Pub Date : 2024-01-06DOI: 10.22141/2224-0713.19.7.2023.1025
S.K. Byelyavsky, B.M. Borysov, V. I. Lutsenko, K.F. Trinus, M. Trishchynska, L.M. Shipilo
We have studied the influence of neurological loadings on heart rate (HR) in patients with dizziness and correlations between types of dizziness and changes in the electrocardiography (ECG) parameters. Two hundred and twenty-one patients aged 44.82 ± 14.15 years were examined. ECG and HR have been recorded before and after neurological loadings: calculation, Takahashi, tracking, lowering the bed and diadochokinesis. All the tests resulted in HR changes. The data obtained have been discussed from the point of view of somatomorphic disorders, cardiac neurosis (F45.3 according to ICD-10) and the possibility of their detection in patients with cardiac complaints in whom ECG studies did not reveal any abnormalities. Correlations between certain types of dizziness and ECG interval indicators are discussed.
{"title":"Electrocardiogram in different types of dizziness","authors":"S.K. Byelyavsky, B.M. Borysov, V. I. Lutsenko, K.F. Trinus, M. Trishchynska, L.M. Shipilo","doi":"10.22141/2224-0713.19.7.2023.1025","DOIUrl":"https://doi.org/10.22141/2224-0713.19.7.2023.1025","url":null,"abstract":"We have studied the influence of neurological loadings on heart rate (HR) in patients with dizziness and correlations between types of dizziness and changes in the electrocardiography (ECG) parameters. Two hundred and twenty-one patients aged 44.82 ± 14.15 years were examined. ECG and HR have been recorded before and after neurological loadings: calculation, Takahashi, tracking, lowering the bed and diadochokinesis. All the tests resulted in HR changes. The data obtained have been discussed from the point of view of somatomorphic disorders, cardiac neurosis (F45.3 according to ICD-10) and the possibility of their detection in patients with cardiac complaints in whom ECG studies did not reveal any abnormalities. Correlations between certain types of dizziness and ECG interval indicators are discussed.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"9 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139380285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-06DOI: 10.22141/2224-0713.19.7.2023.1026
F. Hladkykh
Background. Demyelinating diseases of the central nervous system (CNS) are a heterogeneous group of disorders characterized by a damage to the myelin sheath of nerve cell axons. Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the CNS affecting more than 2.9 million people worldwide. The purpose was to summarize current information about the features of the immunopathogenesis of multiple sclerosis according to the data from open sources of information. Materials and methods. The selection of publications covering the features of the immunopathogenesis of multiple sclerosis was carried out in the PubMed, Clinical Key Elsevier, Cochrane Library, eBook Business Collection and Google Scholar databases using the following keywords: multiple sclerosis, demyelinating diseases, neurodegeneration, oligodendrocytes. Results. The course of MS has three successive phases/forms known as relapsing-remitting, primary progressive and secondary progressive. Abnormalities of immune mechanisms are proposed as protagonists of the pathogenesis of MS. Autoreactive myelin-specific lymphocytes are activated outside the CNS, they cross the blood-brain barrier and form new inflammatory demyelinating lesions. The myelinating oligodendrocyte is a target during the adaptive immune response in MS. The inflammatory reaction in the brain of patients with progressive MS is observed mainly in the large connective tissues of the meninges and the periventricular space. Treatment of MS can be divided into three categories: treatment of acute relapse, disease-modifying treatment, and symptomatic treatment. Conclusions. On the T cell side, both hel-per (CD4+) and cytotoxic (CD8+) T cells are involved in the CNS damage in MS. Peripherally activated subsets of T cells (CD4+ Th1 and Th17, CD8+) migrate through the blood-brain barrier and activate B-cells and macrophages, which causes a neuroinflammatory reaction and leads to demyelination and neurodegeneration in the CNS. Oligodendrocyte progenitor cells, which are widely distributed throughout the CNS, mediate myelination and remyelination. One of the desired features of new methods for treating MS is the restoration of antigen-specific tolerance.
