Pub Date : 2024-02-16DOI: 10.1017/S1041610223000960
Helen Lavretsky, Anne Margriet Pot
{"title":"Global crisis and mental health and well-being of older adults.","authors":"Helen Lavretsky, Anne Margriet Pot","doi":"10.1017/S1041610223000960","DOIUrl":"https://doi.org/10.1017/S1041610223000960","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1-2"},"PeriodicalIF":7.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.1017/S1041610224000371
Dylan J Jester, Kexin Yu
{"title":"Social Media Use is an Understated Social Determinant of Mental Health.","authors":"Dylan J Jester, Kexin Yu","doi":"10.1017/S1041610224000371","DOIUrl":"https://doi.org/10.1017/S1041610224000371","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1-5"},"PeriodicalIF":7.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.1017/S1041610224000395
Hanna E Bodde, Janne M Papma, Jackie M Poos
{"title":"Disentangling factors that influence the spousal relationship of people with young-onset dementia: starting points for person-centered care and support?","authors":"Hanna E Bodde, Janne M Papma, Jackie M Poos","doi":"10.1017/S1041610224000395","DOIUrl":"https://doi.org/10.1017/S1041610224000395","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1-8"},"PeriodicalIF":7.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-08DOI: 10.1017/S1041610224000085
Sandeep R Pagali, Rakesh Kumar, Allison M LeMahieu, Michael R Basso, Bradley F Boeve, Paul E Croarkin, Jennifer R Geske, Leslie C Hassett, John Huston, Simon Kung, Brian N Lundstrom, Ronald C Petersen, Erik K St Louis, Kirk M Welker, Gregory A Worrell, Alvaro Pascual-Leone, Maria I Lapid
Objective: We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment.
Design: Systematic review, Meta-Analysis.
Setting: We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023.
Participants and interventions: RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included.
Measurement: Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423).
Results: The systematic review included 143 studies (n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer's Disease Assessment Scale-Cognitive Subscale (SMD = -0.96 [-1.32, -0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity.
Conclusion: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.
{"title":"Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis.","authors":"Sandeep R Pagali, Rakesh Kumar, Allison M LeMahieu, Michael R Basso, Bradley F Boeve, Paul E Croarkin, Jennifer R Geske, Leslie C Hassett, John Huston, Simon Kung, Brian N Lundstrom, Ronald C Petersen, Erik K St Louis, Kirk M Welker, Gregory A Worrell, Alvaro Pascual-Leone, Maria I Lapid","doi":"10.1017/S1041610224000085","DOIUrl":"10.1017/S1041610224000085","url":null,"abstract":"<p><strong>Objective: </strong>We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment.</p><p><strong>Design: </strong>Systematic review, Meta-Analysis.</p><p><strong>Setting: </strong>We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023.</p><p><strong>Participants and interventions: </strong>RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included.</p><p><strong>Measurement: </strong>Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423).</p><p><strong>Results: </strong>The systematic review included 143 studies (<i>n</i> = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], <i>p</i> = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], <i>p</i> = 0.005), Alzheimer's Disease Assessment Scale-Cognitive Subscale (SMD = -0.96 [-1.32, -0.60], <i>p</i> < 0.001)) in MCI and AD, although with significant heterogeneity.</p><p><strong>Conclusion: </strong>The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1-49"},"PeriodicalIF":4.6,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1017/s1041610223002260
Manuel Martín-Carrasco
It is clear that old people do not necessarily lose their autonomy as they age and nor should they lose their rights to make their own decisions, including the right to request euthanasia or assisted suicide, if the Law of the jurisdiction allows it. However, there are also vulnerable elderly and there is a concern that frail older people could be coerced into ending their lives because of their fears about being a burden on either their family or society. This presentation analyses how ageism can influence the formation of the desire to die in the elderly, especially in those of greater physical and/or mental frailty
{"title":"Euthanasia and Ageism","authors":"Manuel Martín-Carrasco","doi":"10.1017/s1041610223002260","DOIUrl":"https://doi.org/10.1017/s1041610223002260","url":null,"abstract":"It is clear that old people do not necessarily lose their autonomy as they age and nor should they lose their rights to make their own decisions, including the right to request euthanasia or assisted suicide, if the Law of the jurisdiction allows it. However, there are also vulnerable elderly and there is a concern that frail older people could be coerced into ending their lives because of their fears about being a burden on either their family or society. This presentation analyses how ageism can influence the formation of the desire to die in the elderly, especially in those of greater physical and/or mental frailty","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"3 2 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139661869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1017/s1041610223002016
Hilde Verbeek
