International Wound Journal最新文献

Pressure ulcers (PUs) impose a significant economic burden on healthcare systems, affecting patient quality of life and leading to substantial treatment costs. This study presents a cost-of-illness analysis of PU treatment in hospitalized patients in the Czech Republic, based on real-world clinical data. The analysis was conducted using a comprehensive methodology at a Czech university hospital, involving 304 hospitalizations. The study included all hospitalized patients with PUs. Data were collected employing a bottom-up, person-based approach, which refers to the collection and analysis of cost data at the individual patient level. This method captures detailed resource utilization for each patient. The methodology accounted for both systemic and local costs, including materials, medications, caregiver time, and procedures. The study involved 304 hospitalizations, with a mean length of stay of 13 days. The total cost of PU treatment, excluding pharmacotherapy, had a median of €678, while including pharmacotherapy, the median cost rose to €929. Younger patients incurred higher treatment costs. Significant cost variations were observed among different departments. We developed and applied a novel cost model to quantify the expenses associated with PUs, which accurately highlighted the financial burden in the hospital care setting. We present a rigorous methodology for PU cost-of-illness analysis, providing a valuable tool for future research and clinical practice. This comprehensive approach supports the development of targeted interventions to reduce the incidence and severity of PUs, ultimately improving patient care and reducing healthcare costs.

Retraction: J. Liu, C. Fu, Z. Chen, and G. Li, "Perineal Wound Complications After Vertical Rectus Abdominis Myocutaneous Flap and Mesh Closure Following Abdominoperineal Surgery and Pelvic Exenteration of Anal and Rectal Cancers: A Meta-Analysis," International Wound Journal 20, no. 10 (2023): 3963-3973, https://doi.org/10.1111/iwj.14284. The above article, published online on 04 August 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. In addition, the investigation found unattributed textual overlap between this article and another article by different authors (Buscail, et al. 2021 [https://doi.org/10.3390/cancers13040721]). The editors have therefore decided to retract the article. The authors disagree with the retraction.

Retraction: S. Zhu, J. Gao, W. Yu, J. Xiong, "Platelet-Rich Plasma Influence on the Sternal Wounds Healing: A Meta-Analysis," International Wound Journal 20, no. 9 (2023): 3794-3801, https://doi.org/10.1111/iwj.14279. The above article, published online on 23 June 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. Author S. Zhu disagrees with the retraction. All other authors did not respond to the notice regarding the retraction.

Negative pressure wound therapy is used often in the management of surgical incisions, chronic wounds and subacute lesions, and there are numerous publications discussing its clinical application and outcomes. However, whilst clinical use and associated literature have expanded since these systems became commercially available in the 90s, important research and discussion around the mode of action have waned, leading to a deficit in the understanding of how this important therapy influences healing. Further, much research and many publications are predominantly reflective, discussing early theorem, some of which have been proven incorrect, or at least not fully resolved leading to misunderstandings as to how the therapy works, thus potentially denying the clinician the opportunity to optimise use towards improved clinical and economic outcomes. In this narrative review, we discuss established beliefs and challenges to same where appropriate and introduce important new research that addresses the manner in which mechanical strain energy (i.e., deformations) is transferred to tissue and how this influences biological response and healing. In addition, we assess and discuss the effect of different negative pressure dressing formats, how they influence the mode of action and how this understanding can lead to more efficient and effective use and clinical economic outcomes.

