首页 > 最新文献

Iranian journal of kidney diseases最新文献

英文 中文
A Report of Claudin-19 Mutation Causing Nephrocalcinosis and End-Stage Kidney Disease from Iran. 一份关于伊朗 Claudin-19 基因突变导致肾钙化和终末期肾病的报告。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-08-20
Shokoufeh Savaj, Saghar Chehrazi

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder that affect children and young adults. Mutation in gene that coding the tight junction proteins Claudin-16 and Claudin-19(CLDN19) is responsible of this rare disorder. Hypomagnesemia, hypercalciuria, kidney failure and visual impairment (in CLDN 19 gene mutation) are the most common presentations of FHHNC. Here we present a 31-year-old woman with end-stage kidney disease (ESKD) on routine hemodialysis for the past eight years and was referred to Firoozgar nephrology clinic for kidney transplantation. Her past medical history included recurrent kidney stones. Although FHHNC is a rare disease, genetic evaluation recommended in patients with ESKD and concomitant nephrocalcinosis.

家族性高镁血症伴高钙尿症和肾钙化症(FHHNC)是一种常染色体隐性遗传疾病,多发于儿童和青少年。编码紧密连接蛋白 Claudin-16 和 Claudin-19 (CLDN19)的基因突变是导致这种罕见疾病的原因。低镁血症、高钙血症、肾衰竭和视力障碍(CLDN 19 基因突变时)是 FHHNC 最常见的表现。在此,我们介绍一名患有终末期肾病(ESKD)的 31 岁女性,她在过去八年中一直接受常规血液透析,并被转诊至 Firoozgar 肾病诊所接受肾移植。她的既往病史包括反复肾结石。虽然 FHHNC 是一种罕见疾病,但仍建议对患有 ESKD 并伴有肾钙化的患者进行遗传评估。
{"title":"A Report of Claudin-19 Mutation Causing Nephrocalcinosis and End-Stage Kidney Disease from Iran.","authors":"Shokoufeh Savaj, Saghar Chehrazi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder that affect children and young adults. Mutation in gene that coding the tight junction proteins Claudin-16 and Claudin-19(CLDN19) is responsible of this rare disorder. Hypomagnesemia, hypercalciuria, kidney failure and visual impairment (in CLDN 19 gene mutation) are the most common presentations of FHHNC. Here we present a 31-year-old woman with end-stage kidney disease (ESKD) on routine hemodialysis for the past eight years and was referred to Firoozgar nephrology clinic for kidney transplantation. Her past medical history included recurrent kidney stones. Although FHHNC is a rare disease, genetic evaluation recommended in patients with ESKD and concomitant nephrocalcinosis.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 4","pages":"125"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Exchange Systems and Procedure on Long Term Peritonitis in ESKD Patients Undergoing CAPD :A Retrospective Comparative Cohort Study. 交换系统和程序对接受 CAPD 的 ESKD 患者长期腹膜炎的影响:一项回顾性队列比较研究。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-08-20
Phongsak Dandecha, Atthaphong Phongphithakchai

Introduction: Peritoneal dialysis utilizes two distinct double-bag exchange systems (ANDY-Disc from Fresenius Medical Care in Bad Homburg, Germany, and DIANEAL from Baxter in Deerfield, IL). These systems are widely used across the globe. The long-term outcomes of peritonitis with different types of treatment are still questionable. Therefore, we conducted a retrospective comparative cohort study to assess the long-term impact of these two distinct exchange procedures on the true peritonitis rate and the technique durability in real-world settings.

Methods: One hundred and twenty patients, treated with a double-bag exchange system in a Songklanagarind Hospital, located in the south of Thailand from January 2009 to December 2020 were included. The primary outcome was the incidence rate of peritonitis by treatment arm (ANDY-disc and DIANEAL). Secondary outcomes included the pathogenic organism causing peritonitis, time to the first peritonitis, and survival technique between the two systems.

Results: The peritonitis rate for patients using the ANDY-disc in continuous ambulatory peritoneal dialysis (CAPD) was 0.28 episodes per patient-year, while the DIANEAL group had a rate of 0.29 episodes per patient-year. There was no difference in the peritonitis rate between the two groups (P = .816). Gram-positive bacterial peritonitis accounted for 33.4% in the ANDY-disc arm and 43.7% in the DIANEAL arm. The 10-year technique survival was 86.1% in the ANDY-Disc group and 73.5% in the DIANEAL group; this did not reach statistical significance.

Conclusion: The ANDY-Disc and DIANEAL exchange systems are comparable in the long-term incidence of peritonitis. Both systems have similar long-term technique survival. However, this should be confirmed by a high-quality trial.