Key goals of the dementia care environment focus on increasing autonomy, supporting independence and trying to enable the own lifestyle of older people living with dementia for as long as possible. To meet these goals, innovative, small-scale and homelike care environments have been developed across the world that have radically changed of the physical, social and organizational aspects. This symposium presents examples of these facilities in the Netherlands (Green Care Farms) and Germany (Shared Housing Arrangements) for people living with dementia. These presentations cover the whole spectrum of long-term care from day-care services, assisted living facilities and nursing home care. It focuses on the concepts and their impact on older people living with dementia. Furthermore, it presents an overview of other innovative long-term care environments across the world, aiming to provide care for older people living with dementia. The first presentation will highlight working mechanisms of green care farms as alternative to nursing homes in the Netherlands and how these mechanisms can be transferred to other regular care settings. The second presentation focuses on the potential of green care farming as a daycare service for older people living with dementia from ethnic minority backgrounds. The third presentation discusses shared housing arrangements in Germany and has investigated the impact of a complex care intervention to reduce the number of hospital admissions for people living with dementia in these facilities. The final presentation provides an overview of international concepts of innovative care environments for older people living with dementia and gives insights in their characteristics.
{"title":"S9: Green care farms and other innovative care environments for older people living with dementia: concept, mechanisms and impact on residents","authors":"Hilde Verbeek","doi":"10.1017/s1041610223002016","DOIUrl":"https://doi.org/10.1017/s1041610223002016","url":null,"abstract":"Key goals of the dementia care environment focus on increasing autonomy, supporting independence and trying to enable the own lifestyle of older people living with dementia for as long as possible. To meet these goals, innovative, small-scale and homelike care environments have been developed across the world that have radically changed of the physical, social and organizational aspects. This symposium presents examples of these facilities in the Netherlands (Green Care Farms) and Germany (Shared Housing Arrangements) for people living with dementia. These presentations cover the whole spectrum of long-term care from day-care services, assisted living facilities and nursing home care. It focuses on the concepts and their impact on older people living with dementia. Furthermore, it presents an overview of other innovative long-term care environments across the world, aiming to provide care for older people living with dementia. The first presentation will highlight working mechanisms of green care farms as alternative to nursing homes in the Netherlands and how these mechanisms can be transferred to other regular care settings. The second presentation focuses on the potential of green care farming as a daycare service for older people living with dementia from ethnic minority backgrounds. The third presentation discusses shared housing arrangements in Germany and has investigated the impact of a complex care intervention to reduce the number of hospital admissions for people living with dementia in these facilities. The final presentation provides an overview of international concepts of innovative care environments for older people living with dementia and gives insights in their characteristics.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"14 2 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139661878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1017/s1041610223002971
Harleen Rai, David Kernaghan, Linda Schoonmade, Kieren J Egan, Anne Margriet Pot
Background:Dementia poses significant and sustained challenges to global society. Diagnosis can lead to increased feelings of loneliness and social isolation. People with dementia living alone are particularly at risk. Considering the growing number of technologies proposed to aid people with dementia address social isolation and loneliness, we reviewed the existing literature.Objective:To collate and summarize current evidence for digital technologies to prevent social isolation and loneliness for people with dementia.Methods:Following the PRISMA guidelines, we systematically searched five databases to identify studies of digital technologies designed to support or prevent social isolation or loneliness for people with dementia. Pre-specified outcomes included social isolation, loneliness, and quality of life. We used deductive thematic analysis to synthesize the major themes emerging from the studies.Results:Ten studies met our inclusion criteria where all studies reported improvements in quality of life and seven reported benefits regarding social inclusion or a reduction in loneliness. Technologies were varied across purpose, delivery format, theoretical models, and levels of personalization. Two studies clearly described the involvement of people with dementia in the study design and five technologies were available outside the research context.Conclusion:There is limited—but increasing—evidence that technologies hold potential to improve quality of life and reduce isolation/loneliness for people with dementia. Results presented are largely based in small-scale research studies. Involvement of people with dementia was limited and few research concepts are reaching implementation. Closer collaboration with people with dementia to provide affordable, inclusive, and person-centered solutions is urgently required.