背景。中枢神经系统（CNS）脱髓鞘疾病是一类以神经细胞轴突髓鞘受损为特征的异质性疾病。多发性硬化症（MS）是中枢神经系统最常见的慢性炎症性脱髓鞘疾病，影响着全球 290 多万人。本研究的目的是根据公开信息来源的数据，总结目前有关多发性硬化症免疫发病机制特征的信息。材料和方法。使用以下关键词在 PubMed、Clinical Key Elsevier、Cochrane Library、eBook Business Collection 和 Google Scholar 数据库中筛选涉及多发性硬化症免疫发病机制特征的出版物：多发性硬化症、脱髓鞘疾病、神经变性、少突胶质细胞。研究结果多发性硬化症的病程分为三个连续的阶段/形式，即复发缓解期、原发性进展期和继发性进展期。免疫机制异常被认为是多发性硬化症发病机制的主角。自反应性髓鞘特异性淋巴细胞在中枢神经系统外被激活，它们穿过血脑屏障，形成新的炎性脱髓鞘病变。在多发性硬化症的适应性免疫反应中，髓鞘化少突胶质细胞是一个靶点。进行性多发性硬化症患者脑部的炎症反应主要发生在脑膜的大结缔组织和脑室周围间隙。多发性硬化症的治疗可分为三类：急性复发治疗、疾病改变治疗和对症治疗。结论在T细胞方面，hel-per（CD4+）和细胞毒性（CD8+）T细胞都参与了多发性硬化症的中枢神经系统损伤。外周激活的 T 细胞亚群（CD4+ Th1 和 Th17，CD8+）通过血脑屏障迁移，激活 B 细胞和巨噬细胞，从而引起神经炎症反应，导致中枢神经系统脱髓鞘和神经变性。在中枢神经系统中广泛分布的少突胶质祖细胞介导髓鞘化和再髓鞘化。治疗多发性硬化症的新方法所需的特征之一是恢复抗原特异性耐受。
{"title":"The role of autoimmune processes in demyelinating diseases of the nervous system: focus on multiple sclerosis","authors":"F. Hladkykh","doi":"10.22141/2224-0713.19.7.2023.1026","DOIUrl":"https://doi.org/10.22141/2224-0713.19.7.2023.1026","url":null,"abstract":"Background. Demyelinating diseases of the central nervous system (CNS) are a heterogeneous group of disorders characterized by a damage to the myelin sheath of nerve cell axons. Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the CNS affecting more than 2.9 million people worldwide. The purpose was to summarize current information about the features of the immunopathogenesis of multiple sclerosis according to the data from open sources of information. Materials and methods. The selection of publications covering the features of the immunopathogenesis of multiple sclerosis was carried out in the PubMed, Clinical Key Elsevier, Cochrane Library, eBook Business Collection and Google Scholar databases using the following keywords: multiple sclerosis, demyelinating diseases, neurodegeneration, oligodendrocytes. Results. The course of MS has three successive phases/forms known as relapsing-remitting, primary progressive and secondary progressive. Abnormalities of immune mechanisms are proposed as protagonists of the pathogenesis of MS. Autoreactive myelin-specific lymphocytes are activated outside the CNS, they cross the blood-brain barrier and form new inflammatory demyelinating lesions. The myelinating oligodendrocyte is a target during the adaptive immune response in MS. The inflammatory reaction in the brain of patients with progressive MS is observed mainly in the large connective tissues of the meninges and the periventricular space. Treatment of MS can be divided into three categories: treatment of acute relapse, disease-modifying treatment, and symptomatic treatment. Conclusions. On the T cell side, both hel-per (CD4+) and cytotoxic (CD8+) T cells are involved in the CNS damage in MS. Peripherally activated subsets of T cells (CD4+ Th1 and Th17, CD8+) migrate through the blood-brain barrier and activate B-cells and macrophages, which causes a neuroinflammatory reaction and leads to demyelination and neurodegeneration in the CNS. Oligodendrocyte progenitor cells, which are widely distributed throughout the CNS, mediate myelination and remyelination. One of the desired features of new methods for treating MS is the restoration of antigen-specific tolerance.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139380507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.22141/2224-0713.19.6.2023.1018
K.V. Duve