简介:腹膜透析使用两种不同的双袋交换系统(德国巴德洪堡费森尤斯医疗用品公司的ANDY-Disc和伊利诺伊州迪尔菲尔德百特公司的DIANEAL)。这些系统在全球广泛使用。不同类型治疗腹膜炎的长期疗效仍有疑问。因此,我们进行了一项回顾性队列比较研究,以评估这两种不同的交换程序对真实腹膜炎率和实际环境中技术耐久性的长期影响:研究纳入了 2009 年 1 月至 2020 年 12 月在泰国南部 Songklanagarind 医院接受双袋交换系统治疗的 120 名患者。主要结果是治疗组(ANDY-disc 和 DIANEAL)的腹膜炎发生率。次要结果包括引起腹膜炎的病原体、首次腹膜炎的时间以及两种治疗方法的存活率:结果:在持续非卧床腹膜透析(CAPD)中使用 ANDY-Disc 的患者腹膜炎发病率为 0.28 次/年,而 DIANEAL 组的发病率为 0.29 次/年。两组腹膜炎发病率无差异(P = .816)。革兰氏阳性菌腹膜炎在 ANDY-Disc 组中占 33.4%,在 DIANEAL 组中占 43.7%。ANDY-Disc组的10年技术存活率为86.1%,DIANEAL组为73.5%;这没有达到统计学意义:结论:在腹膜炎的长期发生率方面,ANDY-Disc 和 DIANEAL 交换系统不相上下。两种系统的长期技术存活率相似。不过,这一点应通过高质量的试验来证实。
{"title":"Effect of Exchange Systems and Procedure on Long Term Peritonitis in ESKD Patients Undergoing CAPD :A Retrospective Comparative Cohort Study.","authors":"Phongsak Dandecha, Atthaphong Phongphithakchai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Peritoneal dialysis utilizes two distinct double-bag exchange systems (ANDY-Disc from Fresenius Medical Care in Bad Homburg, Germany, and DIANEAL from Baxter in Deerfield, IL). These systems are widely used across the globe. The long-term outcomes of peritonitis with different types of treatment are still questionable. Therefore, we conducted a retrospective comparative cohort study to assess the long-term impact of these two distinct exchange procedures on the true peritonitis rate and the technique durability in real-world settings.</p><p><strong>Methods: </strong>One hundred and twenty patients, treated with a double-bag exchange system in a Songklanagarind Hospital, located in the south of Thailand from January 2009 to December 2020 were included. The primary outcome was the incidence rate of peritonitis by treatment arm (ANDY-disc and DIANEAL). Secondary outcomes included the pathogenic organism causing peritonitis, time to the first peritonitis, and survival technique between the two systems.</p><p><strong>Results: </strong>The peritonitis rate for patients using the ANDY-disc in continuous ambulatory peritoneal dialysis (CAPD) was 0.28 episodes per patient-year, while the DIANEAL group had a rate of 0.29 episodes per patient-year. There was no difference in the peritonitis rate between the two groups (P = .816). Gram-positive bacterial peritonitis accounted for 33.4% in the ANDY-disc arm and 43.7% in the DIANEAL arm. The 10-year technique survival was 86.1% in the ANDY-Disc group and 73.5% in the DIANEAL group; this did not reach statistical significance.</p><p><strong>Conclusion: </strong>The ANDY-Disc and DIANEAL exchange systems are comparable in the long-term incidence of peritonitis. Both systems have similar long-term technique survival. However, this should be confirmed by a high-quality trial.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 4","pages":"212-220"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Insights into Oxidative Stress and Antioxidant Enzymes in Acute Antibody-Mediated Rejection of Renal Allografts. 急性抗体介导的肾移植排斥反应中氧化应激和抗氧化酶的新见解
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-08-20
Mohsen Nafar, Iraj Khodadadi, Shiva Kalantari, Heidar Tayebinia, Jamshid Karimi, Shiva Samavat, Nooshin Dalili, Somaye-Sadat Heidari

Introduction: Antibody mediated rejection (AMR) is a major challenge in kidney transplantation and adversely affects allograft survival. Oxidative stress (OS) is implicated in AMR pathogenesis by triggering inflammation, apoptosis and fibrosis in the graft tissue. However, the status of OS and antioxidant defense in AMR patients remains unclear. We aimed to evaluate the levels of OS markers and antioxidant enzymes in AMR patients.  Methods. We conducted a case-control study involving 22 biopsy-proven AMR patients (test group) and 14 kidney recipients with stable graft function (control group). Serum total oxidant status (TOS), total antioxidant capacity (TAC), total thiol groups, nitric oxide (NO), 8-isoprostane (8-IP) were determined and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured by spectrophotometric methods.

Results: Data analysis showed significant increases in TOS, TAC and 8-IP levels together with marked reductions in NO and total thiol groups in AMR patients. CAT and GPx activities did not differ between groups, however SOD activity was significantly lower in AMR patients.

Conclusion: Our study showed increased OS and impaired antioxidant defense in AMR patients. NO level may serve as a potential biomarker of OS severity and immune response in AMR. Further studies are required to elucidate the mechanisms and consequences of OS in AMR and to explore the therapeutic potential of antioxidants.

导言:抗体介导的排斥反应(AMR)是肾移植的一大挑战,对异体移植物的存活造成了不利影响。氧化应激(OS)通过引发移植物组织的炎症、凋亡和纤维化而被认为与AMR的发病机制有关。然而,AMR 患者体内的氧化应激和抗氧化防御状况仍不清楚。我们旨在评估AMR患者体内OS标记物和抗氧化酶的水平。 方法。我们进行了一项病例对照研究,涉及 22 名经活检证实的 AMR 患者(试验组)和 14 名移植物功能稳定的肾脏受者(对照组)。采用分光光度法测定血清总氧化状态(TOS)、总抗氧化能力(TAC)、总硫醇基团、一氧化氮(NO)、8-异前列腺素(8-IP)以及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPx)的活性:数据分析显示,AMR 患者的 TOS、TAC 和 8-IP 水平明显升高,NO 和总硫醇组明显降低。AMR患者的CAT和GPx活性在不同组间没有差异,但SOD活性明显降低:我们的研究表明,AMR 患者的操作系统增加,抗氧化防御能力受损。NO水平可作为AMR患者OS严重程度和免疫反应的潜在生物标志物。还需要进一步研究,以阐明AMR中OS的机制和后果,并探索抗氧化剂的治疗潜力。
{"title":"Novel Insights into Oxidative Stress and Antioxidant Enzymes in Acute Antibody-Mediated Rejection of Renal Allografts.","authors":"Mohsen Nafar, Iraj Khodadadi, Shiva Kalantari, Heidar Tayebinia, Jamshid Karimi, Shiva Samavat, Nooshin Dalili, Somaye-Sadat Heidari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Antibody mediated rejection (AMR) is a major challenge in kidney transplantation and adversely affects allograft survival. Oxidative stress (OS) is implicated in AMR pathogenesis by triggering inflammation, apoptosis and fibrosis in the graft tissue. However, the status of OS and antioxidant defense in AMR patients remains unclear. We aimed to evaluate the levels of OS markers and antioxidant enzymes in AMR patients.  Methods. We conducted a case-control study involving 22 biopsy-proven AMR patients (test group) and 14 kidney recipients with stable graft function (control group). Serum total oxidant status (TOS), total antioxidant capacity (TAC), total thiol groups, nitric oxide (NO), 8-isoprostane (8-IP) were determined and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured by spectrophotometric methods.</p><p><strong>Results: </strong>Data analysis showed significant increases in TOS, TAC and 8-IP levels together with marked reductions in NO and total thiol groups in AMR patients. CAT and GPx activities did not differ between groups, however SOD activity was significantly lower in AMR patients.</p><p><strong>Conclusion: </strong>Our study showed increased OS and impaired antioxidant defense in AMR patients. NO level may serve as a potential biomarker of OS severity and immune response in AMR. Further studies are required to elucidate the mechanisms and consequences of OS in AMR and to explore the therapeutic potential of antioxidants.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 4","pages":"227-235"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Kidney Injury in Critically Ill Pregnant Women:A Retrospective Study on Risk Factors and Outcomes. 重症孕妇急性肾损伤:关于风险因素和结果的回顾性研究。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-08-20
Qifeng Song, Jia Jia, Chen Chen, Guofu Li

Introduction: Despite the significant decline in the incidence of pregnancy-related acute kidney injury (AKI) in recent decades due to advancements in medicine and increased awareness of this disease, it remains an important risk factor for maternal morbidity and mortality. However, as fertilization techniques allow women of advanced age to become pregnant, the incidence of pregnancy-related AKI has increased. Consequently, early identification of and intervention for pregnancy-related AKI are particularly important.