{"title":"P67: Digital Technologies to Prevent Social Isolation and Loneliness in Dementia: A Systematic Review","authors":"Harleen Rai, David Kernaghan, Linda Schoonmade, Kieren J Egan, Anne Margriet Pot","doi":"10.1017/s1041610223002971","DOIUrl":"https://doi.org/10.1017/s1041610223002971","url":null,"abstract":"Background:Dementia poses significant and sustained challenges to global society. Diagnosis can lead to increased feelings of loneliness and social isolation. People with dementia living alone are particularly at risk. Considering the growing number of technologies proposed to aid people with dementia address social isolation and loneliness, we reviewed the existing literature.Objective:To collate and summarize current evidence for digital technologies to prevent social isolation and loneliness for people with dementia.Methods:Following the PRISMA guidelines, we systematically searched five databases to identify studies of digital technologies designed to support or prevent social isolation or loneliness for people with dementia. Pre-specified outcomes included social isolation, loneliness, and quality of life. We used deductive thematic analysis to synthesize the major themes emerging from the studies.Results:Ten studies met our inclusion criteria where all studies reported improvements in quality of life and seven reported benefits regarding social inclusion or a reduction in loneliness. Technologies were varied across purpose, delivery format, theoretical models, and levels of personalization. Two studies clearly described the involvement of people with dementia in the study design and five technologies were available outside the research context.Conclusion:There is limited—but increasing—evidence that technologies hold potential to improve quality of life and reduce isolation/loneliness for people with dementia. Results presented are largely based in small-scale research studies. Involvement of people with dementia was limited and few research concepts are reaching implementation. Closer collaboration with people with dementia to provide affordable, inclusive, and person-centered solutions is urgently required.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"7 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1017/s1041610223003083
Kyoungae Kim, Eun Jin Na, Kwan Woo Choi, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hong Jin Jeon
This study aimed to characterize the association between paranoid ideation without psychosis (PIP) and suicide attempts in a general population. A total of 12,532 adults were randomly selected as the study sample through one-person-per-household method. Subjects completed a face-to-face interview. Among 12,532 subjects, 471 (3.76%) met criteria for the PIP group. The PIP group was younger with more divorced/widowed/separated and lower income than the non-PIP group. The PIP group showed more than fivefold higher lifetime suicide attempt (LSA) rates and ninefold multiple attempt rates than the non-PIP group. Among PIP symptoms, “spouse was being unfaithful” showed the strongest association with LSA (adjusted odds ratio [AOR], 4.49; 95% confidence interval, 2.95-6.85). Major depressive disorder (MDD) in combination with PIP was associated with a higher risk of LSA (AOR, 15.39; 95% confidence interval, 9.63-24.59) compared with subjects without MDD or PIP. In conclusion, PIP, especially “doubting spouse,” was significantly associated with LSA. PIP in combination with comorbid MDD showed higher risk of LSA than subjects without PIP or MDD.
