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The Association between Obesity and Cancer Risk: A Meta-Analysis of Observational Studies from 1985 to 2011. 肥胖与癌症风险之间的关系:1985年至2011年观察性研究的荟萃分析
Pub Date : 2013-04-04 eCollection Date: 2013-01-01 DOI: 10.5402/2013/680536
M Dobbins, K Decorby, B C K Choi

Background. Cancer and cardiovascular diseases are the leading causes of mortality and morbidity worldwide. The purpose of this meta-analysis is to synthesize the evidence evaluating the association between obesity and 13 cancers shown previously to be significantly associated with obesity. Methods. Relevant papers from a previously conducted review were included in this paper. In addition, database searches of Medline and Embase identified studies published from the date of the search conducted for the previous review (January, 2007) until May, 2011. The reference lists of relevant studies and systematic reviews were screened to identify additional studies. Relevance assessment, quality assessment, and data extraction for each study were conducted by two reviewers independently. Meta-analysis was performed for men and women separately using DerSimonian and Laird's random effects model. Results. A total of 98 studies conducted in 18 countries from 1985 to 2011 were included. Data extraction was completed on the 57 studies judged to be of strong and moderate methodological quality. Results illustrated that obese men were at higher risk for developing colon (Risk Ratio (RR), 1.57), renal (1.57), gallbladder (1.47), pancreatic (1.36), and malignant melanoma cancers (1.26). Obese women were at higher risk for esophageal adenocarcinoma (2.04), endometrial (1.85), gallbladder (1.82), renal (1.72), pancreatic (1.34), leukemia (1.32), postmenopausal breast (1.25), and colon cancers (1.19). Conclusions. The results of this meta-analysis illustrate a significant, positive, and, for some cancers, strong association between obesity and cancer incidence. Given that approximately 23% of Canadians are obese, a significant proportion of cancer in Canada could be avoided if obesity was eliminated or significantly reduced.

背景。癌症和心血管疾病是全世界死亡和发病的主要原因。这项荟萃分析的目的是综合评估肥胖和13种癌症之间的关系的证据,这些癌症之前被证明与肥胖有显著关系。方法。本文包含了先前进行的综述的相关论文。此外,Medline和Embase的数据库检索确定了从上一次综述检索日期(2007年1月)到2011年5月之间发表的研究。筛选相关研究和系统评价的参考文献列表以确定其他研究。每项研究的相关性评估、质量评估和数据提取均由两名审稿人独立进行。采用DerSimonian和Laird随机效应模型分别对男性和女性进行meta分析。结果。共纳入了1985年至2011年在18个国家进行的98项研究。完成了57项研究的数据提取,这些研究被认为具有很强的和中等的方法学质量。结果表明,肥胖男性患结肠癌(风险比1.57)、肾癌(风险比1.57)、胆囊癌(风险比1.47)、胰腺癌(风险比1.36)和恶性黑色素瘤(风险比1.26)的风险更高。肥胖女性患食管癌(2.04)、子宫内膜癌(1.85)、胆囊癌(1.82)、肾癌(1.72)、胰腺癌(1.34)、白血病(1.32)、绝经后乳腺癌(1.25)和结肠癌(1.19)的风险更高。结论。这项荟萃分析的结果表明,对于某些癌症来说,肥胖和癌症发病率之间存在显著的、积极的、强烈的联系。鉴于大约23%的加拿大人肥胖,如果消除或显著减少肥胖,加拿大很大一部分癌症是可以避免的。
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引用次数: 175
Infectious diseases and vaccination strategies: how to protect the "unprotectable"? 传染病和疫苗接种策略:如何保护“无法保护的”?
Pub Date : 2013-04-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/765354
Elena Bozzola, Mauro Bozzola, Valeria Calcaterra, Salvatore Barberi, Alberto Villani

Introduction. The circulation of infectious diseases puts small infants too young to be vaccinated at risk of morbidity and mortality, often requiring prolonged hospitalization. Material and Methods. We have reviewed the medical records of children not eligible for vaccination because of age, admitted to hospital for pertussis, measles, or varicella from February 1, 2010, till February 1, 2012. Results. Of the case records scrutinized, 21 were hospitalized for pertussis, 18 for measles, and 32 for varicella. Out of them, 42%, 66%, and 78% diagnosed with, respectively, pertussis, measles, and varicella had a complicated course of the disease. Discussion. To avoid infectious disease circulation, childhood immunization strategies should be adopted, such as vaccination of healthcare givers, adult household contacts, and parents planning to have, or who have had, a newborn baby.

