Asri Peni Wulandari, Annisa Abdiwijaya Qaromah, Karen Kezia Lolowang, D. H. P. Huspa, Ade Zuhrotun
Introduction: One strategy for molecular cancer therapy is to know the key mechanism of cytotoxic compounds that can kill cancer cells. Ramie (Boehmeria nivea L. Gaud.) leaves contain active compounds that have important effects on cancer chemoprevention. Objective: To obtain the active fraction of a Ramie leaf extract in inhibiting the proliferation of MCF-7 breast cancer cell lines and to determine the mechanism of apoptosis induction using MCF-7 and Saccharomyces cerevisiae strains 1140, 1353, and 1138. Method: Fractions were prepared using n-hexane, dichloromethane (CH2Cl2), ethyl acetate, and n-butanol as solvents. All fractions were tested qualitatively through phytochemical. The MTT-based cytotoxicity assay used MCF-7 (in vitro) to obtain the IC50 value, whereas the model system that targets the enzymatic (topoisomerase) used a yeast-based bioassay to obtain the IC12 value. Apoptotic induction of the active fraction in MCF-7 was performed using flow cytometry and qPCR (2-ΔΔCt method). Results: The phytochemical analysis indicated that the extract fraction consisted of alkaloids and steroids. The smallest IC50 value was obtained from the CH2Cl2 fraction as 3.79 g/mL, potentially act as an anticancer. A higher percentage of apoptosis than that of necrotizing cells and live cells was observed through flow cytometry. The CH2Cl2 fraction with an IC12 value < 8000 in strains 1140, 1353, and 1138 consistently showed the mechanism of apoptosis induction as topoisomerase I and II inhibitors. Also, another mechanism could be through the intrinsic pathway, indicated by the highest expression level in p53. Conclusions: The CH2Cl2 fraction of Ramie leaves can inhibits the proliferation of MCF-7 cells in the active and strong categories. The CH2Cl2 fraction induces apoptosis by increasing p53 gene expression and inhibiting topoisomerase I and II. Thus, it showed potential as an anticancer drug candidate.
分子癌症治疗的策略之一是了解细胞毒性化合物杀死癌细胞的关键机制。苎麻(Boehmeria nivea L. Gaud.)叶含有对癌症化学预防有重要作用的活性化合物。目的:获得苎麻叶提取物的活性部位对MCF-7乳腺癌细胞株增殖的抑制作用，并探讨MCF-7与酿酒酵母1140、1353和1138诱导凋亡的机制。方法:以正己烷、二氯甲烷(CH2Cl2)、乙酸乙酯、正丁醇为溶剂制备馏分。所有馏分均通过植物化学定性检测。基于mtt的细胞毒性试验使用MCF-7(体外)获得IC50值，而针对酶(拓扑异构酶)的模型系统使用基于酵母的生物测定获得IC12值。采用流式细胞术和qPCR (2-ΔΔCt方法)对MCF-7活性部位进行凋亡诱导。结果:植物化学分析表明，提取部位含有生物碱和甾类化合物。CH2Cl2组分的IC50值最小，为3.79 g/mL，具有潜在的抗癌作用。流式细胞术观察到细胞凋亡率高于坏死细胞和活细胞。在菌株1140、1353和1138中，IC12值< 8000的CH2Cl2组分一致显示其作为拓扑异构酶I和II抑制剂诱导细胞凋亡的机制。另一种机制可能是通过内在途径，在p53中表达水平最高。结论:苎麻叶CH2Cl2组分对MCF-7细胞的增殖有抑制作用，且具有活性和强活性。CH2Cl2片段通过增加p53基因表达和抑制拓扑异构酶I和II诱导细胞凋亡。因此，它显示出作为抗癌候选药物的潜力。
{"title":"Anti-Cancer Assessment of a Ramie (Boehmeria nivea L. Gaud.) Leaf Extract Using Mcf-7 Cell Line and a Yeast-Based Bioassay","authors":"Asri Peni Wulandari, Annisa Abdiwijaya Qaromah, Karen Kezia Lolowang, D. H. P. Huspa, Ade Zuhrotun","doi":"10.11594/ijmp.02.01.01","DOIUrl":"https://doi.org/10.11594/ijmp.02.01.01","url":null,"abstract":"Introduction: One strategy for molecular cancer therapy is to know the key mechanism of cytotoxic compounds that can kill cancer cells. Ramie (Boehmeria nivea L. Gaud.) leaves contain active compounds that have important effects on cancer chemoprevention. Objective: To obtain the active fraction of a Ramie leaf extract in inhibiting the proliferation of MCF-7 breast cancer cell lines and to determine the mechanism of apoptosis induction using MCF-7 and Saccharomyces cerevisiae strains 1140, 1353, and 1138. Method: Fractions were prepared using n-hexane, dichloromethane (CH2Cl2), ethyl acetate, and n-butanol as solvents. All fractions were tested qualitatively through phytochemical. The MTT-based cytotoxicity assay used MCF-7 (in vitro) to obtain the IC50 value, whereas the model system that targets the enzymatic (topoisomerase) used a yeast-based bioassay to obtain the IC12 value. Apoptotic induction of the active fraction in MCF-7 was performed using flow cytometry and qPCR (2-ΔΔCt method). Results: The phytochemical analysis indicated that the extract fraction consisted of alkaloids and steroids. The smallest IC50 value was obtained from the CH2Cl2 fraction as 3.79 g/mL, potentially act as an anticancer. A higher percentage of apoptosis than that of necrotizing cells and live cells was observed through flow cytometry. The CH2Cl2 fraction with an IC12 value < 8000 in strains 1140, 1353, and 1138 consistently showed the mechanism of apoptosis induction as topoisomerase I and II inhibitors. Also, another mechanism could be through the intrinsic pathway, indicated by the highest expression level in p53. Conclusions: The CH2Cl2 fraction of Ramie leaves can inhibits the proliferation of MCF-7 cells in the active and strong categories. The CH2Cl2 fraction induces apoptosis by increasing p53 gene expression and inhibiting topoisomerase I and II. Thus, it showed potential as an anticancer drug candidate.