{"title":"P107: Paranoid Ideation Without Psychosis Is Associated With Depression, Anxiety, and Suicide Attempts in General Population","authors":"Kyoungae Kim, Eun Jin Na, Kwan Woo Choi, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hong Jin Jeon","doi":"10.1017/s1041610223003083","DOIUrl":"https://doi.org/10.1017/s1041610223003083","url":null,"abstract":"This study aimed to characterize the association between paranoid ideation without psychosis (PIP) and suicide attempts in a general population. A total of 12,532 adults were randomly selected as the study sample through one-person-per-household method. Subjects completed a face-to-face interview. Among 12,532 subjects, 471 (3.76%) met criteria for the PIP group. The PIP group was younger with more divorced/widowed/separated and lower income than the non-PIP group. The PIP group showed more than fivefold higher lifetime suicide attempt (LSA) rates and ninefold multiple attempt rates than the non-PIP group. Among PIP symptoms, “spouse was being unfaithful” showed the strongest association with LSA (adjusted odds ratio [AOR], 4.49; 95% confidence interval, 2.95-6.85). Major depressive disorder (MDD) in combination with PIP was associated with a higher risk of LSA (AOR, 15.39; 95% confidence interval, 9.63-24.59) compared with subjects without MDD or PIP. In conclusion, PIP, especially “doubting spouse,” was significantly associated with LSA. PIP in combination with comorbid MDD showed higher risk of LSA than subjects without PIP or MDD.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"24 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1017/s1041610223001886
Veronika Matuskova, Katerina Veverova, Dylan Jester, Vaclav Matoska, Zahinoor Ismail, Katerina Sheardova, Hana Horakova, Jan Laczó, Jakub Hort, Martin Vyhnalek
Objective:We aimed to examine the profile and severity of mild behavioral impairment (MBI) in a sample of β-amyloid positive individuals with amnestic mild cognitive impairment (aMCI)compared to cognitively normal older adults (CN). Within aMCI, we further examined the potential influence of APOE and BDN Frisk genetic polymorphisms on MBI severity.Methods:We included 64 β-amyloid positive aMCI participants and 50 CN older adults from the Czech Brain Aging Study. The participants underwent neurological, comprehensive neuropsychological examination, APOE and BDNF genotyping, and magnetic resonance imaging.MBI was diagnosed with the Mild behavioral impairment checklist (MBI-C) developed for MBI case detection, and the diagnosis was based on the MBI-C total score ≥7. Additionally, self-report instruments for anxiety (the Beck Anxiety Inventory) and depressive symptoms (the Geriatric Depression Scale-15) were administered. The participants were stratified based on the presence of at least one risk allele in genes for APOE (i.e., e4 carriers and non-carriers) and BDNF (i.e., Met carriers and non-carriers). We used linear regressions to examine the between-group differences.Results:MBI symptoms (MBI-C total score ≥1) were present in 28% CN and 83% aMCI. Almost half (48.4%) of the aMCI individuals met the criteria for the MBI syndrome. Compared to the CN, the aMCI group displayed more affective, apathy, and impulse dyscontrol symptoms (p<0.001) but not social inappropriateness or psychotic symptoms. Furthermore, aMCI participants reported more depressive (p<0.01) but similar anxiety symptoms to CN on self-report measures. Within the aMCI group, APOE e4 and BDNF Met carriers did not differ from non-carriers in the severity of NPS in either instrument. However, the results suggested that an interaction between these polymorphisms influenced self-reported anxiety (p=0.034), with Met carriers/e4 non-carriers reporting the highest anxiety levels.Conclusion:MBI is frequent in prodromal Alzheimer´s disease and characterized by affective, apathy, and impulse dyscontrol symptoms. APOE and BDNF risk genetic polymorphisms did not influence the NPS severity when considered separately; however, their interaction might influence anxiety, which warrants further investigation.The research has received funding from the EEA/ Norway Grants 2014-2021 and the Technology Agency of the Czech Republic – project number TO01000215, Ministry of Health of the Czech Republic, grant no. 19-04-00560, National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) - funded by the European Union – Next Generation EU and GAČR 22-33968S.