介绍。传染病的传播使年龄太小而不能接种疫苗的小婴儿面临发病和死亡的危险,往往需要长期住院治疗。材料和方法。我们审查了2010年2月1日至2012年2月1日期间因百日咳、麻疹或水痘住院的年龄不符合疫苗接种条件的儿童的医疗记录。结果。在审查的病例记录中,21人因百日咳住院,18人因麻疹住院,32人因水痘住院。其中,分别有42%、66%和78%被诊断为百日咳、麻疹和水痘的患者病程复杂。讨论。为避免传染病传播,应采取儿童免疫接种策略,如卫生保健提供者、成年家庭接触者以及计划生育或曾经生育过新生儿的父母接种疫苗。
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引用次数: 10
Perceptions of preventive health care and healthy lifestyle choices for low income families: a qualitative study. 低收入家庭对预防保健和健康生活方式选择的看法:一项定性研究。
Pub Date : 2013-04-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/189180
Sasha A Fleary, Reynolette Ettienne-Gittens, Robert W Heffer

This paper examines Head Start parents' perceptions of preventive health and healthy lifestyle choices and Head Start administrators' perceptions of the needs of parents they serve. To address the preventive health of the population, it is necessary that we explore perceptions, risks, and protective factors of preventive health. Focus groups were conducted with parents and administrators to elicit this information and to obtain suggestions for improving preventive health and healthy lifestyle choices among this group. Overall, nutrition and physical activity emerged as themes in parents' definition of preventive health and healthy lifestyle choices. They further identified social support and education as major protective factors for engaging in preventive health and healthy lifestyle choices. Results of this study can be used to inform research and practice to develop interventions to increase preventive health and healthy lifestyle choices among low income families.

本文考察了启智计划父母对预防性健康和健康生活方式选择的看法,以及启智计划管理者对他们所服务的父母需求的看法。为了解决人口的预防性保健问题,我们有必要探讨对预防性保健的认识、风险和保护因素。与家长和行政人员进行了焦点小组讨论,以获取这方面的信息,并获得改善这一群体的预防保健和健康生活方式选择的建议。总的来说,营养和体育活动成为父母对预防健康和健康生活方式选择的定义的主题。他们进一步指出,社会支持和教育是参与预防保健和选择健康生活方式的主要保护因素。本研究的结果可用于研究和实践,以制定干预措施,以增加低收入家庭的预防性健康和健康生活方式的选择。
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引用次数: 6
A six-month study of pulmonary cancer in Albanian women. 为期六个月的阿尔巴尼亚妇女肺癌研究。
Pub Date : 2013-03-04 eCollection Date: 2013-01-01 DOI: 10.5402/2013/824670
Jolanda Nikolla, Milda Nanushi, Gentian Vyshka, Hasan Hafizi

Lung cancer is a potentially lethal disease, whose prevalence in Albania is constantly increasing, especially in women. Early diagnosis is extremely important with regard to life expectancy and quality. The authors conducted a survey on the behaviour in a sample group of Albanian women diagnosed with primary and secondary lung cancers. A discussion upon diagnostic methods, smoking habits, histological type, Karnofsky performance status (KPS), and treatment modalities is made. The data collected by the authors suggest that nonsmokers formed the main group of lung cancer female patients. The most frequent histological type was adenocarcinoma. Mesothelioma was the most frequent of the secondary pulmonary lung cancers, followed from metastasizing breast cancer. Despite a generally good performance of the cases, the diagnosis of pulmonary cancer is delayed. The data collected could not find a convincing etiological role of tobacco smoking, but caution is needed, regarding the short time length of the study and the sustained number of participants.

肺癌是一种潜在的致命疾病,其发病率在阿尔巴尼亚不断上升,特别是在妇女中。早期诊断对于预期寿命和质量极为重要。作者对诊断为原发性和继发性肺癌的阿尔巴尼亚妇女样本组的行为进行了调查。讨论了诊断方法,吸烟习惯,组织学类型,Karnofsky性能状态(KPS)和治疗方式。作者收集的数据表明,不吸烟者构成了肺癌女性患者的主要群体。最常见的组织学类型是腺癌。间皮瘤是继发性肺癌中最常见的,其次是转移性乳腺癌。尽管这些病例一般表现良好,但肺癌的诊断却被推迟了。收集的数据无法找到吸烟的令人信服的病因作用,但考虑到研究时间短和持续的参与者人数,需要谨慎。
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引用次数: 2
Media and cultural influences in african-american girls' eating disorder risk. 媒体和文化对非裔美国女孩饮食失调风险的影响。
Pub Date : 2013-02-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/319701
Lakaii A Jones, Catherine Cook-Cottone

Objective. To investigate media and cultural influences in eating disorder development in African-American adolescent females. Method. Fifty-seven participants were recruited through churches and community organizations to complete a questionnaire. Results. Mainstream sociocultural identification was associated with more eating disorder behavior in African-American females; cultural ethnic identification was not significantly associated with eating disorder behavior in African-American females, mainstream sociocultural identification, cultural ethnic identification, and body dissatisfaction significantly predicted eating disorder behavior; and cultural ethnic identification was positively correlated with mainstream sociocultural identification. This study provides support for the importance of eating disorder prevention interventions that focus specifically on African-American girls.

