synthesize the major themes emerging from the studies.Results:Ten studies met our inclusion criteria where all studies reported improvements in quality of life and seven reported benefits regarding social inclusion or a reduction in loneliness. Technologies were varied across purpose, delivery format, theoretical models, and levels of personalization. Two studies clearly described the involvement of people with dementia in the study design and five technologies were available outside the research context.Conclusion:There is limited—but increasing—evidence that technologies hold potential to improve quality of life and reduce isolation/loneliness for people with dementia. Results presented are largely based in small-scale research studies. Involvement of people with dementia was limited and few research concepts are reaching implementation. Closer collaboration with people with dementia to provide affordable, inclusive, and person-centered solutions is urgently required.
背景:痴呆症给全球社会带来了持续的重大挑战。诊断可能导致孤独感和社会隔离感的增加。独居的痴呆症患者面临的风险尤其大。考虑到越来越多的技术被提出来帮助痴呆症患者解决社交孤立和孤独问题,我们对现有文献进行了回顾。目的:整理并总结当前有关数字技术预防痴呆症患者社交孤立和孤独的证据。方法:根据PRISMA指南,我们系统地检索了五个数据库,以确定有关旨在支持或预防痴呆症患者社交孤立或孤独的数字技术的研究。预先确定的结果包括社会隔离、孤独感和生活质量。结果:10 项研究符合我们的纳入标准,其中所有研究都报告了生活质量的改善情况,7 项研究报告了在社会包容或减少孤独感方面的益处。各种技术在目的、提供形式、理论模型和个性化程度方面各不相同。有两项研究清楚地描述了痴呆症患者参与研究设计的情况,有五项技术是在研究范围之外提供的。结论:有有限但越来越多的证据表明,技术具有改善痴呆症患者生活质量和减少孤独/寂寞的潜力。这些结果主要基于小规模的研究。痴呆症患者的参与程度有限,而且很少有研究概念能够付诸实施。当务之急是与痴呆症患者密切合作,提供负担得起、具有包容性和以人为本的解决方案。
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引用次数: 0
P107: Paranoid Ideation Without Psychosis Is Associated With Depression, Anxiety, and Suicide Attempts in General Population P107: 无精神病的妄想症与普通人群中的抑郁、焦虑和自杀企图有关
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-02 DOI: 10.1017/s1041610223003083
Kyoungae Kim, Eun Jin Na, Kwan Woo Choi, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hong Jin Jeon
This study aimed to characterize the association between paranoid ideation without psychosis (PIP) and suicide attempts in a general population. A total of 12,532 adults were randomly selected as the study sample through one-person-per-household method. Subjects completed a face-to-face interview. Among 12,532 subjects, 471 (3.76%) met criteria for the PIP group. The PIP group was younger with more divorced/widowed/separated and lower income than the non-PIP group. The PIP group showed more than fivefold higher lifetime suicide attempt (LSA) rates and ninefold multiple attempt rates than the non-PIP group. Among PIP symptoms, “spouse was being unfaithful” showed the strongest association with LSA (adjusted odds ratio [AOR], 4.49; 95% confidence interval, 2.95-6.85). Major depressive disorder (MDD) in combination with PIP was associated with a higher risk of LSA (AOR, 15.39; 95% confidence interval, 9.63-24.59) compared with subjects without MDD or PIP. In conclusion, PIP, especially “doubting spouse,” was significantly associated with LSA. PIP in combination with comorbid MDD showed higher risk of LSA than subjects without PIP or MDD.