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115513700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Until now, the practice of exclusive breastfeeding is still far from the national target. The success of exclusive breastfeeding is determined by many factors, including the mother’s education, knowledge, and awareness about the importance of breastfeeding for child growth. This study aims to determine the relationship between the mother’s level of education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten, Indonesia. Methods: This study uses a cross-sectional design with data collection methods through interviews and direct observation. The population consists of mothers who have children under 2 years of age. The study was conducted for 6 months from November 2019. The variables studied included the mother’s age, occupation, number of children, education, and knowledge of exclusive breastfeeding. Result: As many as 99.6% of respondents have a good level of knowledge about exclusive breastfeeding. The level of education is low at 44.6%, medium at 50.9%, and high at 4.4%. The results showed there was no significant relationship between the mother’s last education and exclusive breastfeeding (p = 0.860) and there was no significant relationship between the mother's level of knowledge and exclusive breastfeeding (p = 0.558). Conclusion: No significant relationship was observed between the mother’s education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten.
{"title":"Relationship Between Maternal Education and Knowledge on Coverage of Exclusive Breastfeeding in Ten Stunting Locus Villages in Pandeglang District, Banten","authors":"S. Wuryanti, H. Marsiati","doi":"10.11594/ijmp.02.01.05","DOIUrl":"https://doi.org/10.11594/ijmp.02.01.05","url":null,"abstract":"Introduction: Until now, the practice of exclusive breastfeeding is still far from the national target. The success of exclusive breastfeeding is determined by many factors, including the mother’s education, knowledge, and awareness about the importance of breastfeeding for child growth. This study aims to determine the relationship between the mother’s level of education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten, Indonesia. Methods: This study uses a cross-sectional design with data collection methods through interviews and direct observation. The population consists of mothers who have children under 2 years of age. The study was conducted for 6 months from November 2019. The variables studied included the mother’s age, occupation, number of children, education, and knowledge of exclusive breastfeeding. Result: As many as 99.6% of respondents have a good level of knowledge about exclusive breastfeeding. The level of education is low at 44.6%, medium at 50.9%, and high at 4.4%. The results showed there was no significant relationship between the mother’s last education and exclusive breastfeeding (p = 0.860) and there was no significant relationship between the mother's level of knowledge and exclusive breastfeeding (p = 0.558). Conclusion: No significant relationship was observed between the mother’s education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129287823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Otomycosis affects about 9% of patients with otitis externa. One of the predisposing factor is impacted cerumen. Earphone usage causes cerumen impaction. In the light of the recent COVID-19 pandemic, people are housebound due to prolonged lockdown. Hence people are more technology dependent as working from home and studying online has become the norm. Therefore, usage of earphones has proportionately increased, and the impacted cerumen cases have increased. Methods: This cross-sectional study aimed to analyze data from questionnaire to assess the prevalence of otomycosis among patients with impacted cerumen due to excessive earphone usage, establish associations between otomycosis and symptoms such as pain and hearing loss as well as the correlation between fungal growth and the long hours of earphones usage. The relationship between the age of participants and the usage of earphones during the pandemic was also explored. The data was collected from 100 individuals aged 14 to 51 years who sought treatment for symptomatic impacted wax at an ENT clinic in Malaysia. Results: