Pub Date : 2018-07-01DOI: 10.1158/1538-7755.DISP17-C45
Samira Khan, Christian R. Alvarado, M. Wirth, N. Shivappa, J. Hébert
Introduction: Chronic inflammation is a risk factor for many chronic diseases. The Dietary Inflammatory Index (DII) is a literature-derived index developed to measure the inflammatory potential of diet. A Children9s Dietary Inflammatory Index (CDII) was developed to understand the association between diet and chronic inflammation-related health outcomes in children. Methods: Food parameters that comprise the CDII include several nutrients like carbohydrates, various vitamins, minerals, and whole foods. To develop a reliable CDII scoring algorithm, aggregate data on children ages 6-14 were obtained from 16 different countries. This forms the basis for a world standard database to which all individuals9 intakes can be standardized. Using this global database, CDII scores were calculated using dietary data from children between 6 and 14 years of age (n=3300) who participated in the U.S. National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Construct validation was performed using linear regression models with CDII as the independent variable and C-reactive protein (CRP) as the outcome. Results: Positive associations were observed between the CDII and CRP (mg/l) (p-value Conclusion: Results indicate that the CDII predicts CRP among children aged 6-14 years. Further validation and analyses using NHANES, as well as other data sets, are required to deepen understanding of inflammation in child health and the CDII in predicting inflammation levels in children. Learning Objectives: Describe how the CDII was created Describe the process of construct validation Discuss the use of CDII as a means for informing primary prevention and for educating physician, parents, and children on the importance of healthy diet to reduce chronic disease rates and to enhance feels of well-being and to improve quality of life. Acknowledgment: All authors received funding from USDA 2016-01022. Citation Format: Samira Khan, Christian Alvarado, Michael Wirth, Nitin Shivappa, James R. Hebert. Development and validation of Children Dietary Inflammatory Index (CDII) [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C45.
慢性炎症是许多慢性疾病的危险因素。饮食炎症指数(Dietary Inflammatory Index, DII)是一种基于文献的指数，用来衡量饮食的炎症潜能。儿童饮食炎症指数(CDII)旨在了解儿童饮食与慢性炎症相关健康结果之间的关系。方法:构成CDII的食物参数包括几种营养素，如碳水化合物、各种维生素、矿物质和天然食物。为了开发可靠的CDII评分算法，从16个不同国家获得了6-14岁儿童的汇总数据。这构成了一个世界标准数据库的基础，所有个人的摄入量都可以标准化。使用这个全球数据库，CDII评分是根据2005年至2010年参加美国国家健康与营养检查调查(NHANES)的6至14岁儿童(n=3300)的饮食数据计算的。采用线性回归模型进行结构验证，CDII为自变量，c反应蛋白(CRP)为结果。结果:CDII与CRP (mg/l)呈正相关(p值)。结论:CDII可预测6-14岁儿童CRP。需要使用NHANES以及其他数据集进一步验证和分析，以加深对儿童健康中的炎症和CDII预测儿童炎症水平的理解。学习目标:描述CDII是如何创建的描述结构验证的过程讨论CDII作为告知初级预防和教育医生、家长和儿童健康饮食的重要性的一种手段，以减少慢性疾病的发病率，增强幸福感和提高生活质量。致谢:所有作者都获得了美国农业部2016-01022的资助。引文格式:Samira Khan, Christian Alvarado, Michael Wirth, Nitin Shivappa, James R. Hebert。儿童膳食炎症指数(CDII)的建立与验证[摘要]。见:第十届AACR会议论文集:种族/少数民族和医疗服务不足人群的癌症健康差异科学;2017年9月25-28日;亚特兰大,乔治亚州。费城(PA): AACR;癌症流行病学杂志，2018;27(7增刊):摘要nr C45。
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