Methods: This was a retrospective clinical analysis. Data were collected from pregnant patients who were treated in the ICU of Shengjing Hospital of China Medical University from January 2014 to June 2020; The patients were divided into two groups based on their kidney function status: AKI and non-AKI. Additionally, they were further categorized into recovered and non-recovered groups based on their prognosis. The Wilcoxon rank sum test and the chi-square test were used for multigroup comparisons, while logistic regression analysis was used for the analysis of risk factors. P < .05 was considered to indicate a statistically significant difference in all correlation analyses.

Results: Among 874 pregnant women in this study, 136 had AKI (15.56%), while 36 developed chronic renal insufficiency (26.47%). Statistically significant associations were shown for shock (P = .002), sepsis (P < .001), coagulopathies (P = .001), liver insufficiency (P < .001), postpartum hemorrhage (P = .016), intrauterine fetal death (P = .042) and mechanical ventilation (P = .006) between the AKI-group and the non-AKI group. The development of AKI based on an elevated baseline creatinine level was significantly related to the outcome of renal function (P < .001), while a significant difference was shown in the use of continuous renal replacement therapy (CRRT) between the recovery group and the non-recovery group (P = .023).

Conclusion: We identified the relevant risk factors leading to pregnancy-related AKI and affecting the patients' prognosis. Shock, sepsis, coagulation disorders, liver insufficiency, postpartum hemorrhage, intrauterine fetal death and mechanical ventilation are independent risk factors for pregnancy-related AKI, while an elevated baseline creatine level is a key factor for poor prognosis. Meanwhile, early CRRT can effectively reverse renal outcomes.

导言:尽管近几十年来,由于医学的进步和人们对这种疾病认识的提高,妊娠相关急性肾损伤(AKI)的发病率大幅下降,但它仍然是孕产妇发病和死亡的一个重要风险因素。然而,由于受精技术允许高龄产妇怀孕,妊娠相关急性肾损伤的发病率也随之增加。因此,早期识别和干预妊娠相关性 AKI 尤为重要:这是一项回顾性临床分析。数据来源于2014年1月至2020年6月在中国医科大学附属盛京医院ICU接受治疗的妊娠期患者:根据肾功能状态将患者分为两组:AKI 组和非 AKI 组。此外,根据预后将患者进一步分为康复组和未康复组。多组比较采用 Wilcoxon 秩和检验和卡方检验,风险因素分析采用逻辑回归分析。在所有相关分析中,P < .05 被认为表明差异具有统计学意义:结果:在这项研究的 874 名孕妇中,136 人(15.56%)发生了 AKI,36 人(26.47%)出现了慢性肾功能不全。在休克(P = .002)、败血症(P < .001)、凝血功能障碍(P = .001)、肝功能不全(P < .001)、产后出血(P = .016)、胎儿宫内死亡(P = .042)和机械通气(P = .006)方面,AKI 组和非 AKI 组之间存在统计学意义上的关联。基线肌酐水平升高导致的AKI与肾功能结果有显著相关性(P < .001),而恢复组和非恢复组在使用持续肾脏替代疗法(CRRT)方面存在显著差异(P = .023):我们确定了导致妊娠相关性 AKI 并影响患者预后的相关风险因素。休克、脓毒症、凝血功能障碍、肝功能不全、产后出血、胎儿宫内死亡和机械通气是妊娠相关性 AKI 的独立危险因素,而基线肌酸水平升高是预后不良的关键因素。同时,早期的 CRRT 可以有效地逆转肾脏预后。
{"title":"Acute Kidney Injury in Critically Ill Pregnant Women:A Retrospective Study on Risk Factors and Outcomes.","authors":"Qifeng Song, Jia Jia, Chen Chen, Guofu Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the significant decline in the incidence of pregnancy-related acute kidney injury (AKI) in recent decades due to advancements in medicine and increased awareness of this disease, it remains an important risk factor for maternal morbidity and mortality. However, as fertilization techniques allow women of advanced age to become pregnant, the incidence of pregnancy-related AKI has increased. Consequently, early identification of and intervention for pregnancy-related AKI are particularly important.</p><p><strong>Methods: </strong>This was a retrospective clinical analysis. Data were collected from pregnant patients who were treated in the ICU of Shengjing Hospital of China Medical University from January 2014 to June 2020; The patients were divided into two groups based on their kidney function status: AKI and non-AKI. Additionally, they were further categorized into recovered and non-recovered groups based on their prognosis. The Wilcoxon rank sum test and the chi-square test were used for multigroup comparisons, while logistic regression analysis was used for the analysis of risk factors. P < .05 was considered to indicate a statistically significant difference in all correlation analyses.</p><p><strong>Results: </strong>Among 874 pregnant women in this study, 136 had AKI (15.56%), while 36 developed chronic renal insufficiency (26.47%). Statistically significant associations were shown for shock (P = .002), sepsis (P < .001), coagulopathies (P = .001), liver insufficiency (P < .001), postpartum hemorrhage (P = .016), intrauterine fetal death (P = .042) and mechanical ventilation (P = .006) between the AKI-group and the non-AKI group. The development of AKI based on an elevated baseline creatinine level was significantly related to the outcome of renal function (P < .001), while a significant difference was shown in the use of continuous renal replacement therapy (CRRT) between the recovery group and the non-recovery group (P = .023).</p><p><strong>Conclusion: </strong>We identified the relevant risk factors leading to pregnancy-related AKI and affecting the patients' prognosis. Shock, sepsis, coagulation disorders, liver insufficiency, postpartum hemorrhage, intrauterine fetal death and mechanical ventilation are independent risk factors for pregnancy-related AKI, while an elevated baseline creatine level is a key factor for poor prognosis. Meanwhile, early CRRT can effectively reverse renal outcomes.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 4","pages":"195-203"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Safety of Prednisone Plus Dipyridamole Versus Prednisone Plus Valsartan in the Treatment of Children with Primary Nephrotic Syndrome. 泼尼松加双嘧达莫与泼尼松加缬沙坦治疗原发性肾病综合征患儿的安全性比较。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-08-20
Guoqiang Chen, Wenliang Li

Introduction: In recent years, the incidence of pediatric nephrotic syndrome (NS) has been increasing, and timely and effective treatment is critical to protect the health of children with NS. This study is an attempt to compare the therapeutic effects of prednisone  (Pred) plus dipyridamole (DIP) versus Pred plus valsartan (VAL)on pediatric NS.