Background. Given the synergistic effect of the ACE and AT2R1 genes and their impact on the maintenance of homeostatic processes, the aim of our research was to identify the associations of the studied polymorphic variants of the ACE and AT2R1 genes with neuroimaging changes, data from arterial duplex ultrasound and cognitive functioning in patients with chronic vascular encephalopathy (CVE). Materials and methods. A retrospective analysis of 145 medical records of patients with CVE was conducted, of which 18 patients underwent a molecular genetic study. The control group consisted of 12 people representative in terms of age and gender. Neuroimaging was performed using multislice computed tomography or magnetic resonance imaging. The state of cerebral blood flow was studied using transcranial duplex ultrasound of intracranial and extracranial vessels. The cognitive functioning was tested using the Montreal Cognitive Assessment. Results. When analyzing the associations of polymorphic I/D variants of the ACE gene and A1166C of the AT2R1 gene with neuroimaging changes and parameters of cerebral hemodynamics in CVE among carriers of I and D alleles of the ACE gene, a probable relationship was found between their frequency distribution and the presence/absence of gliosis phenomena (62.69 % of D allele carriers were diagnosed with gliosis, p < 0.05); a probable relationship between the frequency distribution of the D/D genotype of the ACE gene and the presence of angiospasm (in 72.73 % of patients), insufficiency of blood flow in the carotid system (72.73 % of cases) and vertebrobasilar insufficiency (in 36.36 % of people). When evaluating the dependence of cognitive functions based on the Montreal Cognitive Assessment score in patients with CVE on the polymorphic I/D variants of the ACE gene and A1166C of the AT2R1 gene, probable changes were revealed in the frequency distribution of genotypes and alleles of the polymorphic I/D variant of the ACE gene (χ2 = 11.33; p = 0.023), while all carriers of the D/D genotype have impaired cognitive functioning (moderate in 36.36 % and mild in 63.64 % of cases), which also corresponds to the frequency of the D allele distribution in this cohort of patients (29.63 % of people have a moderate cognitive impairment and 70.37 % — a mild cognitive impairment, p = 0.013). Conclusions. The study results indicate that the ACE gene may be involved in the development of neuroimaging changes and cognitive decline in CVE.
{"title":"ACE and AT2R1 gene polymorphism in patients with chronic vascular encephalopathy: association with neuroimaging changes and cognitive functioning","authors":"K.V. Duve","doi":"10.22141/2224-0713.19.6.2023.1018","DOIUrl":"https://doi.org/10.22141/2224-0713.19.6.2023.1018","url":null,"abstract":"Background. Given the synergistic effect of the ACE and AT2R1 genes and their impact on the maintenance of homeostatic processes, the aim of our research was to identify the associations of the studied polymorphic variants of the ACE and AT2R1 genes with neuroimaging changes, data from arterial duplex ultrasound and cognitive functioning in patients with chronic vascular encephalopathy (CVE). Materials and methods. A retrospective analysis of 145 medical records of patients with CVE was conducted, of which 18 patients underwent a molecular genetic study. The control group consisted of 12 people representative in terms of age and gender. Neuroimaging was performed using multislice computed tomography or magnetic resonance imaging. The state of cerebral blood flow was studied using transcranial duplex ultrasound of intracranial and extracranial vessels. The