The mean age of participants was 25.9 years. There was a 31% prevalence of otomycosis among these patients. Otalgia was present in 60% of patients with otomycosis (t value 2.94, coefficient 0.27). Approximately 37% of patients had a large air-bone gap indicating conductive hearing loss. There was an insignificant correlation between otomycosis and the longer hours of earphones usage (t value 1.51, coefficient 0.00015). No correlation was found between age of participants and the total hours of earphone usage (t value 0.63, coefficient 0.0012). Conclusion: This study offers initial evidence that earphone usage could be a predisposing factor in developing otomycosis. However, there was no evidence of longer hours of earphones usage increasing the chances of developing otomycosis. Additionally, symptoms like otalgia and conductive hearing loss could be present in both earwax impaction and otomycosis.
{"title":"Prevalence of otomycosis in patients with cerumen impaction due to ear-phone usage during COVID-19","authors":"S. Suresh, Suraj Suresh, Sudha Sivasamy","doi":"10.11594/ijmp.02.01.04","DOIUrl":"https://doi.org/10.11594/ijmp.02.01.04","url":null,"abstract":"Background: Otomycosis affects about 9% of patients with otitis externa. One of the predisposing factor is impacted cerumen. Earphone usage causes cerumen impaction. In the light of the recent COVID-19 pandemic, people are housebound due to prolonged lockdown. Hence people are more technology dependent as working from home and studying online has become the norm. Therefore, usage of earphones has proportionately increased, and the impacted cerumen cases have increased. Methods: This cross-sectional study aimed to analyze data from questionnaire to assess the prevalence of otomycosis among patients with impacted cerumen due to excessive earphone usage, establish associations between otomycosis and symptoms such as pain and hearing loss as well as the correlation between fungal growth and the long hours of earphones usage. The relationship between the age of participants and the usage of earphones during the pandemic was also explored. The data was collected from 100 individuals aged 14 to 51 years who sought treatment for symptomatic impacted wax at an ENT clinic in Malaysia. Results: The mean age of participants was 25.9 years. There was a 31% prevalence of otomycosis among these patients. Otalgia was present in 60% of patients with otomycosis (t value 2.94, coefficient 0.27). Approximately 37% of patients had a large air-bone gap indicating conductive hearing loss. There was an insignificant correlation between otomycosis and the longer hours of earphones usage (t value 1.51, coefficient 0.00015). No correlation was found between age of participants and the total hours of earphone usage (t value 0.63, coefficient 0.0012). Conclusion: This study offers initial evidence that earphone usage could be a predisposing factor in developing otomycosis. However, there was no evidence of longer hours of earphones usage increasing the chances of developing otomycosis. Additionally, symptoms like otalgia and conductive hearing loss could be present in both earwax impaction and otomycosis.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"1992 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128617254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. A. Rahmah, H. Harliansyah, F. Suyatna, M. Kanoko, P. Rustamadji, J. Prihartono, A. Bustami, S. Haryono, B. Hernowo
Introduction: Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specific mechanism of curcumin cytotoxicity remains controversial because of many anti- and pro-apoptotic signaling pathways in various cell types. This study aims to examine the relationship among curcumin on RASSF1A, Bax protein levels, and caspase-3 activity in supporting the apoptotic mechanism in CSA03 breast cancer cells. Method: Curcumin administration to cancer cells is based on differences in dosage with 24-hour incubation. Cytotoxicity after curcumin administration was determined using MTS. RASSF1A and Bax protein levels were tested through ELISA. Caspase-3 activity was used to determine apoptosis and was tested using flow cytometry. Results: The results indicated that curcumin had a cytotoxicity effect of 40.85 µg/mL. At concentrations of 40 µg/mL and 50 µg/mL, curcumin increases levels of protein RASSF1A (∆ = 26.53% and 47.35%, respectively), Bax (∆ = 48.79% and 386.15%), and caspase-3 (∆ = 1,678.51% and 1,871.889%) significantly. Conclusions: Curcumin exhibits anti-proliferative activity and apoptotic (Caspase-3) effects through activation of RASSF1A and Bax.