目的:我们旨在研究β-淀粉样蛋白阳性的失忆性轻度认知障碍(aMCI)患者与认知正常的老年人(CN)相比,轻度行为障碍(MBI)的特征和严重程度。在 aMCI 中,我们进一步研究了 APOE 和 BDN Frisk 遗传多态性对 MBI 严重程度的潜在影响。方法:我们纳入了64名β-淀粉样蛋白阳性的aMCI参与者和50名捷克脑衰老研究中的CN老年人,对他们进行了神经学、综合神经心理学检查、APOE和BDNF基因分型以及磁共振成像检查。MBI的诊断依据是为MBI病例检测而开发的轻度行为障碍检查表(MBI-C),诊断标准是MBI-C总分≥7分。此外,还使用了焦虑(贝克焦虑量表)和抑郁症状(老年抑郁量表-15)的自我报告工具。根据 APOE(即 e4 携带者和非携带者)和 BDNF(即 Met 携带者和非携带者)基因中至少一个风险等位基因的存在情况,对参与者进行了分层。结果显示:28%的 CN 和 83% 的 aMCI 患者存在 MBI 症状(MBI-C 总分≥1)。近一半(48.4%)的 aMCI 患者符合 MBI 综合征的标准。与中国人相比,aMCI 组显示出更多的情感、冷漠和冲动控制障碍症状(p<0.001),但没有社交不当或精神病性症状。此外,aMCI 参与者报告的抑郁症状(p<0.01)更多,但自我报告的焦虑症状与 CN 相似。在 aMCI 组中,APOE e4 和 BDNF Met 携带者与非携带者在 NPS 的严重程度上没有任何差异。然而,研究结果表明,这些多态性之间的相互作用影响了自我报告的焦虑程度(p=0.034),Met 携带者/e4 非携带者报告的焦虑程度最高。APOE和BDNF风险基因多态性在单独考虑时不会影响NPS的严重程度;但是,它们之间的相互作用可能会影响焦虑,这值得进一步研究。该研究得到了欧洲经济区/挪威2014-2021年赠款、捷克共和国技术局(项目编号TO01000215)、捷克共和国卫生部(赠款编号19-04-00560)、国家神经学研究所(EXCELES计划,ID项目编号LX22NPO5107)的资助--由欧盟-下一代欧盟和GAČR 22-33968S资助。
{"title":"Mild behavioral impairment in prodromal Alzheimer´s disease and its association with APOE and BDNF risk genetic polymorphisms","authors":"Veronika Matuskova, Katerina Veverova, Dylan Jester, Vaclav Matoska, Zahinoor Ismail, Katerina Sheardova, Hana Horakova, Jan Laczó, Jakub Hort, Martin Vyhnalek","doi":"10.1017/s1041610223001886","DOIUrl":"https://doi.org/10.1017/s1041610223001886","url":null,"abstract":"Objective:We aimed to examine the profile and severity of mild behavioral impairment (MBI) in a sample of β-amyloid positive individuals with amnestic mild cognitive impairment (aMCI)compared to cognitively normal older adults (CN). Within aMCI, we further examined the potential influence of APOE and BDN Frisk genetic polymorphisms on MBI severity.Methods:We included 64 β-amyloid positive aMCI participants and 50 CN older adults from the Czech Brain Aging Study. The participants underwent neurological, comprehensive neuropsychological examination, APOE and BDNF genotyping, and magnetic resonance imaging.MBI was diagnosed with the Mild behavioral impairment checklist (MBI-C) developed for MBI case detection, and the diagnosis was based on the MBI-C total score ≥7. Additionally, self-report instruments for anxiety (the Beck Anxiety Inventory) and depressive symptoms (the Geriatric Depression Scale-15) were administered. The participants were stratified based on the presence of at least one risk allele in genes for APOE (i.e., e4 carriers and non-carriers) and BDNF (i.e., Met carriers and non-carriers). We used linear regressions to examine the between-group differences.Results:MBI symptoms (MBI-C total score ≥1) were present in 28% CN and 83% aMCI. Almost half (48.4%) of the aMCI individuals met the criteria for the MBI syndrome. Compared to the CN, the aMCI group displayed more affective, apathy, and impulse dyscontrol symptoms (p<0.001) but not social inappropriateness or psychotic symptoms. Furthermore, aMCI participants reported more depressive (p<0.01) but similar anxiety symptoms to CN on self-report measures. Within the aMCI group, APOE e4 and BDNF Met carriers did not differ from non-carriers in the severity of NPS in either instrument. However, the results suggested that an interaction between these polymorphisms influenced self-reported anxiety (p=0.034), with Met carriers/e4 non-carriers reporting the highest anxiety levels.Conclusion:MBI is frequent in prodromal Alzheimer´s disease and characterized by affective, apathy, and impulse dyscontrol symptoms. APOE and BDNF risk genetic polymorphisms did not influence the NPS severity when considered separately; however, their interaction might influence anxiety, which warrants further investigation.The research has received funding from the EEA/ Norway Grants 2014-2021 and the Technology Agency of the Czech Republic – project number TO01000215, Ministry of Health of the Czech Republic, grant no. 19-04-00560, National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) - funded by the European Union – Next Generation EU and GAČR 22-33968S.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"22 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139667043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}