cognitive functioning was tested using the Montreal Cognitive Assessment. Results. When analyzing the associations of polymorphic I/D variants of the ACE gene and A1166C of the AT2R1 gene with neuroimaging changes and parameters of cerebral hemodynamics in CVE among carriers of I and D alleles of the ACE gene, a probable relationship was found between their frequency distribution and the presence/absence of gliosis phenomena (62.69 % of D allele carriers were diagnosed with gliosis, p < 0.05); a probable relationship between the frequency distribution of the D/D genotype of the ACE gene and the presence of angiospasm (in 72.73 % of patients), insufficiency of blood flow in the carotid system (72.73 % of cases) and vertebrobasilar insufficiency (in 36.36 % of people). When evaluating the dependence of cognitive functions based on the Montreal Cognitive Assessment score in patients with CVE on the polymorphic I/D variants of the ACE gene and A1166C of the AT2R1 gene, probable changes were revealed in the frequency distribution of genotypes and alleles of the polymorphic I/D variant of the ACE gene (χ2 = 11.33; p = 0.023), while all carriers of the D/D genotype have impaired cognitive functioning (moderate in 36.36 % and mild in 63.64 % of cases), which also corresponds to the frequency of the D allele distribution in this cohort of patients (29.63 % of people have a moderate cognitive impairment and 70.37 % — a mild cognitive impairment, p = 0.013). Conclusions. The study results indicate that the ACE gene may be involved in the development of neuroimaging changes and cognitive decline in CVE.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"29 38","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.22141/2224-0713.19.6.2023.1017
O.V. Tkachenko, O.V. Demydas
Somatic-neurological and psychosomatic relationships are an integral part of the pathophysiological mechanisms in numerous diseases. The results of one of the fragments of a comprehensive clinical and paraclinical study of the nervous system state indexes in active duodenal ulcer (DU) are reported. It aimed to assess the effect of Helicobacter pylori (H.pylori) on clinical-neurological and laboratory indexes. Sixty persons with an average age of 39.80 ± 1.29 years were examined. The patients were divided into two groups based on H.pylori presence or absence. The examinations included the following: analysis of complaints according to the developed questionnaire, neurological status assessment, autonomic dysfunction analysis (by A.M. Vayn questionnaire), complete blood count, evaluating the levels of C-reactive protein, total cholesterol, urea and creatinine in blood, neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio calculation. The appropriate statistical methods were used for data processing. It was found that complaints of headache, dizziness and paresthesia as well as asthenodepressive syndrome and polyneuropathy of various severity and with different clinical manifestations were more common (p < 0.05) in patients with active DU on the background of Н.pylori. Sympathicotonia was significantly more frequent and eutonia was significantly less frequent in the active DU in patients infected with Н.pylori. An increased C-reactive protein level was significantly more common in Н.pylori patients. The identified neurological and laboratory features indicate a probable pathophysiological significance of Н.pylori in somatoneurological relationships, particularly in DU.