Methods: Two hundred pediatric cases of NS were selected as the research participants, including 109 cases (group A) receiving Pred + DIP and 91 cases (group B) receiving Pred + VAL. The clinical efficacy, adverse reactions, and renal, coagulation functions and blood lipid levels, as well as the pre- and post-treatment levels of inflammatory factors (IFs) and immunoglobulins (Igs) were comparatively analyzed.

Results: No statistically significant differences were found between groups in terms of clinical efficacy, incidence of adverse reactions and renal function (P > .05). After receiving the corresponding treatment, group A showed better coagulation and immune functions than group B, but higher levels of IFs and poorer blood lipid function (P < .05).

Conclusion: Both Pred + DIP and Pred + VAL combination therapies can be used for the treatment of pediatric NS, with the former contributing to more obviously enhanced coagulation and immune functions, and the latter leading to more significantly inhibited inflammation and better regulated blood lipid function.

导言:近年来,小儿肾病综合征(NS)的发病率不断上升,及时有效的治疗对于保护NS患儿的健康至关重要。本研究试图比较泼尼松(Prednisone,Pred)加双嘧达莫(DIP)与泼尼松加缬沙坦(VAL)对小儿肾病综合征的治疗效果:选取200例小儿NS患者作为研究对象,其中109例(A组)接受强的松+双嘧达莫治疗,91例(B组)接受强的松+缬沙坦治疗。对比分析两组的临床疗效、不良反应、肾功能、凝血功能、血脂水平以及治疗前后炎症因子(IFs)和免疫球蛋白(Igs)水平:结果:各组在临床疗效、不良反应发生率和肾功能方面差异无统计学意义(P>0.05)。接受相应治疗后,A 组的凝血功能和免疫功能优于 B 组,但 IFs 水平较高,血脂功能较差(P < .05):结论:Pred + DIP 和 Pred + VAL 联合疗法均可用于治疗小儿 NS,前者能更明显地增强凝血和免疫功能,后者能更显著地抑制炎症和更好地调节血脂功能。
{"title":"Comparison of the Safety of Prednisone Plus Dipyridamole Versus Prednisone Plus Valsartan in the Treatment of Children with Primary Nephrotic Syndrome.","authors":"Guoqiang Chen, Wenliang Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the incidence of pediatric nephrotic syndrome (NS) has been increasing, and timely and effective treatment is critical to protect the health of children with NS. This study is an attempt to compare the therapeutic effects of prednisone  (Pred) plus dipyridamole (DIP) versus Pred plus valsartan (VAL)on pediatric NS.</p><p><strong>Methods: </strong>Two hundred pediatric cases of NS were selected as the research participants, including 109 cases (group A) receiving Pred + DIP and 91 cases (group B) receiving Pred + VAL. The clinical efficacy, adverse reactions, and renal, coagulation functions and blood lipid levels, as well as the pre- and post-treatment levels of inflammatory factors (IFs) and immunoglobulins (Igs) were comparatively analyzed.</p><p><strong>Results: </strong>No statistically significant differences were found between groups in terms of clinical efficacy, incidence of adverse reactions and renal function (P > .05). After receiving the corresponding treatment, group A showed better coagulation and immune functions than group B, but higher levels of IFs and poorer blood lipid function (P < .05).</p><p><strong>Conclusion: </strong>Both Pred + DIP and Pred + VAL combination therapies can be used for the treatment of pediatric NS, with the former contributing to more obviously enhanced coagulation and immune functions, and the latter leading to more significantly inhibited inflammation and better regulated blood lipid function.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 4","pages":"204-211"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nighttime Blood Pressure Abnormalities in Iranian CKD Patients: Necessity to Perform Ambulatory Blood Pressure Monitoring. 伊朗慢性肾脏病患者夜间血压异常:进行动态血压监测的必要性。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-05-01 DOI: 10.52547/q4b5rx79
Mohammad Taghi Najafi, Mohammad Reza Abbasi, Seyed Mansour Gatmiri, Mohammad Reza Khatami, Atefeh Mokhtardokht, Mohammad Hossein Shojamoradi

Introduction: Ambulatory blood pressure monitoring (ABPM) is a valuable tool for detecting abnormalities in nighttime blood pressure (BP), including non-dipping and nighttime hypertension. These abnormalities are independent predictors of a poor prognosis in patients with chronic kidney disease (CKD). The aim of our study  was to analyze ABPM data and evaluate nighttime BP abnormalities in an Iranian CKD population.

Methods: This cross-sectional study was conducted on sixty two patients at stages III and IV of CKD who were referred to a nephrology clinic in Tehran, Iran. The patients were classified as either dippers (19.4%) or non-dippers (80.6%), as well as nighttime normotensives (38.7%) or hypertensives (61.3%), based on ABPM  data and in accordance with 2023 ESC/ESH guidelines. We compared demographic data, estimated glomerular filtration rate (eGFR), and daytime BP levels among these groups.

Results: The mean age of patients was 56.34 years, with 61.1% of them being male. Daytime pulse pressure was significantly greater in non-dippers compared to dippers (52.67 vs. 44 mmHg, P = .02). We found a significant correlation between the extent of BP dipping and eGFR (R = 0.281, P = .02). Systolic and diastolic daytime BP levels were significantly higher in individuals with nighttime hypertension. Diabetic patients were more likely to be non-dippers and have nighttime hypertension. After adjusting for age, diabetes mellitus, and daytime pulse pressure in a multivariable model, we determined that eGFR independently predicted the  extent of BP dipping.