{"title":"Curcumin as an Anti-Proliferative Agent in Breast Cancer through RASSF1A, Bax, and Caspase-3 Protein","authors":"N. A. Rahmah, H. Harliansyah, F. Suyatna, M. Kanoko, P. Rustamadji, J. Prihartono, A. Bustami, S. Haryono, B. Hernowo","doi":"10.11594/ijmp.02.01.03","DOIUrl":"https://doi.org/10.11594/ijmp.02.01.03","url":null,"abstract":"Introduction: Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specific mechanism of curcumin cytotoxicity remains controversial because of many anti- and pro-apoptotic signaling pathways in various cell types. This study aims to examine the relationship among curcumin on RASSF1A, Bax protein levels, and caspase-3 activity in supporting the apoptotic mechanism in CSA03 breast cancer cells. Method: Curcumin administration to cancer cells is based on differences in dosage with 24-hour incubation. Cytotoxicity after curcumin administration was determined using MTS. RASSF1A and Bax protein levels were tested through ELISA. Caspase-3 activity was used to determine apoptosis and was tested using flow cytometry. Results: The results indicated that curcumin had a cytotoxicity effect of 40.85 µg/mL. At concentrations of 40 µg/mL and 50 µg/mL, curcumin increases levels of protein RASSF1A (∆ = 26.53% and 47.35%, respectively), Bax (∆ = 48.79% and 386.15%), and caspase-3 (∆ = 1,678.51% and 1,871.889%) significantly. Conclusions: Curcumin exhibits anti-proliferative activity and apoptotic (Caspase-3) effects through activation of RASSF1A and Bax.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125980239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Asiah, Agnes Yohana Sondi, N. Parlina, D. Jovanka
Introduction: Indonesia Population Demographic Survey in 2017 recorded that 8% of teenage boys and 2% of teenage girls admitted to having sexual intercourse. This certainly worries all of us who hope today's youth will be a demographic bonus. Sexual behavior is at risk of impacting the issue of Unwanted Pregnancy (KTD), abortion, Sexually Transmitted Infections (STIs), and the ongoing incidence of HIV and AIDS. Objective: to confirm the relationship of attitudes and knowledge with risky sexual behavior in adolescent boys in Indonesia. Methods: This type of research is quantitative analytics using a cross-sectional design and sourced from secondary data of the Indonesian Health Demographic Survey 2017. The population in this study was 13,079 adolescent men aged 15-24, sampling 10,710 with saturated sampling techniques. Bivariate data analysis using the chi-square test (0.05). Results: were obtained by adolescents with a positive attitude of 52.1%, knowledgeable 77.8%, and 13.1% risky sexual behavior. Test results showed there was an attitude relationship with risky sexual behavior with p-value = 0.000 and there was a knowledge relationship with risky sexual behavior with p-value = 0.000. Conclusions: This study are expected to be used as input for the creation of risky sexual behavior prevention programs in adolescents and form the basis for the creation of an educational model related to adolescent reproductive health for parents and educational institutions.