{"title":"Some neurological and laboratory indexes in active duodenal ulcer depending on Helicobacter pylori presence","authors":"O.V. Tkachenko, O.V. Demydas","doi":"10.22141/2224-0713.19.6.2023.1017","DOIUrl":"https://doi.org/10.22141/2224-0713.19.6.2023.1017","url":null,"abstract":"Somatic-neurological and psychosomatic relationships are an integral part of the pathophysiological mechanisms in numerous diseases. The results of one of the fragments of a comprehensive clinical and paraclinical study of the nervous system state indexes in active duodenal ulcer (DU) are reported. It aimed to assess the effect of Helicobacter pylori (H.pylori) on clinical-neurological and laboratory indexes. Sixty persons with an average age of 39.80 ± 1.29 years were examined. The patients were divided into two groups based on H.pylori presence or absence. The examinations included the following: analysis of complaints according to the developed questionnaire, neurological status assessment, autonomic dysfunction analysis (by A.M. Vayn questionnaire), complete blood count, evaluating the levels of C-reactive protein, total cholesterol, urea and creatinine in blood, neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio calculation. The appropriate statistical methods were used for data processing. It was found that complaints of headache, dizziness and paresthesia as well as asthenodepressive syndrome and polyneuropathy of various severity and with different clinical manifestations were more common (p < 0.05) in patients with active DU on the background of Н.pylori. Sympathicotonia was significantly more frequent and eutonia was significantly less frequent in the active DU in patients infected with Н.pylori. An increased C-reactive protein level was significantly more common in Н.pylori patients. The identified neurological and laboratory features indicate a probable pathophysiological significance of Н.pylori in somatoneurological relationships, particularly in DU.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"1 S1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135340428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.22141/2224-0713.19.6.2023.1016
A.Ya. Sabovchyk, M.M. Oros
Background. The article examines the relationship between nerve conduction indicators and polyneuropathy severity in patients with type 2 diabetes. The influence of polyneuropathy severity on nerve conduction was studied, as well as the effect of insulin therapy on these indicators. Objective: to determine the influence of polyneuropathy severity and the need for additional insulin administration in patients with type 2 diabetes on nerve conduction indicators and the development of pain syndrome. Materials and methods. Eighty patients with type 2 diabetes were examined, 49 men and 31 women. All of them underwent general clinical and biochemical laboratory tests to evaluate the hematopoietic system, li-ver, kidneys, fat and carbohydrate metabolism. The need for insulin therapy was assessed by the C-peptide level. To verify the diagnosis of diabetic polyneuropathy, complaints, clinical and instrumental examination data were evaluated. The main indicators of nerve conduction were taken into account when determining polyneuritis disorders, namely: рeroneal motor nerve conduction velocity, sensory nerve action potential of the sural nerve, sensory nerve conduction velocity of the sural nerve. Results. A dependence of nerve conduction on polyneuropathy severity was revealed, рeroneal motor nerve conduction velocity was the lowest in the group with severe polyneuropathy. A correlation was also found between the levels of sensory indicators (sensory nerve action potential and sensory nerve conduction velocity) and polyneuropathy severity, nerve conduction velocity decreases with an increase in the latter. The influence of polyneuropathy severity on the painful or painless form has been found. Among patients with severe polyneuropathy, the painful form was observed more often. No relationship was found between the need for insulin therapy and the painful or painless form of polyneuropathy. Conclusions. Indicators of nerve conduction depend on polyneuropathy severity. The presence and severity of pain syndrome directly depends on polyneuropathy severity. The need for additional insulin administration affects sensory indicators but has no effect on the development of the painful form of polyneuropathy.