目标。探讨媒体和文化对非裔美国青少年女性饮食失调发展的影响。方法。通过教会和社区组织招募了57名参与者来完成一份调查问卷。结果。主流社会文化认同与非裔美国女性更多的饮食失调行为有关;非裔美国女性的文化族群认同与饮食失调行为无显著相关,主流社会文化认同、文化族群认同和身体不满意显著预测饮食失调行为;文化族群认同与主流社会文化认同正相关。这项研究为特别关注非洲裔美国女孩的饮食失调预防干预的重要性提供了支持。
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引用次数: 4
PRE-VIEW: Development and Pilot Testing of An Interactive Video Doctor Plus Provider Alert to Increase Cancer Screening. 预览:开发和试点测试的交互式视频医生加提供者警报,以增加癌症筛查。
Pub Date : 2013-01-01 DOI: 10.5402/2013/935487
Millie Arora, Barbara Gerbert, Michael B Potter, Ginny Gildengorin, Judith M E Walsh

Background: Interventions to increase recommended cancer screening tests and discussions are needed.

Methods: We developed PRE-VIEW (The PREventive VIdeo Education in Waiting Rooms Program), a multimedia cancer prevention intervention for primary care clinics based on the Transtheoretical Model of Behavior Change We pilot tested PRE-VIEW An Interactive Video Doctor plus Provider Alert for feasibility and acceptability in primary care clinic settings in the San Francisco Bay Area, California in 2009-2010.

Results: Eighty participants (33 men and 47 women; more than half non-white) at 5 primary care clinics were included. After PRE-VIEW, 87% of women were definitely interested in mammography when due and 77% were definitely interested in a Pap test. 73% of participants were definitely interested in colorectal cancer screening when due, and 79% of men were definitely interested in a discussion about the PSA test. The majority indicated that they received an appropriate amount of information from PRE-VIEW and that the information presented helped them decide whether or not to be screened.

Conclusions: PRE-VIEW was well received and accepted and potentially provides an innovative and practical way to support physicians' efforts to increase cancer screening.

背景:需要采取干预措施增加推荐的癌症筛查试验和讨论。方法:我们开发了PRE-VIEW(候诊室预防性视频教育项目),这是一种基于行为改变跨理论模型的初级保健诊所的多媒体癌症预防干预措施。我们在2009-2010年在加利福尼亚州旧金山湾区的初级保健诊所环境中试点测试了PRE-VIEW一种交互式视频医生加提供者警报的可行性和可接受性。结果:80名参与者(33名男性,47名女性;其中包括5个初级保健诊所的一半以上非白人。预检后,87%的女性对乳房x光检查很感兴趣,77%的女性对巴氏试验很感兴趣。73%的参与者对结肠直肠癌筛查非常感兴趣,79%的男性对PSA测试的讨论非常感兴趣。大多数人表示,他们从PRE-VIEW中获得了适量的信息,所提供的信息有助于他们决定是否进行筛选。结论:PRE-VIEW被广泛接受和接受,并可能提供一种创新和实用的方法来支持医生努力增加癌症筛查。
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引用次数: 13
Surgical site infection complicating breast cancer surgery in kuwait. 手术部位感染并发科威特乳腺癌手术。
Pub Date : 2012-12-27 eCollection Date: 2013-01-01 DOI: 10.5402/2013/295783
Abeer A Omar, Haifaa H Al-Mousa

Background and Objectives. Surgical site infection (SSI) is the most common postoperative complication associated with breast cancer surgery. The present investigation aimed to determine the SSI rate after breast cancer surgeries and the causative microorganisms. Patients and Methods. All patients who underwent breast surgery in Kuwait Cancer Control Center as a treatment for breast cancer from January 2009-December 2010 were prospectively followed for the development of SSI. Indirect detection was used to identify SSIs through medical record to review and discussion with the treating surgeons. Results. The number of operations was 438. Females represented 434 (99.1%) cases while males constituted only 4 (0.9%) cases. SSIs were diagnosed after 10 operations, all for female cases. Most of the SSIs (8 cases; 80%) were detected after patients were discharged, during outpatient followup. Out of those 5/8; (62.5%) were readmitted for management of SSI. Nine patients (90%) received systemic antibiotic therapy for management of their wound infection. The SSI rate was 2.3%. The main causative organism was Staphylococcus aureus (S. aureus) which was responsible for 40% of infections. Gram negative bacteria were isolated from 40% of the cases. Conclusion. SSI is an important complication following breast cancer surgery. Microbiological diagnosis is an essential tool for proper management of such patients.