{"title":"Attitude and Knowledge Relationship with Sexual Behavior at Risk of Sexually Transmitted Infection (STI) in Male Adolescents in Indonesia (IDHS Data Analysis 2017)","authors":"N. Asiah, Agnes Yohana Sondi, N. Parlina, D. Jovanka","doi":"10.11594/ijmp.02.01.02","DOIUrl":"https://doi.org/10.11594/ijmp.02.01.02","url":null,"abstract":"Introduction: Indonesia Population Demographic Survey in 2017 recorded that 8% of teenage boys and 2% of teenage girls admitted to having sexual intercourse. This certainly worries all of us who hope today's youth will be a demographic bonus. Sexual behavior is at risk of impacting the issue of Unwanted Pregnancy (KTD), abortion, Sexually Transmitted Infections (STIs), and the ongoing incidence of HIV and AIDS. Objective: to confirm the relationship of attitudes and knowledge with risky sexual behavior in adolescent boys in Indonesia. Methods: This type of research is quantitative analytics using a cross-sectional design and sourced from secondary data of the Indonesian Health Demographic Survey 2017. The population in this study was 13,079 adolescent men aged 15-24, sampling 10,710 with saturated sampling techniques. Bivariate data analysis using the chi-square test (0.05). Results: were obtained by adolescents with a positive attitude of 52.1%, knowledgeable 77.8%, and 13.1% risky sexual behavior. Test results showed there was an attitude relationship with risky sexual behavior with p-value = 0.000 and there was a knowledge relationship with risky sexual behavior with p-value = 0.000. Conclusions: This study are expected to be used as input for the creation of risky sexual behavior prevention programs in adolescents and form the basis for the creation of an educational model related to adolescent reproductive health for parents and educational institutions.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125360887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Covid-19 is a new infectious viral illness. The first one appeared in Wuhan, and within two months, it became a pandemic. Medical diagnosis is confirmed by fever, cough, shortness of breath, combined with neutrophil ratio lymphocyte analysis and chest x-ray or chest C.T. radiology imaging, with a ground-glass appearance. C.T. scans are not widely available in hospitals in Indonesia. Many hospitals only own x-ray for covid-19 as radiologic diagnostic imaging. With digital imaging capabilities, Due to the similarity of applications such as the radiological workstation, Adobe Photoshop Express will improve the capacity to diagnose Covid-19 from a chest x-ray. Adobe Photoshop Express has outstanding digital processing capabilities to enhance the presentation of images so that the efficiency of diagnosing plain x-ray thorax image cases with Covid-19 becomes easier and more manageable.
{"title":"Adobe Photoshop Express Application Enhances the Diagnosis of X-Ray Thorax of Covid-19 Patient","authors":"Ahmad Mochtar Jamil, M. Putra, Muhammad Anas","doi":"10.11594/ijmp.01.02.05","DOIUrl":"https://doi.org/10.11594/ijmp.01.02.05","url":null,"abstract":"Covid-19 is a new infectious viral illness. The first one appeared in Wuhan, and within two months, it became a pandemic. Medical diagnosis is confirmed by fever, cough, shortness of breath, combined with neutrophil ratio lymphocyte analysis and chest x-ray or chest C.T. radiology imaging, with a ground-glass appearance. C.T. scans are not widely available in hospitals in Indonesia. Many hospitals only own x-ray for covid-19 as radiologic diagnostic imaging. With digital imaging capabilities, Due to the similarity of applications such as the radiological workstation, Adobe Photoshop Express will improve the capacity to diagnose Covid-19 from a chest x-ray. Adobe Photoshop Express has outstanding digital processing capabilities to enhance the presentation of images so that the efficiency of diagnosing plain x-ray thorax image cases with Covid-19 becomes easier and more manageable.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131551919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oski Illiandri, D. Setyohadi, Aji Ilman Sjidan, Aldiya Jamila, Adwa Humaira, M. Ibrahim, Ahmad Rofii
Superficially, Intelligence is an ability to planning, thinking, talking, rationalization, comparing, and understand with other. One of many methods to rate for intelligence, is Draw-A-Man test, it’s introduced by Goodenough in 1926 to researching children’s creativity, mental age, and visual and motoric intelligence with some code based on picture that the children drawed. The aim of this study was to determine the correlation between head circumference and head length with Intelligence Quotient of the 3rd grade Karang Mekar 1 Banjarmasin elementary school’s student. The methodsof this study used observational analytics with a cross-sectional approach. The sampling technique was total sampling with a sample of 65 students aged 7 to 10 years and fulfilling the inclusion and exclusion criteria. The results of data analysis using the Spearman correlation test showed that the correlation point on the head circumference and head length with IQ were p=0.888 and p=0.985. Based on the results of this study, it can be concluded that there is no significant correlation between the the head circumference and head length with Intelligence Quotien in elementary student.