{"title":"The effect of polyneuropathy severity on nerve conduction and pain syndrome in patients with type 2 diabetes","authors":"A.Ya. Sabovchyk, M.M. Oros","doi":"10.22141/2224-0713.19.6.2023.1016","DOIUrl":"https://doi.org/10.22141/2224-0713.19.6.2023.1016","url":null,"abstract":"Background. The article examines the relationship between nerve conduction indicators and polyneuropathy severity in patients with type 2 diabetes. The influence of polyneuropathy severity on nerve conduction was studied, as well as the effect of insulin therapy on these indicators. Objective: to determine the influence of polyneuropathy severity and the need for additional insulin administration in patients with type 2 diabetes on nerve conduction indicators and the development of pain syndrome. Materials and methods. Eighty patients with type 2 diabetes were examined, 49 men and 31 women. All of them underwent general clinical and biochemical laboratory tests to evaluate the hematopoietic system, li-ver, kidneys, fat and carbohydrate metabolism. The need for insulin therapy was assessed by the C-peptide level. To verify the diagnosis of diabetic polyneuropathy, complaints, clinical and instrumental examination data were evaluated. The main indicators of nerve conduction were taken into account when determining polyneuritis disorders, namely: рeroneal motor nerve conduction velocity, sensory nerve action potential of the sural nerve, sensory nerve conduction velocity of the sural nerve. Results. A dependence of nerve conduction on polyneuropathy severity was revealed, рeroneal motor nerve conduction velocity was the lowest in the group with severe polyneuropathy. A correlation was also found between the levels of sensory indicators (sensory nerve action potential and sensory nerve conduction velocity) and polyneuropathy severity, nerve conduction velocity decreases with an increase in the latter. The influence of polyneuropathy severity on the painful or painless form has been found. Among patients with severe polyneuropathy, the painful form was observed more often. No relationship was found between the need for insulin therapy and the painful or painless form of polyneuropathy. Conclusions. Indicators of nerve conduction depend on polyneuropathy severity. The presence and severity of pain syndrome directly depends on polyneuropathy severity. The need for additional insulin administration affects sensory indicators but has no effect on the development of the painful form of polyneuropathy.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"2 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135340424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.22141/2224-0713.19.6.2023.1019
I.S. Zozulya, A.O. Volosovets, A.V. Boiko
Today, the problem of managing patients in the pre- and post-stroke period is associated with the target level of blood pressure. However, it is difficult to determine, because patients differ in age, duration and stage of hypertension, and comorbidities. Instrumental studies of the brain reveal its various lesions, as well as damage to the heart, impaired autoregulation of cerebral circulation, atherosclerosis of the major vessels of the head and neck. All these factors are certainly crucial for planning the long-term antihypertensive therapy.
{"title":"Target blood pressure level in patients in the pre- and post-stroke period: features of antihypertensive therapy depending on the stage of hypertension (literature review)","authors":"I.S. Zozulya, A.O. Volosovets, A.V. Boiko","doi":"10.22141/2224-0713.19.6.2023.1019","DOIUrl":"https://doi.org/10.22141/2224-0713.19.6.2023.1019","url":null,"abstract":"Today, the problem of managing patients in the pre- and post-stroke period is associated with the target level of blood pressure. However, it is difficult to determine, because patients differ in age, duration and stage of hypertension, and comorbidities. Instrumental studies of the brain reveal its various lesions, as well as damage to the heart, impaired autoregulation of cerebral circulation, atherosclerosis of the major vessels of the head and neck. All these factors are certainly crucial for planning the long-term antihypertensive therapy.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"25 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.22141/2224-0713.19.6.2023.1020
M.A. Trishchynska, V.M. Dubynetska
The article describes the prevalence of inherited neuromuscular disease, specifically neural amyotrophy, or Charcot-Marie-Tooth disease, its key clinical and neurological features, promising blood biomarkers for future diagnosis and therapeutic strategy assessment, along with current treatment methods under investigation, taking into account gene therapy. A clinical case is presented describing Charcot-Marie-Tooth disease type IA in a young man, which was confirmed by molecular genetic testing. The study of diagnostic criteria for nosologies of this spectrum is relevant, taking into account the rarity of the disease and certain difficulties in making a diagnosis.