Conclusion: Our results showed that both non-dipping and nighttime hypertension are highly prevalent in CKD patients, but they have distinct contributing factors. The eGFR was identified as an independent predictor of BP dipping, whereas nighttime BP levels were primarily determined by daytime BP levels. DOI: 10.52547/ijkd.7559.

导言:动态血压监测(ABPM)是检测夜间血压(BP)异常(包括非降压和夜间高血压)的重要工具。这些异常是慢性肾脏病(CKD)患者预后不良的独立预测因素。我们的研究旨在分析 ABPM 数据并评估伊朗 CKD 患者的夜间血压异常情况:这项横断面研究的对象是转诊到伊朗德黑兰一家肾病诊所的 62 名 CKD III 期和 IV 期患者。根据 ABPM 数据和 2023 年 ESC/ESH 指南,这些患者被分为尿毒症患者(19.4%)和非尿毒症患者(80.6%),以及夜间血压正常者(38.7%)和高血压患者(61.3%)。我们比较了这些组别的人口统计学数据、估计肾小球滤过率(eGFR)和日间血压水平:患者的平均年龄为 56.34 岁,61.1% 为男性。非糖尿病患者的日间脉压明显高于糖尿病患者(52.67 vs. 44 mmHg,P = .02)。我们发现血压下降的程度与 eGFR 之间存在明显的相关性(R = 0.281,P = 0.02)。夜间高血压患者的日间收缩压和舒张压水平明显较高。糖尿病患者更有可能是非降压者和夜间高血压患者。在多变量模型中对年龄、糖尿病和日间脉压进行调整后,我们确定 eGFR 可独立预测血压下降的程度:我们的研究结果表明,非浸润性高血压和夜间高血压在慢性肾脏病患者中都非常普遍,但它们有不同的诱发因素。结论:我们的研究结果表明,非浸润性高血压和夜间高血压在慢性肾脏病患者中都很普遍,但它们有不同的诱因。eGFR 是血压浸润的独立预测因子,而夜间血压水平主要由白天血压水平决定。DOI: 10.52547/ijkd.7559.
{"title":"Nighttime Blood Pressure Abnormalities in Iranian CKD Patients: Necessity to Perform Ambulatory Blood Pressure Monitoring.","authors":"Mohammad Taghi Najafi, Mohammad Reza Abbasi, Seyed Mansour Gatmiri, Mohammad Reza Khatami, Atefeh Mokhtardokht, Mohammad Hossein Shojamoradi","doi":"10.52547/q4b5rx79","DOIUrl":"10.52547/q4b5rx79","url":null,"abstract":"<p><strong>Introduction: </strong>Ambulatory blood pressure monitoring (ABPM) is a valuable tool for detecting abnormalities in nighttime blood pressure (BP), including non-dipping and nighttime hypertension. These abnormalities are independent predictors of a poor prognosis in patients with chronic kidney disease (CKD). The aim of our study  was to analyze ABPM data and evaluate nighttime BP abnormalities in an Iranian CKD population.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on sixty two patients at stages III and IV of CKD who were referred to a nephrology clinic in Tehran, Iran. The patients were classified as either dippers (19.4%) or non-dippers (80.6%), as well as nighttime normotensives (38.7%) or hypertensives (61.3%), based on ABPM  data and in accordance with 2023 ESC/ESH guidelines. We compared demographic data, estimated glomerular filtration rate (eGFR), and daytime BP levels among these groups.</p><p><strong>Results: </strong>The mean age of patients was 56.34 years, with 61.1% of them being male. Daytime pulse pressure was significantly greater in non-dippers compared to dippers (52.67 vs. 44 mmHg, P = .02). We found a significant correlation between the extent of BP dipping and eGFR (R = 0.281, P = .02). Systolic and diastolic daytime BP levels were significantly higher in individuals with nighttime hypertension. Diabetic patients were more likely to be non-dippers and have nighttime hypertension. After adjusting for age, diabetes mellitus, and daytime pulse pressure in a multivariable model, we determined that eGFR independently predicted the  extent of BP dipping.</p><p><strong>Conclusion: </strong>Our results showed that both non-dipping and nighttime hypertension are highly prevalent in CKD patients, but they have distinct contributing factors. The eGFR was identified as an independent predictor of BP dipping, whereas nighttime BP levels were primarily determined by daytime BP levels. DOI: 10.52547/ijkd.7559.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 3","pages":"150-158"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-33a Overexpression Exacerbates Diabetic Nephropathy Through Sirt6-dependent Notch Signaling. MiR-33a 的过度表达会通过 Sirt6 依赖性 Notch 信号转导加剧糖尿病肾病。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-05-01 DOI: 10.52547/g7kbp983
Yingying Wang, Shasha Dai, Jing Yang, Jun Ma, Peng Wang, Xiaowei Zhao, Jua Liu, Ao Xiao, Yahui Song, Lipin Gao

Introduction: Diabetic nephropathy (DN) belongs to the major cause of end-stage kidney disease. We probed the functions of a microRNA miR-33a in inducing podocytes injury during childhood  DN (CDN).

Methods: Kidney samples were collected from 20 children with DN. Matrix deposition and glomerular basement membranes thickness were examined by periodic acid-Schiff staining. Immunofluorescence staining was performed to assess kidney function-related proteins. MicroRNA (MiR)-33a mimic together with miR-33a inhibitor was transfected into podocytes for determining the roles of miR-33a. Glomerular podocyte apoptosis was determined by terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining along with flow cytometry.

Results: Down-regulation of Nephrin and Podocin and increased podocyte apoptosis rate were observed in the glomerulus of CDN as well as podocytes treated with high glucose. MiR-33a was up regulated in the glomeruli and glucose-treated podocytes. Injury in podocytes was aggravated with miR-33a elevation but alleviated with miR-33a inhibition. Moreover, the expression of Sirtuin 6 (Sirt6) was decreased while the levels of notch receptor 1 (Notch1) and notch receptor 4 (Notch4) were elevated in the glomerulus and glucose-treated podocytes. Decreased level of Sirt6 upon glucose treatment was abrogated by miR-33a inhibition, and the podocytes injury induced by glucose exposure was relieved by Sirt6 via Notch signaling.

Conclusion: These findings indicated that miR-33a promoted podocyte injury via targeting Sirt6-dependent Notch signaling in CDN, which might provide a novel sight for CDN treatment. DOI: 10.52547/ijkd.7904.