背景和目标。手术部位感染(SSI)是乳腺癌手术后最常见的并发症。本研究旨在了解乳腺癌术后SSI发生率及致病微生物。患者和方法。2009年1月至2010年12月在科威特癌症控制中心接受乳房手术治疗乳腺癌的所有患者进行SSI的前瞻性随访。通过病历回顾和与治疗外科医生讨论,采用间接检测方法确定ssi。结果。操作次数为438次。女性434例(99.1%),男性4例(0.9%)。10例手术后诊断为ssi,均为女性。大多数ssi(8例;80%)在患者出院后、门诊随访时被发现。在这5/8中;(62.5%)再次入院治疗SSI。9例患者(90%)接受全身抗生素治疗以处理伤口感染。SSI率为2.3%。主要病原菌为金黄色葡萄球菌(S. aureus),占感染病例的40%。从40%的病例中分离出革兰氏阴性菌。结论。SSI是乳腺癌手术后的一个重要并发症。微生物学诊断是对此类患者进行适当治疗的必要工具。
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引用次数: 7
An overview of the malaria control programme in zambia. 赞比亚疟疾控制方案概述。
Pub Date : 2012-12-09 eCollection Date: 2013-01-01 DOI: 10.5402/2013/495037
Emmanuel Chanda, Mulakwa Kamuliwo, Richard W Steketee, Michael B Macdonald, Olusegun Babaniyi, Victor M Mukonka

The Zambian national malaria control programme has made great progress in the fight against Malaria. The country has solid, consistent, and coordinated policies, strategies, and guidelines for malaria control, with government prioritizing malaria in both the National Health Strategic Plan and the National Development Plan. This has translated into high coverage of proven and effective key preventive, curative, and supportive interventions with concomitant marked reduction in both malaria cases and deaths. The achievements attained can be attributed to increased advocacy, communication and behaviour changes, efficient partnership coordination including strong community engagement, increased financial resources, and evidence-based deployment of key technical interventions in accordance with the national malaria control programme policy and strategic direction. The three-ones strategy has been key for increased and successful public-private sector partner coordination, strengthening, and mobilization. However, maintaining the momentum and the gains is critical as the programme strives to achieve universal coverage of evidence-based and proven interventions. The malaria control programme's focus is to maintain the accomplishments, by mobilizing more resources and partners, increasing the government funding towards malaria control, scaling up and directing interventions based on epidemiological evidence, and strengthen active malaria surveillance and response to reduce transmission and to begin considering elimination.

赞比亚国家疟疾控制规划在防治疟疾方面取得了巨大进展。我国有扎实、一致和协调的疟疾控制政策、战略和指导方针,政府在《国家卫生战略计划》和《国家发展计划》中将疟疾列为优先事项。这已转化为经证实有效的关键预防、治疗和支持性干预措施的高覆盖率,同时疟疾病例和死亡人数显著减少。取得的成就可归功于加强宣传、沟通和行为改变,有效的伙伴关系协调,包括强有力的社区参与,增加财政资源,以及根据国家疟疾控制规划政策和战略方向,以证据为基础部署关键技术干预措施。“三个一”战略是加强和成功地协调、加强和动员公私部门伙伴关系的关键。然而,在该规划努力实现以证据为基础和经过验证的干预措施的普遍覆盖之际,保持势头和成果至关重要。疟疾控制规划的重点是通过调动更多的资源和合作伙伴,增加政府对疟疾控制的供资,根据流行病学证据扩大和指导干预措施,以及加强积极的疟疾监测和应对,以减少传播并开始考虑消除疟疾,从而保持已取得的成就。
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引用次数: 26
Parental perceptions of giardiasis: a study in an outpatient paediatric hospital setting in havana, cuba. 父母对贾第虫病的看法:在古巴哈瓦那儿科门诊医院进行的一项研究。
Pub Date : 2012-12-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/364647
Pedro Almirall, Angel A Escobedo, Yohana Salazar, Maydel Alfonso, Ivonne Avila, Sergio Cimerman, Isabel V Dawkins