Using a 6-week porcine full-thickness excisional wound grafting model, we evaluated the Autologous Regeneration of Tissue (ART®) System, a novel skin harvesting device designed to collect autologous full-thickness autologous microcolumns (FTAM) at 0.5 mm in diameter. The donor skin sites were harvested using the ART® System and compared to split-thickness skin grafts (STSGs). Recipient sites were divided into three treatment groups: FTAM, STSG and Untreated control. Comparing the FTAM donor sites to the STSG donor sites, we observed significantly faster re-epithelization by Day 4 (p < 0.05), earlier adnexal structures and rete ridge formation by Week 3, and increased collagen and elastin content by Week 6. We also observed an increased rate of healing at the FTAM donor site whilst limiting donor site morbidity compared to traditional STSG donor sites. Time to recipient site closure was 2.4 weeks for STSG treated, 3.3 weeks for FTAM treated and 4.1 weeks for the Untreated control (p < 0.05). The STSG and FTAM recipient sites reached complete re-epithelialization by Weeks 4 and 5, respectively which was significantly faster compared to the Untreated control. However, the FTAM recipient site received only 10% of the donor site tissue relative to the recipient site area and the amount of donor site tissue grafted on the STSG recipient sites was 5× more than the FTAM recipient sites. Additionally, the FTAMs harvested by the ART® System augmented recipient wound site healing as a result of ‘epithelial island’ expansion in contrast to Untreated control sites that closed primarily by contracture.

The objective of the study was to show the clinical performance and cost-effectiveness of a Silicone foam dressing with 3DFit™ Technology compared to current standard of care. This was an open-labelled, two-arm, randomised controlled multicentre study conducted from February to December 2023. One hundred and two participants with an exuding, non-infected and chronic ulcer were randomised in a 1:1 fashion and treated with either a Silicone foam with 3DFit™ Technology or standard of care (a filler combined with a secondary dressing), stratified by venous leg ulcers and diabetic foot ulcers. After a 4-week study period, wound size and total costs were evaluated. After 4 weeks of treatment, a comparable percentage in wound area reduction was observed in both treatment arms with mean and 95% confidence interval of 54.3% (37.1%; 71.5%) and 43.0% (26.5%; 59.6%) for the investigational and comparator dressing, respectively. This corresponded to a mean difference of 11.3% ([−10.22; 32.86], p = 0.299). Total mean estimated costs were significantly lower for the investigational dressing (£14.3, 95% confidence interval [£9.6; £19.0]) compared to the two-dressing regime (£21.4 [£16.9; £26.0]), corresponding to a 33% price reduction (p = 0.033) after 4 weeks of treatment. With this RCT, a conforming Silicone foam dressing with 3DFit™ Technology was shown to be clinically comparable and a cost-effective alternative to using a filler and a secondary dressing at a significantly lower cost in both venous leg ulcers and diabetic foot ulcers up to 2 cm in depth.

RETRACTION: J. Han and X.-J. Liu, “ Effects of Application of the Clinical Nursing Pathway on Surgical Site Wound Infection and Postoperative Complication Rates in Patients with Total Knee Arthroplasty: A Meta-Analysis,” International Wound Journal 21, no. 2 (2024): e14469, https://doi.org/10.1111/iwj.14469.

The above article, published online on 27 October 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.

RETRACTION: Y.-B. Xu, Z.-Q. Chen, X.-H. Su, and Y. Cao, “ Influences of Evidence-Based Nursing Intervention on Pressure Ulcers in Intensive Care Units: A Meta-Analysis,” International Wound Journal 21, no. 4 (2024): e14834, https://doi.org/10.1111/iwj.14834.

The above article, published online on 22 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors disagree with the retraction.

Friction blisters are common among outdoor enthusiasts, yet their causes remain uncertain. This study aimed to compare foot hydration in long-distance hikers with and without blisters, and to assess variability based on age and sex. An observational case–control study involving 86 hikers was conducted. Skin hydration was measured using a corneometer on various foot zones. Data on blister count, footwear, sex, age, and temperature were recorded. The most hydrated zones were the digital area, forefoot, and heel. Higher hydration was found in the blister group (61.6%) compared to the control group (38.4%). A significant relationship between hydration and blisters was observed in the left foot (p = 0.032). Total foot hydration was higher in women (p = 0.007) and inversely related to age (r = −0.333; p = 0.002). Hydration values above 30.40 a.u. in the right foot and 27.37 a.u. in the left foot were linked to blisters with 80% sensitivity. This study highlights the variability in foot hydration and its relationship with blisters. The influence of age and wet socks underscores the complexity of blister formation, emphasizing the need for future research on effective prevention.