导言:糖尿病肾病(DN)是导致终末期肾病的主要原因。我们研究了微RNA miR-33a在诱导儿童糖尿病肾病(CDN)荚膜细胞损伤中的功能:方法:收集 20 名 DN 患儿的肾脏样本。方法:收集 20 名 DN 患儿的肾脏样本,用周期性酸性-Schiff 染色法检测基质沉积和肾小球基底膜厚度。采用免疫荧光染色法评估肾功能相关蛋白。将microRNA (MiR)-33a模拟物和miR-33a抑制剂转染到荚膜细胞中,以确定miR-33a的作用。通过末端脱氧核苷酸转移酶(TdT)dUTP镍末端标记(TUNEL)染色和流式细胞术检测肾小球荚膜细胞凋亡:结果:在 CDN 肾小球和高糖处理的荚膜细胞中观察到 Nephrin 和 Podocin 下调,荚膜细胞凋亡率增加。MiR-33a在肾小球和葡萄糖处理的荚膜细胞中上调。miR-33a 升高会加重荚膜细胞的损伤,而抑制 miR-33a 则会减轻损伤。此外,在肾小球和葡萄糖处理的荚膜细胞中,Sirtuin 6(Sirt6)的表达降低,而缺口受体 1(Notch1)和缺口受体 4(Notch4)的水平升高。葡萄糖处理时 Sirt6 水平的降低被 miR-33a 抑制所逆转,Sirt6 通过 Notch 信号转导缓解了葡萄糖暴露诱导的荚膜损伤:这些研究结果表明,miR-33a通过靶向Sirt6依赖的Notch信号转导促进CDN中荚膜细胞的损伤,这可能为CDN的治疗提供了一个新的视角。DOI: 10.52547/ijkd.7904.
{"title":"MiR-33a Overexpression Exacerbates Diabetic Nephropathy Through Sirt6-dependent Notch Signaling.","authors":"Yingying Wang, Shasha Dai, Jing Yang, Jun Ma, Peng Wang, Xiaowei Zhao, Jua Liu, Ao Xiao, Yahui Song, Lipin Gao","doi":"10.52547/g7kbp983","DOIUrl":"10.52547/g7kbp983","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy (DN) belongs to the major cause of end-stage kidney disease. We probed the functions of a microRNA miR-33a in inducing podocytes injury during childhood  DN (CDN).</p><p><strong>Methods: </strong>Kidney samples were collected from 20 children with DN. Matrix deposition and glomerular basement membranes thickness were examined by periodic acid-Schiff staining. Immunofluorescence staining was performed to assess kidney function-related proteins. MicroRNA (MiR)-33a mimic together with miR-33a inhibitor was transfected into podocytes for determining the roles of miR-33a. Glomerular podocyte apoptosis was determined by terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining along with flow cytometry.</p><p><strong>Results: </strong>Down-regulation of Nephrin and Podocin and increased podocyte apoptosis rate were observed in the glomerulus of CDN as well as podocytes treated with high glucose. MiR-33a was up regulated in the glomeruli and glucose-treated podocytes. Injury in podocytes was aggravated with miR-33a elevation but alleviated with miR-33a inhibition. Moreover, the expression of Sirtuin 6 (Sirt6) was decreased while the levels of notch receptor 1 (Notch1) and notch receptor 4 (Notch4) were elevated in the glomerulus and glucose-treated podocytes. Decreased level of Sirt6 upon glucose treatment was abrogated by miR-33a inhibition, and the podocytes injury induced by glucose exposure was relieved by Sirt6 via Notch signaling.</p><p><strong>Conclusion: </strong>These findings indicated that miR-33a promoted podocyte injury via targeting Sirt6-dependent Notch signaling in CDN, which might provide a novel sight for CDN treatment. DOI: 10.52547/ijkd.7904.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 3","pages":"168-178"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tacrolimus Intrapatient Variability on Graft Outcomes in Adherent Renal Transplantation Patients: A Cross-Sectional Study. 他克莫司对坚持治疗的肾移植患者移植结果的患者内变异性:一项横断面研究
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-05-01 DOI: 10.52547/54drw293
Mohsen Nafar, Sara Keshtkari, Shadi Ziaie, Ahmad Firouzan, Nasrin Borumandnia, Nooshin Dalili, Fatemeh Poorrezagholi, Fariba Samadian, Shiva Samavat

Introduction: Tacrolimus is the mainstem of immunosuppressive therapy in kidney transplant patients. It has high intrapatient variability (Tac-IPV), which has been reported to affect graft function by predisposing patients to rejection or nephrotoxicity. We conducted this study with the aim of assessing the influence of Tac-IPV on 2-year graft function, biopsy-proven rejection, and infections in compliant renal recipients.

Methods: In this single-center retrospective analytic cross-sectional study, 250 patients who underwent transplantation from March 21, 2018, to March 20, 2020 and had at least three outpatient tacrolimus trough levels on the same daily dose 6 to 12 months after transplantation were recruited. Tac-IPV was defined as a coefficient variation of > 15%. Graft function, biopsy-proven rejection, cytomegalovirus (CMV) and BK virus viremia, and calcineurin inhibitor (CNI) toxicity were evaluated.

Results: Of 202 transplant recipients, 128 were included with a mean age of 45.48 ± 13.14 years. The median Tac-IPV was 13.28% with 43.75% of patients with Tac-IPV > 15%. There were no significant differences in graft function, rejection, CNI toxicity, and CMV viremia among the groups during the 24-month study (P > .05).  However, BK viremia was significantly higher among patients with Tac-IPV > 15% (13 vs. 2.9%, P = .042). The risk of antibody mediated rejection alone (22.7 vs. 2.9%) or any kind of rejection (22.7 vs. 11.8%) was significantly higher in patients with higher Tac-IPV, and in those who had mean trough levels below 7 ng/mL (P = .015, .032; respectively).

Conclusion: Tac-IPV is low in adherent patients (with the median of 13.28%) and maintaining tacrolimus trough level above 7 ng/mL can overcome the adverse graft outcome of Tac-IPV in compliant kidney transplant recipients. DOI: 10.52547/ijkd.7815.