{"title":"Neural amyotrophy of Charcot-Marie-Tooth (clinical case)","authors":"M.A. Trishchynska, V.M. Dubynetska","doi":"10.22141/2224-0713.19.6.2023.1020","DOIUrl":"https://doi.org/10.22141/2224-0713.19.6.2023.1020","url":null,"abstract":"The article describes the prevalence of inherited neuromuscular disease, specifically neural amyotrophy, or Charcot-Marie-Tooth disease, its key clinical and neurological features, promising blood biomarkers for future diagnosis and therapeutic strategy assessment, along with current treatment methods under investigation, taking into account gene therapy. A clinical case is presented describing Charcot-Marie-Tooth disease type IA in a young man, which was confirmed by molecular genetic testing. The study of diagnostic criteria for nosologies of this spectrum is relevant, taking into account the rarity of the disease and certain difficulties in making a diagnosis.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"27 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22141/2224-0713.19.5.2023.1011
V.V. Marshtupa, T.I. Nasonova
A review of the literature reveals a wide range of terms for conditions after coronavirus disease (COVID-19): post-COVID syndrome, post-acute COVID syndrome, chronic COVID-19, long-term complications of COVID-19, long COVID-19, and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection. All these terms and others indicate that after COVID-19, a person does not return to his/her usual state of health. Many scientists are researching and looking for the causes of these symptoms, why and when they occur, and how to diagnose and treat them. Therefore, the aim of the study was to improve the diagnosis of post-COVID syndrome in patients with cerebrovascular disease (CVD) by studying clinical, neurological, laboratory and neuropsychological markers. Materials and methods. The study uses psychometric methods — Beck Anxiety Inventory, Hamilton Depression Rating Scale, Fatigue Assessment Scale; neuropsychological — Montreal Cognitive Assessment; clinical — neurological status; laboratory — hemoglobin, C-reactive protein, fibrinogen, albumin, ferritin, lactate dehydrogenase. All patients were divided into four groups: the first group included 20 people with post-COVID syndrome and CVD, the second — 15 individuals with post-COVID syndrome without CVD, the third — 15 patients without post-COVID syndrome with CVD, and the fourth — 15 people without post-COVID syndrome and without CVD. Results. In the group of patients with post-COVID syndrome with cerebrovascular disease (n1 = 20), the average level of hemoglobin (M = 115.15 ± 4.93) and albumin (M = 32.15 ± 1.53) was below the normal range; the content of fibrinogen (M = 6.04 ± 0.82), C-reactive protein (M = 5.50 ± 0.68) was above normal. Data of the Hamilton Depression Rating Scale indicate that patients with post-COVID syndrome and cerebrovascular disease Data of the Hamilton Depression Rating Scale indicate that patients with post-COVID syndrome and cerebrovascular disease (n1 = 20) had a mild depression (M = 6.75 ± 3.90; M = 8.60 ± ± 3.06). Correlation analysis revealed a direct relationship between cognitive functions and hemoglobin (r = 0.455, p ≤ 0.01), albumin (r = 0.571, p ≤ 0.01) and an inverse relationship between cognitive functions and fibrinogen (r = –0.605, p ≤ 0.01), C-reactive protein (r = –0.547, p ≤ 0.01), ferritin (r = 0.408, p ≤ 0.01). There was an inverse correlation between anxiety and hemoglobin (r = –0.619, p ≤ 0.01) and albumin (r = –0.567, p ≤ 0.01) and a direct relationship between anxiety and fibrinogen (r = 0.550, p ≤ 0.01) and C-reactive protein (r = 0.537, p ≤ 0.01). The depression scale negatively correlates with the level of hemoglobin (r = –0.597, p ≤ 0.01), albumin (r = –0.543, p ≤ 0.01) and directly with the content of fibrinogen (r = 0.433, p ≤ 0.01), C-reactive protein (r = 0.383, p ≤ 0.01) and lactate dehydrogenase (r = 0.276, p ≤ 0.05). The indicators of fibrinogen, C-reactive protein, and ferritin were the highest in the group of patients w
