Pub Date : 2025-12-12DOI: 10.1016/j.jcin.2025.10.058
Chantal Y Asselin,Kostantinos Koulogiannis,Robert Kipperman,John Brown,David Freilich,Linda Gillam,Philippe Généreux,Gennaro Giustino
{"title":"Transseptal BATMAN for Re-Do Valve-in-MAC With Near-Zero Neo-LVOT and Commissural Misalignment.","authors":"Chantal Y Asselin,Kostantinos Koulogiannis,Robert Kipperman,John Brown,David Freilich,Linda Gillam,Philippe Généreux,Gennaro Giustino","doi":"10.1016/j.jcin.2025.10.058","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.10.058","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDTranscatheter tricuspid valve replacement (TTVR) is a promising therapy for tricuspid regurgitation (TR), but comprehensive comparison of clinical outcomes stratified by annular size remains understudied.OBJECTIVESThe aim of this study was to evaluate and compare early outcomes in patients treated with transjugular TTVR stratified by annular size.METHODSPatients with grade ≥3 TR undergoing LuX-Valve Plus TTVR were enrolled across 13 centers from May 2022 to March 2024. They were stratified into a large-annulus group (LAG) (perimeter-derived annular diameter ≥51 mm or maximal annular diameter ≥55 mm) and a small-annulus group (SAG). Early outcomes included device, procedural, or intraprocedural success; TR reduction; and 30-day primary endpoints or clinical success.RESULTSAmong 159 patients, baseline TR severity was greater in the LAG (n = 42) than the SAG (n = 117). Superior trial-defined device or procedural success (81.0% vs 97.4%; P = 0.001) and Tricuspid Valve Academic Research-defined intraprocedural success (78.6% vs 96.6%; P = 0.001) were observed in the SAG. At 30 days, primary endpoint rates were similar (trial defined, 16.7% vs 14.5% [P = 0.936]; TRISCEND II [Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel Device] defined, 21.4% vs 22.2% [P = 1.000]), but Tricuspid Valve Academic Research Consortium clinical success favored the SAG (73.8% vs 94.9%; P = 0.001). Severe paravalvular regurgitation (7.1% vs 0.0%; P = 0.017) occurred only in the LAG, while new-onset third-degree atrioventricular block or pacemaker implantation (0.0% vs 9.4%) was exclusive to the SAG. Severe bleeding was comparable between the groups (14.3% vs 9.4%; P = 0.391).CONCLUSIONSLuX-Valve Plus TTVR appears to be safe and effective in TR patients regardless of annular size, but TR reduction was more significant in the SAG, with specific differences in some major adverse events between groups.
背景：经导管三尖瓣置换术（TTVR）是治疗三尖瓣反流（TR）的一种很有前景的治疗方法，但根据环大小分层的临床结果的综合比较仍有待研究。目的：本研究的目的是评估和比较按环大小分层的经颈静脉TTVR患者的早期预后。方法在2022年5月至2024年3月期间，在13个中心接受LuX-Valve Plus TTVR治疗的≥3级TR患者入组。将患者分为大环组（LAG）和小环组（SAG）。大环组为周源环径≥51 mm或最大环径≥55 mm。早期结果包括器械、手术或术中成功；TR减少;30天的主要终点或临床成功。结果159例患者中，LAG组（n = 42）的基线TR严重程度大于SAG组（n = 117）。在SAG中观察到更好的试验定义的器械或手术成功率（81.0% vs 97.4%, P = 0.001）和三尖瓣学术研究定义的术中成功率（78.6% vs 96.6%, P = 0.001）。30天时，主要终点率相似（试验定义，16.7% vs 14.5% [P = 0.936]； TRISCEND II [Edwards EVOQUE经导管三尖瓣置换术：使用新型装置安全性和临床疗效的关键临床研究]定义，21.4% vs 22.2% [P = 1.000]），但三尖瓣学术研究联盟的临床成功更有利于SAG （73.8% vs 94.9%; P = 0.001）。严重瓣旁反流（7.1% vs 0.0%; P = 0.017）仅发生在LAG，而新发三度房室传导阻滞或起搏器植入（0.0% vs 9.4%）仅发生在SAG。严重出血在两组间具有可比性（14.3% vs 9.4%; P = 0.391）。结论slax - valve + TTVR对TR患者安全有效，与环大小无关，但在SAG中TR减少更为显著，在一些主要不良事件上组间存在特异性差异。
{"title":"Comparison of Early Outcomes Following Transjugular Transcatheter Tricuspid Valve Replacement Between Large vs Small Annulus.","authors":"Fei Chen,Xinyue Yang,Fan Qiao,Yuan Feng,Zhengang Zhao,Xin Wei,Xi Li,Tianyuan Xiong,Yi Zhang,Junbo Ge,Fanglin Lu,Mao Chen","doi":"10.1016/j.jcin.2025.11.013","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.11.013","url":null,"abstract":"BACKGROUNDTranscatheter tricuspid valve replacement (TTVR) is a promising therapy for tricuspid regurgitation (TR), but comprehensive comparison of clinical outcomes stratified by annular size remains understudied.OBJECTIVESThe