简介他克莫司是肾移植患者免疫抑制治疗的主要药物。据报道,它的患者间变异性(Tac-IPV)很高,容易导致患者出现排斥反应或肾毒性,从而影响移植物功能。我们进行这项研究的目的是评估 Tac-IPV 对顺应性肾移植受者 2 年移植物功能、活检证实的排斥反应和感染的影响:在这项单中心回顾性分析横断面研究中,招募了 250 名在 2018 年 3 月 21 日至 2020 年 3 月 20 日期间接受移植手术的患者,这些患者在移植后 6 至 12 个月内至少有三次门诊他克莫司谷值达到相同的日剂量。Tac-IPV的定义是变异系数大于15%。对移植功能、活检证实的排斥反应、巨细胞病毒(CMV)和BK病毒感染以及钙神经蛋白抑制剂(CNI)毒性进行了评估:在 202 名移植受者中,有 128 人接受了治疗,平均年龄(45.48 ± 13.14)岁。中位 Tac-IPV 为 13.28%,43.75% 的患者 Tac-IPV > 15%。在为期 24 个月的研究中,各组间的移植物功能、排斥反应、CNI 毒性和 CMV 病毒血症无明显差异(P > .05)。 然而,Tac-IPV>15%的患者的BK病毒血症明显更高(13% vs. 2.9%,P = .042)。Tac-IPV较高的患者和平均谷值低于7纳克/毫升的患者发生抗体介导的单纯排斥反应(22.7% vs. 2.9%)或任何类型排斥反应(22.7% vs. 11.8%)的风险明显更高(P = .015,.032;分别为.015和.032):结论:依从性患者的 Tac-IPV 较低(中位数为 13.28%),将他克莫司谷值维持在 7 纳克/毫升以上可克服依从性肾移植受者 Tac-IPV 带来的不良移植结果。DOI: 10.52547/ijkd.7815.
{"title":"Tacrolimus Intrapatient Variability on Graft Outcomes in Adherent Renal Transplantation Patients: A Cross-Sectional Study.","authors":"Mohsen Nafar, Sara Keshtkari, Shadi Ziaie, Ahmad Firouzan, Nasrin Borumandnia, Nooshin Dalili, Fatemeh Poorrezagholi, Fariba Samadian, Shiva Samavat","doi":"10.52547/54drw293","DOIUrl":"https://doi.org/10.52547/54drw293","url":null,"abstract":"<p><strong>Introduction: </strong>Tacrolimus is the mainstem of immunosuppressive therapy in kidney transplant patients. It has high intrapatient variability (Tac-IPV), which has been reported to affect graft function by predisposing patients to rejection or nephrotoxicity. We conducted this study with the aim of assessing the influence of Tac-IPV on 2-year graft function, biopsy-proven rejection, and infections in compliant renal recipients.</p><p><strong>Methods: </strong>In this single-center retrospective analytic cross-sectional study, 250 patients who underwent transplantation from March 21, 2018, to March 20, 2020 and had at least three outpatient tacrolimus trough levels on the same daily dose 6 to 12 months after transplantation were recruited. Tac-IPV was defined as a coefficient variation of > 15%. Graft function, biopsy-proven rejection, cytomegalovirus (CMV) and BK virus viremia, and calcineurin inhibitor (CNI) toxicity were evaluated.</p><p><strong>Results: </strong>Of 202 transplant recipients, 128 were included with a mean age of 45.48 ± 13.14 years. The median Tac-IPV was 13.28% with 43.75% of patients with Tac-IPV > 15%. There were no significant differences in graft function, rejection, CNI toxicity, and CMV viremia among the groups during the 24-month study (P > .05).  However, BK viremia was significantly higher among patients with Tac-IPV > 15% (13 vs. 2.9%, P = .042). The risk of antibody mediated rejection alone (22.7 vs. 2.9%) or any kind of rejection (22.7 vs. 11.8%) was significantly higher in patients with higher Tac-IPV, and in those who had mean trough levels below 7 ng/mL (P = .015, .032; respectively).</p><p><strong>Conclusion: </strong>Tac-IPV is low in adherent patients (with the median of 13.28%) and maintaining tacrolimus trough level above 7 ng/mL can overcome the adverse graft outcome of Tac-IPV in compliant kidney transplant recipients. DOI: 10.52547/ijkd.7815.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 3","pages":"187-194"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Research on Acute Kidney Injury: A Bibliometric Analysis of Academic Journals Published Between the Years 2000 and 2022. 急性肾损伤的研究趋势:2000年至2022年出版的学术期刊文献计量分析》。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-05-01 DOI: 10.52547/tvy8jz17
Yunxi Tao, Shenglong Xu, Xuhua Ge

Acute kidney injury (AKI) is a significant global health concern that was first recognized in 2004 and has subsequently affected more than thirteen million individuals each year, resulting in 1.7 million deaths. The present study explored the evolving of the research on AKI worldwide, specifically addressing the analysis of the  trends between the years 2000 and 2022 using the Web of Science Core Collection (WOSCC). CiteSpace software was employed to analyze 19,741 literature sources, which revealed shifts in keyword dynamics from foundational disease research to treatment prognosis and humanistic care. The keyword outbreaks occurred in the years 2004, 2010, and 2019 (i.e., significant occurrences or peaks related  to the specified keyword were observed in the years 2004, 2010, and 2019). The present study highlighted the transition of AKI studies from the initial concerns regarding definitions to further comprehensive inquiries regarding biomarkers, etiology, inductors, prediction, and prognosis. The future research focus could include  the Corona Virus Disease 2019 (COVID-19), machine learning, and continuous renal replacement treatment within the AKI realm. DOI: 10.52547/ijkd.8018.