{"title":"Head Size and Intelligence Quotient (IQ) in Elementary School Students","authors":"Oski Illiandri, D. Setyohadi, Aji Ilman Sjidan, Aldiya Jamila, Adwa Humaira, M. Ibrahim, Ahmad Rofii","doi":"10.11594/ijmp.01.02.01","DOIUrl":"https://doi.org/10.11594/ijmp.01.02.01","url":null,"abstract":"Superficially, Intelligence is an ability to planning, thinking, talking, rationalization, comparing, and understand with other. One of many methods to rate for intelligence, is Draw-A-Man test, it’s introduced by Goodenough in 1926 to researching children’s creativity, mental age, and visual and motoric intelligence with some code based on picture that the children drawed. The aim of this study was to determine the correlation between head circumference and head length with Intelligence Quotient of the 3rd grade Karang Mekar 1 Banjarmasin elementary school’s student. The methodsof this study used observational analytics with a cross-sectional approach. The sampling technique was total sampling with a sample of 65 students aged 7 to 10 years and fulfilling the inclusion and exclusion criteria. The results of data analysis using the Spearman correlation test showed that the correlation point on the head circumference and head length with IQ were p=0.888 and p=0.985. Based on the results of this study, it can be concluded that there is no significant correlation between the the head circumference and head length with Intelligence Quotien in elementary student.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128490508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saurabh Sharma, Sandhya Gupta, Tushar Nagyan, Md. Abu Nasar, Sowbir Some, P. Agarwal
Laryngoscope is one of the most important lifesaving tools in the armamentarium of medical personnel. As is the case with any other tool, this too is susceptible to rare failures. One of these rare malfunctions is the dislodgement of bulb during endotracheal intubation. This can be associated with serious consequences if patient aspirates or ingests the bulb. In the following communication we report this off chance mishap while intubating a patient in trauma ICU.
{"title":"A Case of Ingested Laryngoscope Bulb During Emergency Endotracheal Intubation","authors":"Saurabh Sharma, Sandhya Gupta, Tushar Nagyan, Md. Abu Nasar, Sowbir Some, P. Agarwal","doi":"10.11594/ijmp.01.02.04","DOIUrl":"https://doi.org/10.11594/ijmp.01.02.04","url":null,"abstract":"Laryngoscope is one of the most important lifesaving tools in the armamentarium of medical personnel. As is the case with any other tool, this too is susceptible to rare failures. One of these rare malfunctions is the dislodgement of bulb during endotracheal intubation. This can be associated with serious consequences if patient aspirates or ingests the bulb. In the following communication we report this off chance mishap while intubating a patient in trauma ICU.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124036637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Abulude, A. Akinnusotu, S. Oluwagbayide, Usha Damodharan, I. Abulude
COVID - 19 is an issue ravaging the whole world. Numerous deaths have been recorded particularly elderly individuals and the most vulnerable. In Nigeria, the case isn't extraordinary. The aim of the study was to quantify the number of cases reported in Nigeria. To this effect, the global literature cited in the Nigeria Centre for Disease Control (NCDC) website, the WHO COVID-19 database, other expert-referred scientific articles, and bibliographic databases were used. The results show that as at the sixteenth of May 2020, 288 new affirmed cases and 3 deaths were recorded in Nigeria. Till date, 5445 cases have been affirmed, 778 cases have been released and 171 deaths have been recorded in 34 states and the Federal Capital Territory, While Lagos State is for the most part influenced with 36 deaths in comparison with the cases revealed by the World Health Organization (4,425,485 cases affirmed, 89,269 new cases and 302,059 deaths). The death rate in Nigeria is about 0.05% of the global deaths. The explanation could be because of high temperature (> 30 oC), the intake of garlic, ginger, honey, and heated water by the individuals, and to stop the spread, the Nigerian government has implemented the utilization of nose cover, social distancing, and semi-lockdown of the towns and urban communities. Like HIV and Laser fever this pandemic will be an issue of the past when the adequate vaccine is made available.