{"title":"Laboratory, clinical, neurological and neuropsychological features of the course of post-COVID syndrome in patients with cerebrovascular disease","authors":"V.V. Marshtupa, T.I. Nasonova","doi":"10.22141/2224-0713.19.5.2023.1011","DOIUrl":"https://doi.org/10.22141/2224-0713.19.5.2023.1011","url":null,"abstract":"A review of the literature reveals a wide range of terms for conditions after coronavirus disease (COVID-19): post-COVID syndrome, post-acute COVID syndrome, chronic COVID-19, long-term complications of COVID-19, long COVID-19, and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection. All these terms and others indicate that after COVID-19, a person does not return to his/her usual state of health. Many scientists are researching and looking for the causes of these symptoms, why and when they occur, and how to diagnose and treat them. Therefore, the aim of the study was to improve the diagnosis of post-COVID syndrome in patients with cerebrovascular disease (CVD) by studying clinical, neurological, laboratory and neuropsychological markers. Materials and methods. The study uses psychometric methods — Beck Anxiety Inventory, Hamilton Depression Rating Scale, Fatigue Assessment Scale; neuropsychological — Montreal Cognitive Assessment; clinical — neurological status; laboratory — hemoglobin, C-reactive protein, fibrinogen, albumin, ferritin, lactate dehydrogenase. All patients were divided into four groups: the first group included 20 people with post-COVID syndrome and CVD, the second — 15 individuals with post-COVID syndrome without CVD, the third — 15 patients without post-COVID syndrome with CVD, and the fourth — 15 people without post-COVID syndrome and without CVD. Results. In the group of patients with post-COVID syndrome with cerebrovascular disease (n1 = 20), the average level of hemoglobin (M = 115.15 ± 4.93) and albumin (M = 32.15 ± 1.53) was below the normal range; the content of fibrinogen (M = 6.04 ± 0.82), C-reactive protein (M = 5.50 ± 0.68) was above normal. Data of the Hamilton Depression Rating Scale indicate that patients with post-COVID syndrome and cerebrovascular disease Data of the Hamilton Depression Rating Scale indicate that patients with post-COVID syndrome and cerebrovascular disease (n1 = 20) had a mild depression (M = 6.75 ± 3.90; M = 8.60 ± ± 3.06). Correlation analysis revealed a direct relationship between cognitive functions and hemoglobin (r = 0.455, p ≤ 0.01), albumin (r = 0.571, p ≤ 0.01) and an inverse relationship between cognitive functions and fibrinogen (r = –0.605, p ≤ 0.01), C-reactive protein (r = –0.547, p ≤ 0.01), ferritin (r = 0.408, p ≤ 0.01). There was an inverse correlation between anxiety and hemoglobin (r = –0.619, p ≤ 0.01) and albumin (r = –0.567, p ≤ 0.01) and a direct relationship between anxiety and fibrinogen (r = 0.550, p ≤ 0.01) and C-reactive protein (r = 0.537, p ≤ 0.01). The depression scale negatively correlates with the level of hemoglobin (r = –0.597, p ≤ 0.01), albumin (r = –0.543, p ≤ 0.01) and directly with the content of fibrinogen (r = 0.433, p ≤ 0.01), C-reactive protein (r = 0.383, p ≤ 0.01) and lactate dehydrogenase (r = 0.276, p ≤ 0.05). The indicators of fibrinogen, C-reactive protein, and ferritin were the highest in the group of patients w","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135406940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22141/2224-0713.19.5.2023.1012
V.M. Dubynetska
The article presents clinical and paraclinical features and criteria for diagnosis, drug therapy of antiphospholipid syndrome as one of the common causes of ischemic stroke in young people. Criterion and non-criterion diagnostic factors of making a diagnosis were distinguished. In addition, we present a clinical case of ischemic stroke in a young female patient due to a newly diagnosed primary criterion antiphospholipid syndrome, which will allow clinicians to diagnose the pathology more accurately.
{"title":"Ischemic stroke on the background of antiphospholipid syndrome(clinical case)","authors":"V.M. Dubynetska","doi":"10.22141/2224-0713.19.5.2023.1012","DOIUrl":"https://doi.org/10.22141/2224-0713.19.5.2023.1012","url":null,"abstract":"The article presents clinical and paraclinical features and criteria for diagnosis, drug therapy of antiphospholipid syndrome as one of the common causes of ischemic stroke in young people. Criterion and non-criterion diagnostic factors of making a diagnosis were distinguished. In addition, we present a clinical case of ischemic stroke in a young female patient due to a newly diagnosed primary criterion antiphospholipid syndrome, which will allow clinicians to diagnose the pathology more accurately.","PeriodicalId":14476,"journal":{"name":"INTERNATIONAL NEUROLOGICAL JOURNAL","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135407248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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