急性肾损伤(AKI)是全球关注的重大健康问题,2004 年首次被发现,随后每年影响超过 1,300 万人,导致 170 万人死亡。本研究探讨了全球 AKI 研究的发展情况,特别是利用科学网核心数据库(WOSCC)分析了 2000 年至 2022 年间的趋势。研究使用 CiteSpace 软件分析了 19,741 篇文献,发现关键词的动态变化从基础疾病研究到治疗预后和人文关怀。关键词爆发发生在 2004 年、2010 年和 2019 年(即在 2004 年、2010 年和 2019 年观察到与指定关键词相关的显著出现或峰值)。本研究强调了 AKI 研究从最初关注定义到进一步全面探究生物标志物、病因、诱因、预测和预后的转变。未来的研究重点可能包括 AKI 领域的科罗娜病毒病 2019(COVID-19)、机器学习和持续肾脏替代治疗。DOI: 10.52547/ijkd.8018.
{"title":"Trends in Research on Acute Kidney Injury: A Bibliometric Analysis of Academic Journals Published Between the Years 2000 and 2022.","authors":"Yunxi Tao, Shenglong Xu, Xuhua Ge","doi":"10.52547/tvy8jz17","DOIUrl":"https://doi.org/10.52547/tvy8jz17","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a significant global health concern that was first recognized in 2004 and has subsequently affected more than thirteen million individuals each year, resulting in 1.7 million deaths. The present study explored the evolving of the research on AKI worldwide, specifically addressing the analysis of the  trends between the years 2000 and 2022 using the Web of Science Core Collection (WOSCC). CiteSpace software was employed to analyze 19,741 literature sources, which revealed shifts in keyword dynamics from foundational disease research to treatment prognosis and humanistic care. The keyword outbreaks occurred in the years 2004, 2010, and 2019 (i.e., significant occurrences or peaks related  to the specified keyword were observed in the years 2004, 2010, and 2019). The present study highlighted the transition of AKI studies from the initial concerns regarding definitions to further comprehensive inquiries regarding biomarkers, etiology, inductors, prediction, and prognosis. The future research focus could include  the Corona Virus Disease 2019 (COVID-19), machine learning, and continuous renal replacement treatment within the AKI realm. DOI: 10.52547/ijkd.8018.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 3","pages":"137-149"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race. 高级糖化终产物受体基因 G82S 多态性和可溶性血清 RAGE 水平与白种人(亚洲人)糖尿病肾病之间的关系。
IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-05-01 DOI: 10.52547/wngvvr19
Asma Rezaei Arnesa, Sepideh Hajian, Saeede Salemi Bazargani, Iman Salahshourifar, Sahar Moghbelinejad, Zohreh Abdolvahabi, Hayedeh Yaghoobzadeh, Mojtaba Fathi, Hossein Piri

Introduction: Diabetic nephropathy is one of the most common severe symptoms of diabetes mellitus. Hyperglycemia can lead to tissue damage and inflammation due to mediators such as receptor for advanced glycation end-products (RAGE). Therefore, in this study, we aimed to investigate the association between the G82S polymorphism of the RAGE gene and diabetic nephropathy in diabetic patients.

Methods: In this case-control study, 356 participants (158 men and 198 women) of Asian race, aged 45 to 65 years, who were diagnosed with type 2 diabetes mellitus based on their fasting plasma glucose levels were enrolled. DNA was isolated from the participants' blood samples and genotyped using TETRA -Primer ARMS-PCR. Serum protein concentration of soluble RAGE (sRAGE) was also determined by enzyme-linked immunosorbent assay (ELISA).

Results: Although we found differences in genotyping of participants between homozygous AA and GG and heterozygous GA in the studied groups, the differences were not significant (P = .568). In addition, we found no significant correlation between the G82S polymorphism of RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared with diabetic patients (P > .05).

Conclusion: The results of this study indicate no significant association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared to diabetic patients without nephropathy. Therefore, the study suggests that there is probably no association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. DOI: 10.52547/ijkd.7872.

导言:糖尿病肾病是糖尿病最常见的严重症状之一。在高级糖化终产物受体(RAGE)等介质的作用下,高血糖可导致组织损伤和炎症。因此,本研究旨在探讨糖尿病患者 RAGE 基因 G82S 多态性与糖尿病肾病之间的关联:在这项病例对照研究中,我们招募了 356 名根据空腹血浆葡萄糖水平确诊为 2 型糖尿病的亚洲人(男性 158 人,女性 198 人)。从参与者的血样中分离出 DNA,并使用 TETRA -Primer ARMS-PCR 进行基因分型。此外,还通过酶联免疫吸附试验(ELISA)测定了血清中可溶性 RAGE(sRAGE)蛋白的浓度:结果:尽管我们发现在研究组中,参与者的基因分型在同源 AA 和 GG 与异源 GA 之间存在差异,但差异并不显著(P = .568)。此外,我们还发现 RAGE 的 G82S 多态性与糖尿病肾病的发生无明显相关性。与糖尿病患者相比,糖尿病肾病患者血清中的 sRAGE 水平仅略有下降(P > .05):结论:本研究结果表明,RAGE 基因的 G82S 多态性与糖尿病肾病的发生无明显关联。与无肾病的糖尿病患者相比,糖尿病肾病患者血清中的 sRAGE 水平仅略有下降。因此,该研究表明,RAGE 基因的 G82S 多态性与糖尿病肾病的发生可能没有关联。DOI: 10.52547/ijkd.7872.
{"title":"Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race.","authors":"Asma Rezaei Arnesa, Sepideh Hajian, Saeede Salemi Bazargani, Iman Salahshourifar, Sahar Moghbelinejad, Zohreh Abdolvahabi, Hayedeh Yaghoobzadeh, Mojtaba Fathi, Hossein Piri","doi":"10.52547/wngvvr19","DOIUrl":"10.52547/wngvvr19","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy is one of the most common severe symptoms of diabetes mellitus. Hyperglycemia can lead to tissue damage and inflammation due to mediators such as receptor for advanced glycation end-products (RAGE). Therefore, in this study, we aimed to investigate the association between the G82S polymorphism of the RAGE gene and diabetic nephropathy in diabetic patients.</p><p><strong>Methods: </strong>In this case-control study, 356 participants (158 men and 198 women) of Asian race, aged 45 to 65 years, who were diagnosed with type 2 diabetes mellitus based on their fasting plasma glucose levels were enrolled. DNA was isolated from the participants' blood samples and genotyped using TETRA -Primer ARMS-PCR. Serum protein concentration of soluble RAGE (sRAGE) was also determined by enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Although we found differences in genotyping of participants between homozygous AA and GG and heterozygous GA in the studied groups, the differences were not significant (P = .568). In addition, we found no significant correlation between the G82S polymorphism of RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared with diabetic patients (P > .05).</p><p><strong>Conclusion: </strong>The results of this study indicate no significant association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared to diabetic patients without nephropathy. Therefore, the study suggests that there is probably no association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. DOI: 10.52547/ijkd.7872.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 3","pages":"179-186"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Iranian journal of kidney diseases
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1