‘Head and neck cancer’ is a general term for malignant neoplasms arising from subsites of the head and neck area and consists of various histology. Among them, recurrent or metastatic squamous cell carcinoma from the oral cavity, oropharynx, hypopharynx, or larynx (RM-HNSCC) is a primary target of the drug development, the evidence for RM-HNSCC has been adopted for the chemotherapy of oral cancer. Currently, an immune checkpoint inhibitor (ICI) is the main drug for the chemotherapy for RM-HNSCC; the treatment should be performed after fully understanding the difference of the evidence in ‘platinum-sensitive’ or ‘platinum-refractory’ disease. Notably, managing immune-related adverse events (irAE) is essential in ICI therapy because delayed treatment for irAE can lead to fatal events. The physicians in charge must understand the irAE management deeply and distinguish irAE between what should be treated by oneself and what should be consulted with specialists.
{"title":"口腔がんの薬物療法","authors":"Yoshitaka HONMA","doi":"10.5794/jjoms.69.366","DOIUrl":"https://doi.org/10.5794/jjoms.69.366","url":null,"abstract":"‘Head and neck cancer’ is a general term for malignant neoplasms arising from subsites of the head and neck area and consists of various histology. Among them, recurrent or metastatic squamous cell carcinoma from the oral cavity, oropharynx, hypopharynx, or larynx (RM-HNSCC) is a primary target of the drug development, the evidence for RM-HNSCC has been adopted for the chemotherapy of oral cancer. Currently, an immune checkpoint inhibitor (ICI) is the main drug for the chemotherapy for RM-HNSCC; the treatment should be performed after fully understanding the difference of the evidence in ‘platinum-sensitive’ or ‘platinum-refractory’ disease. Notably, managing immune-related adverse events (irAE) is essential in ICI therapy because delayed treatment for irAE can lead to fatal events. The physicians in charge must understand the irAE management deeply and distinguish irAE between what should be treated by oneself and what should be consulted with specialists.","PeriodicalId":14571,"journal":{"name":"Japanese Journal of Oral and Maxillofacial Surgery","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135937575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"「真の学際的研究を実現するために？」","authors":"一人 里村","doi":"10.5794/jjoms.69.365","DOIUrl":"https://doi.org/10.5794/jjoms.69.365","url":null,"abstract":"","PeriodicalId":14571,"journal":{"name":"Japanese Journal of Oral and Maxillofacial Surgery","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135937577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"「病院歯科口腔外科の役割」","authors":"義彦 横江","doi":"10.5794/jjoms.69.331","DOIUrl":"https://doi.org/10.5794/jjoms.69.331","url":null,"abstract":"","PeriodicalId":14571,"journal":{"name":"Japanese Journal of Oral and Maxillofacial Surgery","volume":"412 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Hamada, Koichi Koizumi, M. Higaki, F. Obayashi, Shinnichi Sakamoto, S. Toratani
{"title":"歯内歯様の奇形を呈する埋伏過剰歯由来と考えられる含歯性囊胞の1例","authors":"A. Hamada, Koichi Koizumi, M. Higaki, F. Obayashi, Shinnichi Sakamoto, S. Toratani","doi":"10.5794/jjoms.69.337","DOIUrl":"https://doi.org/10.5794/jjoms.69.337","url":null,"abstract":"","PeriodicalId":14571,"journal":{"name":"Japanese Journal of Oral and Maxillofacial Surgery","volume":"245 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kojiro Abe, T. Yamashita, Itsuki Hayashi, Keisuke Inoue, M. Toida, Toshi-Aki Shibata
{"title":"前舌腺由来と考えられた上皮筋上皮癌の1例","authors":"Kojiro Abe, T. Yamashita, Itsuki Hayashi, Keisuke Inoue, M. Toida, Toshi-Aki Shibata","doi":"10.5794/jjoms.69.341","DOIUrl":"https://doi.org/10.5794/jjoms.69.341","url":null,"abstract":"","PeriodicalId":14571,"journal":{"name":"Japanese Journal of Oral and Maxillofacial Surgery","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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