Background. Giardia lamblia is an important cause of diarrhoeal disease throughout the world. Giardiasis- a mild and self-limiting disease that this protozoan causes- is perceived as a harmful disease. Aim. To explore the general level of awareness about giardiasis, clinical features, mode of transmission, prevention, and consequences and describe the sources and channels of information caregivers would prefer using to be informed about this disease. Methods. A cross-sectional survey was conducted among caregivers attending to the outpatient paediatric hospital setting in Havana. Results. A total of 202 caregivers were interviewed. Nearly 73% considered giardiasis as a modern problem, and 39% considered that it could be a fatal disease. Although 76.7% were aware that small intestine is the organ affected, other localizations were cited. Abdominal pain and diarrhoea were recognized as the commonest symptoms. Around one-third could identify that giardiasis may spread through drinking unboiled water and unwashed vegetables other incorrect ways were mentioned; respondents with more than 12 years of formal education were more likely to have better knowledge. Discussion. Strategies to control giardiasis need to be through an integrated approach aiming at boosting caregivers' knowledge and encouraging healthcare workers to act as a readily available source for health information.

背景。贾第鞭毛虫是全世界腹泻病的一个重要病因。贾第虫病是由这种原生动物引起的一种轻度和自限性疾病,被认为是一种有害的疾病。的目标。探讨贾第虫病的一般认识水平、临床特征、传播方式、预防和后果,并描述护理人员倾向于使用的信息来源和渠道。方法。在哈瓦那儿科门诊医院的护理人员中进行了一项横断面调查。结果。共采访了202名护理人员。近73%的人认为贾第虫病是一个现代问题,39%的人认为它可能是一种致命的疾病。虽然76.7%的人知道小肠是受影响的器官,但其他部位被引用。腹痛和腹泻被认为是最常见的症状。大约三分之一的人可以通过饮用未煮沸的水和未清洗的蔬菜来识别贾第虫病的传播,其他不正确的方式也被提到;接受过12年以上正规教育的受访者更有可能拥有更好的知识。讨论。控制贾第虫病的战略需要通过一种综合方法,旨在提高护理人员的知识,并鼓励卫生保健工作者作为随时可用的卫生信息来源。
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引用次数: 4
High blood pressure prevalence and significant correlates: a quantitative analysis from coastal karnataka, India. 高血压患病率及其显著相关性:印度卡纳塔克邦沿海地区的定量分析。
Pub Date : 2012-12-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/574973
Chythra R Rao, Veena G Kamath, Avinash Shetty, Asha Kamath

Hypertension is a premier risk factor for cardiovascular disease which can be recognized if sought and treated effectively. Effective management of high blood pressure is possible when the magnitude of the problem is identified. So, a cross-sectional community based survey among 1,239 respondents aged ≥30 years was designed to estimate the prevalence and the sociodemographic correlates of hypertension among adults aged ≥30 years. Data was collected by personal interviews, followed by anthropometric and blood pressure measurements. Analysis was done using Statistical Package for the Social Sciences (SPSS) version 11.5. The prevalence of hypertension was 43.3%, with the prevalence being more among males (51.6%) as compared to females (38.9%). Of the total prevalence 23.1% (287) were known cases, and 20.2% (250) were newly detected cases. Based on the seventh report of the Joint National Committee (JNC VII) on high blood pressure, prehypertension was noted among 38.7%. Advancing age, male gender, current diabetic status, central obesity, overweight and obesity as defined by body mass index, and family history of hypertension were identified as significant correlates for hypertension by multivariate logistic regression.

高血压是心血管疾病的首要危险因素,如果寻求和有效治疗,是可以识别的。当问题的严重性被确定时,有效的管理高血压是可能的。因此,对1239名年龄≥30岁的受访者进行了一项基于社区的横断面调查,旨在估计年龄≥30岁的成年人中高血压的患病率和社会人口学相关因素。数据通过个人访谈收集,随后进行人体测量和血压测量。使用社会科学统计软件包(SPSS) 11.5版进行分析。高血压患病率为43.3%,男性(51.6%)高于女性(38.9%)。其中,已知病例287例(23.1%),新发现病例250例(20.2%)。根据全国联合委员会(JNC VII)关于高血压的第七次报告,38.7%的人患有高血压前期。多因素logistic回归分析发现,高龄、男性、当前糖尿病状态、中心性肥胖、体重指数定义的超重和肥胖以及高血压家族史是高血压的显著相关因素。
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引用次数: 55
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