aim of this study was to evaluate and compare early outcomes in patients treated with transjugular TTVR stratified by annular size.METHODSPatients with grade ≥3 TR undergoing LuX-Valve Plus TTVR were enrolled across 13 centers from May 2022 to March 2024. They were stratified into a large-annulus group (LAG) (perimeter-derived annular diameter ≥51 mm or maximal annular diameter ≥55 mm) and a small-annulus group (SAG). Early outcomes included device, procedural, or intraprocedural success; TR reduction; and 30-day primary endpoints or clinical success.RESULTSAmong 159 patients, baseline TR severity was greater in the LAG (n = 42) than the SAG (n = 117). Superior trial-defined device or procedural success (81.0% vs 97.4%; P = 0.001) and Tricuspid Valve Academic Research-defined intraprocedural success (78.6% vs 96.6%; P = 0.001) were observed in the SAG. At 30 days, primary endpoint rates were similar (trial defined, 16.7% vs 14.5% [P = 0.936]; TRISCEND II [Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel Device] defined, 21.4% vs 22.2% [P = 1.000]), but Tricuspid Valve Academic Research Consortium clinical success favored the SAG (73.8% vs 94.9%; P = 0.001). Severe paravalvular regurgitation (7.1% vs 0.0%; P = 0.017) occurred only in the LAG, while new-onset third-degree atrioventricular block or pacemaker implantation (0.0% vs 9.4%) was exclusive to the SAG. Severe bleeding was comparable between the groups (14.3% vs 9.4%; P = 0.391).CONCLUSIONSLuX-Valve Plus TTVR appears to be safe and effective in TR patients regardless of annular size, but TR reduction was more significant in the SAG, with specific differences in some major adverse events between groups.","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.jcin.2025.11.014
Antonio Mangieri,Francesco Tartaglia
{"title":"TTVR in Large or Small Annuli: The More We Know, the Less We Fear.","authors":"Antonio Mangieri,Francesco Tartaglia","doi":"10.1016/j.jcin.2025.11.014","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.11.014","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.jcin.2025.10.025
Muhammed Gerçek, Felix Rudolph
{"title":"What Can CT Tell Us About Biventricular Function After TTVR That Echocardiography Can’t?","authors":"Muhammed Gerçek, Felix Rudolph","doi":"10.1016/j.jcin.2025.10.025","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.10.025","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.jcin.2025.10.023
Robin Le Ruz, Vratika Agarwal, Isaac George, Jay S. Leb, Mark Lebehn, Michael Brener, Mahesh V. Madhavan, Lauren Ranard, Carolina Pinheiro Rezende, Joanna Bartkowiak, Eun Kyoung Kim, Vivian Ng, Torsten P. Vahl, Tamim Nazif, Martin B. Leon, Susheel K. Kodali, Rebecca T. Hahn
{"title":"Cardiac Remodeling After Transcatheter Tricuspid Valve Replacement","authors":"Robin Le Ruz, Vratika Agarwal, Isaac George, Jay S. Leb, Mark Lebehn, Michael Brener, Mahesh V. Madhavan, Lauren Ranard, Carolina Pinheiro Rezende, Joanna Bartkowiak, Eun Kyoung Kim, Vivian Ng, Torsten P. Vahl, Tamim Nazif, Martin B. Leon, Susheel K. Kodali, Rebecca T. Hahn","doi":"10.1016/j.jcin.2025.10.023","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.10.023","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1016/j.jcin.2025.10.052
Karl Poon, Alexander Incani, Dale Murdoch, Simon Cheung-Chi Lam, Gilbert H.L. Tang, Christopher O. Raffel
{"title":"Coronary anchor wire to facilitate BA-BASILICA for protruding left main stent","authors":"Karl Poon, Alexander Incani, Dale Murdoch, Simon Cheung-Chi Lam, Gilbert H.L. Tang, Christopher O. Raffel","doi":"10.1016/j.jcin.2025.10.052","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.10.052","url":null,"abstract":"","PeriodicalId":14666,"journal":{"name":"JACC: Cardiovascular Interventions","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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