{"title":"Coronavirus Pandemic: Situation in Nigeria","authors":"F. Abulude, A. Akinnusotu, S. Oluwagbayide, Usha Damodharan, I. Abulude","doi":"10.11594/ijmp.01.02.03","DOIUrl":"https://doi.org/10.11594/ijmp.01.02.03","url":null,"abstract":"COVID - 19 is an issue ravaging the whole world. Numerous deaths have been recorded particularly elderly individuals and the most vulnerable. In Nigeria, the case isn't extraordinary. The aim of the study was to quantify the number of cases reported in Nigeria. To this effect, the global literature cited in the Nigeria Centre for Disease Control (NCDC) website, the WHO COVID-19 database, other expert-referred scientific articles, and bibliographic databases were used. The results show that as at the sixteenth of May 2020, 288 new affirmed cases and 3 deaths were recorded in Nigeria. Till date, 5445 cases have been affirmed, 778 cases have been released and 171 deaths have been recorded in 34 states and the Federal Capital Territory, While Lagos State is for the most part influenced with 36 deaths in comparison with the cases revealed by the World Health Organization (4,425,485 cases affirmed, 89,269 new cases and 302,059 deaths). The death rate in Nigeria is about 0.05% of the global deaths. The explanation could be because of high temperature (> 30 oC), the intake of garlic, ginger, honey, and heated water by the individuals, and to stop the spread, the Nigerian government has implemented the utilization of nose cover, social distancing, and semi-lockdown of the towns and urban communities. Like HIV and Laser fever this pandemic will be an issue of the past when the adequate vaccine is made available.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116789224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pterygium is a degenerative and invasive disorder of the subconjunctival tissue that can reach the cornea area which is become a worldwide health problem. UV exposure is the biggest risk factor for pterygium. A profession as a fisherman is one of the occupations that are often related to the appearance of pterygium, because of long-term exposure to UV rays. This study aimed to determine the correlation between age and duration as a fisherman with the degree of pterygium in Kedung Cowek village, Bulak Surabaya district, East Java - Indonesia. The research design was an analytic observational using consecutive sampling during March - July 2011; with the total number of respondents is 42 fishermen who met the inclusion criteria. The results of the statistical analysis test showed that there was a strong and significant relationship between the age of the fishermen (p = 0.007; coefficient correlation = 502) and the duration of working as a fisherman (p = 0.029; coefficient correlation = 409) with the severity of the pterygium. Based on these results it can be concluded that the age and duration of work as fishermen are related to the severity of the pterygium in fishermen in the Kedung Cowek sub-district, Surabaya, East Java-Indonesia.
{"title":"Increased Age and Long Working Period Associated with Increased Severi-ty of Pterygium Among Fishermen in Kedung Cowek Sub-District, Surabaya, East Java-Indonesia","authors":"I. A. Pasaribu, P. Utami","doi":"10.11594/ijmp.01.02.02","DOIUrl":"https://doi.org/10.11594/ijmp.01.02.02","url":null,"abstract":"Pterygium is a degenerative and invasive disorder of the subconjunctival tissue that can reach the cornea area which is become a worldwide health problem. UV exposure is the biggest risk factor for pterygium. A profession as a fisherman is one of the occupations that are often related to the appearance of pterygium, because of long-term exposure to UV rays. This study aimed to determine the correlation between age and duration as a fisherman with the degree of pterygium in Kedung Cowek village, Bulak Surabaya district, East Java - Indonesia. The research design was an analytic observational using consecutive sampling during March - July 2011; with the total number of respondents is 42 fishermen who met the inclusion criteria. The results of the statistical analysis test showed that there was a strong and significant relationship between the age of the fishermen (p = 0.007; coefficient correlation = 502) and the duration of working as a fisherman (p = 0.029; coefficient correlation = 409) with the severity of the pterygium. Based on these results it can be concluded that the age and duration of work as fishermen are related to the severity of the pterygium in fishermen in the Kedung Cowek sub-district, Surabaya, East Java-Indonesia.","PeriodicalId":145411,"journal":{"name":"Indonesian Journal of Medical Sciences and Public Health","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115070338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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