本研究旨在描述普通人群中无精神病的偏执性意念(PIP)与自杀企图之间的关系。研究采用一人一户的方法,随机抽取了 12,532 名成年人作为研究样本。受试者完成了一次面对面的访谈。在 12,532 名受试者中,有 471 人(3.76%)符合 PIP 组的标准。与非 PIP 群体相比,PIP 群体更年轻,离婚/鳏寡/分居者更多,收入更低。与非 PIP 组相比,PIP 组的终生自杀未遂率(LSA)高出五倍多,多次自杀未遂率高出九倍。在 PIP 症状中,"配偶不忠 "与 LSA 的关系最为密切(调整后的几率比 [AOR],4.49;95% 置信区间,2.95-6.85)。重度抑郁障碍(MDD)合并 PIP 与无 MDD 或 PIP 的受试者相比,LSA 风险更高(AOR,15.39;95% 置信区间,9.63-24.59)。总之,PIP(尤其是 "怀疑配偶")与 LSA 有显著相关性。与没有 PIP 或 MDD 的受试者相比,PIP 合并 MDD 的受试者患 LSA 的风险更高。
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引用次数: 0
Mild behavioral impairment in prodromal Alzheimer´s disease and its association with APOE and BDNF risk genetic polymorphisms 阿尔茨海默病前驱期的轻度行为障碍及其与 APOE 和 BDNF 风险基因多态性的关系
IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-02-02 DOI: 10.1017/s1041610223001886
Veronika Matuskova, Katerina Veverova, Dylan Jester, Vaclav Matoska, Zahinoor Ismail, Katerina Sheardova, Hana Horakova, Jan Laczó, Jakub Hort, Martin Vyhnalek
Objective:We aimed to examine the profile and severity of mild behavioral impairment (MBI) in a sample of β-amyloid positive individuals with amnestic mild cognitive impairment (aMCI)compared to cognitively normal older adults (CN). Within aMCI, we further examined the potential influence of APOE and BDN Frisk genetic polymorphisms on MBI severity.Methods:We included 64 β-amyloid positive aMCI participants and 50 CN older adults from the Czech Brain Aging Study. The participants underwent neurological, comprehensive neuropsychological examination, APOE and BDNF genotyping, and magnetic resonance imaging.MBI was diagnosed with the Mild behavioral impairment checklist (MBI-C) developed for MBI case detection, and the diagnosis was based on the MBI-C total score ≥7. Additionally, self-report instruments for anxiety (the Beck Anxiety Inventory) and depressive symptoms (the Geriatric Depression Scale-15) were administered. The participants were stratified based on the presence of at least one risk allele in genes for APOE (i.e., e4 carriers and non-carriers) and BDNF (i.e., Met carriers and non-carriers). We used linear regressions to examine the between-group differences.Results:MBI symptoms (MBI-C total score ≥1) were present in 28% CN and 83% aMCI. Almost half (48.4%) of the aMCI individuals met the criteria for the MBI syndrome. Compared to the CN, the aMCI group displayed more affective, apathy, and impulse dyscontrol symptoms (p<0.001) but not social inappropriateness or psychotic symptoms. Furthermore, aMCI participants reported more depressive (p<0.01) but similar anxiety symptoms to CN on self-report measures. Within the aMCI group, APOE e4 and BDNF Met carriers did not differ from non-carriers in the severity of NPS in either instrument. However, the results suggested that an interaction between these polymorphisms influenced self-reported anxiety (p=0.034), with Met carriers/e4 non-carriers reporting the highest anxiety levels.Conclusion:MBI is frequent in prodromal Alzheimer´s disease and characterized by affective, apathy, and impulse dyscontrol symptoms. APOE and BDNF risk genetic polymorphisms did not influence the NPS severity when considered separately; however, their interaction might influence anxiety, which warrants further investigation.The research has received funding from the EEA/ Norway Grants 2014-2021 and the Technology Agency of the Czech Republic – project number TO01000215, Ministry of Health of the Czech Republic, grant no. 19-04-00560, National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) - funded by the European Union – Next Generation EU and GAČR 22-33968S.
目的:我们旨在研究β-淀粉样蛋白阳性的失忆性轻度认知障碍(aMCI)患者与认知正常的老年人(CN)相比,轻度行为障碍(MBI)的特征和严重程度。在 aMCI 中,我们进一步研究了 APOE 和 BDN Frisk 遗传多态性对 MBI 严重程度的潜在影响。方法:我们纳入了64名β-淀粉样蛋白阳性的aMCI参与者和50名捷克脑衰老研究中的CN老年人,对他们进行了神经学、综合神经心理学检查、APOE和BDNF基因分型以及磁共振成像检查。MBI的诊断依据是为MBI病例检测而开发的轻度行为障碍检查表(MBI-C),诊断标准是MBI-C总分≥7分。此外,还使用了焦虑(贝克焦虑量表)和抑郁症状(老年抑郁量表-15)的自我报告工具。根据 APOE(即 e4 携带者和非携带者)和 BDNF(即 Met 携带者和非携带者)基因中至少一个风险等位基因的存在情况,对参与者进行了分层。结果显示:28%的 CN 和 83% 的 aMCI 患者存在 MBI 症状(MBI-C 总分≥1)。近一半(48.4%)的 aMCI 患者符合 MBI 综合征的标准。与中国人相比,aMCI 组显示出更多的情感、冷漠和冲动控制障碍症状(p<0.001),但没有社交不当或精神病性症状。此外,aMCI 参与者报告的抑郁症状(p<0.01)更多,但自我报告的焦虑症状与 CN 相似。在 aMCI 组中,APOE e4 和 BDNF Met 携带者与非携带者在 NPS 的严重程度上没有任何差异。然而,研究结果表明,这些多态性之间的相互作用影响了自我报告的焦虑程度(p=0.034),Met 携带者/e4 非携带者报告的焦虑程度最高。APOE和BDNF风险基因多态性在单独考虑时不会影响NPS的严重程度;但是,它们之间的相互作用可能会影响焦虑,这值得进一步研究。该研究得到了欧洲经济区/挪威2014-2021年赠款、捷克共和国技术局(项目编号TO01000215)、捷克共和国卫生部(赠款编号19-04-00560)、国家神经学研究所(EXCELES计划,ID项目编号LX22NPO5107)的资助--由欧盟-下一代欧盟和GAČR 22-33968S资助。
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International psychogeriatrics
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